Abstract：
:Platelet shape change (PSC) is an early phase of platelet activation that precedes platelet aggregation. This phase of platelet activation is essentially aspirin resistant. PSC was monitored, by measuring the median platelet volume (MPV) using a high resolution channelyser. Angiotensin (Ang) II, added in vitro, caused a significant (P = 0.004) increase in MPV in platelet rich plasma prepared from healthy subjects (n = 14). This increase in MPV was marked (>0.40 fl) in 57% (n = 8) of these subjects and was significantly inhibited (P<0.008) by losartan (a selective Ang II antagonist) at concentrations similar to those achieved in the circulation during treatment. Ang II also significantly enhanced sub-maximal PSC induced by ADP and serotonin in all subjects tested. Losartan significantly (n = 9; P<0.001) inhibited U46619 (a thromboxane A2 analogue)-induced PSC. These findings suggest that losartan, in addition to its blood pressure lowering action, has antiplatelet activity. This property may be clinically relevant because of the increased risk of vascular events in hypertensive patients.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Jagroop IA,Mikhailidis DPdoi
10.1038/sj.jhh.1001102subject
Has Abstractpub_date
2000-09-01 00:00:00pages
581-5issue
9eissn
0950-9240issn
1476-5527journal_volume
14pub_type
杂志文章abstract：:This study endeavours to clarify the effect of alcohol consumption on changes in the blood pressure of Japanese men. The subjects, who were followed from 1990 to 1995, were 2189 male normotensive steelworkers aged from 40 to 54 years in 1990. Drinking habits were represented by two variables: average daily baseline al...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001191
更新日期：2001-06-01 00:00:00
abstract：:Stroke is a very common cause of death and disability. Several lines of evidence point to stroke as a polygenic multifactoral phenotype and there are also a number of well studied single gene Mendelian stroke conditions. Rat models have identified several chromosomal sites linked to stroke, and this together with othe...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1000486
更新日期：1997-09-01 00:00:00
abstract：:While the arterial tree is exposed to increased pressure flow, paradoxically the complications of hypertension are mainly thrombotic rather than haemorrhage. Improved techniques have allowed the identification of haemorrheological indices, coagulation factors and markers of arteriolar endothelial and platelet dysfunct...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：
更新日期：1994-09-01 00:00:00
abstract：:The presence of hepatic steatosis was determined in 180 middle-aged male workers by ultrasonography and was found in 39 (22%) of them. Body mass index (BMI), systolic and diastolic blood pressure (BP) and serum levels of asparate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transpeptidase ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-02-01 00:00:00
abstract：:Renal denervation (RDN) has been shown in several studies to reduce blood pressure (BP) in patients with resistant hypertension (RH). Data on potential biomarkers associated with BP changes remain scarce. We evaluated whether soluble vascular endothelial growth factor receptor (sVEGFR-1) is affected by the procedure. ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2016.64
更新日期：2017-04-01 00:00:00
abstract：:Non-modulating is a highly reproducible type of sodium-sensitive hypertension. The aim of this study was to evaluate in non-modulating individuals the erythrocyte sodium-lithium countertransport (SLC) abnormalities, which have been mentioned as a marker of non-modulation, and the association with increased microalbumi...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001358
更新日期：2002-03-01 00:00:00
abstract：:Resistant hypertension (RHTN) includes both patients whose blood pressure (BP) is uncontrolled on three or more medications (uncontrolled RHTN (UCRH)) and patients whose BP is controlled with use of four or more drugs (controlled RHTN (CRH)). It is unknown whether endothelial function and nocturnal drop demonstrate a ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2011.43
更新日期：2011-11-01 00:00:00
abstract：:The insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene may be involved in determining blood pressure changes. The aim of the present study was to assess the relationship between the ACE I/D gene and the change of blood pressure levels during follow-up. We calculated the difference be...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1002229
更新日期：2007-09-01 00:00:00
abstract：:The Chinese Hypertension Intervention Efficacy Study (CHIEF) is a multi-centre randomized controlled clinical trial comparing the effects of amlodipine+angiotensin II receptor blocker and amlodipine+diuretics on the incidence of cardiovascular events, represented as a composite of non-fatal stroke, non-fatal myocardia...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/jhh.2010.45
更新日期：2011-04-01 00:00:00
abstract：:Patients with severe hypertension (>180/110 mm Hg) require large blood pressure (BP) reductions to reach recommended treatment goals (<140/90 mm Hg) and usually require combination therapy to do so. This 8-week, multicenter, randomized, double-blind, parallel-group study compared the tolerability and antihypertensive ...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/sj.jhh.1002220
更新日期：2007-10-01 00:00:00
abstract：:Evidence suggests long-term chronic inflammation, as the pathological basis of formation and development, plays an important part in atherosclerosis. Immunoglobulins (Igs) provided key information on the humoral immune status. However, few studies have evaluated the correlation between Igs and hypertension and blood p...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-018-0029-2
更新日期：2018-03-01 00:00:00
abstract：:The C(-344)T promoter polymorphism of the human aldosterone synthase (CYP11B2) gene has been associated with hypertension and cardiac hypertrophy, but there were contrasting data. We analysed the genotype/phenotype associations between this polymorphism and cardiovascular variables in a young adult population, where i...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001619
更新日期：2003-12-01 00:00:00
abstract：:The burden of Type II diabetes is growing rapidly worldwide, across high-, middle- and low-income countries. This burden is associated primarily with increased risks of macrovascular and microvascular diseases, and it is agreed that multifactorial treatment regimens are required to reduce it. ADVANCE (Action in Diabet...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1001890
更新日期：2005-06-01 00:00:00
