Abstract:
BACKGROUND:A genetic susceptibility to coeliac disease is well established, involving HLA and non-HLA components. CTLA4 is an important regulator of T-cell function and some studies have suggested that sequence variation in the gene might be a determinant of disease susceptibility, although the evidence is conflicting. METHODS:Sixty-two children with biopsy-proven coeliac disease attending a single centre in Sweden were studied. All were genotyped for presence of the HLA-DQA1*0501, B 1*0201 alleles. Those who carried the HLA-DQ heterodimer (58/62) were genotyped for the +49 (A/G) exon I polymorphism. The transmission disequilibrium test (TDT) was used to test for association between coeliac disease and the A allele. The entire CTLA4 gene was screened for other sequence variants using a combination of conformation-sensitive gel electrophoresis and direct sequencing. RESULTS:A significant association between the exon I polymorphism and coeliac disease was observed (P = 0.02). No other sequence variants in CTLA4 were detected. CONCLUSIONS:This study provides further evidence that variation in CTLA4 is a determinant of coeliac disease susceptibility. If not mediated through the +49 (A/G) dimorphism directly, then the effect is likely to be mediated through linkage disequilibrium.
journal_name
Scand J Gastroenteroljournal_title
Scandinavian journal of gastroenterologyauthors
Popat S,Hearle N,Wixey J,Hogberg L,Bevan S,Lim W,Stenhammar L,Houlston RSdoi
10.1080/003655202753387310subject
Has Abstractpub_date
2002-01-01 00:00:00pages
28-31issue
1eissn
0036-5521issn
1502-7708journal_volume
37pub_type
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journal_title:Scandinavian journal of gastroenterology
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journal_title:Scandinavian journal of gastroenterology
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journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-03-01 00:00:00
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更新日期:2018-12-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2018-06-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
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更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:Helicobacter pylori has been found to be only a minor risk factor for gastroduodenal complications in kidney transplantation patients. The aim of the study was to follow up the course of H. pylori infection in a group of immunosuppressed kidney transplantation patients. METHODS:After a median follow-up of 6...
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更新日期:2003-01-01 00:00:00