Abstract:
:A case of myoepithelial carcinoma arising in a benign myoepithelioma of the minor salivary gland in a 71-year-old patient is reported. The tumor presented initially on the palate and had been diagnosed as "benign lesion" 40 years before. It recurred 22, 36, and 40 years after initial presentation, and a similar histopathological diagnosis was rendered. One year after the last recurrence, the tumor recurred showing typical changes of malignant transformation, and the diagnosis was malignant myoepithelioma. The light microscopy and ultrastructural features of the initial tumor were typical of plasmocytoid myoepithelioma. There were abundant round cells and rare spindle cells with uniform dispersed filaments, sometimes arranged in parallel streams without evidence of dense bodies. These cells showed micropinocytotic vesicles along the cell membrane with poorly developed intercellular junctions and were surrounded by a basal membrane. The malignant counterpart showed fewer plasmocytoid cells and a rather epithelial pattern with marked nuclear pleomorphism and formation of small, or rarely large, glandular lumina. The immunohistochemical features were similar for the benign and malignant tumors, with positivity for S-100 protein, vimentin, cytokeratins, and CAM 5.2, and were negative for GFAP, muscle-specific actin, CEA, and desmin. Flow cytometry showed a change in the DNA content profile. The benign myoepithelioma had a diploid DNA content with a low S-phase fraction of 3.9% and proliferative index of 9.1%, while the myoepithelial carcinoma had an evident aneuploid DNA stem line and an increased S-phase fraction of 8.3% with a proliferative index of 18.1%.
journal_name
Ultrastruct Patholjournal_title
Ultrastructural pathologyauthors
Bombí JA,Alós L,Rey MJ,Mallofré C,Cuchi A,Trasserra J,Cardesa Adoi
10.3109/01913129609016309subject
Has Abstractpub_date
1996-03-01 00:00:00pages
145-54issue
2eissn
0191-3123issn
1521-0758journal_volume
20pub_type
杂志文章,评审abstract::Mitochondrial abnormalities have received relatively little attention in the ultrastructural evaluation of paragangliomas. Review of the few literature references dealing with this issue, however, reveals that quantitative and qualitative changes of these organelles occur in that context. A bladder paraganglioma is de...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129409021899
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Bacillus Calmette-Guerin (BCG) immunotherapy is regarded as the current treatment of choice for non muscle invasive bladder cancer (NMIBC), though its efficacy is limited by high recurrence and progression rate. Identification of factor prognosticators that might be helpful in discriminating between responde...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2012.681833
更新日期:2012-10-01 00:00:00
abstract::Electron microscopy is an essential component of myopathology, both in diagnostics and research of neuromuscular diseases. Although recently reduced in the diagnostic armamentarium, it has greatly been expanded to mouse models in research. Mostly it is descriptive, but a few additional techniques in combination with t...
journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
doi:10.3109/01913123.2013.810690
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abstract::Conidiobolus coronatus is a major insect pathogen belonging to the fungal order Entomophthorales, causing a rare subcutaneous infection of the nasofacial region, resulting in swelling of predominantly the nose, mouth, and perinasal tissue. Later in the course of the infection firm, painless, subcutaneous nodules devel...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120500482013
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2013.810686
更新日期:2013-10-01 00:00:00
abstract::Sclerosing stromal tumors are rare, benign ovarian neoplasms of unknown etiology and histogenesis. Three sclerosing stromal tumors were evaluated by immunohistochemistry and electron microscopy and were compared to two thecomas and nonneoplastic ovarian mesenchymal tissue. The sclerosing stromal tumors and thecomas we...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129209061364
更新日期:1992-05-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128009141413
更新日期:1980-04-01 00:00:00
abstract::Electrophoresis revealed two cases of malignant lymphoma that each contained three M-proteins (IgM lambda.lgG kappa.lgG lambda and IgM lambda.IgM kappa.lgG kappa) in the sera. To determine cellular origin of each M-protein, atypical lymphoid and plasmacytoid cells of both cases were examined by electron microscopy. At...
journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
doi:10.3109/01913129809032277
更新日期:1998-11-01 00:00:00
abstract::Four cases of epithelioid hemangioendothelioma of bone--a borderline malignant tumor of vascular origin--were studied ultrastructurally and immunohistochemically. The epithelioid tumor cells were positive for vimentin, polyclonal and monoclonal cytokeratins, and the endothelial markers factor VIII-related antigen (FVI...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
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更新日期:1990-03-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128409018570
更新日期:1984-01-01 00:00:00
abstract::Six malignant schwannomas were studied by electron microscopy and immunohistochemistry for S-100 protein at the light and electron microscopic levels to clarify the nature of the tumor cells. Three tumors (group A) were composed of poorly differentiated tumor cells and showed no immunoreactivity for S-100 protein. One...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128809048479
更新日期:1988-01-01 00:00:00
abstract::Elastofibromas have been described as ill-defined tumors, composed of fibroblastic stromal cells and a dense collagenous stroma. A total of 5 elastofibromas from 4 Japanese patients were examined by ultrastructural and immunohistochemical methods. The proliferating fibroblastic stromal cells in the lesion showed Cx43-...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120701350365
更新日期:2007-05-01 00:00:00
abstract::Abstract Diagnosis of primary ciliary dyskinesia (PCD) by identification of dynein arm loss in transmission electron microscopy (TEM) images can be confounded by high background noise due to random electron-dense material within the ciliary matrix, leading to diagnostic uncertainty even for experienced morphologists. ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章,随机对照试验
doi:10.3109/01913123.2013.815081
更新日期:2014-08-01 00:00:00
abstract::By means of optical and electron microscopy and by atomic absorption spectrophotometry in a graphite chamber, this study evaluated the effect of temperature (22-35 degrees C) on lesions in the kidney, liver, and brain, and on concentrations of lead caused by the administration of 2 and 5 mg/kg/IP of lead acetate to Sw...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129609016324
更新日期:1996-05-01 00:00:00
abstract::Dysembryoplastic neuroectodermal tumor (DNT) is a rare brain neoplasm. Although the tumor pathology is relatively well charactererized, its full clinicopathological spectrum is still discussed, and ultrastructural data on it are very limited. Here, the authors describe detailed ultrastructural pathology of 7 cases of ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/019131201753343494
更新日期:2001-11-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2014.888113
更新日期:2014-05-01 00:00:00
abstract::Recently the authors have reported the potent beneficial effect of caffeic acid phenethyl ester (CAPE) on cholestatic oxidative liver injury induced by acute bile ligation in Swiss albino rats. Herein, they report the ultrastructural hepatocellular alterations induced by acute bile duct ligation and the effect of CAPE...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913121003788729
更新日期:2010-10-01 00:00:00
abstract::Abstract Metastases to the pituitary occur more frequently in patients with widespread cancer and mainly involve the posterior lobe. A few cases of metastatic carcinoma to a pituitary adenoma have been described so far. Here, the authors present an additional case of a clear cell renal cell carcinoma (CCRCC) metastati...
journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
doi:10.3109/01913123.2014.937843
更新日期:2014-12-01 00:00:00
abstract::The objective of this study was to investigate the ultrastructural characteristics of hybrid acute leukemia (HAL). Fifteen cases of HAL were studied by transmission electron microscopy (TEM), focusing on organelles and myeloperoxidase (MPO) reaction of leukemic cells. By TEM, 5 out 15 cases of HAL were consistent with...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/019131290968722
更新日期:2005-09-01 00:00:00
abstract::Eighty-four cortical neoplasms were studied for cytokeratin and vimentin expression by immunohistochemistry and for intermediate filament aggregates by electron microscopy. Twenty oncocytomas expressed cytokeratin, 16 in a distinctive punctate pattern. These same 16 tumors also contained small globular filamentous bod...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129109016259
更新日期:1991-07-01 00:00:00
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120500323456
更新日期:2005-11-01 00:00:00
abstract::In a vascular anomaly showing moderate edema, the extracellular space appeared apparently normal, exhibiting a membrane to membrane space of about 20 nm in width. In congenital hydrocephalus, this space appeared notably enlarged and occupied by an electron transparent, nonproteinaceous interstitial edema fluid, due to...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120902787076
更新日期:2009-01-01 00:00:00
abstract::To investigate the effects of X-ray irradiation on the proliferation and apoptosis of MCF-7 breast cancer cells; MCF-7 breast cancer cells were irradiated with X-ray. After irradiation, morphological changes and growth inhibition rate of the irradiated cells were observed under an inverted microscope. 3-(4,5-dimethylt...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2013.861569
更新日期:2014-05-01 00:00:00
abstract::Mitochondrial morphology was studied in 60 renal epithelial neoplasms, including clear cell, papillary, chromophobe cell, and oncocytomas, to see if there are significant differences among the various subtypes. Mitochondria from the nephron tubular system obtained from 36 patients with glomerular diseases served as co...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129709021939
更新日期:1997-09-01 00:00:00
abstract::A 69-year-old woman presented with visual disturbance. Perimetry testing revealed a bitemporal hemianopia. Brain MRI demonstrated a 2.2-cm gadolinium-enhancing pituitary mass. Previously she had been treated for hypothyroidism, hypertension, and dyslipidemia. She had hyperprolactinemia. Endoscopic transsphenoidal debu...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2011.642465
更新日期:2012-04-01 00:00:00
abstract::Pathologic changes induced in the small intestine of suckling mice by rotavirus infection were studied by conventional histology, immunofluorescence, scanning electron microscopy, and electron microscopy of ultrathin sections. Infection could be detected within 24 hours in a few mice, but after 2 days it was well esta...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
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更新日期:1981-01-01 00:00:00
abstract::Deciduoid mesothelioma was first described in young females and in the peritoneum, which led to the suggestion that deciduoid mesothelioma was a distinct subtype with specific clinical and pathologic features. Later reports, however, have shown that this type of mesothelioma may also occur in elderly people and in the...
journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
doi:10.1080/0913120290104647
更新日期:2002-11-01 00:00:00
abstract::The authors report a renal cell carcinoma composed largely of spindle cells of Fuhrman's nuclear grade II in which the bland appearance of the cells and low mitotic index were reminiscent of a benign or low-grade smooth muscle tumor. Keratin immunostaining was positive, but evidence of epithelial differentiation was o...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129809032262
更新日期:1998-01-01 00:00:00