Abstract：
:The media of most blood vessels is occupied by vascular smooth muscle cells. In areas they may be replaced by glomus cells, pericytes or renin-secreting myoepithelioid cells. These cells may be regarded as phenotypic variants of vascular smooth muscle cells. In disease, ordinary vascular smooth muscle cells may also assume a spectrum of phenotypes ranging from contractile to largely secretory types. Therefore, the phenotype of smooth muscle cells that is involved in a disease process such as hypertension or one of its complications is likely to affect the structural outcome in blood vessels.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Lindop GB,Boyle JJ,McEwan P,Kenyon CJsubject
Has Abstractpub_date
1995-06-01 00:00:00pages
475-8issue
6eissn
0950-9240issn
1476-5527journal_volume
9pub_type
杂志文章,评审abstract：:This report analysed data from the Health Survey for England 1994 to evaluate blood pressure (BP) management in relation to cigarette smoking. Data were analysed for 12 013 adults aged > or = 16 years living in England in 1994. Among 2280 subjects with BP > or = 160/95 mm Hg or treated with BP-lowering medication, rat...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001275
更新日期：2001-11-01 00:00:00
abstract：:This multicentre, double-blind, trial in subjects with severe hypertension compared the efficacy and tolerability of two parallel drug regimens: A/B (amlodipine/benazepril: 5/20 or 10/40 mg daily, if necessary) with A (amlodipine: 5 or 10 mg daily, if necessary). The principal dependent variable was the proportion of ...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/jhh.2009.80
更新日期：2010-06-01 00:00:00
abstract：:Genetic influences in cerebrovascular disease (CVD) may act either independently or by predisposing to, or modulating, the effect of risk factors such as hypertension. Factors involved in the pathogenesis of atherosclerosis, thrombosis and vasoconstriction are important in CVD. The angiotensinogen gene has recently be...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-08-01 00:00:00
abstract：:Determining blood pressure (BP) values at different daily time periods is a well recognised measure to assess the risk of end-organ damage. However, the use of various definitions of these periods, eg, day vs night, sleep vs wake or arbitrary definitions, makes clinical decisions based on available data difficult. In ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000910
更新日期：1999-11-01 00:00:00
abstract：:The influence of high density lipoproteins (HDL) on platelet function were examined in vivo and in vitro. Intraplatelet, ionised calcium concentrations ([Ca2+]i) were measured using the fluorescent dye Quin-2. In vitro, platelet responses to AVP were measured in the presence or absence of HDL. Pre-treating platelets f...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：:The treatment of hypertension is based on an assessment of the balance between the effects of therapy on survival on the one hand and effects of the patient's symptoms and well-being on the other. The concept of quality of life is used to summarise the latter effects. Preservation of quality of life involves both the ...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：
更新日期：1993-02-01 00:00:00
abstract：:It has been claimed that calcium lowers BP. The present randomised, double-blind, placebo-controlled crossover study is the first to investigate the effect on BP of a high oral dose of calcium given for a long period to patients with previously untreated hypertension. Elemental calcium (2 g) was administered for 12 we...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1993-02-01 00:00:00
abstract：:A screening programme for cardiovascular risk factors in men aged 50-59 was undertaken in North Uist, and the results compared with an age- and sex-matched control group from Dundee screened as part of the Scottish Heart Health Study. Blood pressure levels were higher in the Islanders than in controls (148 +/- 20/89 +...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：:Studies of populations or communities with no rise in blood pressure (BP) with advancing age and low prevalence of hypertension, may provide aetiological clues on the cause of hypertension. Within westernised societies, low blood pressures have been reported amongst chronic psychiatric in-patients and closed order sec...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000853
更新日期：1999-07-01 00:00:00
abstract：:Mild to moderate hypertension is usually asymptomatic and therefore the impact on quality of life and side-effects of the antihypertensive treatment can have a negative effect on treatment compliance. A number of comparative studies have addressed quality of life issues with various antihypertensive agents, and the re...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
abstract：:A random sample of 200 East Anglian general practitioners was surveyed to establish current trends in the management of hypertension, including measurement of blood pressure (BP), patient investigation, treatment and follow-up. A total of 125 (62.5%) completed questionnaires was returned. Responses were used to assess...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-10-01 00:00:00
abstract：:An association of obesity and hypertension is well recognised and there is a direct positive relationship between body weight or body mass index (BMI) and blood pressure (BP), although the mechanisms responsible for weight-related increases of BP are still unknown. Obesity does appear to be an independent risk factor ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：:Erythrocyte Na/K flux ratio was examined in relation to a family history of essential hypertension (FH-HT) and plasma and urine electrolytes in 84 normotensive children (13-15 yrs old), and in relation to sodium intake in six children with acute glomerulonephritis or IgA nephropathy who had normal renal function (6-13...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1993-02-01 00:00:00
abstract：:In our study we investigated 36 patients with renal disease, 22 of whom were hypertensive. In all proteinuria was present (4.30 +/- 5.05 g protein/day) and renal lesions were proved by renal biopsy. Blood cadmium in non-smokers was significantly (P less than 0.05) lower than in smokers. We found a positive correlation...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1989-02-01 00:00:00
