Plasminogen activators and plasminogen activator inhibitor in portal blood from patients with and without gastric malignancy.

Abstract:

BACKGROUND:Plasminogen activators (PA) may be released by the gut and eliminated by the liver. Patients with liver disorders or malignancy often have abnormal plasma levels of PAs. Some tumours may produce PAs. METHODS:In patients undergoing gastric surgery for malignant (n = 18) or benign (n = 21) disorders., blood drawn from the portal vein and a peripheral vein was analysed for tissue-type plasminogen activator antigen and activity (tPA: Ag, tPA: Act), single-chain urokinase-type plasminogen activator activity (scuPA: Act), and plasminogen activator inhibitor antigen and activity (PAI: Ag, PAI: Act). RESULTS AND CONCLUSIONS:In both groups tPA: Act and scuPA: Act levels were significantly higher in portal blood than in peripheral blood, but tPA: Ag and PAI: Act levels did not differ. PAI: Act levels were significantly lower in patients with malignant disease, but levels of the other markers did not differ in the two groups.

journal_name

Scand J Gastroenterol

authors

Rahr HB,Sørensen JV,Larsen JF,Jensen FS,Bredahl C

doi

10.3109/00365529609031982

subject

Has Abstract

pub_date

1996-02-01 00:00:00

pages

170-4

issue

2

eissn

0036-5521

issn

1502-7708

journal_volume

31

pub_type

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