Selective inhibitors of COX-2--are they safe for the stomach?

abstract：BACKGROUND:The aim of this study was to investigate whether changes in lymph node size in the hepatoduodenal ligament reflect changes in biochemical and histologic markers of cholestasis, hepatocellular damage, and humoral immunoreactivity in patients with primary biliary cirrhosis (PBC). METHODS:Twenty-three consecut...

journal_title：Scandinavian journal of gastroenterology

authors： Lyttkens K,Prytz H,Forsberg L,Hägerstrand I

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:The mechanisms for the observed low prevalence of Helicobacter pylori infection in inflammatory bowel disease (IBD) are unknown, but might be important for the pathogenesis of IBD. We have studied the seroprevalence of H. pylori in different categories of IBD and evaluated the role of medical therapy, smokin...

journal_title：Scandinavian journal of gastroenterology

authors： Väre PO,Heikius B,Silvennoinen JA,Karttunen R,Niemelä SE,Lehtola JK,Karttunen TJ

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVE:To assess the impact of increased use of low-dose aspirin, other non-steroidal anti-inflammatory drugs (NSAIDs), warfarin, corticosteroids and selective serotonin re-uptake inhibitors (SSRIs) on the site and outcome of non-variceal gastrointestinal (GI) bleeds. METHODS:Retrospective review of 731 patients wi...

journal_title：Scandinavian journal of gastroenterology

authors： Ahsberg K,Höglund P,Kim WH,von Holstein CS

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:Pancreatic cancer continues to be an urgent clinical problem. We used the novel DNA methyltransferase inhibitor Zebularine and the histone deacetylase inhibitor SAHA to investigate the epigenetic influence on viability and differentiation of the pancreatic cancer cell lines YAP C, DAN G and Panc-89 in vitro a...

journal_title：Scandinavian journal of gastroenterology

authors： Neureiter D,Zopf S,Leu T,Dietze O,Hauser-Kronberger C,Hahn EG,Herold C,Ocker M

更新日期：2007-01-01 00:00:00

abstract：:Rabbit colonic biopsy specimens cultured in vitro showed an optimal release of prostaglandin E2 (PGE2) after 6-7 h of incubation. The amplitude but not the PGE2 production profile was dependent on stimuli applied--that is, A23187 greater than phorbol 12-myristate 13-acetate greater than control. This study was underta...

journal_title：Scandinavian journal of gastroenterology

authors： Nygård G,Berglindh T

更新日期：1991-02-01 00:00:00

abstract：:Both oxyntic mucosal progenitor cells and enterochromaffin-like (ECL) cells are under the trophic control of gastrin. We studied the effect of discontinuing omeprazole-induced hypergastrinemia on cell proliferation and ECL cell function in the rat oxyntic mucosa. All rats had hypergastrinemia after 16 days' omeprazole...

journal_title：Scandinavian journal of gastroenterology

authors： Tielemans Y,Chen D,Sundler F,Håkanson R,Willems G

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:Intravenously administered infliximab, a monoclonal antibody directed against tumor necrosis factor-alpha, has been proven to be efficacious in the treatment of fistulas in patients with Crohn's disease. It has recently been suggested that local injections of infliximab might be beneficial as well. The aim of...

journal_title：Scandinavian journal of gastroenterology

authors： Asteria CR,Ficari F,Bagnoli S,Milla M,Tonelli F

更新日期：2006-09-01 00:00:00

abstract：:Of 120 patients who were investigated for moderately elevated liver function tests as the only sign of liver disease, 6 young persons had alpha-1-antitrypsin (AAT) deficiency. Three had a homozygous (Pi ZZ) and three had a heterozygous (Pi MZ) AAT deficiency as measured with isoelectric focusing. An extensive investig...

journal_title：Scandinavian journal of gastroenterology

authors： Hultcrantz R,Jelf E,Nilsson LH

更新日期：1984-05-01 00:00:00

abstract：:Objective: Upfront surgery is the standard treatment for resectable pancreatic ductal adenocarcinomas (R-PDACs); however, these tumors often recur. We investigated the factors governing recurrence and prognosis in patients with R-PDAC. Methods: We analyzed 359 patients who underwent upfront surgery for R-PDAC between ...

journal_title：Scandinavian journal of gastroenterology

authors： Izumo W,Higuchi R,Furukawa T,Yazawa T,Uemura S,Shiihara M,Yamamoto M

更新日期：2019-06-01 00:00:00

abstract：:Coeliac disease is a common and important gastrointestinal disease. It affects at least 1%, most Western European populations and in Nordic countries it is even more frequent. It is strongly associated with certain Human Leukocyte Antigen-DQ genes and triggered by ingestion of wheat gluten and related cereals from rye...

