Abstract:
:The burden of Type II diabetes is growing rapidly worldwide, across high-, middle- and low-income countries. This burden is associated primarily with increased risks of macrovascular and microvascular diseases, and it is agreed that multifactorial treatment regimens are required to reduce it. ADVANCE (Action in Diabetes and Vascular disease: Preterax and Diamicron-MR Controlled Evaluation) is a large-scale, 2 x 2 factorial, randomised clinical trial. It will investigate the potential benefits of blood pressure lowering, using a fixed low-dose combination of perindopril and indapamide vs placebo, and of tighter glucose control, using an intensive gliclazide-MR-based glucose control regimen vs a standard guidelines-based regimen, separately and together. The two primary outcomes are a composite macrovascular end point of nonfatal stroke, nonfatal myocardial infarction and cardiovascular death; and a composite microvascular end point of new or worsening nephropathy or microvascular eye disease. Following successful recruitment and randomisation of 11,140 participants by March 2003, the study is currently half way through its planned follow-up of 4.5 years. Adherence to randomised study treatment is good; and loss to follow-up is minimal. It is hoped that the study will answer a number of unresolved issues. The blood pressure lowering arm will investigate the possible reduction in major vascular disease in patients with Type II diabetes whether or not they have hypertension, and the possible benefits of blood pressure lowering in such patients already receiving background therapy with the ACE inhibitor perindopril. The glucose control arm will investigate the possible reduction in both macrovascular and microvascular disease achieved with tighter glucose control, targeting an HbA1c of 6.5% and a fasting blood glucose of 6.0 mmol/l. Finally, the factorial design will enable investigation of the combined effects of more intensive glucose control and tighter control of blood pressure.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Patel A,Chalmers J,Poulter Ndoi
10.1038/sj.jhh.1001890subject
Has Abstractpub_date
2005-06-01 00:00:00pages
S27-32eissn
0950-9240issn
1476-5527pii
1001890journal_volume
19 Suppl 1pub_type
杂志文章,评审abstract::Calcium plays a central role in maintaining vascular tone. Recent studies indicate that there are continuous relationships between systemic calcium metabolism and BP, as over the whole range of normal and raised BPs there is an inverse correlation between plasma ionised calcium concentration and BP. Twenty-two subject...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1989-08-01 00:00:00
abstract::The objectives of the study were to appraise the knowledge which the patients have about their hypertension, and to assess the knowledge and involvement of pharmacists in the management of the hypertensive patient. All the pharmacies in the Poitou-Charentes area were invited both to participate in a training session a...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001859
更新日期:2005-07-01 00:00:00
abstract::When captopril was first introduced for the management of hypertension, its short plasma half-life led to its use as a thrice daily regimen. However, further experience suggests that the biological action is more prolonged than the plasma half-life might suggest. This study examined the effect of varying the frequency...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章
doi:
更新日期:1988-08-01 00:00:00
abstract::Genetic influences in cerebrovascular disease (CVD) may act either independently or by predisposing to, or modulating, the effect of risk factors such as hypertension. Factors involved in the pathogenesis of atherosclerosis, thrombosis and vasoconstriction are important in CVD. The angiotensinogen gene has recently be...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1995-08-01 00:00:00
abstract::We describe three patients with abdominal aortic aneurysm (AAA) and renal artery stenosis (RAS). These patients were treated by placement of an aortic endograft and angioplasty or stenting of the renal artery. After the procedure renal function improved or remained stable in two patients and deteriorated slightly in o...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001367
更新日期:2002-05-01 00:00:00
abstract::The cholesterol:phospholipid ratio was measured in platelet plasma membrane, red blood cell (RBC) membranes, low density lipoprotein (LDL) and whole plasma in patients with primary hypertension and in matched normal controls. The cholesterol:phospholipid ratio was raised in the platelet membrane from hypertensive pati...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
abstract::Blood pressure (BP) above optimal (< or =120/< or =80 mmHg) is established as a major cardiovascular disease (CVD) risk factor. Prevalence of adverse BP is high in most adult populations; until recently research has been sparse on reasons for this. Since the 1980s, epidemiologic studies confirmed that salt, alcohol in...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:10.1038/sj.jhh.1001603
更新日期:2003-09-01 00:00:00
abstract::This study investigated the period of time that blood pressure (BP) should be measured at home in older patients in order to obtain steady BP values. Thirty-six men and 38 women (> or =60 years) were recruited at one family practice. At one office visit the family physician measured supine, sitting and standing BPs th...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1000517
更新日期:1997-10-01 00:00:00
abstract::The contribution of hypertension to adult mortality in Africa has not been well studied. Although cross-sectional surveys have provided data on the prevalence of this condition, the relative risk of death associated with hypertension has not been defined. In the face of high levels of competing mortality from infectio...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract::Hypertensive disorders of pregnancy (HDP) as a group of medical complications in pregnancy are believed to be associated with an increased risk of poor fetal growth, but the influence on offspring's body composition is not clear. The aim of the present study was to evaluate the association between maternal HDP and ove...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2017.17
更新日期:2017-11-01 00:00:00
abstract::The aim of this study was to assess the effect of alcohol on blood pressure and arterial compliance over 24 h in a group of volunteers, comparing the same group of subjects on two consecutive but separate days, one with alcohol intake (alcohol day) and one free of alcohol (control day). We studied 18 healthy subjects ...
