Abstract:
:Treatment of hypertension with thiazide diuretics may trigger hypokalemia, hyperglycemia, and hyperuricemia. Some studies suggest simultaneous potassium supplementation in hypertensive patients using thiazide diuretics. However, few clinical studies have reported the impact of long-term potassium supplementation on thiazide diuretic-induced abnormalities in blood glucose and uric acid (UA) metabolisms. One hundred hypertensive patients meeting the inclusion criteria were equally randomized to two groups: IND group receiving indapamide (1.25-2.5 mg daily) alone, and IND/KCI group receiving IND (1.25-2.5 mg daily) plus potassium chloride (40 mmol daily), both for 24 weeks. At the end of 24-week follow-up, serum K+ level in IND group decreased from 4.27 ± 0.28 to 3.98 ± 0.46 mmol/L (P < 0.001), and fasting plasma glucose (FPG) and UA increased from 5.11 ± 0.52 to 5.31 ± 0.57 mmol/L (P < 0.05), and from 0.404 ± 0.078 to 0.433 ± 0.072 mmol/L (P < 0.05), respectively. Serum K+ level in IND/KCl group decreased from 4.27 ± 0.36 to 3.89 ± 0.28 mmol/L (P < 0.001), and FPB and UA increased from 5.10 ± 0.41 to 5.35 ± 0.55 mmol/L (P < 0.01), and from 0.391 ± 0.073 to 0.457 ± 0.128 mmol/L (P < 0.001), respectively. The difference value between the serum K+ level and FPG before and after treatment was not statistically significant between the two groups. However, the difference value in UA in IND/KCl group was significantly higher than that in IND group (0.066 (95% confidence interval (CI): 0.041-0.090) mmol/L vs. 0.029 (95% CI: 0.006-0.058) mmol/L, P < 0.05). The results showed that long-term routine potassium supplementation could not prevent or attenuate thiazide diuretic-induced abnormalities of glucose metabolism in hypertensive patients; rather, it may aggravate the UA metabolic abnormality.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Zhang JL,Yu H,Hou YW,Wang K,Bi WS,Zhang L,Wang Q,Li P,Yu ML,Zhao XXdoi
10.1038/s41371-018-0036-3subject
Has Abstractpub_date
2018-04-01 00:00:00pages
301-310issue
4eissn
0950-9240issn
1476-5527pii
10.1038/s41371-018-0036-3journal_volume
32pub_type
杂志文章,随机对照试验abstract::When captopril was first introduced for the management of hypertension, its short plasma half-life led to its use as a thrice daily regimen. However, further experience suggests that the biological action is more prolonged than the plasma half-life might suggest. This study examined the effect of varying the frequency...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章
doi:
更新日期:1988-08-01 00:00:00
abstract::Hypertension has been associated with hyperinsulinemia and insulin resistance. The elevations in plasma insulin are the apparent adaptation of the pancreatic beta cell to the resistance to insulin. Maintenance of normal insulin release is therefore of great importance for subjects with hypertension. The potassium chan...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1996-04-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1995-05-01 00:00:00
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journal_title:Journal of human hypertension
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journal_title:Journal of human hypertension
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journal_title:Journal of human hypertension
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2014.88
更新日期:2015-05-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2011-06-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
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更新日期:2014-07-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
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更新日期:2002-05-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/s41371-018-0029-2
更新日期:2018-03-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:10.1038/jhh.2011.37
更新日期:2012-02-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1993-02-01 00:00:00
abstract::Diabetic patients with hypertension are at particularly high risk of vascular damage and consequently cardiovascular and renal disease. Fibulin-1, an extracellular matrix glycoprotein, is increased in arterial tissue and plasma from individuals with type 2 diabetes. This study aimed to evaluate whether antihypertensiv...
journal_title:Journal of human hypertension
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/jhh.2014.27
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journal_title:Journal of human hypertension
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1996-02-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
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journal_title:Journal of human hypertension
pub_type: 杂志文章
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journal_title:Journal of human hypertension
pub_type: 杂志文章
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更新日期:2005-08-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
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journal_title:Journal of human hypertension
pub_type: 杂志文章
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更新日期:1995-10-01 00:00:00
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journal_title:Journal of human hypertension
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journal_title:Journal of human hypertension
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更新日期:1987-09-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of human hypertension
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