Abstract：
:A clear relationship exists between elevated blood pressure (BP) and various manifestations of cardiovascular disease. Despite the availability of numerous treatment guidelines, hypertension remains inadequately controlled, with only a small proportion of patients achieving target BP levels. Many factors, both patient and physician related, contribute to this poor level of hypertension control. Major determinants include the implementation of inappropriate treatment regimens that do not enable patients to achieve goal and poor patient compliance. For example, it is widely acknowledged that most patients require two or more antihypertensive drugs to achieve BP goal; however, physicians may be reluctant to employ such treatment strategies. The aim of this review is to explore factors that contribute to poor hypertension control rates and how to overcome these, including the rationale for selecting combination therapy, with particular reference to angiotensin II receptor blocker combinations.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Heagerty Adoi
10.1038/sj.jhh.1002079subject
Has Abstractpub_date
2006-11-01 00:00:00pages
841-9issue
11eissn
0950-9240issn
1476-5527pii
1002079journal_volume
20pub_type
杂志文章,评审abstract：:The objective of the study is to compare fatal and nonfatal cardiovascular endpoints in hypertensive patients randomised to the calcium-channel blocker, nifedipine GITS or a thiazide diuretic, co-amilozide. A total of 6592 patients from nine countries (UK, France, Israel, Spain, Italy, The Netherlands, Sweden, Denmark...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-09-01 00:00:00
abstract：:We have investigated the use of captopril as a screening test for renovascular hypertension and compared the effects of captopril on renal function in patients with renovascular hypertension and those without renovascular hypertension. The captopril test and kidney gamma scintigraphy were carried out in 50 hypertensiv...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：:The renin-angiotensin system is central to the pathophysiology of a number of cardiovascular disorders. Most obviously this is so with renin secreting tumours, but the system is of central importance in other disorders such as scleroderma renal crisis and most cases of malignant hypertension. Activation of the renin-a...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1000638
更新日期：1998-05-01 00:00:00
abstract：:The objective of this study was to examine the associations of red meat, poultry, and egg consumption with the risk of hypertension (HTN). The electronic databases of PubMed, Web of Science, and Embase were searched up to August 2017, for prospective cohort studies on the associations between red meat, poultry, or egg...
journal_title：Journal of human hypertension
pub_type： 杂志文章,meta分析
doi：10.1038/s41371-018-0068-8
更新日期：2018-07-01 00:00:00
abstract：:Stroke is a very common cause of death and disability. Several lines of evidence point to stroke as a polygenic multifactoral phenotype and there are also a number of well studied single gene Mendelian stroke conditions. Rat models have identified several chromosomal sites linked to stroke, and this together with othe...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1000486
更新日期：1997-09-01 00:00:00
abstract：:The treatment of hypertension is based on an assessment of the balance between the effects of therapy on survival on the one hand and effects of the patient's symptoms and well-being on the other. The concept of quality of life is used to summarise the latter effects. Preservation of quality of life involves both the ...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：
更新日期：1993-02-01 00:00:00
abstract：:Seventeen untreated and 36 treated hypertensives aged 65 years or more were referred to our clinic because of repeated values of systolic blood pressure > or = 160 mmHg and diastolic blood pressure > or = 95 mmHg. All 53 patients underwent 24h blood pressure monitoring during their customary daily activities. Eleven (...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：:A study of doxazosin added to baseline therapy with a beta-adrenoceptor blocker plus a diuretic in the treatment of patients 'resistant' to the baseline therapy, showed that it was effective and generally well tolerated. The study was, however, open-label and lacked comparison with other third-line drugs. ...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:The role of the direct renin inhibitor aliskiren in hypertension is not fully established and use of aliskiren in diabetic patients is especially controversial. A systematic review investigating both short-term diastolic and systolic blood pressure (DBP and SBP) reduction and long-term cardiovascular outcomes has not ...
journal_title：Journal of human hypertension
pub_type： 杂志文章,meta分析
doi：10.1038/s41371-018-0149-8
更新日期：2019-11-01 00:00:00
abstract：:Results of an analysis of the cost-effectiveness of hypertension treatment in Sweden are presented. The cost per life-year gained decreases with age for both men and women and is relatively low for middle-aged and older men and women even in the blood pressure range 90-94 mmHg. The results indicate that it is in gener...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：:European guidelines indicate the importance of the evaluation of global cardiovascular risk (CVR) to determine the management of the hypertensive patients (EH). However, in primary care, the diagnostic work-up (PCD) only includes the metabolic risk factors. The aim of this study was to assess the importance of microal...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001971
更新日期：2006-03-01 00:00:00
abstract：:The association of single nucleotide polymorphisms (SNPs) from seven candidate genes, including genotype-by-baseline fitness and genotype-by-baseline body mass index (BMI) interactions, with incident hypertension over 20 years was investigated in 2663 participants (1301 blacks, 1362 whites) of the Coronary Artery Risk...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2010.94
更新日期：2011-08-01 00:00:00
abstract：:The use of heart rate in clinical practice is limited by its variability under measurement situations. The mean heart rate on ambulatory monitoring provides a more robust statistic for clinical use. We examined the relationship between mean heart rate on initial referral ambulatory blood pressure monitoring (ABPM) to ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000586
更新日期：1998-04-01 00:00:00
