Abstract：
:Sympathetic activation has been associated with the development and complications of hypertension. While the prevalence of hypertension and its cardiovascular risks in women are found to be less than in men and tend to become similar to men after the menopause, there have been no data on the level of sympathetic activation in postmenopausal women relative to men. Therefore, we planned to find out whether muscle sympathetic nerve hyperactivity of essential hypertension (EHT) in postmenopausal women is different from that in matched men. We quantified muscle sympathetic nerve activity (MSNA) as mean frequency of single units (s-MSNA) and multiunit bursts (b-MSNA) in 21 postmenopausal women with EHT (W-EHT) relative to 21 matched men with EHT (M-EHT), in comparison to two control groups of 21 normal women (W-NC) and 21 men (M-NC), respectively. The EHT groups had greater MSNA indices than NC groups. W-EHT had lower (P<0.05) s-MSNA (63+/-22.7 impulses per 100 cardiac beats) than M-EHT (78+/-11.2 impulses per 100 cardiac beats). W-NC had lower (P<0.05) s-MSNA (53+/-12.4 impulses per 100 cardiac beats) than M-NC (65+/-16.3 impulses per 100 cardiac beats). Similar results were obtained for b-MSNA. Postmenopausal women with EHT had lower level of central sympathetic hyperactivity than men. Similarly, normal postmenopausal women had lower MSNA than men. These findings suggest that postmenopausal women continue to have a lower sympathetic nerve activity than men even after the development of EHT, and that this could have implications for gender-specific management of hypertension.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Hogarth AJ,Burns J,Mackintosh AF,Mary DAdoi
10.1038/jhh.2008.31subject
Has Abstractpub_date
2008-08-01 00:00:00pages
544-9issue
8eissn
0950-9240issn
1476-5527pii
jhh200831journal_volume
22pub_type
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journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
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abstract：:Hypertension is the number one risk factor for cardiovascular diseases worldwide and yet its diagnosis among adolescents, based on blood pressure percentiles which are age, height, and sex-specific, is complex. Our study intended to determine the suitability of blood pressure height index in defining adolescent hypert...
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journal_title：Journal of human hypertension
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pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：2002-03-01 00:00:00
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journal_title：Journal of human hypertension
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pub_type： 杂志文章
doi：10.1038/sj.jhh.1000958
更新日期：2000-02-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1002316
更新日期：2008-03-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
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更新日期：1990-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-05-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001619
更新日期：2003-12-01 00:00:00
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pub_type： 杂志文章
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章,多中心研究
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
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