Abstract：
:Three controlled dietary intervention studies were carried out in 1981-1983 in North Karelia, Finland, to asses the impact of dietary fat intake modification on blood pressure (BP). All these studies involved middle-aged men and women in rural or semirural areas and comprised a baseline period, a six week (or 12 weeks in the third study) intervention period and a four to six week return to baseline. During the intervention period the total fat intake was reduced from 39% to 24% of energy and the polyunsaturated/saturated (P/S) ratio increased from 0.2 to 0.4-1.2. In all groups energy intake was kept constant. For the present report data from the three studies were pooled for a series of stepwise regression analyses to predict changes in BP with different dietary changes. For both systolic (SBP) and diastolic (DBP) blood pressure, change in polyunsaturated fatty acid intake was the strongest dietary predictor of BP change. Changes in body weight, total fat intake, urinary sodium and potassium did not have significant predictive power in any of the analyses. The findings support the hypothesis that modification of dietary fat intake is a significant predictor of change in BP.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Nissinen A,Pietinen P,Tuomilehto J,Vartiainen E,Iacono JM,Puska Psubject
Has Abstractpub_date
1987-12-01 00:00:00pages
167-73issue
3eissn
0950-9240issn
1476-5527journal_volume
1pub_type
临床试验,杂志文章,随机对照试验abstract：:The accuracy of the TM-2420 ambulatory blood pressure monitor (A&D Co, Japan) has been assessed by the indirect method according to the recommendations of the Association for the Advancement of Medical Instrumentation (AAMI). Ninety subjects (43 men and 47 women), aged 19-89 with a range of systolic blood pressures (S...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章
doi：
更新日期：1991-04-01 00:00:00
abstract：:The C(-344)T promoter polymorphism of the human aldosterone synthase (CYP11B2) gene has been associated with hypertension and cardiac hypertrophy, but there were contrasting data. We analysed the genotype/phenotype associations between this polymorphism and cardiovascular variables in a young adult population, where i...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001619
更新日期：2003-12-01 00:00:00
abstract：:To investigate the involvement of the sympathetic nervous system and cell membrane sodium transport in hypertensive cardiac hypertrophy, we divided 51 middle-aged male patients with essential hypertension into cardiac hypertrophy and noncardiac hypertrophy groups. We then compared the plasma noradrenaline concentratio...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：:The phenomenon that blood pressure rises sharply in the morning is called 'Morning Blood Pressure Surge' (MBPS). Serum gamma-glutamyltransferase (GGT) is a proinflammatory marker involved in the pathogenesis of cardiovascular diseases. Although both are novel cardiovascular risk factors associated with inflammation an...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2014.74
更新日期：2015-05-01 00:00:00
abstract：:A total of 930 patients have been evaluated for safety in a programme of clinical trials for lisinopril-hydrochlorothiazide combination treatment. Combination therapy with these two agents is generally well tolerated. In clinical trials, adverse experiences in patients treated with a lisinopril-hydrochlorothiazide com...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：:Endothelin-1 (ET-1) is a potent vasoconstrictor peptide derived from endothelium. The presence of ET-1 in human vascular endothelium and in the plasma suggests that it may play a role in the regulation of vascular tone and blood pressure (BP) in humans. The aim of this study was to evaluate the behaviour of plasma ET-...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
abstract：:Genetic influences in cerebrovascular disease (CVD) may act either independently or by predisposing to, or modulating, the effect of risk factors such as hypertension. Factors involved in the pathogenesis of atherosclerosis, thrombosis and vasoconstriction are important in CVD. The angiotensinogen gene has recently be...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-08-01 00:00:00
abstract：:miR-33a has been described as a key regulator in the initiation and progression of atherosclerosis. However, its role in arterial hypertension (HTA) has not been elucidated. Therefore, the aim of this study was to determine the association between the expression of miR-33a (5p and 3p) and the carotid intima-media thic...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-018-0102-x
更新日期：2018-10-01 00:00:00
abstract：:Blood pressure (BP) measurement is the basis for the diagnosis and management of arterial hypertension. The aim of this study was to compare BP measurements performed in the office and at home (home blood pressure monitoring, HBPM) in children and adolescents with chronic arterial hypertension. HBPM was performed by t...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2008.167
更新日期：2009-07-01 00:00:00
abstract：:We aimed to investigate whether the effect of problematic alcohol drinking on hypertension differed according to metabolic health statuses. Male participants from the fifth Korea National Health and Nutrition Examination Survey were recruited. Problematic alcohol drinkers were designated as subjects with heavy drinkin...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2015.102
更新日期：2016-10-01 00:00:00
abstract：:We investigated the effect of elevated concentrations of fasting plasma glucose (FPG) or hemoglobin A1c (HbA1c) on the risk of development of hypertension among apparently healthy Japanese. Studied were 9584 individuals without known diabetes and hypertension. During a 5-year follow-up period, 1098 individuals develop...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2014.77
更新日期：2015-04-01 00:00:00
abstract：AIMS:To define the prevalence of hypertension, a major cause of morbidity and mortality in blacks, and related biosocial factors in an urban African population group. METHODS:The setting was that of a civil service population in Ibadan, a major city in Southwestern Nigeria. Nine hundred and ninety-eight civil servants...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/sj.jhh.1000975
更新日期：2000-04-01 00:00:00
abstract：:The purpose of this work was to assess the best haemodynamic determinant of left ventricular hypertrophy (LVH) in patients with essential hypertension. We studied the relationships between left ventricular mass (LVM) and casual, exercise and 24h ambulatory blood pressure monitoring (ABPM) in 60 newly discovered patien...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：:This is the first report of long-term use (one year) of isradipine, a new dihydropyridine calcium channel blocker, in the treatment of elderly patients with essential hypertension. Patients completing a three month, double-blind, multicentre study comparing isradipine to hydrochlorothiazide (HCTZ) were eligible to enr...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：1994-12-01 00:00:00
abstract：:Hypertension is a major risk factor for cardiovascular disease, which is the leading cause of mortality in women in developed countries. This pooled analysis assessed the antihypertensive efficacy, safety and tolerability of monotherapy with the direct renin inhibitor aliskiren (150 mg and 300 mg) over 8-12 weeks in w...
