Abstract：
:The assessment of sodium sensitivity requires to measure the difference in mean arterial pressure (MAP) at the end of sodium-loading (SLoad) and sodium-depletion (SDepl) maneuvers with an arm-cuff manometer. Aim of this study is to evaluate whether MAP measuring devices based on the volume-clamp method at the finger can also be used for assessing sodium sensitivity. Sixty-eight normotensive volunteers underwent SLoad and SDepl diets in random order. MAP was simultaneously measured at the end of each diet with arm (Spacelabs 90207) and finger (Portapres model-2) cuff devices. The sodium sensitivity was assessed as the difference in MAP at the end of SLoad and SDepl diets (ΔMAP), and as salt-sensitivity index (SSI; SSI = ΔMAP divided by the difference in urinary-sodium-excretion rate at the end of the diets). Discrepancies between finger and arm-cuff devices in ΔMAP or SSI were evaluated by Bland and Altman analysis. Even if discrepancies between devices had null-fixed bias, results showed a significant proportional bias and large limits of agreement (between -25 and 25 mm Hg for ΔMAP, between -196 and 180 mm Hg mol(-1) per day for SSI). The SSI distribution over the group was larger, flatter and less symmetric if derived from finger-cuff rather than arm-cuff devices, and this influenced substantially the identification of salt-sensitive individuals. Therefore, the response of MAP to SLoad/SDepl diets and consequently the assessment of the salt-sensitivity condition depends importantly on the measurement site, and brachial measures should be preferred for consistency with literature and normative data.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Castiglioni P,Parati G,Di Rienzo M,Brambilla V,Brambilla L,Gualerzi M,Lazzeroni D,Coruzzi Pdoi
10.1038/jhh.2014.110subject
Has Abstractpub_date
2015-07-01 00:00:00pages
430-5issue
7eissn
0950-9240issn
1476-5527pii
jhh2014110journal_volume
29pub_type
杂志文章abstract：:We conducted a 1:2 matched case-control study in order to evaluate whether the prevalence of coronary artery calcium (CAC) and electrocardiographic left ventricular hypertrophy (LVH) or strain was higher in patients with uncontrolled hypertension than in subjects from the general population, and evaluate the associati...
journal_title：Journal of human hypertension
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journal_title：Journal of human hypertension
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journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Journal of human hypertension
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journal_title：Journal of human hypertension
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pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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journal_title：Journal of human hypertension
pub_type： 杂志文章,meta分析
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journal_title：Journal of human hypertension
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journal_title：Journal of human hypertension
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journal_title：Journal of human hypertension
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journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
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journal_title：Journal of human hypertension
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journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章
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journal_title：Journal of human hypertension
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doi：
更新日期：1996-07-01 00:00:00
