Diagnosis of acute hepatitis C: anti-HCV or HCV-RNA?

Abstract:

BACKGROUND:In theory, the optimal method for diagnosing acute hepatitis C is nucleotide amplification. This is because of the significant delay in the emergence of hepatitis C virus (HCV) antibodies. We studied whether the use of HCV polymerase chain reaction (PCR) screening for acute HCV infection in a clinical setting would identify otherwise undetected cases. METHODS:Patients clinically suspected of having acute viral hepatitis were tested over a 32-month period (n = 2023). RESULTS:Sixty-four patients were found HCV ribonucleic acid (RNA) positive. Of these, 13 were suffering from an acute infection and 12 of these 13 patients were concomitantly anti-HCV (and HCV-RNA) positive at the time of diagnosis. One patient was HCV-RNA positive and anti-HCV negative. This symptom-free patient was tested because of known exposure to HCV 2 weeks previously. CONCLUSION:Anti-HCV is reliable in screening for acute hepatitis C. In cases of known/possible HCV exposure, we find that HCV PCR is the diagnostic of choice.

journal_name

Scand J Gastroenterol

authors

Møller JM,Krarup HB

doi

10.1080/00365520310002526

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

556-8

issue

5

eissn

0036-5521

issn

1502-7708

journal_volume

38

pub_type

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