Abstract:
OBJECTIVE:The European Arteriosclerosis Study (EARS) was designed to identify variables which discriminate subjects with a paternal history of premature coronary heart disease (CHD) from controls and to study the distribution of these variables across Europe. In this article we report on the blood pressure (BP) data. DESIGN:Comparison of young individuals (18 to 26 years) from 14 different European universities with and without paternal history of premature (before 55) myocardial infarction (MI). SUBJECTS AND METHODS:1994 university students were recruited, 682 with a positive paternal history of premature MI (cases) and 1312 age and sex-matched controls. Following a rigid fieldwork and analyses protocol, data on life style, BP, anthropometric and analytical measurements were obtained. RESULTS:Only diastolic BP in female patients was different between cases and controls (P < 0.05). A significantly higher prevalence of high BP personal history in male cases than in controls was observed (P < 0.02). BP means showed significant regional differences with higher values in the northern and middle European countries respect to southern regions (P < 0.0001). BP values were positively correlated to body mass index (BMI) and waist to hip (W/H) ratio, no correlations were observed with alcohol consumption in this age group. Tobacco showed a negative independent correlation with both systolic and diastolic BP (P < 0.0001). The use of contraceptive pills was associated with higher systolic (P < 0.0001) and diastolic (P < 0.05) BP levels. After adjustment for covariants, only weak correlations were observed between BP, lipids and apolipoproteins. Apo E showed a positive correlation with BP. Lp(a) and fibrinogen showed no significant regression coefficients with BP. Among cholesterylesters, oleic acid percentages were negatively correlated to BP values (mainly diastolic BP: P < 0.001), while the correlation with linoleic acid was positive (P < 0.001). Fasting glucose levels showed an independent correlation with systolic BP (P < 0.0001) in a multiple regression analysis. CONCLUSIONS:In the group with paternal history of premature MI, the higher prevalence of personal history of high BP in males and the higher diastolic BP values in females suggest that high BP could play a role in the elevated CHD risk of this group. Epidemiological observations on BP distribution and its relation with anthropometric and biochemical covariants in a young group of age from different European countries are reported.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Masana L,Farinaro E,De Henauw S,Nicaud Vsubject
Has Abstractpub_date
1996-04-01 00:00:00pages
207-13issue
4eissn
0950-9240issn
1476-5527journal_volume
10pub_type
杂志文章abstract::It has been suggested that the prevalence of coronary artery disease (CAD) is steadily increasing in sub-Saharan Africa. To address this issue, we conducted a Medline search of English language articles on cardiovascular diseases-and specifically CAD in Africa- from 1966 to 1997. The prevalence of CAD and related comp...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001562
更新日期:2003-06-01 00:00:00
abstract::Prevalence, awareness, treatment and control of hypertension were assessed in 1032 (90%) of 1147 elderly (> or = 65 years) inhabitants of three Italian villages. Blood pressure (BP) was measured at home on two separate occasions following a standardised protocol. Persons taking antihypertensive drugs or with BP values...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001117
更新日期:2000-12-01 00:00:00
abstract::There are complications in diagnosing hypertension in children and adolescents due to variation of blood pressure (BP) values to age, gender and height. This study was aimed at assessing whether the performance of BP-to-height ratio (BPHR) can be an effective tool for screening prehypertension and hypertension in Elli...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2017.25
更新日期:2017-09-01 00:00:00
abstract::Hypertension is a major risk factor for cardiovascular disease, which is the leading cause of mortality in women in developed countries. This pooled analysis assessed the antihypertensive efficacy, safety and tolerability of monotherapy with the direct renin inhibitor aliskiren (150 mg and 300 mg) over 8-12 weeks in w...
