Decreased blood viscosity and serum levels of erythropoietin after anti-hypertensive treatment with amlodipine or metoprolol: results of a cross-over study.

Abstract:

:The increased viscosity of blood of hypertensive patients can be assumed to be a risk factor for the development of cardiovascular diseases. The aim of the present study was to elucidate whether anti-hypertensive treatment has any impact on blood rheology. Twenty patients with previously untreated hypertension who consecutively attended our outpatient hypertension clinic were included in this prospective, open, cross-over study. The patients were randomly selected to treatment with amlodipine or metoprolol. The anti-hypertensive therapy was switched after 4 months. Haemorheological and haemodynamic variables were measured with rotational viscometry and impedance cardiography, respectively. Fifteen and 16 patients could be evaluated after amlodipine or metoprolol treatment respectively. The mean blood pressure (BP) decreased from 159 +/- 22/105 +/- 7 to 139 +/- 21/91 +/- 6 mm Hg on amlodipine and from 162 +/- 22/104 +/- 5 to 145 +/- 24/90 +/- 8 mm Hg on metoprolol therapy. After amlodipine treatment, the total peripheral resistance index decreased whereas metoprolol treatment was accompanied by a decrease in the cardiac index. Decreases in whole blood viscosity, haematocrit and serum erythropoietin were found after amlodipine as well as metoprolol treatment. After amlodipine the plasma viscosity decreased and the erythrocyte deformability increased in the majority of patients. Plasma fibrinogen decreased after metoprolol treatment. Despite the differences in haemodynamic mechanisms underlying the decrease in BP, amlodipine and metoprolol exert beneficial effects on blood viscosity. Haemodilution and a decrease in serum erythropoietin may be factors underlying this decrease in blood viscosity.

journal_name

J Hum Hypertens

authors

Linde T,Sandhagen B,Hägg A,Mörlin C,Danielson BG

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

199-205

issue

3

eissn

0950-9240

issn

1476-5527

journal_volume

10

pub_type

临床试验,杂志文章,随机对照试验
  • A clinical evaluation of the Accutracker--a lightweight ambulatory blood pressure monitor.

    abstract::An evaluation of the 'Accutracker', a new lightweight ambulatory blood pressure monitor, has been carried out in 14 subjects. Using a cross-over study design, BP readings obtained by the monitor were compared with BP measurements carried out in the opposite arm by a random zero sphygmomanometer. Both the systolic and ...

    journal_title:Journal of human hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Phillips DI,Braithwaite J,Newcombe RG,Lazarus JH

    更新日期:1989-12-01 00:00:00

  • Ambulatory monitoring of blood pressure (AMBP) in patients with primary hyperparathyroidism.

    abstract::The purpose of our study was to evaluate the behaviour of blood pressure (BP) by ambulatory monitoring of blood pressure (AMBP) in 53 patients with primary hyperparathyroidism (PHPT) compared to 100 essential hypertensive (EH) and 31 healthy subjects (HS). The correlations between calcium-phosphorus metabolism and hae...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章

    doi:10.1038/sj.jhh.1001907

    authors: Letizia C,Ferrari P,Cotesta D,Caliumi C,Cianci R,Cerci S,Petramala L,Celi M,Minisola S,D'Erasmo E,Mazzuoli GF

    更新日期:2005-11-01 00:00:00

  • Diagnosis of primary aldosteronism in the hypertension specialist centers in Italy: a national survey.

    abstract::Primary aldosteronism (PA) is the most common endocrine cause of resistant hypertension. Individuals with PA are at increased cardiovascular risk, and an appropriate management and treatment would ideally reduce such risk. Screening and diagnosis of PA requires a specific diagnostic test which is considered time- and ...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章

    doi:10.1038/s41371-018-0094-6

    authors: Pucci G,Monticone S,Agabiti Rosei C,Balbi G,Bertacchini F,Ragazzo F,Saladini F,Pengo MF,Young Investigator Group of the Italian Hypertension Society (Società Italiana dell’Ipertensione Arteriosa).

