Acetazolamide interferes with the protective effect of prostaglandin E2 in the rat gastric mucosa.

Abstract:

:Oral prostaglandin E2 protected the gastric mucosa against the damage induced by intraperitoneal indomethacin in the rat. Blocking of the gastric alkaline secretion by subcutaneous acetazolamide potentiated the ulcerogenic action of indomethacin and reduced or abolished the protective effect of a submaximal dose prostaglandin E2. The results are compatible with the hypothesis that stimulation of the alkaline secretion is one of the mechanisms by which prostaglandin E2 protects the gastric mucosa.

journal_name

Scand J Gastroenterol

authors

Kollberg B,Aly A,Rubio C,Johansson C

doi

10.3109/00365528109181985

subject

Has Abstract

pub_date

1981-04-01 00:00:00

pages

385-7

issue

3

eissn

0036-5521

issn

1502-7708

journal_volume

16

pub_type

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