abstract：:The present study was conducted to determine whether Valyl-Tyrosine (VY) has an antihypertensive effect on high-normal blood pressure and mild essential hypertension, as well as spontaneous hypertensive rats (SHR). A randomised double-blind placebo-controlled study was carried out on 29 volunteers. A 100-ml drink cont...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.jhh.1001065
更新日期：2000-08-01 00:00:00
abstract：:The clinical syndrome of supine hypertension associated with orthostatic hypotension (OH) in given individuals is recognized by specialists, but is underdiagnosed in the community. The objective of this study was to assess supine hypertension associated with hypotensive reactions on head-up tilt (SH-HRT) among patient...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001947
更新日期：2006-02-01 00:00:00
abstract：:Hypertension is a modifiable risk factor for cardiovascular disease, but its aetiology has not been fully elucidated. Recently, attention has been focused on the direct relations of plasma homocysteine (Hcy) to blood pressure (BP). The purpose of this study was to determine the relationship of Hcy with BP and other ca...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001911
更新日期：2005-11-01 00:00:00
abstract：:This study evaluated insulin secretion and insulin sensitivity before and after short-term oral administration of doxazosin in patients with essential hypertension. The hypertensive group consisted of 11 nonobese subjects (aged 41.0 +/- 2.5 years (mean +/- SEM), body mass index 24.0 +/- 0.53 kg/m2). The normotensive g...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1994-08-01 00:00:00
abstract：:The Guangzhou Biobank Cohort Study (GBCS, n=30 519, age >or=50 years) was established to examine the effects of genetic and environmental influences on health problems and chronic disease development. Guangzhou is undergoing massive economic development, but from a baseline that had remained unchanged for millennia. T...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究
doi：10.1038/jhh.2009.52
更新日期：2010-02-01 00:00:00
abstract：:Our study was aimed to assess the clinical correlates of different degrees of renal dysfunction in a wide group of non-diabetic hypertensive patients, free from cardiovascular (CV) complications and known renal diseases, participating to the REDHY (REnal Dysfunction in HYpertension) study. A total of 1856 hypertensive...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2009.41
更新日期：2010-01-01 00:00:00
abstract：:Randomized trials have shown significant blood pressure (BP) reductions after increased protein compared with carbohydrate intake, but the effect on BP maintenance after initial weight loss is unclear. We examined the effect of a high-protein diet on the maintenance of reduced BP after weight loss in 420 overweight ad...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/jhh.2014.30
更新日期：2015-01-01 00:00:00
abstract：:The commonly used methods of estimating the 24-h urinary sodium (UNa) and urinary potassium (UK) from spot urine (SU) are the Kawasaki method (K-method), INTERSALT method (I-method), and Tanaka method (T-method), but the method that is suitable for use in the general Chinese population is still uncertain. We aimed to ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-019-0274-z
更新日期：2020-02-01 00:00:00
abstract：:A sodium intervention project was carried out in Tianjin, China, as part of the Tianjin Project, which is a national pilot, community-based intervention programme to reduce non-communicable diseases. The aim of this 3 year sodium project was to evaluate the feasibility and effects of sodium reduction in the population...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：:Blood pressure, one of the important vital signs, is affected by multiple genetic and environmental factors. Recently, several genome-wide association (GWA) studies have successfully identified genetic factors that influence blood pressure and hypertension risk. In this study, we report results of the Korean Associati...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2009.86
更新日期：2010-06-01 00:00:00
abstract：:The haemodynamic effects of 45 min of treadmill exercise (at 70% of resting heart rate reserve) were determined in 5 young adults with hypertension and rapid resting heart rates (greater than 90 beats/min in clinic) and were compared with those of 5 age-matched normotensive subjects. Blood pressure was lower after exe...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：:To understand the prevalence of high blood pressure among the general adult population under the new diagnostic criteria. PubMed and Embase databases were systematically searched. Two investigators independently performed data extraction and quality assessment, and the disagreements were resolved by consensus with a t...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/s41371-020-00454-8
更新日期：2020-12-08 00:00:00
abstract：:It has been suggested that risks of hypertension and cardiovascular disease begin in utero and that maternal nutrition plays an important role. We have examined the relation between maternal factors and BP in a study of 1,311 children in which physical measurements at 9-11 years of age have been linked to a parental q...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：:Essential hypertension is a major risk factor for cardiovascular disease in humans, and originates from both genetic and environmental factors. Data from animal and more recently human studies have indicated the presence of a gene influencing blood pressure on human chromosome 17. This study tested for linkage of mark...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001025
更新日期：2000-06-01 00:00:00
abstract：:This report analysed data from the Health Survey for England 1994 to evaluate blood pressure (BP) management in relation to cigarette smoking. Data were analysed for 12 013 adults aged > or = 16 years living in England in 1994. Among 2280 subjects with BP > or = 160/95 mm Hg or treated with BP-lowering medication, rat...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001275
更新日期：2001-11-01 00:00:00
abstract：:The role of the direct renin inhibitor aliskiren in hypertension is not fully established and use of aliskiren in diabetic patients is especially controversial. A systematic review investigating both short-term diastolic and systolic blood pressure (DBP and SBP) reduction and long-term cardiovascular outcomes has not ...
journal_title：Journal of human hypertension
pub_type： 杂志文章,meta分析
doi：10.1038/s41371-018-0149-8
更新日期：2019-11-01 00:00:00
abstract：:C-reactive protein (CRP), the prototypical acute-phase reactant, is one of the most widely known biomarkers of cardiovascular disease. Circulating levels of CRP are clinically used to predict the occurrence of cardiovascular events and to aide in the selection of therapies based on more accurate risk assessment in ind...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/jhh.2013.111
更新日期：2014-07-01 00:00:00
