Erythrocyte sodium-lithium countertransport: relationship with plasma renin activity, aldosterone and atrial natriuretic peptide in a population study.


:The objective of this study was to investigate the relationships between erythrocyte Na-Li countertransport, plasma renin activity (PRA), plasma aldosterone and plasma atrial natriuretic peptide (ANP) in a population-based study, in a cross-sectional observation of a randomly selected sample of a male working population, conducted at the Medical Care Center at the Olivetti Factory in Pozzuoli (Naples). One hundred and seventy-nine male employees aged 45.3 +/- 6.8 years (mean +/- SD), all on unrestricted diet and on no pharmacological treatment were studied. Statistical associations between Na-Li countertransport activity and the hormonal factors being studied were investigated, with control for the possible confounding effects of age, BP and sodium intake. Na-Li countertransport was significantly and positively associated with plasma aldosterone concentration (r = 0.228, P < 0.01) but not with PRA or plasma ANP. Men in the highest quartile of the Na-Li countertransport distribution had significantly higher plasma aldosterone levels than men in the other quartiles (P < 0.01) and this difference was independent of age, body mass, PRA, urinary sodium excretion and blood pressure. It is concluded that plasma aldosterone levels are enhanced and disproportionately high relative to plasma renin activity in individuals with high Na-Li countertransport, independently of known potential confounders.


J Hum Hypertens


Strazzullo P,Cappuccio FP,Miller MA,Buckley MG,Sagnella GA,Trevisan M,Pagano E,MacGregor GA


Has Abstract


1994-03-01 00:00:00












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    journal_title:Journal of human hypertension

    pub_type: 杂志文章


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    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Elsurer R,Afsar B

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    journal_title:Journal of human hypertension

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    journal_title:Journal of human hypertension

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    authors: Reitblat T,Polishchuk I,Zamir D,Isakov I,Oren S

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    journal_title:Journal of human hypertension

    pub_type: 临床试验,杂志文章


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    更新日期:1988-10-01 00:00:00

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    journal_title:Journal of human hypertension

    pub_type: 杂志文章,评审


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    更新日期:1989-10-01 00:00:00

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    journal_title:Journal of human hypertension

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    authors: MacDonald K,Lee CS,Chen HC,Ko ML,Fidel GE,Brié H,Hermans C,Vancayzeele S,Reel S,Van der Niepen P,Abraham I

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    journal_title:Journal of human hypertension

    pub_type: 杂志文章,评审


    authors: Heagerty A

    更新日期:2006-11-01 00:00:00

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    journal_title:Journal of human hypertension

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    authors: Nawrot TS,Thijs L,Den Hond EM,Roels HA,Staessen JA

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    journal_title:Journal of human hypertension

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    更新日期:1990-06-01 00:00:00

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    journal_title:Journal of human hypertension

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    authors: Ruediger H,Seibt R,Scheuch K,Krause M,Alam S

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  • Factors affecting variability in home blood pressure in patients with type 2 diabetes: post hoc analysis of a cross-sectional multicenter study.

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    journal_title:Journal of human hypertension

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    authors: Ushigome E,Fukui M,Hamaguchi M,Tanaka T,Atsuta H,Mogami SI,Oda Y,Yamazaki M,Hasegawa G,Nakamura N

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  • Tailoring anti-hypertensive treatment in the elderly.

    abstract::The treatment of hypertension in the elderly has to take into account co-existing pathology. However, the benefit from treatment are large in terms owing to the frequency of cardiovascular events in the elderly. The benefits observed in randomised controlled trials are reviewed together with the adverse effects of the...

    journal_title:Journal of human hypertension

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    journal_title:Journal of human hypertension

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    journal_title:Journal of human hypertension

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  • On the sex ratio of urinary cation excretion obtained from Intersalt and other epidemiological studies.

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    journal_title:Journal of human hypertension

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    journal_title:Journal of human hypertension

    pub_type: 杂志文章


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    journal_title:Journal of human hypertension

    pub_type: 杂志文章,随机对照试验


    authors: Konrady AO,Kasherininov YR,Shavarov AA,Shavarova EK,Vachrameeva NV,Krutikov AN,Smirnova EV,Shlyakhto EV

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    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Mattace-Raso FU,Sie MP,van der Cammen TJ,Safar ME,Hofman A,van Duijn CM,Witteman JC

    更新日期:2007-09-01 00:00:00

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    journal_title:Journal of human hypertension

    pub_type: 杂志文章,meta分析


    authors: Mizushima S,Cappuccio FP,Nichols R,Elliott P

    更新日期:1998-07-01 00:00:00