Abstract:
:This paper addresses approaches to evaluating the importance of different childhood behaviours on subsequent risk of high blood pressure and related cardiovascular risk factors and outlines results of a randomised controlled trial of nutrition and exercise interventions in schoolchildren. Clustering of cardiovascular risk factors was studied in relation to diet, blood pressure, fitness, fatness and blood cholesterol in a representative sample of 555 Perth schoolchildren aged 15 years. Twenty-one percent of males and females had high risk profiles associated with dietary excesses, particularly in fat, cholesterol and sodium intake, and deficiencies of minerals, vitamins and dietary fibre. Socio-economic status was inversely associated with cardiovascular risk and undernutrition in girls. Thus 21% of the school children shared unhealthy lifestyles putting them at substantial risk of subsequent cardiovascular disease. A randomised controlled trial designed to reduce cardiovascular risk was conducted in 1147 children 10-12 years old, assigned to one of six groups for a year. The groups were fitness, fitness and school nutrition, school nutrition, school and home nutrition, home nutrition or controls. On cluster analysis 30% of the children were at higher risk at baseline in terms of blood pressure, blood cholesterol levels, fitness and body fat. With the fitness programmes fitness increased in both high and low risk girls but only in high risk cluster boys. Systolic pressure fell more in the high risk boys in the fitness group than in low risk boys, while diastolic pressure fell in girls regardless of initial risk. Triceps skinfold thickness fell more in higher than lower risk girls in the school and home nutrition group, and more in high risk boys in the home nutrition group. Higher risk girls showed a greater reduction in fat intake and increase in dietary fibre with home nutrition programmes. We concluded that higher risk children do show greater responses to lifestyle intervention programmes in general, with the greatest effects seen with home nutrition or fitness programmes. The results indicate the need for different approaches to prevention of hypertension and cardiovascular risk in higher and lower risk children and for boys and girls.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Beilin L,Burke V,Milligan Rsubject
Has Abstractpub_date
1996-02-01 00:00:00pages
S51-4eissn
0950-9240issn
1476-5527journal_volume
10 Suppl 1pub_type
临床试验,杂志文章,随机对照试验abstract::Although 24-h urine collection is widely considered the 'gold standard' for estimation of population sodium intake, spot urine collection is increasingly used as a convenient and affordable alternative. We used four published formulae to convert spot urine sodium into estimates of 24-h sodium excretion in order to est...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2014.10
更新日期:2014-11-01 00:00:00
abstract::New onset of seizures in young adults is frequently related to alcohol withdrawal, toxic exposure, central nervous system trauma and neoplasm. We describe a young soldier presenting to the emergency department with seizures and transient coma. On admission, he had hypertension, marked leukocytosis, hyper-glycaemia, ac...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001499
更新日期:2003-01-01 00:00:00
abstract::Primary aldosteronism (PA), the most common cause of secondary hypertension, is a well-recognized condition that can lead to cardiovascular and renal complications. PA is frequently left undiagnosed and untreated, leading to aldosterone-specific morbidity and mortality. In this review we highlight the evidence linking...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:10.1038/s41371-019-0294-8
更新日期:2020-01-01 00:00:00
abstract::The prediction of risk profile trends associated with non-communicable diseases in developing countries is among the greatest global health challenges. The aim of this study is to estimate prevalence, awareness, treatment and control of hypertension in Dakar (Senegal). This study was carried out between January and Ju...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2013.142
更新日期:2014-08-01 00:00:00
