The role of "watch and wait" in intestinal follicular lymphoma in rituximab era.

Abstract:

OBJECTIVE:There is no consensus regarding the best treatment for intestinal follicular lymphoma (FL). We used "watch and wait" for patients with intestinal FL with low-tumor-burden (LTB) criteria and without mass formation causing bowel obstruction. We investigated the overall survival (OS) and time to treatment required (TTR). METHODS:Thirty-three intestinal FL patients [clinical stage (CS) I:16, II1:0, II2:7, IV:10; median observation period: 45.5 months, range: 13-110 months] were diagnosed via endoscopy. Detailed clinical and pathological examinations were performed, and neoplastic process behavior was monitored. RESULTS:All of the 33 patients were WHO grade 1. FL lesions in the digestive tract were found frequently in the second-fourth portion of the duodenum in 91% of the patients; 87% of those patients had lesions in a broader area including the small intestine. Two patients had an enlargement of the area of the lesions and a worsening of the macroscopic findings. Three patients had CS progression; however, these remained within the indication for "watch and wait." Two patients with transformation into diffuse large B-cell lymphoma received rituximab and chemotherapy, which led to complete remission. The OS was 100%. The time to treatment required (TTR) was 49 months in one patient and 37 months in one patient. CONCLUSION:Intestinal FL in CS I-IV with broad infiltration of the digestive tract meeting the criteria for LTB had a remarkably slow course. This study suggests that "watch and wait" is appropriate for the treatment of LTB intestinal FL even in the era of rituximab.

journal_name

Scand J Gastroenterol

authors

Tari A,Asaoku H,Takata K,Fujimori S,Tanaka S,Fujihara M,Koga T,Yoshino T

doi

10.3109/00365521.2015.1087589

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

321-8

issue

3

eissn

0036-5521

issn

1502-7708

journal_volume

51

pub_type

杂志文章
  • High anti-TNF alfa drugs trough levels are not associated with the occurrence of adverse events in patients with inflammatory bowel disease.

    abstract::Objectives: Up to 40% of inflammatory bowel disease (IBD) patients treated with anti-TNF drugs lose response within 1 year of treatment, therefore requiring drug optimization. Although higher drug trough levels (TLs) are associated with sustained clinical outcomes, there are concerns that they may be associated with a...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1666914

    authors: Bodini G,Demarzo MG,Saracco M,Coppo C,De Maria C,Baldissarro I,Savarino E,Savarino V,Giannini EG

    更新日期:2019-10-01 00:00:00

  • Effect of omeprazole, a substituted benzimidazole, on 24-h intragastric acidity in patients with peptic ulcer disease.

    abstract::Intragastric pH was measured during physiological conditions over 24-h periods in patients with peptic ulcer disease. After single oral doses of 20, 40, and 80 mg omeprazole we found a dose-dependent reduction in mean intragastric acidity ranging from 38% to 99%. After treatment for 1 week with omeprazole, 40 mg daily...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Naesdal J,Bodemar G,Walan A

    更新日期:1984-10-01 00:00:00

  • Human galanin modulates human colonic motility in vitro. Characterization of structural requirements.

    abstract:BACKGROUND:Human galanin (hGal) is a 30-residue non-amidated gut-brain peptide that shows considerable sequence divergence compared with galanin (Gal) forms of other species. Conflicting results have been reported with regard to the structural requirements for its modulatory action on gut motility. METHODS:We investig...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529609006763

    authors: Katsoulis S,Clemens A,Morys-Wortmann C,Schwörer H,Schaube H,Klomp HJ,Fölsch UR,Schmidt WE

    更新日期:1996-05-01 00:00:00

  • Plasma kinetics and biliary excretion of colchicine in patients with chronic liver disease after oral administration of a single dose and after long-term treatment.