    更新日期:2018-11-01 00:00:00

  • Trends in antihypertensive drugs in the elderly: the decline of thiazides.

    abstract::The last decade has seen the publication of different editions of guidelines for the pharmacological treatment of hypertension that were based on the results of large, randomised trials. Since these guidelines were meant to inform practitioners, we analysed the pattern of prescription of antihypertensive agents betwee...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章

    doi:10.1038/sj.jhh.1001176

    authors: Onder G,Gambassi G,Landi F,Pedone C,Cesari M,Carbonin PU,Bernabei R,Investigators of the GIFA Study (SIGG-ONLUS).

    更新日期:2001-05-01 00:00:00

  • Epidemiology of elevated blood pressure and associated risk factors in Chinese children: the SNEC study.

    abstract::Despite the association of childhood blood pressure (BP) with hypertension later in the life course, there remains dearth of information regarding the prevalence and emergence of hypertension in children, especially in China. To investigate the current status of BP, prevalence of elevated BP and related factors in Chi...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,多中心研究

    doi:10.1038/jhh.2015.104

    authors: Zhou Y,Qian Z,Vaughn MG,Boutwell BB,Yang M,Zeng XW,Liu RQ,Qin XD,Zhu Y,Dong GH

    更新日期:2016-04-01 00:00:00

  • The cost-effectiveness of hypertension treatment in Sweden: an analysis of the criteria for intervention and the choice of drug treatment.

    abstract::Results of an analysis of the cost-effectiveness of hypertension treatment in Sweden are presented. The cost per life-year gained decreases with age for both men and women and is relatively low for middle-aged and older men and women even in the blood pressure range 90-94 mmHg. The results indicate that it is in gener...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章

    doi:

    authors: Johannesson M

    更新日期:1996-02-01 00:00:00

  • Relationship between electrocardiographic left ventricular hypertrophy criteria and vascular structure and function parameters in hypertensive patients.

    abstract::The objective of this study was to determine the electrocardiographic left ventricular hypertrophy (LVH) criterion that best correlated with vascular structure and function parameters in hypertensive patients. A cross-sectional study involving 347 hypertensive patients was performed. The mean age of the subjects was 5...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章

    doi:10.1038/jhh.2013.87

    authors: Gómez-Marcos MA,Recio-Rodríguez JI,Patino-Alonso MC,Agudo-Conde C,Rodríguez-Sánchez E,Gómez-Sánchez L,Gómez-Sánchez M,García-Ortiz L,Vaso risk group.

    更新日期:2014-03-01 00:00:00

  • Treatment patterns of hypertension and dyslipidaemia in hypertensive patients at higher and lower risk of cardiovascular disease in primary care in the United Kingdom.

    abstract::Few studies have investigated the presence of dyslipidaemia in hypertensive individuals. In addition, few data exist on the concurrent treatment of both conditions for the prevention of cardiovascular disease (CVD). This retrospective cohort study examined treatment patterns for hypertension and dyslipidaemia among hy...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,多中心研究

    doi:10.1038/sj.jhh.1002249

    authors: MacDonald TM,Morant SV,Mozaffari E

    更新日期:2007-12-01 00:00:00

  • Antihypertensive efficacy of telmisartan vs ramipril over the 24-h dosing period, including the critical early morning hours: a pooled analysis of the PRISMA I and II randomized trials.

    abstract::Cardiovascular risk is subject to circadian variation, with peak morning incidence of myocardial infarction and stroke correlating with the early morning blood pressure (BP) surge (EMBPS). Ideally, antihypertensive therapy should maintain control of BP throughout the 24-h dosing cycle. In two sister studies, Prospecti...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/jhh.2009.4

    authors: Williams B,Lacourcière Y,Schumacher H,Gosse P,Neutel JM

    更新日期:2009-09-01 00:00:00

  • Acute exercise-induced nitric oxide production contributes to upregulation of circulating endothelial progenitor cells in healthy subjects.