abstract::The treatment of hypertension is based on an assessment of the balance between the effects of therapy on survival on the one hand and effects of the patient's symptoms and well-being on the other. The concept of quality of life is used to summarise the latter effects. Preservation of quality of life involves both the ...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:
更新日期:1993-02-01 00:00:00
abstract::In this study we investigated the role of endogenous endothelin in the cardiovascular response to acute stress, ie mild footshocks in conscious rats. Footshock-stress significantly increased mean arterial pressure and heart rate (P < 0.05). Peripheral or intracerebroventricular (IVT) administration of BQ 788, a select...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001338
更新日期:2002-03-01 00:00:00
abstract::We compared the effects on blood pressure (BP) of three isocaloric diets with reduced total fat and saturated fatty acid (SAFA) contents but with different proportions of monounsaturated (MUFA) and polyunsaturated fatty acids (PUFA). Diet LF (low fat) provided 20 en% fat (7.9% SAFA, 7.8% MUFA, 3.0% PUFA); diet HP (hig...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.jhh.1000610
更新日期:1998-06-01 00:00:00
abstract::To investigate a possible association between miR-101 and apoptosis of human trophoblast cells mediated by endoplasmic reticulum protein 44 (ERp44) in preeclampsia (PE), we explored the expression of miR-101 in PE placentas (n=30) compared with normotensive pregnant placentas (n=30) and the correlation between miR-101...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2014.35
更新日期:2014-10-01 00:00:00
abstract::We examined the association between serum lipoprotein subclasses and the three measures of arterial stiffness, that is, (i) carotid-femoral pulse wave velocity (cfPWV), which is a gold standard measure of central arterial stiffness, (ii) brachial-ankle PWV (baPWV), which is emerging as a combined measure of central an...
journal_title:Journal of human hypertension
pub_type: 杂志文章,多中心研究
doi:10.1038/jhh.2013.60
更新日期:2014-02-01 00:00:00
abstract::A genetic risk score (GRS) based on 29 single nucleotide polymorpysms (SNPs) associated with high blood pressure (BP) was prospectively associated with development of hypertension, stroke and cardiovascular events. The aim of the present study was to evaluate the impact of this GRS on the incidence of aortic disease, ...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/s41371-018-0159-6
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:This study compares the antihypertensive efficacy and tolerability of valsartan, a novel angiotensin II antagonist, given with hydrochlorothiazide (HCTZ) vs placebo or vs valsartan or HCTZ alone. DESIGN:871 adult out-patients with essential hypertension participated in this double-blind study. Patients were ...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1038/sj.jhh.1000718
更新日期:1998-12-01 00:00:00
abstract::A total of 930 patients have been evaluated for safety in a programme of clinical trials for lisinopril-hydrochlorothiazide combination treatment. Combination therapy with these two agents is generally well tolerated. In clinical trials, adverse experiences in patients treated with a lisinopril-hydrochlorothiazide com...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00
abstract::Clinical studies have shown that aldosterone and salt are independently related to hypertension, cardiovascular morbidity and mortality. More recently, studies in humans have demonstrated that, similarly to animals, endogenous aldosterone and dietary salt intake have not only separate, but also combined effects to acc...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:10.1038/jhh.2012.27
更新日期:2013-01-01 00:00:00
abstract::Pulse wave analysis was performed in apparently normal volunteers (n=164) and in essentially hypertensive patients without cardiovascular complications (n=171) using a newly developed non-invasive pulse wave measurement device (HEM-9010AI). Our results suggest that early wave reflections measured by radial augmentatio...
journal_title:Journal of human hypertension
pub_type: 信件
doi:10.1038/sj.jhh.1002278
更新日期:2008-02-01 00:00:00
abstract::The aim of this study was to assess the effect of alcohol on blood pressure and arterial compliance over 24 h in a group of volunteers, comparing the same group of subjects on two consecutive but separate days, one with alcohol intake (alcohol day) and one free of alcohol (control day). We studied 18 healthy subjects ...
