Abstract:
:Erythrocyte Na/K flux ratio was examined in relation to a family history of essential hypertension (FH-HT) and plasma and urine electrolytes in 84 normotensive children (13-15 yrs old), and in relation to sodium intake in six children with acute glomerulonephritis or IgA nephropathy who had normal renal function (6-13 yrs old). Erythrocyte Na/K flux ratio was significantly lower in children with a family history of essential hypertension than in those without. Plasma and urine electrolytes (Na and K) showed no significant differences between children with and without a family history of essential hypertension, although erythrocyte Na/K flux ratio was negatively correlated with serum K level in the whole group. Furthermore, erythrocyte Na/K flux ratio was unchanged before and after the restriction of sodium intake in children with nephropathy. These findings suggest that the erythrocyte Na/K flux ratio may be suppressed in normotensive children with a family history of essential hypertension as previously reported in hypertensive adults, and that plasma K level should be considered first when evaluating the erythrocyte Na/K flux ratio.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Uchiyama M,Satokata Isubject
Has Abstractpub_date
1993-02-01 00:00:00pages
47-51issue
1eissn
0950-9240issn
1476-5527journal_volume
7pub_type
杂志文章abstract::The effects of propranolol and diltiazem on left ventricular systolic and diastolic function in hypertensive subjects (DBP 90-114 mmHg) were examined with M-mode and 2D echocardiograms in 21 patients in a double-blind fashion prior to and after 4 months of treatment. Systolic function was assessed by measurement of fr...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1990-12-01 00:00:00
abstract::The purpose of the study is to observe the relation between anthropometric measurements, focusing on sagittal abdominal diameter (SAD), and insulin sensitivity indices in Chinese hypertensive patients and their siblings. In total, 907 participants, 537 hypertensive and 370 nonhypertensive, from 311 Taiwanese families ...
journal_title:Journal of human hypertension
pub_type: 杂志文章,多中心研究
doi:10.1038/sj.jhh.1001532
更新日期:2003-03-01 00:00:00
abstract::This work examines the association between hypertension and hypothyroidism in geriatric patients seen at a primary care medical office. One hundred and twenty-two geriatric patients with elevated thyroid stimulating hormone (TSH) levels were selected for the study. An equal number of euthyroid geriatric individuals we...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1000799
更新日期:1999-04-01 00:00:00
abstract::miR-33a has been described as a key regulator in the initiation and progression of atherosclerosis. However, its role in arterial hypertension (HTA) has not been elucidated. Therefore, the aim of this study was to determine the association between the expression of miR-33a (5p and 3p) and the carotid intima-media thic...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/s41371-018-0102-x
更新日期:2018-10-01 00:00:00
abstract::The clinical syndrome of supine hypertension associated with orthostatic hypotension (OH) in given individuals is recognized by specialists, but is underdiagnosed in the community. The objective of this study was to assess supine hypertension associated with hypotensive reactions on head-up tilt (SH-HRT) among patient...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001947
更新日期:2006-02-01 00:00:00
abstract::Pulmonary edema is a potentially life-threatening complication of preeclampsia, but only few studies have looked at possible risk factors. This study assessed the association between various potential risk factors and the development of pulmonary edema. An age-matched case-control design with hospital records from a t...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/s41371-020-0300-1
更新日期:2020-10-01 00:00:00
abstract::Our study was aimed to assess the clinical correlates of different degrees of renal dysfunction in a wide group of non-diabetic hypertensive patients, free from cardiovascular (CV) complications and known renal diseases, participating to the REDHY (REnal Dysfunction in HYpertension) study. A total of 1856 hypertensive...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2009.41
更新日期:2010-01-01 00:00:00
abstract::Low-dose diuretics are recommended for the initial choice of antihypertensive therapy in the 7th US Joint National Committee report and are accepted as an appropriate choice among other classes of drugs in the 2003 European Society of Hypertension guidelines. The rationales for the use of low-dose diuretics include th...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:10.1038/sj.jhh.1001798
更新日期:2004-12-01 00:00:00
abstract::In glucocorticoid-remediable aldosteronism (GRA), there is a large interfamily variation of phenotype. We report three subjects with GRA in a single family (parents, two brothers and two sisters), of whom only one (proband) displayed classical features of the mineralocorticoid excess. The proband was a man found to be...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001636
更新日期:2004-01-01 00:00:00
abstract::Most patients with hypertension need more than one drug to achieve blood pressure (BP) control. This randomized, double-blind, multifactorial study evaluated whether combinations of aliskiren and amlodipine provided superior BP reductions to component monotherapies in patients with hypertension (mean sitting diastolic...
