Abstract:
BACKGROUND:Erythromycin has recently been found to be a gastrointestinal prokinetic agent in humans. Acute hyperglycaemia has been associated with delayed gastric emptying in both healthy controls and diabetic patients. Our aim was to investigate in gastroparetic patients (diabetics and idiopathics) whether hyperglycaemia, per se, reduces gastric motility during erythromycin-induced acceleration of gastric emptying of solids. METHODS:In 12 gastroparetic patients, 6 diabetics and 6 idiopathics, gastric emptying of solids was measured scintigraphically after giving placebo in normoglycaemia (5-8.9 mmol/l glucose) or 200 mg erythromycin lactobionate intravenously in normo- or hyperglycaemia (16-19 mmol/l glucose) induced by intravenous glucose infusion in random order on separate days. RESULTS:Erythromycin in normoglycaemia accelerated solids gastric emptying compared with placebo in all patients by abolishing the lag-phase duration and by decreasing the retained percentage of a meal in the stomach at 120 and 150 min (14.5% +/- 5.3% versus 88.4% +/- 10.6% and 3.5% +/- 2.1% versus 70.1% +/- 15.4%, respectively) (P < 0.001). The retained isotopic percentage in the stomach after erythromycin in induced hyperglycaemia compared with erythromycin in normoglycaemia, at 120 and 150 min, was increased (51.9% +/- 9.8% versus 14.5% +/- 5.3%, and 24.5% +/- 5.9% versus 3.5% +/- 2.1%, respectively) (P < 0.001) but was decreased in comparison with placebo (P < 0.001). A significantly increased percentage of isotope was retained in the stomach of the diabetic patients at 120 and 150 min, compared with the idiopathics, only after giving erythromycin in the hyperglycaemic condition (57.6% +/- 8.7% versus 46.1% +/- 7.6% (P = 0.036) and 27.8% +/- 5.7% versus 21.1 +/- 4.4% (P = 0.040), respectively). CONCLUSIONS:Hyperglycaemia attenuates erythromycin-induced acceleration of solid-phase gastric emptying in idiopathic and diabetic gastroparesis and increases the retained isotopic meal in the stomach. Hyperglycaemia reduces gastric motility more in the diabetic patients with gastroparesis than in idiopathic patients.
journal_name
Scand J Gastroenteroljournal_title
Scandinavian journal of gastroenterologyauthors
Petrakis IE,Vrachassotakis N,Sciacca V,Vassilakis SI,Chalkiadakis Gdoi
10.1080/003655299750026416subject
Has Abstractpub_date
1999-04-01 00:00:00pages
396-403issue
4eissn
0036-5521issn
1502-7708journal_volume
34pub_type
临床试验,杂志文章,随机对照试验abstract::Five cats were provided with a gastric fistula (GF) and a Heidenhain pouch (HP), and the proximal small intestine was excluded and provided with a duodenal fistula. A protein-rich meal, introduced into the duodenum (duodenal feeding) caused no serum gastrin increase, which supports our previous conclusion that duodena...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract::OBJECTIVE. Although precut is considered an useful alternative when standard methods of biliary access have failed, there is some controversy about it's safety. The study aim was to evaluate the effectiveness of needle-knife fistulotomy (NKF) after a difficult biliary cannulation and whether common bile duct (CBD) dia...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365521.2014.898085
更新日期:2014-06-01 00:00:00
abstract::Of 120 patients who were investigated for moderately elevated liver function tests as the only sign of liver disease, 6 young persons had alpha-1-antitrypsin (AAT) deficiency. Three had a homozygous (Pi ZZ) and three had a heterozygous (Pi MZ) AAT deficiency as measured with isoelectric focusing. An extensive investig...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:
更新日期:1984-05-01 00:00:00
abstract::Forty-five rats were divided into four groups according to type of operation: 1) end-to-side jejunoileal bypass (ES), 10 rats; 2) end-to-end jejunoileal bypass (EE), 10 rats; 3) jejunoileal resection (R), 10 rats; and 4) no operation, 15 rats. The luminal contents from the proximal jejunum and distal ileum, in groups ...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528309181648
更新日期:1983-07-01 00:00:00
abstract::Objectives: Autoimmune pancreatitis (AIP) sometimes becomes complicated with pancreatic cysts, although their detailed characteristics and management strategy have not been fully determined. We aimed to clarify the efficiency of steroid therapy and the risk factors for cyst formation and cyst-related complications. Me...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365521.2019.1623307
更新日期:2019-06-01 00:00:00
