Angiotensin II can induce and potentiate shape change in human platelets: effect of losartan.


:Platelet shape change (PSC) is an early phase of platelet activation that precedes platelet aggregation. This phase of platelet activation is essentially aspirin resistant. PSC was monitored, by measuring the median platelet volume (MPV) using a high resolution channelyser. Angiotensin (Ang) II, added in vitro, caused a significant (P = 0.004) increase in MPV in platelet rich plasma prepared from healthy subjects (n = 14). This increase in MPV was marked (>0.40 fl) in 57% (n = 8) of these subjects and was significantly inhibited (P<0.008) by losartan (a selective Ang II antagonist) at concentrations similar to those achieved in the circulation during treatment. Ang II also significantly enhanced sub-maximal PSC induced by ADP and serotonin in all subjects tested. Losartan significantly (n = 9; P<0.001) inhibited U46619 (a thromboxane A2 analogue)-induced PSC. These findings suggest that losartan, in addition to its blood pressure lowering action, has antiplatelet activity. This property may be clinically relevant because of the increased risk of vascular events in hypertensive patients.


J Hum Hypertens


Jagroop IA,Mikhailidis DP




Has Abstract


2000-09-01 00:00:00












  • Alcohol consumption and blood pressure change: 5-year follow-up study of the association in normotensive workers.

    abstract::This study endeavours to clarify the effect of alcohol consumption on changes in the blood pressure of Japanese men. The subjects, who were followed from 1990 to 1995, were 2189 male normotensive steelworkers aged from 40 to 54 years in 1990. Drinking habits were represented by two variables: average daily baseline al...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Okubo Y,Suwazono Y,Kobayashi E,Nogawa K

    更新日期:2001-06-01 00:00:00

  • Genetics of stroke.

    abstract::Stroke is a very common cause of death and disability. Several lines of evidence point to stroke as a polygenic multifactoral phenotype and there are also a number of well studied single gene Mendelian stroke conditions. Rat models have identified several chromosomal sites linked to stroke, and this together with othe...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,评审


    authors: Carter ND

    更新日期:1997-09-01 00:00:00

  • Abnormalities of rheology and coagulation in hypertension.

    abstract::While the arterial tree is exposed to increased pressure flow, paradoxically the complications of hypertension are mainly thrombotic rather than haemorrhage. Improved techniques have allowed the identification of haemorrheological indices, coagulation factors and markers of arteriolar endothelial and platelet dysfunct...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,评审


    authors: Lip GY,Beevers DG

    更新日期:1994-09-01 00:00:00

  • Association between hepatic steatosis, insulin resistance and hyperinsulinaemia as related to hypertension in alcohol consumers and obese people.

    abstract::The presence of hepatic steatosis was determined in 180 middle-aged male workers by ultrasonography and was found in 39 (22%) of them. Body mass index (BMI), systolic and diastolic blood pressure (BP) and serum levels of asparate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transpeptidase ...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Ikai E,Ishizaki M,Suzuki Y,Ishida M,Noborizaka Y,Yamada Y

    更新日期:1995-02-01 00:00:00

  • Soluble vascular endothelial growth factor receptor-1 is reduced in patients with resistant hypertension after renal denervation.

    abstract::Renal denervation (RDN) has been shown in several studies to reduce blood pressure (BP) in patients with resistant hypertension (RH). Data on potential biomarkers associated with BP changes remain scarce. We evaluated whether soluble vascular endothelial growth factor receptor (sVEGFR-1) is affected by the procedure. ...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Eikelis N,Hering D,Marusic P,Walton AS,Lambert EA,Sata Y,Krum H,Lambert GW,Esler MD,Schlaich MP

    更新日期:2017-04-01 00:00:00

  • Higher urinary albumin excretion is associated with abnormal erythrocyte Na(+)/Li(+) countertransport (SLC) in non-modulating essential hypertensives and offspring of hypertensive parents.

    abstract::Non-modulating is a highly reproducible type of sodium-sensitive hypertension. The aim of this study was to evaluate in non-modulating individuals the erythrocyte sodium-lithium countertransport (SLC) abnormalities, which have been mentioned as a marker of non-modulation, and the association with increased microalbumi...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Sánchez RA,Giannone C,Masnatta LD,Baglivo HP,Ramírez AJ

    更新日期:2002-03-01 00:00:00

  • Non-dipping pattern relates to endothelial dysfunction in patients with uncontrolled resistant hypertension.

