Cra and the control of carbon flux via metabolic pathways.

Abstract:

:The catabolite repressor-activator (Cra) protein controls the direction of carbon flux through metabolic pathways in enteric bacteria. Cra binds to the control regions of target genes and exerts a negative effect on the expression of genes encoding glycolytic and Entner-Doudoroff enzymes, while exerting a positive effect on genes encoding Krebs cycle, glyoxylate shunt and gluconeogenic enzymes. Cra mediates cyclic AMP-independent catabolite repression of positively Cra-regulated genes and catabolite activation of negatively Cra-controlled genes.

journal_name

Res Microbiol

journal_title

Research in microbiology

authors

Ramseier TM

doi

10.1016/0923-2508(96)84003-4

subject

Has Abstract

pub_date

1996-07-01 00:00:00

pages

489-93

issue

6-7

eissn

0923-2508

issn

1769-7123

pii

0923-2508(96)84003-4

journal_volume

147

pub_type

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