    abstract::Plasma kinetics and biliary excretion of colchicine in patients with chronic liver disease were evaluated after oral administration of a single dose and after long-term treatment. A single oral dose of 1 mg colchicine led to a mean peak concentration of 3.60 +/- 1.04 ng/ml at a peak time of 2.16 +/- 0.34 h and a mean ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529409094847

    authors: Rudi J,Raedsch R,Gerteis C,Schlenker T,Plachky J,Walter-Sack I,Sabouraud A,Scherrmann JM,Kommerell B

    更新日期:1994-04-01 00:00:00

  • Food-stimulated gastroesophageal sphincter pressure in patients with abnormal duodenal loop compared with controls.

    abstract::The gastroesophageal sphincter pressure (GESP) was studied before, during, and after food intake in nine patients with abnormal duodenal loop (AD), six patients with a normal duodenum (controls), and seven healthy volunteers. In normal and control subjects a significant increase in GESP was observed during food intake...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528109182007

    authors: Funch-Jensen P,Oster MJ,Thommesen P

    更新日期:1981-01-01 00:00:00

  • Candidate mucosal and surrogate biomarkers of inflammatory bowel disease in the era of new technology.

    abstract:OBJECTIVE:There is increasing knowledge of the pathophysiology behind inflammatory bowel disease (IBD) although the exact mechanism is far from fully understood. In the era of new technology, over the last years molecular approaches have shed light on the inflammatory mechanisms and their metabolic end products. This o...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3109/00365521.2011.627449

    authors: Florholmen J,Fries W

    更新日期:2011-12-01 00:00:00

  • Clinicopathological characteristics of biliary neuroendocrine neoplasms: a multicenter study.

    abstract:OBJECTIVES:This study assessed the clinicopathological features, therapeutic approaches, and prognosis of patients with biliary neuroendocrine neoplasm (NENs). MATERIALS AND METHODS:Multicenter retrospective study of patients with biliary tract NENs in the gallbladder, the extrahepatic bile duct, or the ampulla of Vat...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1080/00365521.2016.1261938

    authors: Lee KJ,Cho JH,Lee SH,Lee KH,Park BK,Lee JK,Woo SM,Ryu JK,Lee JK,Kim YS,Kim JW,Lee WJ

    更新日期:2017-04-01 00:00:00

  • Health care costs associated with Australian tertiary inflammatory bowel disease care.

    abstract:INTRODUCTION:We aimed to describe the total costs of illness for IBD patients and compare the costs of patients with active disease to those with inactive disease. MATERIALS AND METHODS:Resource use for IBD management was itemized for attributable costs (AUD) among all IBD patients over a 12-month period at an Austral...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2017.1323117

    authors: Jackson B,Con D,Ma R,Gorelik A,Liew D,De Cruz P

    更新日期:2017-08-01 00:00:00

  • Differences in the intrinsic capacity of peripheral blood mononuclear cells to produce tumor necrosis factor alpha and beta in patients with inflammatory bowel disease and healthy controls.

    abstract:BACKGROUND:Tumor necrosis factor alpha (TNF alpha) and beta (TNF beta) appear to play an important role in the regulation of the inflammatory response. The aim of the present study was to investigate the intrinsic capacity of peripheral blood mononuclear cells (PBMC) to produce these cytokines. METHODS:PBMC from 41 pa...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529509101613

    authors: Bouma G,Oudkerk Pool M,Scharenberg JG,Kolkman JJ,von Blomberg BM,Scheper RJ,Meuwissen SG,Peña AS

    更新日期:1995-11-01 00:00:00

  • Effect of mental stress and cisapride on autonomic nerve functions in functional dyspepsia.

    abstract:BACKGROUND:Disordered autonomic nerve function is frequently present in patients with functional dyspepsia (FD). In this study we investigated whether the prokinetic cisapride, which acts via acetylcholine receptors, and stress may modulate these abnormalities. METHODS:Nineteen patients (6 men, 13 women) with FD and 1...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1080/00365529850166824

    authors: Hveem K,Svebak S,Hausken T,Berstad A

    更新日期:1998-02-01 00:00:00

  • Low circulating insulin-like growth factor I in coeliac disease and its relation to bone mineral density.

