In situ expression of transforming growth factor-beta1-3, latent transforming growth factor-beta binding protein and tumor necrosis factor-alpha in liver tissue from patients with chronic hepatitis C.

Abstract:

BACKGROUND:The mechanisms determining liver damage in chronic hepatitis C remain unclear. The aim was to evaluate the in situ expression of transforming growth factor beta (TGF-beta) and tumor necrosis factor-alpha (TNF-alpha), two key cytokines implicated as important pathogenic mediators in the development of liver fibrosis. METHODS:In situ expression of TNF-alpha and of TGF-beta isoforms 1-3, and its transport protein latent TGF-beta binding protein (LTBP), was determined by immunohistochemistry in 9 untreated patients with chronic hepatitis C infection and in 6 controls without liver disease. In addition, TGF-beta1 expression was analyzed in 10 HCV patients before and after treatment with interferon-alpha alone, or in combination with ribavirin. RESULTS:Liver biopsies from HCV patients showed positive staining for TGF-beta1-3 isoforms and LTBP, and to a lesser degree for TNF-alpha, in areas with inflammation and fibrosis. Normal control liver showed no positive staining. TGF-beta1 expression before treatment, quantified by morphometric analysis, did not differ between non-responders and sustained responders. In patients responding to therapy, TGF-beta1 expression decreased in parallel with histological improvement, while no difference in TGF-beta1 expression was seen before and after treatment in non-responders. CONCLUSION:These results suggest that TNF-alpha and all three isoforms of TGF-beta are involved in the pathogenesis of HCV related liver disease, and that treatment leading to eradication of the virus affects the expression of TGF-beta1.

journal_name

Scand J Gastroenterol

authors

Kinnman N,Andersson U,Hultcrantz R

doi

10.1080/003655200453656

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

1294-300

issue

12

eissn

0036-5521

issn

1502-7708

journal_volume

35

pub_type

杂志文章
  • Phenotypic variance in childhood coeliac disease and the HLA-DQ/DR dose effect.

    abstract:OBJECTIVE:Coeliac disease (CD) is associated with HLA-DQ2 and DQ8. The clinical picture is variable and certain human leucocyte antigen (HLA) DQ/DR combinations have a higher relative risk (RR) for CD than others. Moreover, the HLA-DQ gene-dose effect has an impact on the strength of the gluten-specific T-cell response...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520802116422

    authors: Vermeulen BA,Hogen Esch CE,Yuksel Z,Koning F,Verduijn W,Doxiadis II,Schreuder GM,Mearin ML

    更新日期:2009-01-01 00:00:00

  • Mortality in high-risk patients with bleeding Mallory-Weiss syndrome is similar to that of peptic ulcer bleeding. Results of a prospective database study.

    abstract:OBJECTIVE:The aim of this study was to identify the predictive factors influencing mortality in patients with bleeding Mallory-Weiss syndrome in comparison with peptic ulcer bleeding. MATERIAL AND METHODS:Between January 2005 and December 2009, 281 patients with endoscopically confirmed Mallory-Weiss syndrome and 1530...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3109/00365521.2013.846404

    authors: Ljubičić N,Budimir I,Pavić T,Bišćanin A,Puljiz Z,Bratanić A,Troskot B,Zekanović D

    更新日期:2014-04-01 00:00:00

  • Phospholipids prevent enteric bacterial translocation in the early stage of experimental acute liver failure in the rat.

    abstract:BACKGROUND:Bacterial infections and bacteremia in acute liver failure may at least partly be attributed to translocation of enteric bacteria. Attempts to prevent or treat such infections by the use of antibiotics may instead result in overgrowth of surviving microbes. METHODS:In the present study, normal saline (1.5 m...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529409094897

    authors: Wang XD,Andersson R,Soltesz V,Wang WQ,Ar'Rajab A,Bengmark S

    更新日期:1994-12-01 00:00:00

  • Eosinophilic diseases of the gastrointestinal tract.

    abstract::Eosinophilic gastrointestinal disorders (EGIDs) are a diverse group of disorders whose diagnosis is on the rise and are characterized by symptoms caused by infiltration by eosinophils of the different sections of the digestive tract. Although little is known of their etiology, it seems to be multifactorial. Alteration...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3109/00365521003690251

    authors: Lucendo AJ

    更新日期:2010-09-01 00:00:00

  • Cytomegalovirus infection in ulcerative colitis.

    abstract:OBJECTIVE:Cytomegalovirus (CMV) infection has been reported as an exacerbating factor in inflammatory bowel disease but the relationship between CMV infection and ulcerative colitis (UC) remains unclear. There has been no detailed research to elucidate the clinicopathologic features of CMV infection in UC using surgica...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520500408584

    authors: Kojima T,Watanabe T,Hata K,Shinozaki M,Yokoyama T,Nagawa H

    更新日期:2006-06-01 00:00:00

  • The CCK-2 receptor is located on the ECL cell, but not on the parietal cell.