abstract：:A total of 78 Chinese patients with clinically uncomplicated non-insulin-dependent diabetes (NIDDM) who had plasma creatinine concentrations of < 150 mumol/l were studied. Antihypertensive treatment was discontinued for at least six weeks prior to measurements of routine biochemistry, proteinuria, plasma atrial natriu...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：:Although 24-h urine collection is widely considered the 'gold standard' for estimation of population sodium intake, spot urine collection is increasingly used as a convenient and affordable alternative. We used four published formulae to convert spot urine sodium into estimates of 24-h sodium excretion in order to est...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2014.10
更新日期：2014-11-01 00:00:00
abstract：:The phenomenon that blood pressure rises sharply in the morning is called 'Morning Blood Pressure Surge' (MBPS). Serum gamma-glutamyltransferase (GGT) is a proinflammatory marker involved in the pathogenesis of cardiovascular diseases. Although both are novel cardiovascular risk factors associated with inflammation an...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2014.74
更新日期：2015-05-01 00:00:00
abstract：:Hypertension is a known risk factor in the genesis of coronary artery disease. However, the effect of pre-existing hypertension on the long-term mortality in patients with established coronary heart disease is not clear. The present cohort study analysed the influence of baseline mild to moderate treated hypertension ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：:Lipoprotein(a) (Lp(a)) is considered an important risk factor for coronary disease, cerebrovascular pathology and re-stenosis of coronary bypass. Few studies have been conducted on this lipoprotein in essential arterial hypertensive patients. The purpose of our study was to measure the serum concentrations of Lp(a) an...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000540
更新日期：1998-02-01 00:00:00
abstract：:The increased viscosity of blood of hypertensive patients can be assumed to be a risk factor for the development of cardiovascular diseases. The aim of the present study was to elucidate whether anti-hypertensive treatment has any impact on blood rheology. Twenty patients with previously untreated hypertension who con...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-03-01 00:00:00
abstract：:Hypertension is strongly influenced by genetic factors. Although hypertension prevalence in some Hispanic sub-populations is greater than in non-Hispanic whites, genetic studies on hypertension have focused primarily on samples of European descent. A recent meta-analysis of 200 000 individuals of European descent iden...
journal_title：Journal of human hypertension
pub_type： 杂志文章,meta分析,多中心研究
doi：10.1038/jhh.2016.29
更新日期：2016-12-01 00:00:00
abstract：:The major epigenetic features of mammalian cells include DNA methylation, posttranslational histone modifications and RNA-based mechanisms including those controlled by small non-coding RNAs (microRNAs (miRNAs)). An important aspect of epigenetic mechanisms is that they are potentially reversible and may be influenced...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/jhh.2014.132
更新日期：2015-10-01 00:00:00
abstract：:Unravelling the complete genetic predisposition to high blood pressure (BP) has proven to be challenging. This puzzle and the fact that coding regions of the genome account for less than 2% of the entire human DNA support the hypothesis that genetic mechanism besides coding genes are likely to contribute to BP regulat...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/jhh.2014.99
更新日期：2015-08-01 00:00:00
abstract：:The aim of the study was to investigate the effect of therapy by rilmenidine on endothelial and platelet function in 23 patients with the early stages of untreated essential hypertension. The measurements were carried out before therapy, after 1 week of placebo administration, after 1 week, after 1 month and after 3 m...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章
doi：10.1038/sj.jhh.1001427
更新日期：2002-08-01 00:00:00
abstract：:The kinetic properties of sodium-proton exchange are abnormal in human red blood cells of hypertensive patients and it has been demonstrated that the transport protein undergoes post-translational modifications able to affect its kinetic properties. Protein kinase C (PKC) activation decreases the affinity constant for...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000804
更新日期：1999-05-01 00:00:00
abstract：:The pathological myocardial hypertrophy associated with hypertension contains the seed for further maladaptive development. Increased myocardial oxygen consumption, impaired epicardial coronary perfusion, ventricular fibrosis and remodelling, abnormalities in long-axis function and torsion, cause, to a varying degree,...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/jhh.2008.141
更新日期：2009-05-01 00:00:00
abstract：:Thyroid hormones, including free triiodothyronine (FT3), free thyroxine (FT4), have well-recognized effects on the cardiovascular system. However, the evidence is lacking regarding the relationship between repeated FT3, FT4, and thyroid-stimulating hormone (TSH) measurements and incident hypertension. The aim of this ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-020-00474-4
更新日期：2021-01-18 00:00:00
abstract：:Blood pressure-to-height ratio (BPHR) has been reported to perform well for identifying hypertension (HTN) in adolescents but not in young children. Our study was aimed to evaluate the performance of BPHR and modified BPHR (MBPHR) for screening HTN in children. A total of 5268 Chinese children (boys: 53.1%) aged 6-12 ...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/s41371-018-0056-z
更新日期：2018-06-01 00:00:00
abstract：:Aging is associated with cardiovascular remodeling, which can be accelerated in arterial hypertension (AH). The aim of this study was to evaluate the relation between hemodynamic profile and age, as well as to identify the role of sex in hemodynamic patterns of aging in AH. The study comprised 326 patients with AH (me...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2015.63
更新日期：2016-03-01 00:00:00
abstract：:Renal denervation (RDN) has been shown in several studies to reduce blood pressure (BP) in patients with resistant hypertension (RH). Data on potential biomarkers associated with BP changes remain scarce. We evaluated whether soluble vascular endothelial growth factor receptor (sVEGFR-1) is affected by the procedure. ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2016.64
更新日期：2017-04-01 00:00:00
abstract：:Despite the availability of multiple nonpharmacological and pharmacological antihypertensive regimens large scale control of BP on a population basis is still unsatisfactory. To achieve a better quality in hypertension care we have developed and evaluated a structured outpatient hypertension treatment and teaching pro...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
