Abstract:
:Hypertension has been associated with hyperinsulinemia and insulin resistance. The elevations in plasma insulin are the apparent adaptation of the pancreatic beta cell to the resistance to insulin. Maintenance of normal insulin release is therefore of great importance for subjects with hypertension. The potassium channel opener pinacidil has antihypertensive properties. Pinacidil has been shown to inhibit Insulin release in vitro in isolated pancreatic beta cells. We therefore studied the acute effect of pinacidil on insulin secretion and insulin sensitivity in hypertensive and control subjects. The acute effect of pinacidil (25 mg, orally) on plasma insulin was studied during a hyperglycemic clamp (180 min, blood glucose 10 mmol/L) in 10 healthy volunteers and in 10 non-obese hypertensive patients in a randomised, placebo controlled double blind study. Fasting plasma insulin levels were 54.8 +/- 10.9 and 51.1 +/- 8.8 pmol/L in the control group and statistically significantly higher in the hypertensive group: 90.5 +/- 16.6 and 100.0 +/- 16.2 pmol/L (with and without pinacidil, respectively, both P < 0.02 vs control group). Plasma insulin levels rose to maximum levels of 246.7 +/- 44.6 and 267.2 +/- 56.2 pmol/L after 5 min in the control group (with and without pinacidil, respectively, NS) and to maximum levels of 248.9 +/- 37.3 and 238.0 +/- 39.1 pmol/L after 5 min in the hypertensive group (with and without pinacidil, respectively, NS). Areas under the insulin curve (AUCinsulin) of the first and second phase did not differ between the control and hypertensive group, with or without pinacidil. In the control and the hypertensive group separately no statistically significant effect of pinacidil on the mean glucose infusion rate/mean insulin level (M/I) ratio, a measure for insulin sensitivity, was shown. When both groups were taken together, an increase in the M/I ratio under the influence of pinacidil was found for the third hour of the clamp (P < 0.02). In conclusion, fasting insulin levels in the hypertensive subjects were significantly higher than in the control subjects. The potassium channel opener pinacidil did not influence insulin secretion in hypertensive patients and healthy controls. Pinacidil may have an enhancing effect on insulin sensitivity.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Ligtenberg JJ,Leenaers AD,Van Haeften TW,Smit AJ,Sluiter WJ,Reitsma WDsubject
Has Abstractpub_date
1996-04-01 00:00:00pages
269-76issue
4eissn
0950-9240issn
1476-5527journal_volume
10pub_type
临床试验,杂志文章,随机对照试验abstract::Physical exercise can increase urinary albumin excretion rate (UAER) in diabetic patients without microalbuminuria at rest (stage II diabetic nephropathy) or with baseline microalbuminuria (stage III diabetic nephropathy). The aim of this study was to compare the acute effects of captopril, an ACE inhibitor, and nifed...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1991-06-01 00:00:00
abstract::Professional historians generally treat the phrase 'what if' with pardonable scorn. It is a speculation which necessarily will never be tested in the real world. Nevertheless, there is a reasonable likelihood that, if typhoid fever had not carried off Frederick Akbar Mahomed at the age of 35, clinical research in Brit...
journal_title:Journal of human hypertension
pub_type: 传,历史文章,杂志文章
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更新日期:1996-03-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1987-12-01 00:00:00
abstract::We have studied prospectively the acute blood pressure lowering effect on an oral dose of captopril, 25 mg in 240 hypertensive patients. The mean relative reduction of systolic and diastolic BP was 16 and 15% respectively and the mean time to the mean arterial pressure nadir was 59 minutes. Systolic BP fell by more th...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章,多中心研究
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001499
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1000383
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001484
更新日期:2002-11-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1990-12-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/s41371-019-0290-z
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001518
更新日期:2003-02-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2014.110
更新日期:2015-07-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1038/sj.jhh.1001744
更新日期:2004-11-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1038/sj.jhh.1000870
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2010.117
更新日期:2012-01-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章,meta分析
doi:10.1038/sj.jhh.1000641
更新日期:1998-07-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
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journal_title:Journal of human hypertension
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:
更新日期:1992-12-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章,多中心研究
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journal_title:Journal of human hypertension
pub_type: 杂志文章
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journal_title:Journal of human hypertension
pub_type: 杂志文章
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更新日期:2017-10-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1991-06-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2003-03-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
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更新日期:1989-04-01 00:00:00
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pub_type: 杂志文章
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