    abstract::Resistant hypertension (RHTN) includes both patients whose blood pressure (BP) is uncontrolled on three or more medications (uncontrolled RHTN (UCRH)) and patients whose BP is controlled with use of four or more drugs (controlled RHTN (CRH)). It is unknown whether endothelial function and nocturnal drop demonstrate a ...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Quinaglia T,Martins LC,Figueiredo VN,Santos RC,Yugar-Toledo JC,Martin JF,Demacq C,Pimenta E,Calhoun DA,Moreno H Jr

    更新日期:2011-11-01 00:00:00

  • Insertion/deletion gene polymorphism of the angiotensin-converting enzyme and blood pressure changes in older adults. The Rotterdam study.

    abstract::The insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene may be involved in determining blood pressure changes. The aim of the present study was to assess the relationship between the ACE I/D gene and the change of blood pressure levels during follow-up. We calculated the difference be...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Mattace-Raso FU,Sie MP,van der Cammen TJ,Safar ME,Hofman A,van Duijn CM,Witteman JC

    更新日期:2007-09-01 00:00:00

  • The combination of amlodipine and angiotensin receptor blocker or diuretics in high-risk hypertensive patients: rationale, design and baseline characteristics.

    abstract::The Chinese Hypertension Intervention Efficacy Study (CHIEF) is a multi-centre randomized controlled clinical trial comparing the effects of amlodipine+angiotensin II receptor blocker and amlodipine+diuretics on the incidence of cardiovascular events, represented as a composite of non-fatal stroke, non-fatal myocardia...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Wang W,Ma L,Zhang Y,Deng Q,Liu M,Liu L

    更新日期:2011-04-01 00:00:00

  • A comparison of the tolerability of the direct renin inhibitor aliskiren and lisinopril in patients with severe hypertension.

    abstract::Patients with severe hypertension (>180/110 mm Hg) require large blood pressure (BP) reductions to reach recommended treatment goals (<140/90 mm Hg) and usually require combination therapy to do so. This 8-week, multicenter, randomized, double-blind, parallel-group study compared the tolerability and antihypertensive ...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Strasser RH,Puig JG,Farsang C,Croket M,Li J,van Ingen H

    更新日期:2007-10-01 00:00:00

  • Relationship of serum immunoglobulin levels to blood pressure and hypertension in an adult population.

    abstract::Evidence suggests long-term chronic inflammation, as the pathological basis of formation and development, plays an important part in atherosclerosis. Immunoglobulins (Igs) provided key information on the humoral immune status. However, few studies have evaluated the correlation between Igs and hypertension and blood p...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Wang X,Li Y,Li H,Gu Y,Song Y,Zhang Q,Liu L,Meng G,Yao Z,Wu H,Xia Y,Bao X,Shi H,Su Q,Fang L,Yang H,Yu F,Sun S,Wang X,Zhou M,Jiao H,Jia Q,Song K,Wu Y,Chang H,Niu K

    更新日期:2018-03-01 00:00:00

  • Aldosterone synthase alleles and cardiovascular phenotype in young adults.

    abstract::The C(-344)T promoter polymorphism of the human aldosterone synthase (CYP11B2) gene has been associated with hypertension and cardiac hypertrophy, but there were contrasting data. We analysed the genotype/phenotype associations between this polymorphism and cardiovascular variables in a young adult population, where i...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Sarzani R,Salvi F,Dessì-Fulgheri P,Catalini R,Mazzara D,Cola G,Siragusa N,Spagnolo D,Ercolani P,Gesuita R,Carle F,Rappelli A

    更新日期:2003-12-01 00:00:00

  • ADVANCE: action in diabetes and vascular disease.

    abstract::The burden of Type II diabetes is growing rapidly worldwide, across high-, middle- and low-income countries. This burden is associated primarily with increased risks of macrovascular and microvascular diseases, and it is agreed that multifactorial treatment regimens are required to reduce it. ADVANCE (Action in Diabet...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,评审


    authors: Patel A,Chalmers J,Poulter N

    更新日期:2005-06-01 00:00:00

  • Antihypertensive effect of valyl-tyrosine, a short chain peptide derived from sardine muscle hydrolyzate, on mild hypertensive subjects.

    abstract::The present study was conducted to determine whether Valyl-Tyrosine (VY) has an antihypertensive effect on high-normal blood pressure and mild essential hypertension, as well as spontaneous hypertensive rats (SHR). A randomised double-blind placebo-controlled study was carried out on 29 volunteers. A 100-ml drink cont...

