Observations of increased levels of blood coagulation factors and other plasma proteins in cholestatic liver disease.

Abstract:

:One group of 8 patients with primary biliary cirrhosis and one group of 7 patients with common duct stone both had generally high levels of blood coagulation factors and a wide range of other plasma proteins. In contrast, one group of 6 patients with chronic active hepatitis generally had low levels of the same coagulation factors and plasma proteins. Analyses of factor II-VII-X, plasminogen, ceruloplasmin, beta1C/1A-globulin, IgG and IgM are especially helpful in the differentiation between primary biliary cirrhosis and chronic active hepatitis. The data are interpreted as suggesting a generally increased synthesis of liver-produced proteins in cholestasis, although more specific factors may modify the degree of increase of the individual proteins.

journal_name

Scand J Gastroenterol

authors

Cederblad G,Korsan-Bengtsen K,Olsson R

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

391-6

issue

4

eissn

0036-5521

issn

1502-7708

journal_volume

11

pub_type

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