abstract：:Footshocks increases mean arterial pressure and heart rate. Systemic or intracerebroventricular (IVT) administration of losartan, a specific angiotensin AT1 receptor antagonist, not only inhibited the pressor response to footshocks but resulted in vasodepression. Peripheral or IVT administration of PD 123319, a specif...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000986
更新日期：2000-04-01 00:00:00
abstract：:The insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene may be involved in determining blood pressure changes. The aim of the present study was to assess the relationship between the ACE I/D gene and the change of blood pressure levels during follow-up. We calculated the difference be...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1002229
更新日期：2007-09-01 00:00:00
abstract：:Consistent reports indicate that hypertension is a particularly common finding in black populations. Hypertension occurs at younger ages and is often more severe in terms of blood pressure levels and organ damage than in whites, resulting in a higher incidence of cardiovascular disease and mortality. This review provi...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/jhh.2017.18
更新日期：2017-08-01 00:00:00
abstract：:This study aimed to investigate the relationship of ankle-brachial index (ABI) with all-cause mortality and cardiovascular (CV) mortality in Chinese inpatients after 3 years of follow-up. All the participants were inpatients at high risk of atherosclerosis and enrolled from July to November 2004. A total of 3210 patie...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究
doi：10.1038/jhh.2009.49
更新日期：2010-02-01 00:00:00
abstract：:The renin-angiotensin system is central to the pathophysiology of a number of cardiovascular disorders. Most obviously this is so with renin secreting tumours, but the system is of central importance in other disorders such as scleroderma renal crisis and most cases of malignant hypertension. Activation of the renin-a...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1000638
更新日期：1998-05-01 00:00:00
abstract：:Beta-adrenoceptor blocking drugs (beta-blockers) first came into clinical use 25 years ago. Initially, propranolol was the only beta-blocker available but a number of others, similar in chemical composition and action, became available in the following 10 years. Most blocked both beta 1- and beta 2-receptors and diffe...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：
更新日期：1990-06-01 00:00:00
abstract：:The presence of hepatic steatosis was determined in 180 middle-aged male workers by ultrasonography and was found in 39 (22%) of them. Body mass index (BMI), systolic and diastolic blood pressure (BP) and serum levels of asparate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transpeptidase ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-02-01 00:00:00
abstract：:An increasing of arterial stiffness is the path physiological characteristic of hypertension. Cardio-ankle vascular index (CAVI) is a new index of arterial stiffness. In the present study, we investigated the relationship between CAVI and plasma lipids in hypertension subjects. A total of 542 subjects (male/female 336...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2014.37
更新日期：2015-02-01 00:00:00
abstract：:This is the first report of long-term use (one year) of isradipine, a new dihydropyridine calcium channel blocker, in the treatment of elderly patients with essential hypertension. Patients completing a three month, double-blind, multicentre study comparing isradipine to hydrochlorothiazide (HCTZ) were eligible to enr...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：1994-12-01 00:00:00
abstract：:Moderate (grade 2) and severe (grade 3) hypertension are important public health problems associated with high cardiovascular risk. Blood pressure (BP) control becomes more difficult to achieve as hypertension progresses. Therefore, early and effective treatment is essential to prevent hypertensive urgencies and emerg...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/jhh.2008.72
更新日期：2009-01-01 00:00:00
abstract：:Autonomic dysfunction is implicated in prehypertension, and previous studies have suggested that therapies that improve modulation of sympathovagal balance, such as biofeedback and slow abdominal breathing, are effective in patients with prehypertension at rest. However, considering that psychophysiological stressors ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2015.27
更新日期：2016-02-01 00:00:00
abstract：:A deletion/insertion polymorphism in the ACE gene has been reported previously as a potent factor for myocardial infarction. We have tested the frequency of the deletion (D) allele of the ACE gene in 308 consecutive patients admitted to coronary care with chest pain. The gene frequencies were compared with those of 34...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1994-08-01 00:00:00
abstract：:Hypertension is a serious public health threat worldwide. This study sought to explore gaps in urban Chinese adults' awareness and control of hypertension. A cross-sectional study was carried out in eight Chinese cities in 2016. Participants were organized into four groups on the basis of blood pressure (BP) and self-...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-018-0059-9
更新日期：2018-06-01 00:00:00
abstract：:Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important circulating serine protease in low-density lipoprotein cholesterol (LDL-C) metabolism. Increased plasma PCSK9 levels lead to increased plasma levels of LDL-C and an increased risk of cardiovascular disease (CVD). LDL-C is positively correlated with ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2017.56
更新日期：2017-11-01 00:00:00
abstract：:Hypertension has been associated with hyperinsulinemia and insulin resistance. The elevations in plasma insulin are the apparent adaptation of the pancreatic beta cell to the resistance to insulin. Maintenance of normal insulin release is therefore of great importance for subjects with hypertension. The potassium chan...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-04-01 00:00:00
abstract：:Ambulatory blood pressure variability (ABPV) is a predictor of cardiovascular risk in hypertensives. Factors that contribute to ABPV are not well described. This pilot study aimed to investigate the relationship between ABPV and urine catecholamine metabolites in order to rationalise further therapeutic intervention i...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2014.23
更新日期：2015-01-01 00:00:00