journal_title:Journal of human hypertension
pub_type: 杂志文章,meta分析
doi:10.1038/jhh.2010.11
更新日期:2010-11-01 00:00:00
abstract::Platelet shape change (PSC) is an early phase of platelet activation that precedes platelet aggregation. This phase of platelet activation is essentially aspirin resistant. PSC was monitored, by measuring the median platelet volume (MPV) using a high resolution channelyser. Angiotensin (Ang) II, added in vitro, caused...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001102
更新日期:2000-09-01 00:00:00
abstract::Several studies have proposed a relationship between blood pressure and inflammation. Interleukin-6 (IL-6) is a multifunctional cytokine involved in inflammation and tissue injury and potentially influencing blood pressure. Recently, a common polymorphism of the IL-6 gene, associated with differences in the transcript...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001462
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:Hypertension is an important public health problem, with some variability of its epidemiological properties in different populations. OBJECTIVES:The purpose of this study was to estimate the prevalence of hypertension and to determine the hypertension awareness, treatment and control rates in Aydin, a Turki...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1000824
更新日期:1999-06-01 00:00:00
abstract::Erythrocyte Na/K flux ratio was examined in relation to a family history of essential hypertension (FH-HT) and plasma and urine electrolytes in 84 normotensive children (13-15 yrs old), and in relation to sodium intake in six children with acute glomerulonephritis or IgA nephropathy who had normal renal function (6-13...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
abstract::Hypertension and knee osteoarthritis (OA) are frequent comorbidities. Nonsteroidal anti-inflammatory drugs (NSAIDs) are often used to relieve pain in such patients. In the last decade selective NSAIDs are used more commonly since they lead to less gastrointestinal complications. As has been shown, the treatment with N...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001411
更新日期:2002-06-01 00:00:00
abstract::Arterial compliance, assessed by the ratio of stroke volume to pulse pressure, and baroreceptor sensitivity (Oxford method), were determined in ten patients with essential hypertension, treated with placebo or indapamide (2.5 mg/day), in a cross-over, single blind study. After three months of therapy, mean arterial pr...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章
doi:
更新日期:1988-10-01 00:00:00
abstract::We tested the utility of qualitative microalbuminuria (MAU) screening in an office practice setting, in assessing the response of MAU to drug treatment. We enrolled general practitioners throughout Germany, who obtained histories, physical examinations, and routine laboratory values as clinically indicated on > 6000 n...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1996-08-01 00:00:00
abstract::The objective of the study was to assess factors associated with treatment satisfaction among patients receiving antihypertensive therapy. A weighted cross-sectional online survey was conducted with hypertensive patients participating in a chronic disease panel in the US. Patients on monotherapy with medications from ...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001899
更新日期:2005-10-01 00:00:00
abstract::The contribution of hypertension to adult mortality in Africa has not been well studied. Although cross-sectional surveys have provided data on the prevalence of this condition, the relative risk of death associated with hypertension has not been defined. In the face of high levels of competing mortality from infectio...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract::Diabetes mellitus (DM)-linked metabolic alterations and hypertension concomitantly accelerate or precipitate cerebrovascular and coronary heart disease, nephropathy, retinopathy and widespread macroangiopathy, thereby conferring to diabetic patients a very high risk of morbidity, disability and early death. Therefore,...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:
更新日期:1992-12-01 00:00:00
abstract::We have investigated 59 patients with mild-to-moderate uncomplicated essential hypertension in order to estimate whether salt sensitivity is associated with greater urinary albumin excretion. Patients whose average mean blood pressure (BP) value on day 5 of the high-sodium regimen (300 mmol/l NaCl) exceeded 10 mm Hg o...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract::Little is known about how aortic waveform parameters vary with ethnicity and lifestyle factors. We investigated these issues in a large, population-based sample. We carried out a cross-sectional analysis of 4798 men and women, aged 50-84 years from Auckland, New Zealand. Participants were 3961 European, 321 Pacific, 2...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2016.78
更新日期:2017-05-01 00:00:00
abstract::The influence of high density lipoproteins (HDL) on platelet function were examined in vivo and in vitro. Intraplatelet, ionised calcium concentrations ([Ca2+]i) were measured using the fluorescent dye Quin-2. In vitro, platelet responses to AVP were measured in the presence or absence of HDL. Pre-treating platelets f...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