    journal_title:Journal of human hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kawasaki T,Seki E,Osajima K,Yoshida M,Asada K,Matsui T,Osajima Y

    更新日期:2000-08-01 00:00:00

  • Nonspecific dizziness: frequency of supine hypertension associated with hypotensive reactions on head-up tilt.

    abstract::The clinical syndrome of supine hypertension associated with orthostatic hypotension (OH) in given individuals is recognized by specialists, but is underdiagnosed in the community. The objective of this study was to assess supine hypertension associated with hypotensive reactions on head-up tilt (SH-HRT) among patient...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Naschitz JE,Mussafia-Priselac R,Kovalev Y,Zaigraykina N,Slobodin G,Elias N,Storch S,Rosner I

    更新日期:2006-02-01 00:00:00

  • Plasma homocysteine concentration and blood pressure in healthy Iranian adults: the Tehran Homocysteine Survey (2003-2004).

    abstract::Hypertension is a modifiable risk factor for cardiovascular disease, but its aetiology has not been fully elucidated. Recently, attention has been focused on the direct relations of plasma homocysteine (Hcy) to blood pressure (BP). The purpose of this study was to determine the relationship of Hcy with BP and other ca...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Fakhrzadeh H,Ghotbi S,Pourebrahim R,Heshmat R,Nouri M,Shafaee A,Larijani B

    更新日期:2005-11-01 00:00:00

  • Selective alpha 1-adrenergic inhibition improves decrease glucose disposal in patients with essential hypertension.

    abstract::This study evaluated insulin secretion and insulin sensitivity before and after short-term oral administration of doxazosin in patients with essential hypertension. The hypertensive group consisted of 11 nonobese subjects (aged 41.0 +/- 2.5 years (mean +/- SEM), body mass index 24.0 +/- 0.53 kg/m2). The normotensive g...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Yamasaki Y,Shiba Y,Sekiya M,Tsujino T,Hakui N,Kawamori R,Kamada T

    更新日期:1994-08-01 00:00:00

  • An overview of the Guangzhou biobank cohort study-cardiovascular disease subcohort (GBCS-CVD): a platform for multidisciplinary collaboration.

    abstract::The Guangzhou Biobank Cohort Study (GBCS, n=30 519, age >or=50 years) was established to examine the effects of genetic and environmental influences on health problems and chronic disease development. Guangzhou is undergoing massive economic development, but from a baseline that had remained unchanged for millennia. T...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,多中心研究


    authors: Jiang CQ,Lam TH,Lin JM,Liu B,Yue XJ,Cheng KK,Tomlinson B,Wong KS,Cheung BM,Thomas GN

    更新日期:2010-02-01 00:00:00

  • Clinical correlates of renal dysfunction in hypertensive patients without cardiovascular complications: the REDHY study.

    abstract::Our study was aimed to assess the clinical correlates of different degrees of renal dysfunction in a wide group of non-diabetic hypertensive patients, free from cardiovascular (CV) complications and known renal diseases, participating to the REDHY (REnal Dysfunction in HYpertension) study. A total of 1856 hypertensive...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Cerasola G,Mulè G,Nardi E,Cusimano P,Palermo A,Arsena R,Guarneri M,Geraci C,Cottone S

    更新日期:2010-01-01 00:00:00

  • Effect of a high-protein diet on maintenance of blood pressure levels achieved after initial weight loss: the DiOGenes randomized study.

    abstract::Randomized trials have shown significant blood pressure (BP) reductions after increased protein compared with carbohydrate intake, but the effect on BP maintenance after initial weight loss is unclear. We examined the effect of a high-protein diet on the maintenance of reduced BP after weight loss in 420 overweight ad...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Engberink MF,Geleijnse JM,Bakker SJ,Larsen TM,Handjieva-Darlesnka T,Kafatos A,Martinez JA,Pfeiffer AF,Kunešová M,Jebb SA,Holst C,Astrup A,Saris WH,Brink EJ,van Baak MA

    更新日期:2015-01-01 00:00:00

  • Assessment and validation of spot urine in estimating the 24-h urinary sodium, potassium, and sodium/potassium ratio in Chinese adults.

    abstract::The commonly used methods of estimating the 24-h urinary sodium (UNa) and urinary potassium (UK) from spot urine (SU) are the Kawasaki method (K-method), INTERSALT method (I-method), and Tanaka method (T-method), but the method that is suitable for use in the general Chinese population is still uncertain. We aimed to ...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Xu J,Du X,Bai Y,Fang L,Liu M,Ji N,Zhong J,Yu M,Wu J