    abstract:BACKGROUND:The interrelationship between histamine and gastrin in the physiological regulation of gastric acid secretion is still a matter of dispute. CCK-2 receptors are located on enterochromaffin-like (ECL) cells in corpus mucosa and gastrin stimulates acid production by releasing histamine from the ECL cells, which...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520152584734

    authors: Bakke I,Qvigstad G,Sandvik AK,Waldum HL

    更新日期:2001-11-01 00:00:00

  • Enzymatic hydrolysis of long-chain alkanoylcholines in rat intestinal loops.

    abstract:BACKGROUND:The hydrolysis of long-chain alkanoylcholines, presumably catalyzed by butyryl-cholinesterase (EC 3.1.1.8), in rat intestinal loops was studied. The substances have earlier been found to be rapidly degraded in vitro. METHODS:Radiolabeled substrates were used, and a radiochromatographic detection method was ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529509096311

    authors: Chelminska-Bertilsson M,Edebo A,Thompson RA,Edebo L

    更新日期:1995-07-01 00:00:00

  • Novel combination therapy for the eradication of Helicobacter pylori infection in a mouse model.

    abstract:OBJECTIVE:To investigate the combination therapy, consisting of hyperimmune bovine colostrum, N-acetyl cysteine, zinc and amoxicillin on the eradication of Helicobacter pylori in a mouse model. MATERIAL AND METHODS:C57BL/6 female mice (6 weeks of age) were inoculated with 0.1 ml of 1×10(9) H. pylori via a single oro-g...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2010.506245

    authors: Tran CD,Kritas S,Campbell MA,Huynh HQ,Lee SS,Butler RN

    更新日期:2010-12-01 00:00:00

  • Mesalamine promotes intestinal epithelial wound healing in vitro through a TGF-beta-independent mechanism.

    abstract:OBJECTIVE:Treatment with 5-aminosalicylic acid (5-ASA) derivatives is one of the main principles in the therapy of uncomplicated mild to moderate inflammatory bowel diseases (IBD). The beneficial effect of 5-ASA in the treatment of IBD is attributed to its anti-inflammatory and anti-oxidant properties within the inflam...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520510015854

    authors: Baumgart DC,Vierziger K,Sturm A,Wiedenmann B,Dignass AU

    更新日期:2005-08-01 00:00:00

  • Graft-versus-Host disease-like syndrome in malignant thymoma.

    abstract::Allogenic transfusion of immunocompetent T lymphocytes into an immunodeficient recipient is necessary for the development of graft-versus-host-disease (GVHD). The gastrointestinal tract is one of the most involved organs in human GVHD, and single-cell necrosis with apoptotic change and crypt abscess are characteristic...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655200750023660

    authors: Wang MH,Wong JM,Wang CY

    更新日期:2000-06-01 00:00:00

  • Potentiating hypergastrinemic effect by the peroxisome proliferator ciprofibrate and omeprazole in the rat.

    abstract:BACKGROUND:Profound inhibition of gastric acid secretion induces enterochromaffin-like (ECL) cell carcinoids due to hypergastrinemia. Peroxisome proliferators also lead to hypergastrinemia and ECL cell carcinoids but without reducing gastric acidity. Since the peroxisome proliferator ciprofibrate is still in use as lip...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365529850171855

    authors: Hammer TA,Sandvik AK,Waldum HL

    更新日期:1998-06-01 00:00:00

  • Efficacy and safety of endoscopic submucosal dissection for gastrointestinal neuroendocrine tumors: a 10-year data analysis of Northern China.

    abstract::Objective: Endoscopy is the main method to treat gastrointestinal neuroendocrine tumors (GI-NETs), but the specific indications are still controversial. We aim to investigate the clinical outcomes of GI-NETs patients who experienced endoscopic submucosal dissection (ESD). Methods: We retrospectively reviewed the clini...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1588367

    authors: Chen X,Li B,Wang S,Yang B,Zhu L,Ma S,Wu J,He Q,Zhao J,Zheng Z,Li S,Wang T,Liang L

    更新日期:2019-03-01 00:00:00

  • Review of the persistence of gastroesophageal reflux disease in children, adolescents and adults: does gastroesophageal reflux disease in adults sometimes begin in childhood?

    abstract:OBJECTIVE:Understanding the natural history and outcomes of gastroesophageal reflux disease (GERD) in children could help to identify patients at risk of having GERD complications during adulthood. This review aimed to assess evidence of whether GERD in children or adolescents persists into adulthood. MATERIAL AND MET...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3109/00365521.2011.591425

    authors: Winter HS,Illueca M,Henderson C,Vaezi M

    更新日期:2011-10-01 00:00:00

  • Course of choledochal cysts according to the type of treatment.