journal_title:Journal of human hypertension
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/jhh.2012.42
更新日期:2013-05-01 00:00:00
abstract::The aim of this study is to investigate how the blood pressure (BP) circadian rhythm (CR) is influenced by life style. Two groups of subjects were recruited from Nepal and Japan because of the extremely different occupational routines of these countries. The Nepalese represent a rural culture, while the Japanese refle...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract::Studies of populations or communities with no rise in blood pressure (BP) with advancing age and low prevalence of hypertension, may provide aetiological clues on the cause of hypertension. Within westernised societies, low blood pressures have been reported amongst chronic psychiatric in-patients and closed order sec...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1000853
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVES:It has been suggested that hypertensives at high risk of cardiovascular complications can be identified on the basis of their left ventricular mass as determined echographically. However, there is as yet a lack of consensus on the mode of indexation (body surface area, height, height 2.7) of left ventricular...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1000885
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:Hypertension is associated with increased urinary calcium excretion (UCa). A high sodium intake increases both UCa and blood pressure (BP). However, it is not clear whether these effects are modified by gender or ethnic origin. OBJECTIVES:To examine the relationships between BP, urinary sodium (UNa), gender...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001171
更新日期:2001-04-01 00:00:00
abstract::An impaired renal function has been found associated with very high cardiovascular (CV) risk, especially in subjects with type 2 diabetes. Microalbuminuria is a sensitive early marker of renal damage, often preceding the more advanced stages of diabetic nephropathy. Consistent evidence has been provided that any degre...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:10.1038/jhh.2013.96
更新日期:2014-07-01 00:00:00
abstract::This study recruited 85 healthy children and adolescents, aged 6-18 years, from a school-based blood pressure (BP) screening study and performed office BP measurements, 24-h ambulatory blood pressure monitoring (24-h ABPM) and 24-h pulse wave analysis. Prevalence of BP phenotypes was assessed, factors that may predict...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/s41371-020-0318-4
更新日期:2021-01-01 00:00:00
abstract::Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important circulating serine protease in low-density lipoprotein cholesterol (LDL-C) metabolism. Increased plasma PCSK9 levels lead to increased plasma levels of LDL-C and an increased risk of cardiovascular disease (CVD). LDL-C is positively correlated with ...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2017.56
更新日期:2017-11-01 00:00:00
abstract::The purpose of this study is to review the role of dopamine in hypertension and associated conditions. The analysis of literature indicates that present knowledge is mostly based on poor markers and indirect evidence of dopaminergic activity and only few molecular biological data. Alternative markers such as plasma do...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:10.1038/sj.jhh.1000870
更新日期:1999-09-01 00:00:00
abstract::Primary aldosteronism (PA) is the most common endocrine form of hypertension and may carry an increased risk of atrial flutter or fibrillation (AFF). The primary goal of this multicentre cohort study is thus to prospectively establish the prevalence of PA in consecutive hypertensive patients referred for lone (non-val...
journal_title:Journal of human hypertension
pub_type: 杂志文章,多中心研究
doi:10.1038/jhh.2012.21
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:To assess the association between different antihypertensive drug regimens and plasma lipid levels in the general population. METHODS:The Monitoring Project on Cardiovascular Risk Factors was conducted from 1987 to 1991 as a cross-sectional study in The Netherlands. Antihypertensive drug-users and untreated ...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章
doi:10.1038/sj.jhh.1001197
更新日期:2001-10-01 00:00:00
abstract::Mild to moderate hypertension is usually asymptomatic and therefore the impact on quality of life and side-effects of the antihypertensive treatment can have a negative effect on treatment compliance. A number of comparative studies have addressed quality of life issues with various antihypertensive agents, and the re...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
abstract::Beta-blockers are not very effective at lowering blood pressure in elderly hypertensive patients or in Afro-Caribbeans and these two groups represent a large proportion of people with raised blood pressure. Furthermore they do not prevent more heart attacks than the thiazide diuretics. Beta-blockers can also be danger...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:10.1038/sj.jhh.1000701
更新日期:1998-12-01 00:00:00
abstract::Submaximal exercise systolic blood pressure (ExSBP) is a recognised predictor of cardiac mortality. This study examined the possibility that this might be related to increased QT dispersion or prolonged maximum QT(c) interval (QTcmax). Twenty-nine untreated hypertensive subjects were assessed. Each subject underwent a...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001158
更新日期:2001-03-01 00:00:00
abstract::Prevalence, awareness, treatment and control of hypertension were assessed in 1032 (90%) of 1147 elderly (> or = 65 years) inhabitants of three Italian villages. Blood pressure (BP) was measured at home on two separate occasions following a standardised protocol. Persons taking antihypertensive drugs or with BP values...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001117
更新日期:2000-12-01 00:00:00
abstract::It has been suggested that risks of hypertension and cardiovascular disease begin in utero and that maternal nutrition plays an important role. We have examined the relation between maternal factors and BP in a study of 1,311 children in which physical measurements at 9-11 years of age have been linked to a parental q...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract::A screening programme for cardiovascular risk factors in men aged 50-59 was undertaken in North Uist, and the results compared with an age- and sex-matched control group from Dundee screened as part of the Scottish Heart Health Study. Blood pressure levels were higher in the Islanders than in controls (148 +/- 20/89 +...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1988-08-01 00:00:00
abstract::The assessment of sodium sensitivity requires to measure the difference in mean arterial pressure (MAP) at the end of sodium-loading (SLoad) and sodium-depletion (SDepl) maneuvers with an arm-cuff manometer. Aim of this study is to evaluate whether MAP measuring devices based on the volume-clamp method at the finger c...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2014.110
更新日期:2015-07-01 00:00:00
abstract::For the epidemiologist, the development of any new therapy or strategy must respond to the following three questions: does a need exist? Is there a new way of meeting that need? Can a valid assessment be made of the efficacy of the new therapy? New antihypertensive treatments or strategies are needed, even in 1994: in...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:
更新日期:1995-08-01 00:00:00
abstract::Lipoprotein(a) (Lp(a)) is considered an important risk factor for coronary disease, cerebrovascular pathology and re-stenosis of coronary bypass. Few studies have been conducted on this lipoprotein in essential arterial hypertensive patients. The purpose of our study was to measure the serum concentrations of Lp(a) an...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1000540
更新日期:1998-02-01 00:00:00
abstract::European guidelines indicate the importance of the evaluation of global cardiovascular risk (CVR) to determine the management of the hypertensive patients (EH). However, in primary care, the diagnostic work-up (PCD) only includes the metabolic risk factors. The aim of this study was to assess the importance of microal...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001971
更新日期:2006-03-01 00:00:00