Abstract：
:The contribution of hypertension to adult mortality in Africa has not been well studied. Although cross-sectional surveys have provided data on the prevalence of this condition, the relative risk of death associated with hypertension has not been defined. In the face of high levels of competing mortality from infectious disease among the general population, and the virtual absence of atherosclerotic precursors, estimates of risk derived from industrialised countries may not be generalisable to this setting. We conducted a 2-year prospective study among 1344 mean and women in a rural community in south-western Nigeria. The prevalence of hypertension (140/90 mm Hg) at baseline was 9.3%. In the observational phase, 3.0% of the survey participants died each year. Among the 74 decedents, hypertension was nearly twice as common as among those who survived (14.9% vs 8.4%). In multivariate analysis the risk of death increased over 60% for a 20 mm Hg increase in diastolic blood pressure. The population attributable risk, or the reduction in mortality that would have been observed if hypertension were not present in this community, was estimated as 7%. These findings document an identifiable impact of hypertension on all-cause mortality in rural Africa and demonstrate that programs to evaluate potential treatment options are needed.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Kaufman JS,Rotimi CN,Brieger WR,Oladokum MA,Kadiri S,Osotimehin BO,Cooper RSsubject
Has Abstractpub_date
1996-07-01 00:00:00pages
461-4issue
7eissn
0950-9240issn
1476-5527journal_volume
10pub_type
杂志文章abstract：:Sodium-lithium countertransport activity has been proposed as a marker for hypertension and is lower in black compared to Caucasian subjects both with and without vascular disease. The question arises of what is the primary kinetic locus of the altered behaviour of the countertransporter in black subjects and whether ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000555
更新日期：1998-01-01 00:00:00
abstract：:Sympathetic activation has been associated with the development and complications of hypertension. While the prevalence of hypertension and its cardiovascular risks in women are found to be less than in men and tend to become similar to men after the menopause, there have been no data on the level of sympathetic activ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2008.31
更新日期：2008-08-01 00:00:00
abstract：:The purpose of the study is to observe the relation between anthropometric measurements, focusing on sagittal abdominal diameter (SAD), and insulin sensitivity indices in Chinese hypertensive patients and their siblings. In total, 907 participants, 537 hypertensive and 370 nonhypertensive, from 311 Taiwanese families ...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究
doi：10.1038/sj.jhh.1001532
更新日期：2003-03-01 00:00:00
abstract：:Inconsistent results have been reported regarding the association of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and hypertension. Recent studies of population-based samples of three different areas in Japan presented conflicting results regarding this association. We, thus, investiga...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001601
更新日期：2003-10-01 00:00:00
abstract：:To identify the prevalence and magnitude of clinic changes in blood pressure and determine their effects on the diagnosis and treatment of hypertension, 268 patients with a BP greater than or equal to 160/95 mmHg on three consecutive occasions (twice in the general practitioner's surgery and once in the hospital clini...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:Platelet shape change (PSC) is an early phase of platelet activation that precedes platelet aggregation. This phase of platelet activation is essentially aspirin resistant. PSC was monitored, by measuring the median platelet volume (MPV) using a high resolution channelyser. Angiotensin (Ang) II, added in vitro, caused...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001102
更新日期：2000-09-01 00:00:00
abstract：:The objective of this study was to investigate the relationships between erythrocyte Na-Li countertransport, plasma renin activity (PRA), plasma aldosterone and plasma atrial natriuretic peptide (ANP) in a population-based study, in a cross-sectional observation of a randomly selected sample of a male working populati...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:A study was undertaken to determine whether parent-child blood pressure (BP) resemblances reflect parent-child similarities in body build. Those studied were 889 children, 5-18 years old, their parents and relatives because of recognized correlations between body build and BP in individuals, along with familial cluste...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
abstract：:This multicentre, double-blind, trial in subjects with severe hypertension compared the efficacy and tolerability of two parallel drug regimens: A/B (amlodipine/benazepril: 5/20 or 10/40 mg daily, if necessary) with A (amlodipine: 5 or 10 mg daily, if necessary). The principal dependent variable was the proportion of ...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/jhh.2009.80
更新日期：2010-06-01 00:00:00
abstract：:Clinical studies have shown that aldosterone and salt are independently related to hypertension, cardiovascular morbidity and mortality. More recently, studies in humans have demonstrated that, similarly to animals, endogenous aldosterone and dietary salt intake have not only separate, but also combined effects to acc...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/jhh.2012.27
更新日期：2013-01-01 00:00:00
abstract：:The current study comprehensively examined the association between common variants in the Na(+)-coupled bicarbonate transporter (NCBT) genes and blood pressure (BP) responses to dietary sodium intervention. A 7-day low-sodium followed by a 7-day high-sodium dietary intervention was conducted among 1906 Han participant...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章
doi：10.1038/jhh.2015.113
更新日期：2016-09-01 00:00:00
abstract：:Thalassemia minor (Tm), the β-thalassemia carrier state, is followed by favorable lipidemic profile and seems to protect against myocardial infarction mainly in men. However, the cardiovascular risk factor (CRF) and metabolic profile of these subjects has not been thoroughly addressed, although it is not known whether...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2013.102
更新日期：2014-05-01 00:00:00
abstract：:We describe three patients with abdominal aortic aneurysm (AAA) and renal artery stenosis (RAS). These patients were treated by placement of an aortic endograft and angioplasty or stenting of the renal artery. After the procedure renal function improved or remained stable in two patients and deteriorated slightly in o...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001367