abstract::The metabolism of cyclic AMP and HCl secretion has been studied in eight healthy volunteers, in eight duodenal ulcer (DU) patients, and in four pernicious anaemia patients. Pentagastrin showed a tendency to increase adenylate cyclase and cyclic nucleotide phosphodiesterase activities in the fundal mucosa and caused a ...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528809090165
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND AND AIM:If patients with surgically resectable colorectal cancershave synchronous colorectal neoplasms that are difficult to remove by endoscopic mucosal resection, preemptive endoscopic submucosal dissection (ESD) can avoid excessive colorectal resection. The aim of this study was to evaluate the efficacy o...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365521.2020.1792542
更新日期:2020-08-01 00:00:00
abstract::[3H]retinal- or [3h]cholesterol- and [14C]fatty acid-labeled chylomicrons and chylomicron remnants were injected intravenously into normal rats and rats subjected to partial or total obstruction of the bile duct 8 or 48 h earlier. The clearance from plasma of the [3H]retinyl and the [3H]cholesteryl esters in 30-120 mi...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528009181798
更新日期:1980-01-01 00:00:00
abstract::The bone mineral content estimated by gamma ray attenuation method, serum calcium, phosphorus, alkaline phosphatase, and protein was examined in three types of patients with peptic ulcer. The bone mineral content in ulcer patients before surgery did not differ from that of the control series. In patients subjected to ...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
abstract:OBJECTIVE:Coeliac disease (CD) is associated with HLA-DQ2 and DQ8. The clinical picture is variable and certain human leucocyte antigen (HLA) DQ/DR combinations have a higher relative risk (RR) for CD than others. Moreover, the HLA-DQ gene-dose effect has an impact on the strength of the gluten-specific T-cell response...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520802116422
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The aim of the present investigation was to study gastric acid secretion and release of gastrin, cholecystokinin (CCK), and secretin during intraduodenal perfusion of either fish oil or trioleate. METHODS:Seven healthy volunteers were stimulated on two separate days in random order with intraduodenal perfus...
journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/003655299750025282
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Different concentrations of immunoglobulin G (IgG) subclass-producing cells in the mucosa of patients with ulcerative colitis and Crohn's disease have previously been described. METHODS:To evaluate serum concentration of IgG subclasses as a tool for diagnosis and disease activity in chronic inflammatory bow...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365529509093235
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:The hydrolysis of long-chain alkanoylcholines, presumably catalyzed by butyryl-cholinesterase (EC 3.1.1.8), in rat intestinal loops was studied. The substances have earlier been found to be rapidly degraded in vitro. METHODS:Radiolabeled substrates were used, and a radiochromatographic detection method was ...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365529509096311
更新日期:1995-07-01 00:00:00
abstract:OBJECTIVE:There is no consensus regarding the best treatment for intestinal follicular lymphoma (FL). We used "watch and wait" for patients with intestinal FL with low-tumor-burden (LTB) criteria and without mass formation causing bowel obstruction. We investigated the overall survival (OS) and time to treatment requir...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365521.2015.1087589
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:Gastric contents empty from the stomach despite frequent changes in body position. The mechanism that maintains gastric emptying independent of position is poorly understood. The aim of this study was to determine the effects of body position on gastric emptying and motor function. MATERIAL AND METHODS:Twelv...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520600610451
更新日期:2006-10-01 00:00:00
abstract::Histamine was given intravenously to eight human subjects, and the PP concentration in serum increased significantly from 14.8 (7.2-29.3) pM to 27.5 (9.6-39.3) pM and then decreased to the basal level. This histamine-induced PP release was not altered when trimipramine or cimetidine was given in addition to histamine....