    abstract::Exercise has been proved to promote the number and activity of circulating endothelial progenitor cells (EPCs) in humans, which contributes to improvement in endothelial function and maintenance of cardiovascular homoeostasis. However, the mechanism underlying the effect of exercise on circulating EPCs in healthy subj...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章

    doi:10.1038/sj.jhh.1002171

    authors: Yang Z,Wang JM,Chen L,Luo CF,Tang AL,Tao J

    更新日期:2007-06-01 00:00:00

  • Ante-partum and post-partum markers of metabolic syndrome in pre-eclampsia.

    abstract::It is rare for a study to address immediate metabolic change in pre-eclamptic pregnancy. Our aim is to study the ante-partum and post-partum metabolic markers in pre-eclampsia. A total of 33 pre-eclamptic and 200 uncomplicated women with singleton pregnancies were recruited for the prospective research. Immediately an...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章

    doi:10.1038/jhh.2010.29

    authors: Lei Q,Lv LJ,Zhang BY,Wen JY,Liu GC,Lin XH,Niu JM

    更新日期:2011-01-01 00:00:00

  • Non-dipping pattern relates to endothelial dysfunction in patients with uncontrolled resistant hypertension.

    abstract::Resistant hypertension (RHTN) includes both patients whose blood pressure (BP) is uncontrolled on three or more medications (uncontrolled RHTN (UCRH)) and patients whose BP is controlled with use of four or more drugs (controlled RHTN (CRH)). It is unknown whether endothelial function and nocturnal drop demonstrate a ...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章

    doi:10.1038/jhh.2011.43

    authors: Quinaglia T,Martins LC,Figueiredo VN,Santos RC,Yugar-Toledo JC,Martin JF,Demacq C,Pimenta E,Calhoun DA,Moreno H Jr

    更新日期:2011-11-01 00:00:00

  • Peripheral dopamine in hypertension and associated conditions.

    abstract::The purpose of this study is to review the role of dopamine in hypertension and associated conditions. The analysis of literature indicates that present knowledge is mostly based on poor markers and indirect evidence of dopaminergic activity and only few molecular biological data. Alternative markers such as plasma do...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,评审

    doi:10.1038/sj.jhh.1000870

    authors: Kuchel O

    更新日期:1999-09-01 00:00:00

  • Antihypertensive and renoprotective effects of trandolapril/verapamil combination: a meta-analysis of randomized controlled trials.

    abstract::Both trandolapril and verapamil are effective and widely used antihypertensive agents. The aim of this study was to estimate the efficacy and tolerability of trandolapril/verapamil (Tr/Ve) combination for blood pressure control and renoprotection. PubMed, EMBASE and Cochrane Library were searched for relevant studies....

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,meta分析

    doi:10.1038/jhh.2010.60

    authors: Zou Z,Xu FY,Wang L,An MM,Zhang H,Shi XY

    更新日期:2011-03-01 00:00:00

  • Effect of antihypertensive treatment on qualitative estimates of microalbuminuria.

    abstract::We tested the utility of qualitative microalbuminuria (MAU) screening in an office practice setting, in assessing the response of MAU to drug treatment. We enrolled general practitioners throughout Germany, who obtained histories, physical examinations, and routine laboratory values as clinically indicated on > 6000 n...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章

    doi:

    authors: Agrawal B,Wolf K,Berger A,Luft FC

    更新日期:1996-08-01 00:00:00

  • Improvement of cardiovascular risk profile in an elderly population of low social level: the ICON (Improving Cardiovascular risk profile in Older Neapolitans) study.

    abstract::Older age and low socio-economic conditions are associated with poor control of cardiovascular risk factors (RFs). We assessed the prevalence and awareness of cardiovascular RFs in 503 elderly outpatients of low social status attending two public Internal Medicine clinics in Naples, and studied the interaction of educ...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章

    doi:10.1038/sj.jhh.1002098

    authors: Marotta T,Viola S,Ferrara F,Ferrara LA

    更新日期:2007-01-01 00:00:00

  • Assessment of oxidative status markers and NO bioavailability in hypertensive disorders of pregnancy.