journal_title：Scandinavian journal of gastroenterology

authors： Lundin KE,Qiao SW,Snir O,Sollid LM

更新日期：2015-06-01 00:00:00

abstract：:BACKGROUND. Adalimumab (ADA), an antitumor necrosis factor (anti-TNF) monoclonal antibody, is effective in treating moderate-to-severely active Crohn's disease (CD). ADA has been associated with a variety of adverse events (AE). The purpose of this study is to determine the safety and efficacy of ADA in CD patients in...

journal_title：Scandinavian journal of gastroenterology

authors： Teriaky A,Gregor J,Yan B,Ponich T,Chande N,Mosli M

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Collagens are major proteins in the extracellular matrix, providing tissues with tensile strength. They are also important for cell adhesion and the invasion of malignant tumours. METHODS:Thirty-nine samples of human colon (24 diverticulosis, 6 malignant tumours, 9 controls) were collected during elective s...

journal_title：Scandinavian journal of gastroenterology

authors： Bode MK,Karttunen TJ,Mäkelä J,Risteli L,Risteli J

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Ethanol is a well-established 'barrier breaker' in gastric mucosa, but its effects at cellular level remain to be detailed. METHODS:Gastric epithelial cells were isolated from rabbits and cultured to monolayers. Intracellular calcium was measured spectrofluorometrically with fura-2. The patency of gap junct...

journal_title：Scandinavian journal of gastroenterology

authors： Mustonen H,Kiviluoto T,Puolakkainen P,Kivilaakso E

更新日期：2004-02-01 00:00:00

abstract：:Background and aim: Acute-on-chronic liver failure (ACLF) is characterized by the presence of acute decompensation (AD) of cirrhosis, organ failures, and high short-term mortality rates. In present study, we explored whether Pro-adrenomedullin (Pro-ADM), a biomarker of sepsis, is a potential marker of outcome in patie...

journal_title：Scandinavian journal of gastroenterology

authors： Yan H,Jin S,Liang L,Du J,Aithal GP,Li L

更新日期：2020-05-01 00:00:00

abstract：:We measured pressures of the papillary sphincter zone and pancreatic main duct endoscopically in 20 control subjects and in 38 patients with chronic pancreatitis without papillary stenosis, including 19 cases believed to be in the early stages of chronic pancreatitis. There was no significant difference between contro...

journal_title：Scandinavian journal of gastroenterology

authors： Okazaki K,Yamamoto Y,Kagiyama S,Tamura S,Sakamoto Y,Nakazawa Y,Morita M,Yamamoto Y

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:Histologic detection of mast cells cannot adequately reflect their function and state of activation, since degranulated mast cells may escape from histologic assessment. To better define the role of mast cells in inflammatory bowel disease, the spontaneous secretion of mast cell tryptase, a highly mast cell ...

journal_title：Scandinavian journal of gastroenterology

authors： Raithel M,Winterkamp S,Pacurar A,Ulrich P,Hochberger J,Hahn EG

更新日期：2001-02-01 00:00:00

abstract：:In 14 patients with encephalopathy due to cirrhosis of the liver levels of consciousness were assessed by clinical ratings and continuous reaction time measurements. The observations were compared with similar measurements made in patients with chronic brain syndrome, patients sedated with diazepam, and hospitalized c...

journal_title：Scandinavian journal of gastroenterology

authors： Elsass P,Christensen SE,Ranek L,Theilgaard A,Tygstrup N

更新日期：1981-04-01 00:00:00

abstract：:Background & aims: Non-variceal upper gastrointestinal bleeding (NVUGIB) occurs frequently and is associated with a significant morbidity and mortality, especially in patients receiving antiplatelet or anticoagulant therapy (APT and ACT, respectively). We aimed to evaluate adherence to guideline recommendations publis...

journal_title：Scandinavian journal of gastroenterology

authors： Vogt C,Allo G,Buerger M,Kasper P,Chon SH,Gillessen J,Goeser T,Schramm C

更新日期：2019-11-01 00:00:00

abstract：:Studies are presented dealing with the effects on exocrine and endocrine rat pancreas of repeated subcutaneous injections for 10 days of equivalent doses (Ivy dog units) of commercial (10% pure) cholecystokinin-pancreozymin (CCK-PZ) and of the synthetic C-terminal octapeptide of CCK-PZ. Both rats treated with the comm...

journal_title：Scandinavian journal of gastroenterology

authors： Arnesjö II,Lundquist I

更新日期：1976-01-01 00:00:00

abstract：OBJECTIVE:Three CAspase Recruitment Domain (CARD15) mutations have shown to predispose to Crohn's disease in Caucasian populations. The aim of this study was to investigate the mutation frequency in patients with inflammatory bowel disease and in healthy controls in Denmark. MATERIAL AND METHODS:Genotyping of the thre...

journal_title：Scandinavian journal of gastroenterology

authors： Ernst A,Jacobsen B,Østergaard M,Okkels H,Andersen V,Dagiliene E,Pedersen IS,Thorsgaard N,Drewes AM,Krarup HB