journal_title:Journal of human hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1038/jhh.2015.19
更新日期:2016-01-01 00:00:00
abstract::Three controlled dietary intervention studies were carried out in 1981-1983 in North Karelia, Finland, to asses the impact of dietary fat intake modification on blood pressure (BP). All these studies involved middle-aged men and women in rural or semirural areas and comprised a baseline period, a six week (or 12 weeks...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1987-12-01 00:00:00
abstract::To evaluate ethnic differences in cerebral circulation, an index of carotid vascular resistance (RI) was determined by continuous wave Doppler ultrasound. Validation of the index resulted from a significant correlation between RI and carotid vascular resistance obtained from direct measurement of blood pressure and ca...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
abstract::Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important circulating serine protease in low-density lipoprotein cholesterol (LDL-C) metabolism. Increased plasma PCSK9 levels lead to increased plasma levels of LDL-C and an increased risk of cardiovascular disease (CVD). LDL-C is positively correlated with ...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2017.56
更新日期:2017-11-01 00:00:00
abstract::The increased viscosity of blood of hypertensive patients can be assumed to be a risk factor for the development of cardiovascular diseases. The aim of the present study was to elucidate whether anti-hypertensive treatment has any impact on blood rheology. Twenty patients with previously untreated hypertension who con...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1996-03-01 00:00:00
abstract::There is a strong association between cigarette smoking and accelerated hypertension. In mild hypertension smoking cigarettes has a distinct pressor effect and caffeine a small but more prolonged pressor action. Coffee and cigarette smoking together have an additive effect on blood pressure (BP). We have examined the ...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract::We tested the utility of qualitative microalbuminuria (MAU) screening in an office practice setting, in assessing the response of MAU to drug treatment. We enrolled general practitioners throughout Germany, who obtained histories, physical examinations, and routine laboratory values as clinically indicated on > 6000 n...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1996-08-01 00:00:00
abstract::We evaluated the relationship between renal resistive index (RRI) of the intrarenal vasculature and cardiovascular (CV) organ damage such as left ventricular hypertrophy (LVH), diastolic dysfunction and carotid atherosclerosis in a large sample of hypertensive patients. 566 hypertensive patients underwent echocardiogr...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1002145
更新日期:2007-04-01 00:00:00
abstract::Disturbed sympathetic and also parasympathetic activity of the autonomic nervous system points to pathological alterations in the cardiovascular system. Untreated hypertensive subjects were examined with respect to the question of whether an increase in sympathetic activity necessarily goes along with a reduction in p...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001671
更新日期:2004-05-01 00:00:00
abstract::The aims of this study were to determine: (1) the proportion of elderly hypertensive subjects currently attending a hospital hypertension clinic suitable for a trial of antihypertensive drug withdrawal, (2) the proportion of suitable patients who can be successfully withdrawn from drug therapy while receiving nonpharm...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract::Hypertension is common in West Africa and likely to become more common as urbanisation increases. There are at present few facilities for the detection and management of hypertension so the influence it has on overall morbidity and mortality in the population is not clear. The objectives of the study were to assess: (...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1000726
更新日期:1999-01-01 00:00:00
abstract::Previous studies have shown a relationship between coronary or carotid atherosclerosis and C-reactive protein (CRP) concentrations. In the present investigation, we evaluated the relationship between high-sensitivity CRP (hsCRP) concentrations and the presence of atherosclerotic lesions in the renal arteries and/or ab...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001878
更新日期:2005-07-01 00:00:00
abstract::The balance of evidence from animal studies, clinical observations, human experimental studies, and epidemiological studies favours a causal association between sodium and blood pressure. INTERSALT is the largest and most comprehensive study yet published on the sodium-blood pressure relationship, and its significant ...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:
更新日期:1989-10-01 00:00:00
abstract::A forty-two year old woman presented with hypertension, trembling, sweating, visual impairment, headache and weight loss. A right adrenal phaeochromocytoma was diagnosed. The tumour could not be resected because it encircled the inferior vena cava. She was treated at first with phenoxybenzamine and propranolol and lat...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract::In an in vivo study, spontaneously hypertensive rats (SHR) were treated with an angiotensin II (Ang II) type 1 receptor antagonist of candesartan or hydralazine. Untreated SHR progressively developed severe hypertension, and treatment with candesartan or hydralazine decreased blood pressure. Candesartan reduced left v...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:10.1038/sj.jhh.1000747
更新日期:1999-01-01 00:00:00
abstract::Few studies have investigated the presence of dyslipidaemia in hypertensive individuals. In addition, few data exist on the concurrent treatment of both conditions for the prevention of cardiovascular disease (CVD). This retrospective cohort study examined treatment patterns for hypertension and dyslipidaemia among hy...
journal_title:Journal of human hypertension
pub_type: 杂志文章,多中心研究
doi:10.1038/sj.jhh.1002249
更新日期:2007-12-01 00:00:00
abstract::The objective of the study was to assess factors associated with treatment satisfaction among patients receiving antihypertensive therapy. A weighted cross-sectional online survey was conducted with hypertensive patients participating in a chronic disease panel in the US. Patients on monotherapy with medications from ...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001899
更新日期:2005-10-01 00:00:00
abstract::Essential hypertension is a major risk factor for cardiovascular disease in humans, and originates from both genetic and environmental factors. Data from animal and more recently human studies have indicated the presence of a gene influencing blood pressure on human chromosome 17. This study tested for linkage of mark...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001025
更新日期:2000-06-01 00:00:00
abstract::Hypertension is a serious public health threat worldwide. This study sought to explore gaps in urban Chinese adults' awareness and control of hypertension. A cross-sectional study was carried out in eight Chinese cities in 2016. Participants were organized into four groups on the basis of blood pressure (BP) and self-...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/s41371-018-0059-9
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVES:It has been suggested that hypertensives at high risk of cardiovascular complications can be identified on the basis of their left ventricular mass as determined echographically. However, there is as yet a lack of consensus on the mode of indexation (body surface area, height, height 2.7) of left ventricular...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1000885
更新日期:1999-08-01 00:00:00