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528109181016
更新日期:1981-01-01 00:00:00
abstract:AIM:To investigate inflammatory bowel disease (IBD) register-based subtype classifications over a patient's disease course and over time. METHODS:We examined International Classification of Diseases coding in patients with ≥2 IBD diagnostic listings in the National Patient Register 2002-2014 (n = 44,302). RESULTS:18%...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365521.2018.1564361
更新日期:2019-01-01 00:00:00
abstract::During the period 1 January 1980 to 30 June 1986, a total of 543 small-intestinal biopsy specimens from adults with gastrointestinal symptoms were available for routine analysis with correlated scanning electron microscopy and light microscopy. Adhesion of microorganisms was found in 77 biopsy specimens. Microorganism...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528909089229
更新日期:1989-09-01 00:00:00
abstract::Six pigs (49-69 kg) were anaesthetized and fitted with cannulas in the brachiocephalic artery and portal and jugular veins. In addition, inlet-outlet perfusion cannulas were placed in segments of the small and large intestine. Intravenous infusion of urea for 2 h increased arterial plasma urea from a base-line level o...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365529209000129
更新日期:1992-07-01 00:00:00
abstract:OBJECTIVE:Endoscopic mucosal ablation is a promising technique that is used to treat dysplastic Barrett's oesophagus. The purpose of this study was to investigate the efficacy and cost-effectiveness of two promising techniques, argon plasma coagulation (APC) and photodynamic therapy (PDT), in the ablation of dysplastic...
journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/00365520510015737
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Adenocarcinomas of the small and the large intestine share risk factors and morphological features but both tumor types seem to follow different genetic pathways. The aim of this study on small intestinal carcinomas was to analyze alternative mechanisms of activation of pathways that are typically affected i...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520410005847
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:The potential role of superantigens in inflammatory bowel disease (IBD), particularly Crohn disease, has been broached in studies of the functions of T cell receptors. Staphylococcal cells have been found in intestinal lymph follicles of IBDs. To clarify a role of staphylococcal superantigens in IBD, we atte...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/003655201750163079
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVES:Nonalcoholic steatohepatitis (NASH), which is a common and increasing indication for liver transplantation (LT), is known to recur after LT. Since the recurrence of NASH can lead to graft failure, the identification of predictive factors is needed and preventive strategies should be implemented. METHODS:We ...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365521.2019.1577484
更新日期:2019-02-01 00:00:00
abstract::A crude 7alpha-hydroxysteroid dehydrogenase isolate from P. testosteroni requires NADP specifically and provides a simple and specific means for the determination of 7alpha-hydroxy bile acids and their conjugates. A specific and reliable enzymatic-fluorimetric method for the quantitative measurement of the primary bil...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365527709181685
更新日期:1977-01-01 00:00:00
abstract:OBJECTIVE:Intestinal microbiota is important in health and disease. The aim of this study was to evaluate the effect of fructo-oligosaccharides (FOS) and fibre-enriched tube feeding on quality of life and intestinal microbiota (faecal Bifidobacteria). MATERIAL AND METHODS:Nineteen out of 59 home-living, tube-feeding-d...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1080/00365520902839675
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Earlier studies identified a pylorocardial expansion of chronic gastritis. We investigated the age-dependent changes in grading and topography of Helicobacter pylori gastritis. METHODS:Antral, corpus, and cardial biopsy specimens from 216 H. pylori-positive patients with no peptic ulcer disease (PUD), malig...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365529950172989
更新日期:1999-02-01 00:00:00
abstract::Vasoactive intestinal polypeptide (VIP) has powerful vasodilating effects, shown by a striking conductance increase especially in the vertebral artery (+100%), the left descending coronary artery (+200%), the left gastric artery (+550%), the superior pancreaticoduodenal artery (+200%), and the gastroduodenal artery (+...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528309182091
更新日期:1983-09-01 00:00:00
abstract:BACKGROUND:Early observational studies of endoscopic treatment and extracorporeal shock wave lithotripsy (ESWL) reported considerable or complete relief of pain in 50%-80% of patients with chronic pancreatitis. There is no consensus on the measurement of pain, making comparison of observational studies difficult, and l...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520310000663a
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVES:Intraoperative colonoscopy (IC) is routinely used in colorectal surgery procedures, both oncologic and benign ones. Despite its extensive use there is a lack of literature addressing this important issue. The aims of this paper are to determine the contributions of this tool, especially considering changes i...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365521.2017.1362465
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:It has already been demonstrated that the rat esophagus produces retinoic acid from retinol. In this study, this process is further characterized and the effect of acetaldehyde examined to elucidate the possible mechanisms behind the epidemiological evidence that the incidence of esophageal cancer is higher i...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520510023936
更新日期:2006-01-01 00:00:00