abstract::The prediction of risk profile trends associated with non-communicable diseases in developing countries is among the greatest global health challenges. The aim of this study is to estimate prevalence, awareness, treatment and control of hypertension in Dakar (Senegal). This study was carried out between January and Ju...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2013.142
更新日期:2014-08-01 00:00:00
abstract::The accuracy of the TM-2420 ambulatory blood pressure monitor (A&D Co, Japan) has been assessed by the indirect method according to the recommendations of the Association for the Advancement of Medical Instrumentation (AAMI). Ninety subjects (43 men and 47 women), aged 19-89 with a range of systolic blood pressures (S...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract::A blood pressure recording is strictly speaking only relevant for the circumstances under which it is measured. There is increasing evidence that ambulatory recordings have more predictive power than casual BP recordings and are a better discriminator between high and low risk groups of patients, particularly within t...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1990-10-01 00:00:00
abstract::This study evaluated insulin secretion and insulin sensitivity before and after short-term oral administration of doxazosin in patients with essential hypertension. The hypertensive group consisted of 11 nonobese subjects (aged 41.0 +/- 2.5 years (mean +/- SEM), body mass index 24.0 +/- 0.53 kg/m2). The normotensive g...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
abstract::The aim of the present study was to evaluate effects of long-term treatment with rilmenidine compared with atenolol on lipid and glucose metabolism and cardiovascular remodelling in hypertension. In total, 37 patients with hypertension were randomised to rilmenidine 1-2 mg/day or atenolol 50-100 mg/day for 26 weeks. S...
journal_title:Journal of human hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1038/sj.jhh.1002004
更新日期:2006-06-01 00:00:00
abstract::It has been suggested that risks of hypertension and cardiovascular disease begin in utero and that maternal nutrition plays an important role. We have examined the relation between maternal factors and BP in a study of 1,311 children in which physical measurements at 9-11 years of age have been linked to a parental q...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract::This report analysed data from the Health Survey for England 1994 to evaluate blood pressure (BP) management in relation to cigarette smoking. Data were analysed for 12 013 adults aged > or = 16 years living in England in 1994. Among 2280 subjects with BP > or = 160/95 mm Hg or treated with BP-lowering medication, rat...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001275
更新日期:2001-11-01 00:00:00
abstract::A deletion/insertion polymorphism in the ACE gene has been reported previously as a potent factor for myocardial infarction. We have tested the frequency of the deletion (D) allele of the ACE gene in 308 consecutive patients admitted to coronary care with chest pain. The gene frequencies were compared with those of 34...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
abstract::Recent studies have shown that variability in home blood pressure has an important role in the progression of organ damage. The objective of this study was to investigate the factors that affect variability in home blood pressure in patients with type 2 diabetes. We assessed the relationship between home blood pressur...
journal_title:Journal of human hypertension
pub_type: 杂志文章,多中心研究
doi:10.1038/jhh.2014.2
更新日期:2014-10-01 00:00:00
abstract::The cholesterol:phospholipid ratio was measured in platelet plasma membrane, red blood cell (RBC) membranes, low density lipoprotein (LDL) and whole plasma in patients with primary hypertension and in matched normal controls. The cholesterol:phospholipid ratio was raised in the platelet membrane from hypertensive pati...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
abstract::Preeclampsia is a major complication of pregnancy. Risk factors for preeclampsia include population and regional ethnicity. Chinese women living outside the Chinese mainland have a lower prevalence of preeclampsia than resident Caucasians. We performed a retrospective study to identify potential factors that may be as...
journal_title:Journal of human hypertension
pub_type: 杂志文章,多中心研究
doi:10.1038/jhh.2013.148
更新日期:2014-11-01 00:00:00
abstract::The aim of the present longitudinal study was to describe determinants of blood pressure (BP) and echocardiographically calculated left ventricular mass in adolescents with a variable risk of future hypertension. BP was measured and M-mode echocardiography was performed in 52 children, 29 male and 23 female, at a mean...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::Despite the association of childhood blood pressure (BP) with hypertension later in the life course, there remains dearth of information regarding the prevalence and emergence of hypertension in children, especially in China. To investigate the current status of BP, prevalence of elevated BP and related factors in Chi...
journal_title:Journal of human hypertension
pub_type: 杂志文章,多中心研究
doi:10.1038/jhh.2015.104
更新日期:2016-04-01 00:00:00