更新日期：2007-12-01 00:00:00

abstract：:The positional specificity of the phospholipase A in human gallbladder epithelium was studied by using biosynthetically radioabeled diacylphosphoglycerides as substrates. Diacylphosphoglyceride in 14C-palmitic acid-labeled, autoclaved E.coli was hydrolyzed under the formation of monoacylphosphoglyceride and fatty acid...

journal_title：Scandinavian journal of gastroenterology

authors： Tagesson C,Norrby S,Sjödahl R

更新日期：1978-01-01 00:00:00

abstract：:The isolated gastric gland preparation, with aminopyrine accumulation as an index of the parietal cell response, has been used to study the effects of somatostatin (S-14), gastrin-releasing peptide (GRP), cholecystokinin (CCK-8), vasoactive intestinal peptide (VIP), and peptide YY (PYY) on the in vitro acid secretion ...

journal_title：Scandinavian journal of gastroenterology

authors： Leth R,Lundell L,Olbe L

更新日期：1991-01-01 00:00:00

abstract：:Background: Extracellular vesicles (EVs) are implicated in intercellular communication in liver diseases. An EV-associated fraction of the macrophage biomarker soluble CD163, denoted EV-CD163, was recently identified. EV-CD163 may be released during later phases of the inflammatory response as opposed to the acute she...

journal_title：Scandinavian journal of gastroenterology

authors： Nielsen MC,Andersen MN,Grønbæk H,Damgaard Sandahl T,Møller HJ

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:The aim of this investigation was to elucidate retrospectively the therapeutic effect of infliximab in patients with active Crohn's disease (CD) under nutritional therapy. MATERIAL AND METHODS:Using a review of the clinical records in 24 nationwide institutions specializing in inflammatory bowel disease, the...

journal_title：Scandinavian journal of gastroenterology

authors： Matsumoto T,Iida M,Kohgo Y,Imamura A,Kusugami K,Nakano H,Fujiyama Y,Matsu T,Hibi T

更新日期：2005-12-01 00:00:00

abstract：:To study the effects of chronic alcohol consumption on platelet functions, the rate of arachidonate-induced platelet aggregation, the production of malondialdehyde in platelets, and plasma levels of prostaglandin endoperoxide metabolites were examined in 88 chronic alcoholics and 24 healthy controls. The rate of plate...

journal_title：Scandinavian journal of gastroenterology

authors： Arai M,Okuno F,Nagata S,Shigeta Y,Takagi S,Ebihara Y,Kobayashi T,Ishii H,Tsuchiya M

更新日期：1986-11-01 00:00:00

abstract：OBJECTIVE:The peptide hormones guanylin and uroguanylin and their receptor, guanylate cyclase C (GC-C), are expressed in pancreatic duct cells. In colon cancer, guanylin peptides are shown to exert strong anti-tumor activity through the GC-C pathway. The objective of this study was to analyze the role of guanylin and u...

journal_title：Scandinavian journal of gastroenterology

authors： Kloeters O,Friess H,Giese N,Buechler MW,Cetin Y,Kulaksiz H

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Symptoms are essential in the clinical diagnosis of gastro-esophageal reflux disease (GERD). Questionnaires such as GerdQ have been developed as diagnostic aids. GerdQ has been thoroughly validated in well-characterized GERD patients, but has not yet been fully evaluated in a population that includes subject...

journal_title：Scandinavian journal of gastroenterology

authors： Norder Grusell E,Mjörnheim AC,Finizia C,Ruth M,Bergquist H

更新日期：2018-01-01 00:00:00

abstract：:Autoimmune enteropathy is a rare disorder characterized by severe and protracted diarrhea, weight loss from malabsorption and immune-mediated damage to the intestinal mucosa, generally occurring in infants and young children, although some cases of adult onset have been reported in the literature. Pathogenetic mechani...

journal_title：Scandinavian journal of gastroenterology

authors： Montalto M,D'Onofrio F,Santoro L,Gallo A,Gasbarrini A,Gasbarrini G

更新日期：2009-01-01 00:00:00

abstract：:During perfusion of an isotonic solution containing 56 mmol/l glucose and 122 mmol/l sodium chloride, net movements of water and sodium and glucose absorption were measured in the absence and presence of intraluminal hydrocortisone along 20-cm segments of proximal jejunum in five normal subjects and five patients with...

journal_title：Scandinavian journal of gastroenterology

authors： Sandle GI,Keir MJ,Record CO

更新日期：1981-01-01 00:00:00

abstract：:Twenty-four grossly obese patients were operated on with horizontal gastroplasty. One patient died postoperatively of pulmonary embolism. The remaining 23 were extensively studied before and repeatedly after surgery. Eighteen months postoperatively the average weight loss was 34.4 kg (range, 1-71 kg). Seven patients h...

journal_title：Scandinavian journal of gastroenterology

authors： Olsson SA,Nilsson-Ehle P,Pettersson BG,Sörbris R

更新日期：1985-03-01 00:00:00