    abstract:BACKGROUND:Patients with coeliac disease have low bone mineral density (BMD), but the underlying mechanisms are unclear. Our aim was to study circulating insulin-like growth factor I (IGF-I) and its possible relationship to BMD in adults with untreated coeliac disease and after 1 year on a gluten-free diet. METHODS:In...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655299750025381

    authors: Valdimarsson T,Arnqvist HJ,Toss G,Järnerot G,Nyström F,Ström M

    更新日期:1999-09-01 00:00:00

  • Adaptive protection related to clearance of ethanol in gastric mucosa of cats.

    abstract::This study was designed to test the hypothesis that hyperemia after exposure to 2 M NaCl protects the gastric mucosa against damage caused by absolute ethanol by removing ethanol diffusing from the gastric lumen into the mucosa. The stomach of anesthetized cats was perfused with saline at pH 1.0. Gastric mucosal blood...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529309090257

    authors: Gislason H,Herfjord JK,Guttu K,Grong K,Grønbech JE,Ulvik R,Svanes K

    更新日期:1993-04-01 00:00:00

  • Esophageal foreign bodies in adults: systematic review of the literature.

    abstract:OBJECTIVE:Esophageal Foreign Body (FB) impaction represents a major challenge for healthcare providers. Aim of this systematic review was to analyse the current literature evidence on prevalence, presentation, treatment, and outcomes of impacted esophageal FB. MATERIALS AND METHODS:Literature search was conducted betw...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2018.1526317

    authors: Aiolfi A,Ferrari D,Riva CG,Toti F,Bonitta G,Bonavina L

    更新日期:2018-01-01 00:00:00

  • Effects of intraduodenal acid on gallbladder net water absorption and motility in the cat.

    abstract::A recently described perfusion technique has been used in the study of gallbladder function during acid infusion into the duodenum in the anaesthetized cat. The method allows simultaneous measurements of the net water absorption, and thereby the concentrating function of the gallbladder, as well as the motility of the...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527809181750

    authors: Jansson R

    更新日期:1978-01-01 00:00:00

  • The impact of atopic disease on the risk of post-infectious fatigue and irritable bowel syndrome 3 years after Giardia infection. A historic cohort study.

    abstract:OBJECTIVE:To investigate whether atopic disease influences the prevalence of irritable bowel syndrome (IBS) and chronic fatigue (CF) after giardiasis. METHODS:A questionnaire was sent to all confirmed cases of giardiasis after a Norwegian outbreak, with response rate of 65.3% (817/1252). Controls were randomly selecte...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2012.696681

    authors: Hunskar GS,Langeland N,Wensaas KA,Hanevik K,Eide GE,Mørch K,Rortveit G

    更新日期:2012-09-01 00:00:00

  • Propranolol in prevention of rebleeding from oesophageal varices during the course of endoscopic sclerotherapy.

    abstract::Thirty-one patients admitted with the first bleeding episode from oesophageal varices were randomized in a double-blind manner to receive oral propranolol, 160 mg daily, for 6 months (n = 15) or matching placebo (n = 16) for the same period. Endoscopy was performed each month during the 6 months and additionally after...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528909093057

    authors: Jensen LS,Krarup N

    更新日期:1989-04-01 00:00:00

  • Evaluation of preoperative prognostic factors in patients with resectable pancreatic ductal adenocarcinoma.

    abstract::Objective: Upfront surgery is the standard treatment for resectable pancreatic ductal adenocarcinomas (R-PDACs); however, these tumors often recur. We investigated the factors governing recurrence and prognosis in patients with R-PDAC. Methods: We analyzed 359 patients who underwent upfront surgery for R-PDAC between ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1624816

    authors: Izumo W,Higuchi R,Furukawa T,Yazawa T,Uemura S,Shiihara M,Yamamoto M

    更新日期:2019-06-01 00:00:00

  • Incidence and prevalence of adult coeliac disease within a defined geographic area in Denmark.

