Erythrocyte Na/K flux ratio in relation to sodium intake and a family history of essential hypertension in normotensive children.

Abstract:

:Erythrocyte Na/K flux ratio was examined in relation to a family history of essential hypertension (FH-HT) and plasma and urine electrolytes in 84 normotensive children (13-15 yrs old), and in relation to sodium intake in six children with acute glomerulonephritis or IgA nephropathy who had normal renal function (6-13 yrs old). Erythrocyte Na/K flux ratio was significantly lower in children with a family history of essential hypertension than in those without. Plasma and urine electrolytes (Na and K) showed no significant differences between children with and without a family history of essential hypertension, although erythrocyte Na/K flux ratio was negatively correlated with serum K level in the whole group. Furthermore, erythrocyte Na/K flux ratio was unchanged before and after the restriction of sodium intake in children with nephropathy. These findings suggest that the erythrocyte Na/K flux ratio may be suppressed in normotensive children with a family history of essential hypertension as previously reported in hypertensive adults, and that plasma K level should be considered first when evaluating the erythrocyte Na/K flux ratio.

journal_name

J Hum Hypertens

authors

Uchiyama M,Satokata I

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

47-51

issue

1

eissn

0950-9240

issn

1476-5527

journal_volume

7

pub_type

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