Abstract:
:Little is known about how aortic waveform parameters vary with ethnicity and lifestyle factors. We investigated these issues in a large, population-based sample. We carried out a cross-sectional analysis of 4798 men and women, aged 50-84 years from Auckland, New Zealand. Participants were 3961 European, 321 Pacific, 266 Maori and 250 South Asian people. We assessed modifiable lifestyle factors via questionnaires, and measured body mass index (BMI) and brachial blood pressure (BP). Suprasystolic oscillometry was used to derive aortic pressure, from which several haemodynamic parameters were calculated. Heavy alcohol consumption and BMI were positively related to most waveform parameters. Current smokers had higher levels of aortic augmentation index than non-smokers (difference=3.7%, P<0.0001). Aortic waveform parameters, controlling for demographics, antihypertensives, diabetes and cardiovascular disease (CVD), were higher in non-Europeans than in Europeans. Further adjustment for brachial BP or lifestyle factors (particularly BMI) reduced many differences but several remained. Despite even further adjustment for mean arterial pressure, pulse rate, height and total:high-density lipoprotein cholesterol, compared with Europeans, South Asians had higher levels of all measured aortic waveform parameters (for example, for backward pressure amplitude: β=1.5 mm Hg; P<0.0001), whereas Pacific people had 9% higher loge (excess pressure integral) (P<0.0001). In conclusion, aortic waveform parameters varied with ethnicity in line with the greater prevalence of CVD among non-white populations. Generally, this was true even after accounting for brachial BP, suggesting that waveform parameters may have increased usefulness in capturing ethnic variations in cardiovascular risk. Heavy alcohol consumption, smoking and especially BMI may partially contribute to elevated levels of these parameters.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Sluyter JD,Hughes AD,Thom SA,Lowe A,Camargo CA Jr,Hametner B,Wassertheurer S,Parker KH,Scragg RKdoi
10.1038/jhh.2016.78subject
Has Abstractpub_date
2017-05-01 00:00:00pages
305-312issue
5eissn
0950-9240issn
1476-5527pii
jhh201678journal_volume
31pub_type
杂志文章abstract::Hypertension has been associated with hyperinsulinemia and insulin resistance. The elevations in plasma insulin are the apparent adaptation of the pancreatic beta cell to the resistance to insulin. Maintenance of normal insulin release is therefore of great importance for subjects with hypertension. The potassium chan...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1996-04-01 00:00:00
abstract::Epidemiological studies demonstrated that Helicobacter pylori (H. pylori) infection was associated with cardiovascular disease and its risk factors. However, the association between H. pylori infection and hypertension remained unclear. The aim of this study was to investigate the association between H. pylori infecti...
journal_title:Journal of human hypertension
pub_type: 杂志文章
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abstract::The Chinese Hypertension Intervention Efficacy Study (CHIEF) is a multi-centre randomized controlled clinical trial comparing the effects of amlodipine+angiotensin II receptor blocker and amlodipine+diuretics on the incidence of cardiovascular events, represented as a composite of non-fatal stroke, non-fatal myocardia...
journal_title:Journal of human hypertension
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/jhh.2010.45
更新日期:2011-04-01 00:00:00
abstract::Hypertension is a modifiable risk factor for cardiovascular disease, but its aetiology has not been fully elucidated. Recently, attention has been focused on the direct relations of plasma homocysteine (Hcy) to blood pressure (BP). The purpose of this study was to determine the relationship of Hcy with BP and other ca...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001911
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abstract::Plasma gamma-glutamyltransferase (GGT) was suggested to reflect the level of systemic oxidative stress. Oxidative stress induces changes in arterial structure and function and contributes to the development of hypertension. Therefore, GGT may be associated with arterial remodeling and blood pressure (BP) increment, ev...
journal_title:Journal of human hypertension
pub_type: 杂志文章
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journal_title:Journal of human hypertension
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/jhh.2012.42
更新日期:2013-05-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 信件
doi:10.1038/sj.jhh.1002208
更新日期:2007-10-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章
doi:10.1038/sj.jhh.1000905
更新日期:1999-12-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2016.64
更新日期:2017-04-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1000555
更新日期:1998-01-01 00:00:00
abstract::Hypertension (HTN) is an important cause for chronic kidney disease (CKD). There is a paucity of studies exploring the association of HTN with CKD from rural India. The objective of the study was to determine the prevalence and the determinants for HTN in a rural population in South India, focusing on the association ...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2016.81
更新日期:2017-05-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1000697
更新日期:1998-10-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1002020
更新日期:2006-07-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1002229
更新日期:2007-09-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001636
更新日期:2004-01-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章,多中心研究
doi:10.1038/sj.jhh.1001532
更新日期:2003-03-01 00:00:00
abstract::Cognitive impairment is common in patients with hypertension. Left ventricular hypertrophy (LVH) is recognised as a marker of hypertension-related organ damage and is a strong predictor of coronary artery disease, heart failure and stroke. There is evidence that LVH is independently associated with cognitive impairmen...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/s41371-017-0023-0
更新日期:2018-03-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
abstract::This paper addresses approaches to evaluating the importance of different childhood behaviours on subsequent risk of high blood pressure and related cardiovascular risk factors and outlines results of a randomised controlled trial of nutrition and exercise interventions in schoolchildren. Clustering of cardiovascular ...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1996-02-01 00:00:00
abstract::It has been suggested that the prevalence of coronary artery disease (CAD) is steadily increasing in sub-Saharan Africa. To address this issue, we conducted a Medline search of English language articles on cardiovascular diseases-and specifically CAD in Africa- from 1966 to 1997. The prevalence of CAD and related comp...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001562
更新日期:2003-06-01 00:00:00
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journal_title:Journal of human hypertension
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doi:10.1038/jhh.2017.65
更新日期:2017-12-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2008.142
更新日期:2009-05-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2014.74
更新日期:2015-05-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:
更新日期:1989-06-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
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更新日期:1989-10-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
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更新日期:2017-05-01 00:00:00
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journal_title:Journal of human hypertension
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00