    abstract:BACKGROUND:In childhood coeliac disease highly varying incidence rates have recently been disclosed. Very low incidence rates (0.09/1000) were found in Denmark, in contrast to our neighbouring country Sweden (2.93/1000). Whether this was accounted for by the diagnosis being delayed until adult life was unknown. No stud...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529609009152

    authors: Bodé S,Gudmand-Høyer E

    更新日期:1996-07-01 00:00:00

  • High incidence of extrapancreatic carcinoma in chronic pancreatitis.

    abstract::In the prospective clinical long-term study of 246 patients with chronic pancreatitis, 26 patients (24 men) developed 27 histologically proved malignant tumors (11%). Four additional patients with neoplasia were excluded (papilloma, two; Bowen's disease of the tonsils, one; and seminoma, one, occurring 8 years before ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528009181490

    authors: Ammann RW,Knoblauch M,Möhr P,Deyhle P,Largiadèr F,Akovbiantz A,Schüler G,Schneider J

    更新日期:1980-01-01 00:00:00

  • Normalization of mucosal cytokine gene expression levels predicts long-term remission after discontinuation of anti-TNF therapy in Crohn's disease.

    abstract:OBJECTIVE:To investigate mucosal cytokine gene expression levels in healed mucosa after anti-tumor necrosis factor (TNF) therapy in patients with Crohn's disease (CD) as possible risk factors for relapse after discontinuation of therapy. DESIGN:Thirty-seven CD patients treated with anti-TNF agents until complete mucos...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2012.758773

    authors: Rismo R,Olsen T,Cui G,Paulssen EJ,Christiansen I,Johnsen K,Florholmen J,Goll R

    更新日期:2013-03-01 00:00:00

  • The effect of acetaldehyde on pancreatic and gastric secretion.

    abstract::To ascertain whether any of the well-known effects of intravenous ethanol on pancreatic and gastric secretion could be due to its metabolite--acetaldehyde, a strong cytotoxic and sympathomimetic agent--acetaldehyde was given intravenously for 1 h (50, 100, and 200 mg/kg/h) in seven dogs. Acetaldehyde did not modify pa...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528009181534

    authors: Andersen BN,Demol P,Treffot MJ,Sarles H

    更新日期:1980-01-01 00:00:00

  • Validation of microdialysis probes for studying nitrosative chemistry within localized regions of the human upper gastrointestinal tract.

    abstract:BACKGROUND:We have examined the suitability of microdialysis probes for examining nitrosative chemistry within localized regions of the lumen of the gastrointestinal tract. Chemical nitrosation occurs maximally at pH 2.5 in the presence of nitrite and thiocyanate and absence of ascorbic acid. Nitrite and thiocyanate ar...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520310004119

    authors: Suzuki H,Moriya A,Iijima K,McElroy K,Fyfe VE,McColl KE

    更新日期:2003-08-01 00:00:00

  • Intestinal bypass. Bacteriological studies from different parts of the small intestine in rats.

    abstract::Forty-five rats were divided into four groups according to type of operation: 1) end-to-side jejunoileal bypass (ES), 10 rats; 2) end-to-end jejunoileal bypass (EE), 10 rats; 3) jejunoileal resection (R), 10 rats; and 4) no operation, 15 rats. The luminal contents from the proximal jejunum and distal ileum, in groups ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528309181648

    authors: Viddal KO,Midtvedt T,Nygaard K

    更新日期:1983-07-01 00:00:00

  • Fish oil reduces gastric acid secretion.