    abstract::The systemic oxidative status in hypertensives disorders of pregnancy (HDP) and its association with endothelial dysfunction is controversial. In the present study, we evaluated systemic plasma levels of oxidative stress markers (TBARS (thiobarbituric acid-reactive substances) and carbonyl) and total antioxidant statu...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章

    doi:10.1038/jhh.2012.58

    authors: Gomes HF,Palei AC,Machado JS,da Silva LM,Montenegro MF,Jordão AA,Duarte G,Tanus-Santos JE,Cavalli RC,Sandrim VC

    更新日期:2013-06-01 00:00:00

  • Can heart rate predict blood pressure response to anti-hypertensive drug therapy?

    abstract::The use of heart rate in clinical practice is limited by its variability under measurement situations. The mean heart rate on ambulatory monitoring provides a more robust statistic for clinical use. We examined the relationship between mean heart rate on initial referral ambulatory blood pressure monitoring (ABPM) to ...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章

    doi:10.1038/sj.jhh.1000586

    authors: Owens PE,Lyons S,O'Brien E

    更新日期:1998-04-01 00:00:00

  • Blood pressure during siesta: effect on 24-h ambulatory blood pressure profiles analysis.

    abstract::Blood pressure (BP) during siesta declines to levels similar to those of night time sleep. The objective of the study was to assess the effect of siesta on 24-h ambulatory BP (ABP) data. Two different approaches were employed for the definition of day and night periods: (1) actual patient reported day and night interv...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章

    doi:10.1038/sj.jhh.1000383

    authors: Stergiou GS,Malakos JS,Zourbaki AS,Achimastos AD,Mountokalakis TD

    更新日期:1997-02-01 00:00:00

  • The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients.

    abstract::Large-artery stiffness is a risk factor for stroke, including cerebral small-vessel disease. Retinal microvascular changes are thought to mirror those in cerebral microvessels. We investigated the relationship between aortic stiffness and retinal microvascular changes in Asian ischemic stroke patients. We studied 145 ...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章

    doi:10.1038/jhh.2011.88

    authors: De Silva DA,Woon FP,Manzano JJ,Liu EY,Chang HM,Chen C,Wang JJ,Mitchell P,Kingwell BA,Cameron JD,Lindley RI,Wong TY,Wong MC,behalf of the Multi-Centre Retinal Stroke Study Collaborative Group.

    更新日期:2012-12-01 00:00:00

  • Different effect of alcohol consumption on hypertension according to metabolic health status.

    abstract::We aimed to investigate whether the effect of problematic alcohol drinking on hypertension differed according to metabolic health statuses. Male participants from the fifth Korea National Health and Nutrition Examination Survey were recruited. Problematic alcohol drinkers were designated as subjects with heavy drinkin...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章

    doi:10.1038/jhh.2015.102

    authors: Yang HK,Han K,Park YM,Kwon HS,Yoon KH,Lee SH

    更新日期:2016-10-01 00:00:00

  • Risk factors of pulmonary edema in women with preeclampsia from south India: a case-control study.

    abstract::Pulmonary edema is a potentially life-threatening complication of preeclampsia, but only few studies have looked at possible risk factors. This study assessed the association between various potential risk factors and the development of pulmonary edema. An age-matched case-control design with hospital records from a t...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章

    doi:10.1038/s41371-020-0300-1

    authors: Keepanasseril A,Monárrez-Espino J,Vadivelu P,Kumar Maurya D

    更新日期:2020-10-01 00:00:00

  • An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis.

    abstract::Studies on the possible association between blood pressure and blood lead have reached divergent conclusions. In a previous meta-analysis, a doubling of the blood lead concentration was associated with a 1.0/0.6 mm Hg increase in systolic and diastolic blood pressure (BP). This meta-analysis updates the analysis origi...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,meta分析

    doi:10.1038/sj.jhh.1001300

    authors: Nawrot TS,Thijs L,Den Hond EM,Roels HA,Staessen JA

    更新日期:2002-02-01 00:00:00

  • Hypertension and the eye: changing perspectives.

