当前位置： SCI文献检索 > JOURNAL OF HUMAN HYPERTENSION期刊下所有文献 > Trends in antihypertensive drugs in the elderly: the decline of thiazides.

Trends in antihypertensive drugs in the elderly: the decline of thiazides.

Abstract：

:The last decade has seen the publication of different editions of guidelines for the pharmacological treatment of hypertension that were based on the results of large, randomised trials. Since these guidelines were meant to inform practitioners, we analysed the pattern of prescription of antihypertensive agents between 1988 and 1997 among older hospitalised adults. Because of the wealth of data supporting the use of thiazides diuretics, we focused on diuretic prescription, to identify independent predictors of their utilisation. To this end, we used the GIFA database that includes patients admitted to academic medical centres throughout Italy between 1988 and 1997. We studied 5061 patients over 65 years of age selected among a population of 28 411, based on the diagnosis of arterial hypertension at discharge. The use of ACE-inhibitors has been raising steadily through the years, and they are the agents most commonly used since 1996. Calcium channel blockers showed a similar trend and were the top prescribing drug until 1995; afterwards, the documentation of potentially severe side effects has resulted in a nearly 20% reduction of their use. Beta-blockers have remained unpopular throughout the decade. Instead, the prescription of diuretics as a class showed a biphasic trend; an initial decrease with a prolonged steady state and a more recent raise. However, at a separate analysis, it was a evident that a progressive increase of the use of loop diuretics since 1988 has been paralleled by a nearly 50% reduction of thiazides prescriptions. Loop diuretics were more likely to be prescribed to older individuals, those with cardiac heart failure, coronary heart disease and high creatinine level. In contrast, independent predictors of thiazides use were female gender, good functional status, preserved renal function, and absence of cardiovascular comorbidity. In conclusion, despite continued recommendations to use thiazides diuretics for the treatment of hypertension among older individuals, their use has been declining steadily between 1988 and 1997. A possible explanation is that the choice to prescribe a thiazides diuretic is influenced by age, functional status and comorbidity.

journal_name

J Hum Hypertens

journal_title

Journal of human hypertension

authors

Onder G,Gambassi G,Landi F,Pedone C,Cesari M,Carbonin PU,Bernabei R,Investigators of the GIFA Study (SIGG-ONLUS).

doi

10.1038/sj.jhh.1001176

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

291-7

issue

eissn

0950-9240

issn

1476-5527

journal_volume

pub_type

杂志文章

在线工具

Trends in antihypertensive drugs in the elderly: the decline of thiazides.