journal_title：Journal of human hypertension
pub_type： 杂志文章,meta分析
doi：10.1038/jhh.2010.11
更新日期：2010-11-01 00:00:00
abstract：:The role of the direct renin inhibitor aliskiren in hypertension is not fully established and use of aliskiren in diabetic patients is especially controversial. A systematic review investigating both short-term diastolic and systolic blood pressure (DBP and SBP) reduction and long-term cardiovascular outcomes has not ...
journal_title：Journal of human hypertension
pub_type： 杂志文章,meta分析
doi：10.1038/s41371-018-0149-8
更新日期：2019-11-01 00:00:00
abstract：:Hypertension has been associated with hyperinsulinemia and insulin resistance. The elevations in plasma insulin are the apparent adaptation of the pancreatic beta cell to the resistance to insulin. Maintenance of normal insulin release is therefore of great importance for subjects with hypertension. The potassium chan...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-04-01 00:00:00
abstract：:Both trandolapril and verapamil are effective and widely used antihypertensive agents. The aim of this study was to estimate the efficacy and tolerability of trandolapril/verapamil (Tr/Ve) combination for blood pressure control and renoprotection. PubMed, EMBASE and Cochrane Library were searched for relevant studies....
journal_title：Journal of human hypertension
pub_type： 杂志文章,meta分析
doi：10.1038/jhh.2010.60
更新日期：2011-03-01 00:00:00
abstract：:This paper addresses approaches to evaluating the importance of different childhood behaviours on subsequent risk of high blood pressure and related cardiovascular risk factors and outlines results of a randomised controlled trial of nutrition and exercise interventions in schoolchildren. Clustering of cardiovascular ...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-02-01 00:00:00
abstract：:The value of microalbuminuria in predicting hypertensive complications in pregnant patients at high risk was tested in a prospective trial. A total of 276 patients were studied (142 in the study group vs 134 controls). Albumin was measured in 8-h overnight urine collection throughout pregnancy using radioimmunoassay t...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：:Until now, no information is available about the effect of the presence of a doctor-in-training on a patient's blood pressure. We tested the hypothesis that the presence of a last year medical student might increase the blood pressure of the patient, in addition to the possible pressor response to the doctor-trainer. ...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/sj.jhh.1001744
更新日期：2004-11-01 00:00:00
abstract：:Despite the association of childhood blood pressure (BP) with hypertension later in the life course, there remains dearth of information regarding the prevalence and emergence of hypertension in children, especially in China. To investigate the current status of BP, prevalence of elevated BP and related factors in Chi...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究
doi：10.1038/jhh.2015.104
更新日期：2016-04-01 00:00:00
abstract：:Hypertension is one of the most prevalent cardiovascular diseases and its treatment requires multimodal therapeutic approaches. This review aims to provide a summary and update on relevant evidence in hypertension research published in 2019/2020. These include trials dealing with the prognostic effect of systolic and ...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/s41371-020-00477-1
更新日期：2021-01-12 00:00:00
abstract：:A screening programme for cardiovascular risk factors in men aged 50-59 was undertaken in North Uist, and the results compared with an age- and sex-matched control group from Dundee screened as part of the Scottish Heart Health Study. Blood pressure levels were higher in the Islanders than in controls (148 +/- 20/89 +...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：:The National Blood Pressure Programme in Germany (NBP) was established in 1985. The NBP is committed to a process of programme development and implementation that incorporates public health relevance, recent research results, and attempts of scientific module evaluation. Among selected examples of successful modules, ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：:Platelet shape change (PSC) is an early phase of platelet activation that precedes platelet aggregation. This phase of platelet activation is essentially aspirin resistant. PSC was monitored, by measuring the median platelet volume (MPV) using a high resolution channelyser. Angiotensin (Ang) II, added in vitro, caused...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001102
更新日期：2000-09-01 00:00:00
abstract：:A total of 78 Chinese patients with clinically uncomplicated non-insulin-dependent diabetes (NIDDM) who had plasma creatinine concentrations of < 150 mumol/l were studied. Antihypertensive treatment was discontinued for at least six weeks prior to measurements of routine biochemistry, proteinuria, plasma atrial natriu...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：:Despite the availability of multiple nonpharmacological and pharmacological antihypertensive regimens large scale control of BP on a population basis is still unsatisfactory. To achieve a better quality in hypertension care we have developed and evaluated a structured outpatient hypertension treatment and teaching pro...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:Few studies have investigated the presence of dyslipidaemia in hypertensive individuals. In addition, few data exist on the concurrent treatment of both conditions for the prevention of cardiovascular disease (CVD). This retrospective cohort study examined treatment patterns for hypertension and dyslipidaemia among hy...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究
doi：10.1038/sj.jhh.1002249
更新日期：2007-12-01 00:00:00
abstract：:The interactions of intrarenal dopamine (DA) synthesis and natriuresis were studied in 11 healthy volunteers by giving a low and high sodium diet (LoSo, 50 mmol Na+; HiSo, 250 mmol Na+). On 2 days in both dietary phases an acute saline load was given, without or with an infusion of the DA precursor 3, 4-dihydroxypheny...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