    abstract::Systemic hypertension is a common condition associated with significant morbidity and mortality. Hypertension confers cardiovascular risk by causing target-organ damage that includes retinopathy in addition to heart disease, stroke, renal insufficiency and peripheral vascular disease. The recognition of hypertensive r...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,评审

    doi:10.1038/sj.jhh.1001472

    authors: Chatterjee S,Chattopadhyay S,Hope-Ross M,Lip PL

    更新日期:2002-10-01 00:00:00

  • Aldosterone synthase alleles and cardiovascular phenotype in young adults.

    abstract::The C(-344)T promoter polymorphism of the human aldosterone synthase (CYP11B2) gene has been associated with hypertension and cardiac hypertrophy, but there were contrasting data. We analysed the genotype/phenotype associations between this polymorphism and cardiovascular variables in a young adult population, where i...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章

    doi:10.1038/sj.jhh.1001619

    authors: Sarzani R,Salvi F,Dessì-Fulgheri P,Catalini R,Mazzara D,Cola G,Siragusa N,Spagnolo D,Ercolani P,Gesuita R,Carle F,Rappelli A

    更新日期:2003-12-01 00:00:00

  • Comparative effects of amlodipine and felodipine ER on office and ambulatory blood pressure in patients with mild to moderate hypertension. Danish Multicentre Group.

    abstract::The anti-hypertensive efficacy and safety of extended-release (ER) felodipine (5, 10 or 20 mg) and amlodipine (5 or 10 mg) once daily were compared in patients with mild to moderate essential hypertension in a double-blind, double-dummy, randomised, comparative study. One hundred and eighteen patients were randomised ...

    journal_title:Journal of human hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Høegholm A,Wiinberg N,Rasmussen E,Nielsen PE

    更新日期:1995-03-01 00:00:00

  • Improvement of hypertension care by a structured treatment and teaching programme.

    abstract::Despite the availability of multiple nonpharmacological and pharmacological antihypertensive regimens large scale control of BP on a population basis is still unsatisfactory. To achieve a better quality in hypertension care we have developed and evaluated a structured outpatient hypertension treatment and teaching pro...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章

    doi:

    authors: Sawicki PT,Mühlhauser I,Didjurgeit U,Berger M

    更新日期:1993-12-01 00:00:00

  • Characteristics of the patients referred to a Hypertension Unit between 1989 and 2003.

    abstract::The level of blood pressure, the type of antihypertensive treatment and the prevalence of resistant hypertension at the first examination were evaluated in 6254 patients referred to a hospital Hypertension Unit from 1989 to 2003. From 1989-1993 to 1999-2003, we observed a reduced prevalence of grade 2 and grade 3 hype...

    journal_title:Journal of human hypertension

    pub_type: 信件

    doi:10.1038/sj.jhh.1002285

    authors: Leotta G,Rabbia F,Canadè A,Testa E,Papotti G,Mulatero P,Veglio F

    更新日期:2008-02-01 00:00:00

  • Elevated blood pressure in primary care varies in relation to circadian and seasonal changes.

    abstract::Blood pressure (BP) is known to vary by time of day and day of year. Studies differ substantially on the magnitude of the effect and there is doubt whether variation is clinically meaningful. We used more than 2 million BP measurements obtained between 1996 and 2004 from Geisinger Clinic primary care patients. General...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章

    doi:10.1038/jhh.2008.44

    authors: Thomas C,Wood GC,Langer RD,Stewart WF

    更新日期:2008-11-01 00:00:00

  • Race specific altitude effects on blood pressure.

    abstract::Altitude affects blood pressure (BP) depending on duration and absolute altitude of exposure. Until now changes in BP during exposure to altitude were studied only in Caucasians. It is not known whether BP is affected differently in black and white people in response to altitude. During a 6-day climb on Kilimanjaro, B...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章

    doi:10.1038/sj.jhh.1000468

    authors: Hasler E,Suter PM,Vetter W

    更新日期:1997-07-01 00:00:00