    abstract:OBJECTIVE:To compare natural course and treatment results of various types of choledochal cysts. MATERIAL AND METHODS:Complication rate in treated (T) and natural course in not treated (NT) patients with choledochal cysts were compared. The level of bilioenteric anastomosis after cyst resection was categorized and the...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521003675054

    authors: Kim JW,Moon SH,Park DH,Lee SS,Seo DW,Kim MH,Lee SK

    更新日期:2010-06-01 00:00:00

  • Chronic perineal fistula as a late failure manifestation of pseudomyxoma peritonei syndrome.

    abstract::Pseudomyxoma peritonei syndrome (PMP) is a rare but fascinating entity in surgical oncology. It consists of the accumulation of mucus in the peritoneal cavity, sometimes in huge amounts, in most of the cases after rupture of an appendiceal tumor. The diagnosis and management of PMP has changed significantly in the pas...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520410003623

    authors: Sebbag G,Sugarbaker PH,Walfisch S,Levy I

    更新日期:2004-11-01 00:00:00

  • The small-intestinal mucosa in patients with Crohn's disease assessed by scanning electron and light microscopy.

    abstract::Small-intestinal mucosal biopsy specimens obtained by a Watson capsule were assessed by light (LM) and scanning electron (SEM) microscopy in 18 patients with various sites of Crohn's disease and in 6 healthy controls. By means of LM, partial villous atrophy of the upper small-intestinal mucosa was assessed in six pati...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Nyhlin H,Stenling R

    更新日期:1984-05-01 00:00:00

  • Latent cytomegalovirus infection does not influence long-term disease outcomes in inflammatory bowel disease, but is associated with later onset of disease.

    abstract:OBJECTIVES:Cytomegalovirus (CMV) infection is common in the general population. CMV infection negatively affects disease course in transplant recipients and HIV patients. Whereas primary CMV infections may occur sporadically in seronegative patients, all seropositive patients with inflammatory bowel syndrome (IBD) are ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2020.1786853

    authors: van der Sloot KWJ,Voskuil MD,Visschedijk MC,Festen EAM,van Dullemen HM,Weersma RK,Alizadeh BZ,van Leer-Buter C,Dijkstra G

    更新日期:2020-08-01 00:00:00

  • Effect of vasopressin on canine gastric mucosal circulation.

    abstract::Continuous intravenous infusion of small doses of vasopressin (0.05 microgram/kg/h) in anaesthetized dogs was effective in reducing gastric mucosal flow, whereas moderate doses (0.2 micrograms/kg/h) induced a substantial flow reduction. Larger doses of vasopressin (2-4 micrograms/kg/h) precipitated massive gastric flo...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528209181103

    authors: Semb BK,Steen S,Solhaug JH

    更新日期:1982-10-01 00:00:00

  • Endoscopic papillectomy and KRAS expression in the treatment of adenoma in the major duodenal papilla.

    abstract:OBJECTIVE:The use of endoscopic papillectomy for resecting adenomas in the major duodenal papilla is increasing. This study focuses on the following three issues: Can endoscopic papillectomy be performed as a safe diagnostic and/or therapeutic procedure in biopsy-verified or suspected ampullary adenoma? Does expression...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2015.1046912

    authors: Haraldsson E,Swahn F,Verbeke C,Mattsson JS,Enochsson L,Ung KA,Lundell L,Heuchel R,Löhr JM,Arnelo U

    更新日期:2015-01-01 00:00:00

  • Autoantibodies in patients with gut motility disorders and enteric neuropathy.

    abstract:OBJECTIVE:Enteric neuropathy with mild inflammation (ganglionitis) has been described in several motility disorders including irritable bowel syndrome (IBS), enteric dysmotility (ED), slow-transit constipation (STC) and chronic intestinal pseudo-obstruction (CIPO). The purpose of this study was to test the hypothesis t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520701396216

    authors: Törnblom H,Lang B,Clover L,Knowles CH,Vincent A,Lindberg G

    更新日期:2007-11-01 00:00:00

  • Effects of ebrotidine on aspirin-induced gastric mucosal damage and blood flow in humans.

    abstract::Nonsteroidal anti-inflammatory agents (NSAIDs) such as aspirin (ASA) damage the gastric mucosa both in normal subjects and in arthritic patients. The aim of this study was to investigate the protective action of a new H2-receptor antagonist, ebrotidine, in the prevention of ASA-induced acute mucosal injury in the stom...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365529309098307

    authors: Konturek SJ,Kwiecien N,Sito E,Obtulowicz W,Kaminski K,Oleksy J

    更新日期:1993-12-01 00:00:00

  • Effect of platelet-derived growth factor-BB on indomethacin-induced gastric lesions in rats.