    更新日期:2020-02-01 00:00:00

  • Changes in sodium intake and blood pressure in a community-based intervention project in China.

    abstract::A sodium intervention project was carried out in Tianjin, China, as part of the Tianjin Project, which is a national pilot, community-based intervention programme to reduce non-communicable diseases. The aim of this 3 year sodium project was to evaluate the feasibility and effects of sodium reduction in the population...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Tian HG,Guo ZY,Hu G,Yu SJ,Sun W,Pietinen P,Nissinen A

    更新日期:1995-12-01 00:00:00

  • Genetic variations in ATP2B1, CSK, ARSG and CSMD1 loci are related to blood pressure and/or hypertension in two Korean cohorts.

    abstract::Blood pressure, one of the important vital signs, is affected by multiple genetic and environmental factors. Recently, several genome-wide association (GWA) studies have successfully identified genetic factors that influence blood pressure and hypertension risk. In this study, we report results of the Korean Associati...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Hong KW,Go MJ,Jin HS,Lim JE,Lee JY,Han BG,Hwang SY,Lee SH,Park HK,Cho YS,Oh B

    更新日期:2010-06-01 00:00:00

  • Haemodynamic contributions to post-exercise hypotension in young adults with hypertension and rapid resting heart rates.

    abstract::The haemodynamic effects of 45 min of treadmill exercise (at 70% of resting heart rate reserve) were determined in 5 young adults with hypertension and rapid resting heart rates (greater than 90 beats/min in clinic) and were compared with those of 5 age-matched normotensive subjects. Blood pressure was lower after exe...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Floras JS,Wesche J

    更新日期:1992-08-01 00:00:00

  • Prevalence of high blood pressure under 2017 ACC/AHA guidelines: a systematic review and meta-analysis.

    abstract::To understand the prevalence of high blood pressure among the general adult population under the new diagnostic criteria. PubMed and Embase databases were systematically searched. Two investigators independently performed data extraction and quality assessment, and the disagreements were resolved by consensus with a t...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,评审


    authors: Xiong P,Liu Z,Xiong M,Xie F

    更新日期:2020-12-08 00:00:00

  • Maternal factors and development of cardiovascular risk: evidence from a study of blood pressure in children.

    abstract::It has been suggested that risks of hypertension and cardiovascular disease begin in utero and that maternal nutrition plays an important role. We have examined the relation between maternal factors and BP in a study of 1,311 children in which physical measurements at 9-11 years of age have been linked to a parental q...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Whincup P,Cook D,Papacosta O,Walker M,Perry I

    更新日期:1994-05-01 00:00:00

  • Investigation of chromosome 17q as a locus for human essential hypertension in African Caribbeans.

    abstract::Essential hypertension is a major risk factor for cardiovascular disease in humans, and originates from both genetic and environmental factors. Data from animal and more recently human studies have indicated the presence of a gene influencing blood pressure on human chromosome 17. This study tested for linkage of mark...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Knight J,Gardner GT,Clark AJ,Caulfield MJ

    更新日期:2000-06-01 00:00:00

  • Low rates of detection and treatment of hypertension among current cigarette smokers.

    abstract::This report analysed data from the Health Survey for England 1994 to evaluate blood pressure (BP) management in relation to cigarette smoking. Data were analysed for 12 013 adults aged > or = 16 years living in England in 1994. Among 2280 subjects with BP > or = 160/95 mm Hg or treated with BP-lowering medication, rat...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Gulliford MC

    更新日期:2001-11-01 00:00:00

  • The role of aliskiren in the management of hypertension and major cardiovascular outcomes: a systematic review and meta-analysis.

    abstract::The role of the direct renin inhibitor aliskiren in hypertension is not fully established and use of aliskiren in diabetic patients is especially controversial. A systematic review investigating both short-term diastolic and systolic blood pressure (DBP and SBP) reduction and long-term cardiovascular outcomes has not ...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,meta分析


    authors: Bjerre HL,Christensen JB,Buus NH,Simonsen U,Su J

    更新日期:2019-11-01 00:00:00

  • C-reactive protein and hypertension.

    abstract::C-reactive protein (CRP), the prototypical acute-phase reactant, is one of the most widely known biomarkers of cardiovascular disease. Circulating levels of CRP are clinically used to predict the occurrence of cardiovascular events and to aide in the selection of therapies based on more accurate risk assessment in ind...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,评审


    authors: Hage FG

    更新日期:2014-07-01 00:00:00