更新日期：2002-05-01 00:00:00
abstract：:Primary aldosteronism (PA) is the most common endocrine form of hypertension and may carry an increased risk of atrial flutter or fibrillation (AFF). The primary goal of this multicentre cohort study is thus to prospectively establish the prevalence of PA in consecutive hypertensive patients referred for lone (non-val...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究
doi：10.1038/jhh.2012.21
更新日期：2013-03-01 00:00:00
abstract：:The National Blood Pressure Programme in Germany (NBP) was established in 1985. The NBP is committed to a process of programme development and implementation that incorporates public health relevance, recent research results, and attempts of scientific module evaluation. Among selected examples of successful modules, ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：:Cardiovascular diseases caused 2.3 million deaths in India in the year 1990; this is projected to double by the year 2020. Hypertension is directly responsible for 57% of all stroke deaths and 24% of all coronary heart disease deaths in India. Indian urban population studies in the mid-1950s used older WHO guidelines ...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1001633
更新日期：2004-02-01 00:00:00
abstract：:Lipoprotein(a) (Lp(a)) is considered an important risk factor for coronary disease, cerebrovascular pathology and re-stenosis of coronary bypass. Few studies have been conducted on this lipoprotein in essential arterial hypertensive patients. The purpose of our study was to measure the serum concentrations of Lp(a) an...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000540
更新日期：1998-02-01 00:00:00
abstract：:The Chinese Hypertension Intervention Efficacy Study (CHIEF) is a multi-centre randomized controlled clinical trial comparing the effects of amlodipine+angiotensin II receptor blocker and amlodipine+diuretics on the incidence of cardiovascular events, represented as a composite of non-fatal stroke, non-fatal myocardia...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/jhh.2010.45
更新日期：2011-04-01 00:00:00
abstract：:The aim of the study was to investigate the effect of therapy by rilmenidine on endothelial and platelet function in 23 patients with the early stages of untreated essential hypertension. The measurements were carried out before therapy, after 1 week of placebo administration, after 1 week, after 1 month and after 3 m...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章
doi：10.1038/sj.jhh.1001427
更新日期：2002-08-01 00:00:00
abstract：:Studies of populations or communities with no rise in blood pressure (BP) with advancing age and low prevalence of hypertension, may provide aetiological clues on the cause of hypertension. Within westernised societies, low blood pressures have been reported amongst chronic psychiatric in-patients and closed order sec...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000853
更新日期：1999-07-01 00:00:00
abstract：BACKGROUND:Hypertension is associated with increased urinary calcium excretion (UCa). A high sodium intake increases both UCa and blood pressure (BP). However, it is not clear whether these effects are modified by gender or ethnic origin. OBJECTIVES:To examine the relationships between BP, urinary sodium (UNa), gender...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001171
更新日期：2001-04-01 00:00:00
abstract：:A large proportion of hypertensive men and women in Europe and North America are overweight. In obesity, the expanded blood volume increases cardiopulmonary volume, cardiac filling, left ventricular preload, stroke volume and, thereby, left ventricular work. Given enough exposure time, it is probable that all obese pe...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：
更新日期：1990-08-01 00:00:00
abstract：:When captopril was first introduced for the management of hypertension, its short plasma half-life led to its use as a thrice daily regimen. However, further experience suggests that the biological action is more prolonged than the plasma half-life might suggest. This study examined the effect of varying the frequency...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：:For the epidemiologist, the development of any new therapy or strategy must respond to the following three questions: does a need exist? Is there a new way of meeting that need? Can a valid assessment be made of the efficacy of the new therapy? New antihypertensive treatments or strategies are needed, even in 1994: in...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：
更新日期：1995-08-01 00:00:00
abstract：:For nearly two decades, the National High Blood Pressure Education Programme has administered a programme of public, patient, and professional education in an effort to reduce uncontrolled hypertension, an important public health problem in the USA. A broad network has been established and many partners have joined fo...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：
更新日期：1992-12-01 00:00:00
abstract：:To clarify the natriuretic action of endogenous atrial natriuretic peptide (ANP) in patients with essential hypertension (EHT), we examined the relationship between ANP release and urinary sodium excretion in response to hypertonic saline infusion. Plasma ANP levels increased from 13.3 +/- 2.0 pg/ml to 37.0 +/- 3.0 pg...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：OBJECTIVE:The European Arteriosclerosis Study (EARS) was designed to identify variables which discriminate subjects with a paternal history of premature coronary heart disease (CHD) from controls and to study the distribution of these variables across Europe. In this article we report on the blood pressure (BP) data. ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：:In the pre-awakening hours, diastolic blood pressure (DBP) is normally at its lowest, and diastolic hypotension is a risk factor for cardiac ischemia. We investigated pre-awakening DBP values and its predictors in treated hypertensive patients who underwent ambulatory blood pressure monitoring. The pre-awakening perio...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2015.80
更新日期：2016-05-01 00:00:00
abstract：:A study of doxazosin added to baseline therapy with a beta-adrenoceptor blocker plus a diuretic in the treatment of patients 'resistant' to the baseline therapy, showed that it was effective and generally well tolerated. The study was, however, open-label and lacked comparison with other third-line drugs. ...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:A Holter BP monitor and a noninvasive, continuous cardiac output (CO) monitor were concurrently attached to 25 middle-aged hospitalized patients with essential hypertension (EH). Blood pressure, heart rate (HR) and CO were measured every 10 minutes over 24 hours. Circadian variation of mean BP was studied. Comparison ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