    abstract::The effect of platelet-derived growth factor-BB (PDGF-BB) was evaluated in rats with indomethacin-induced gastric lesions. Animals were treated with either saline solution or several doses of PDGF-BB given orally. Rats treated with 0.1 nmol/kg PDGF-BB showed a statistically significant reduction of gastric damage. Hig...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529209000138

    authors: Guglietta A,Hervada T,Nardi RV,Lesch CA

    更新日期:1992-08-01 00:00:00

  • HLA-DR expression and disease activity in ulcerative colitis.

    abstract::In 12 patients with active ulcerative colitis (UC) the rectal epithelial cells were analyzed for HLA-DR antigens by an immunohistochemical technique. The clinical, rectoscopic, and histologic stages were also determined. The investigations were carried out at the beginning of the study and 2 weeks and 3 months later. ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528609003088

    authors: Poulsen LO,Elling P,Sørensen FB,Høedt-Rasmussen K

    更新日期:1986-04-01 00:00:00

  • Managing dyspepsia in the young adult patient: effects of different tests for Helicobacter pylori in a "test-and-scope" approach.

    abstract:AIM:To evaluate how different methods for the detection of Helicobacter pylori influence on a "test, score and scope" decision approach in young dyspeptic patients. RESULTS:Complete data from 341 patients (52.2% males) were analyzed. One hundred and ten (32%) were H. pylori-positive by definition. The rapid serology t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2013.800988

    authors: Valle PC,Breckan RK,Mortensen L,Amin A,Kildahl-Andersen O,Paulssen EJ

    更新日期:2013-08-01 00:00:00

  • Selective inhibitors of COX-2--are they safe for the stomach?

    abstract::NSAIDs are widely used and beneficial for patients with inflammatory pain. However, NSAIDs cause significant adverse upper gastrointestinal effects, including increased mortality from serious ulcer complications. NSAIDs exert their anti-inflammatory effects by inhibiting the activity of the COX enzyme, which was recen...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1080/003655200750056565

    authors: Giercksky KE,Haglund U,Rask-Madsen J

    更新日期:2000-11-01 00:00:00

  • Inhibition of gastrin secretion by pirenzepine (LS 519) in treatment of gastric ulcer.

    abstract::The effects of pirenzepine on the serum gastrin levels in the basal state and in response to a liquid test meal were investigated in nine patients with gastric ulcer. Single-dose administration of the drug caused a significant decrease in the basal gastrin level and significant inhibition of the serum gastrin response...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528109181967

    authors: Tatsuta M,Itoh T,Okuda S,Tamura H,Baba M,Yamamura H

    更新日期:1981-01-01 00:00:00

  • Selected bacterial antibodies in Crohn's disease and ulcerative colitis.

    abstract::Agglutinins to four strains of anaerobic gram-positive coccoid rods (species of Eubacterium, Peptostreptococcus and Coprococcus) were found in significantly higher frequency in Crohn's disease (CD) than in ulcerative colitis (UC) and in other diseased control subjects and were virtually absent in apparently healthy su...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528309181586

    authors: Auer IO,Röder A,Wensinck F,van de Merwe JP,Schmidt H

    更新日期:1983-03-01 00:00:00

  • Acute pancreatitis in children: a tertiary hospital report.

    abstract:INTRODUCTION:The incidence of acute pancreatitis (AP) in children has increased significantly in the past two decades. OBJECTIVE:All cases of AP, acute recurrent pancreatitis (ARP), and chronic pancreatitis examined between May 2002 and May 2012 at Hospital de Braga, Portugal, were reviewed. MATERIAL AND METHODS:Pati...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2014.882403

    authors: Antunes H,Nascimento J,Mesquita A,Correia-Pinto J

    更新日期:2014-05-01 00:00:00

  • Catheter-related septicaemia in patients receiving home parenteral nutrition.

    abstract::Forty-three patients received home parenteral nutrition (HPN) for 4 to 13 months (median, 30 months) with a total treatment period of 153 patient-years. All patients had central venous catheters; 71 PVC subclavian catheters, 138 Broviac catheters, and 16 other catheters were used. Broviac catheters were introduced int...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528609015162

    authors: Rannem T,Ladefoged K,Tvede M,Lorentzen JE,Jarnum S

    更新日期:1986-05-01 00:00:00

  • Comparison of four markers of intestinal permeability in control subjects and patients with coeliac disease.

    abstract:BACKGROUND:Controversy surrounds the issue of intestinal permeability in patients with coeliac disease, polyethylene glycol 400 indicating reduced and di-/mono-saccharide urine excretion ratios and 51Cr-labeled ethylenediaminetetraacetic acid (EDTA) indicating increased permeability. METHODS:We assessed the suitabilit...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529409092484

    authors: Bjarnason I,Maxton D,Reynolds AP,Catt S,Peters TJ,Menzies IS

    更新日期:1994-07-01 00:00:00