Abstract：
:The current study comprehensively examined the association between common variants in the Na(+)-coupled bicarbonate transporter (NCBT) genes and blood pressure (BP) responses to dietary sodium intervention. A 7-day low-sodium followed by a 7-day high-sodium dietary intervention was conducted among 1906 Han participants from rural areas of northern China. Nine BP measurements were obtained at baseline and each intervention using a random-zero sphygmomanometer. A mixed-effect model was used to assess the additive associations of 76 common variants in five NCBT genes, including SLC4A4, SLC4A5, SLC4A7, SLC4A8 and SLC4A10, with salt sensitivity phenotypes. The Bonferroni method was used to adjust for multiple testing. SLC4A4 marker rs4254735 was significantly associated with diastolic BP (DBP) response to low-sodium intervention (P=5.05 × 10(-4)), with mean (95% confidence interval (CI)) response of -2.91 (-3.21, -2.61) and -0.40 (-1.84, 1.05) mmHg for genotype AA and AG, respectively. In addition, BP responses to high-sodium intervention significantly increased with the number of minor C alleles of SLC4A4 marker rs10022637. Mean systolic BP responses among those with genotypes TT, CT and CC were 4.62 (4.29, 4.99), 5.94 (5.31, 6.58) and 6.00 (3.57, 8.43) mmHg (P=1.14 × 10(-4)); mean DBP responses were 1.72 (1.41, 2.03), 3.22 (2.52, 3.92) and 3.94 (1.88, 5.99) mmHg (P=2.26 × 10(-5)) and mean arterial pressure responses were 2.69 (2.40, 2.97), 4.13 (3.57, 4.70) and 4.61 (2.51, 6.71) mmHg (P=2.07 × 10(-6)), respectively. In brief, the present study indicated that common variants in the SLC4A4 gene might contribute to the variation of BP responses to dietary sodium intake in Han Chinese population.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Guo L,Liu F,Chen S,Yang X,Huang J,He J,Jaquish CE,Zhao Q,Gu CC,Hixson JE,Gu Ddoi
10.1038/jhh.2015.113subject
Has Abstractpub_date
2016-09-01 00:00:00pages
543-8issue
9eissn
0950-9240issn
1476-5527pii
jhh2015113journal_volume
30pub_type
临床试验,杂志文章abstract：:C-reactive protein (CRP), the prototypical acute-phase reactant, is one of the most widely known biomarkers of cardiovascular disease. Circulating levels of CRP are clinically used to predict the occurrence of cardiovascular events and to aide in the selection of therapies based on more accurate risk assessment in ind...
journal_title：Journal of human hypertension
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2010.94
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000383
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/jhh.2013.105
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000885
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journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-02-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2013.102
更新日期：2014-05-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/s41371-019-0205-z
更新日期：2019-08-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/jhh.2013.96
更新日期：2014-07-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001462
更新日期：2002-09-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章
doi：10.1038/sj.jhh.1000924
更新日期：1999-12-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001518
更新日期：2003-02-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2008.44
更新日期：2008-11-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：
更新日期：1992-12-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-020-0337-1
更新日期：2020-04-29 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1990-10-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
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journal_title：Journal of human hypertension
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journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究
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journal_title：Journal of human hypertension
pub_type： 杂志文章
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journal_title：Journal of human hypertension
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：
更新日期：1995-06-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,meta分析
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更新日期：2000-07-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2017.56
更新日期：2017-11-01 00:00:00