    abstract:BACKGROUND:The aim of the present investigation was to study gastric acid secretion and release of gastrin, cholecystokinin (CCK), and secretin during intraduodenal perfusion of either fish oil or trioleate. METHODS:Seven healthy volunteers were stimulated on two separate days in random order with intraduodenal perfus...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1080/003655299750025282

    authors: Riber C,Wøjdemann M,Bisgaard T,Ingels H,Rehfeld JF,Olsen O

    更新日期:1999-09-01 00:00:00

  • Cardiovascular risk factors in obese patients treated with jejunoileal bypass operation: a 25-year follow-up study.

    abstract:OBJECTIVE:Jejunoileal (JI) bypass was a widely performed surgical procedure for morbid obesity in the 1970s. The purpose of this study was to assess cardiovascular risk factors and mortality in patients 25 years or more after this operation. MATERIAL AND METHODS:All (n = 36) patients operated on for obesity with JI by...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520410009393

    authors: Våge V,Berstad A,Solhaug JH,Viste A

    更新日期:2005-01-01 00:00:00

  • Effects of omeprazole in duodenal ulcer patients.

    abstract::The efficacy of and tolerance to omeprazole, 40 mg/day, was studied in an open-label study in 18 patients with endoscopically verified duodenal ulcers. The effects of the drug on the oxyntic mucosa and pentagastrin-stimulated acid secretion during and after treatment were also studied. Fifteen patients completed the f...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3109/00365528609015161

    authors: Karvonen AL,Keyriläinen O,Uusitalo A,Salaspuro M,Tarpila S,Andrén K,Helander HF

    更新日期:1986-05-01 00:00:00

  • Response to an extra dose of hepatitis B vaccine and specific antibody persistence in non-responders to primary immunization.

    abstract:BACKGROUND:In a campaign to vaccinate health care workers, a three-dose schedule (0, 1, and 6 months) and a four-dose schedule (0, 1, 2, and 14 months) with hepatitis B (HB) vaccine were used. After primary immunization 26 subjects vaccinated with the 3-dose schedule and 4 subjects vaccinated with the 4-dose schedule h...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529509089796

    authors: Chiaramonte M,Ngatchu T,Majori S,Baldo V,Moschen ME,Renzulli G,Trivello R

    更新日期:1995-06-01 00:00:00

  • Availability of energy substrates during liver regeneration in malnourished rats.

    abstract::A retarded liver regeneration rate during malnutrition has previously been reported. To explore the mechanisms, some energy substrates were studied during liver regeneration and malnutrition. Forty-one rats were allocated to one of three groups (G): GI were normally nourished rats, which were partially hepatectomized;...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529108998607

    authors: Skullman S,Ihse I,Larsson J

    更新日期:1991-11-01 00:00:00

  • p21/waf1/cip1 in gastric cancer: associations with histopathological subtypes, lymphonodal metastasis, prognosis and p53 status.

    abstract:BACKGROUND:Cyclins and cyclin-dependent kinases are determining factors of the cell cycle. In the present study, we investigated the role of p21 and p53 in the biology of gastric cancer, focusing on its influence on progression and prognosis (n = 195). METHODS:P21 and p53 immunoreactivity was analysed immunohistochemi...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655201750305512

    authors: Baldus SE,Schneider PM,Mönig SP,Zirbes TK,Fromm S,Meyer W,Glossmann J,Schüler S,Thiele J,Hölscher AH,Dienes HP

    更新日期:2001-09-01 00:00:00

  • Health-related quality of life after ileal J-pouch-anal anastomosis for ulcerative colitis: long-term results.

    abstract:BACKGROUND:This questionnaire study examined associations between health-related quality of life and long-term follow-up results with J-pouch anal anastomosis for ulcerative colitis. METHODS:A two-part questionnaire was sent to patients treated for ulcerative colitis by handsewn J-pouch-anal anastomosis at our institu...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655299750026065

    authors: Tiainen J,Matikainen M

    更新日期:1999-06-01 00:00:00