Release of vasoactive intestinal polypeptide (VIP) by intraduodenal stimuli.

Abstract:

:The effect of intraduodenal infusion of amino acids, glucose, fat, HCl, ethanol, or saline on plasma VIP concentration was investigated in 7 normal subjects, 5 post-vagotomy patients, and 12 anaesthetized pigs. Furthermore, the concentrations of VIP in plasma after ingestion of a mixed meal were measured in 6 normal subjects. In normal subjects the median peripheral concentration of VIP in the basal state was 4.3 pmol X I-1 (range 0--12.0). No significant changes occurred after amino acids, glucose, saline, or ingestion of a meal. In contrast infusion of HCl, fat, or ethanol resulted in a rise in plasma VIP concentration in all the subjects studied. The peak values (medians and ranges) after HCl, fat, or ethanol were 9.8 (5.9--12.6), 7.5 (2.4--10.2), and 12.6 (7.8--16.8)pmol X I-1, respectively. Truncal vagotomy did not change the response of HCl. The results from measurements in portal plasma of pigs confirmed the findings in peripheral plasma of normal subjects and showed that the levels of VIP in portal plasma are 1.6--2.9 times higher than the levels of VIP in arterial plasma. The pH threshold to release of VIP was pH 1.1--2.1, and the effect of HCl was not abolished by ganglionic blockade.

journal_name

Scand J Gastroenterol

authors

Schaffalitzky de Muckadell OB,Fahrenkrug J,Holst JJ,Lauritsen KB

doi

10.3109/00365527709181722

subject

Has Abstract

pub_date

1977-01-01 00:00:00

pages

793-9

issue

7

eissn

0036-5521

issn

1502-7708

journal_volume

12

pub_type

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