Liver function in asymptomatic adult individuals with severe alpha1-antitrypsin deficiency (Pi Z).

Abstract:

:Eleven adult individuals (aged 24 to 66 years) with severe alpha1-antitrypsin deficiency, Pi Z, and with no clinical signs of liver disease, were investigated with a broad spectrum of liver function tests. Except for low alpha1-antitrypsin levels, no evidence of abnormal hepatic protein synthesis was found. Neither could any biochemical signs of liver cell necrosis or increased liver cell regeneration be disclosed. In spite of the well-known pronounced distension of hepatic endoplasmic reticulum (E.R.) by aggregated asialo-alpha1-antitrypsin in this disease, the function of the E.R. tested with the aminopyrine breath test was not found to be impaired.

journal_name

Scand J Gastroenterol

authors

Larsson C,Eriksson S

doi

10.3109/00365527709181332

subject

Has Abstract

pub_date

1977-01-01 00:00:00

pages

543-6

issue

5

eissn

0036-5521

issn

1502-7708

journal_volume

12

pub_type

杂志文章
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