journal_title:Journal of human hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1038/jhh.2015.19
更新日期:2016-01-01 00:00:00
abstract::A screening programme for cardiovascular risk factors in men aged 50-59 was undertaken in North Uist, and the results compared with an age- and sex-matched control group from Dundee screened as part of the Scottish Heart Health Study. Blood pressure levels were higher in the Islanders than in controls (148 +/- 20/89 +...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1988-08-01 00:00:00
abstract::The renin-angiotensin system is central to the pathophysiology of a number of cardiovascular disorders. Most obviously this is so with renin secreting tumours, but the system is of central importance in other disorders such as scleroderma renal crisis and most cases of malignant hypertension. Activation of the renin-a...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:10.1038/sj.jhh.1000638
更新日期:1998-05-01 00:00:00
abstract::Thalassemia minor (Tm), the β-thalassemia carrier state, is followed by favorable lipidemic profile and seems to protect against myocardial infarction mainly in men. However, the cardiovascular risk factor (CRF) and metabolic profile of these subjects has not been thoroughly addressed, although it is not known whether...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2013.102
更新日期:2014-05-01 00:00:00
abstract::A study of doxazosin added to baseline therapy with a beta-adrenoceptor blocker plus a diuretic in the treatment of patients 'resistant' to the baseline therapy, showed that it was effective and generally well tolerated. The study was, however, open-label and lacked comparison with other third-line drugs. ...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract::Irregular atrial pressure, defective folate and cholesterol metabolism contribute to the pathogenesis of hypertension. However, little is known about the combined roles of the methylenetetrahydrofolate reductase (MTHFR), apolipoprotein-E (ApoE) and angiotensin-converting enzyme (ACE) genes, which are involved in metab...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2014.53
更新日期:2015-02-01 00:00:00
abstract::Hypertension is an easily diagnosed and eminently modifiable risk factor for the development of all clinical manifestations of atherosclerosis. Despite the availability of a simple, non-invasive, and rather accurate method of measuring blood pressure (BP), and overwhelming evidence that reducing BP effectively prevent...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001686
更新日期:2004-08-01 00:00:00
abstract::Hypertension is the number one risk factor for cardiovascular diseases worldwide and yet its diagnosis among adolescents, based on blood pressure percentiles which are age, height, and sex-specific, is complex. Our study intended to determine the suitability of blood pressure height index in defining adolescent hypert...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/s41371-019-0292-x
更新日期:2020-01-01 00:00:00
abstract::Patients with hypertension, particularly those with diabetes mellitus, are at heightened risk for cardiovascular and renal disease. Accumulated evidence indicates that the majority of hypertensive patients at high risk will require more than one antihypertensive agent to reach their blood pressure (BP) target. A reaso...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:10.1038/sj.jhh.1002254
更新日期:2007-10-01 00:00:00
abstract::We aimed to investigate whether the effect of problematic alcohol drinking on hypertension differed according to metabolic health statuses. Male participants from the fifth Korea National Health and Nutrition Examination Survey were recruited. Problematic alcohol drinkers were designated as subjects with heavy drinkin...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2015.102
更新日期:2016-10-01 00:00:00
abstract::The commonly used methods of estimating the 24-h urinary sodium (UNa) and urinary potassium (UK) from spot urine (SU) are the Kawasaki method (K-method), INTERSALT method (I-method), and Tanaka method (T-method), but the method that is suitable for use in the general Chinese population is still uncertain. We aimed to ...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/s41371-019-0274-z
更新日期:2020-02-01 00:00:00
abstract::While the arterial tree is exposed to increased pressure flow, paradoxically the complications of hypertension are mainly thrombotic rather than haemorrhage. Improved techniques have allowed the identification of haemorrheological indices, coagulation factors and markers of arteriolar endothelial and platelet dysfunct...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:
更新日期:1994-09-01 00:00:00
abstract::To evaluate the correlation between endothelial dysfunction and multiple target organ damage (TOD), we measured endothelial function using high-resolution ultrasonography in hypertensive patients with or without TOD. Two hundred and eighty patients with hypertension were divided into four groups as follows: no TOD (Gr...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2009.10
更新日期:2009-11-01 00:00:00
abstract::Evidence from the medical literature is reviewed to indicate that ambulatory monitoring of blood pressure (ABPM) is a better predictor of target organ damage and clinical outcome in the hypertensive patient than clinic measurements of blood pressure (BP). A re-analysis of the documented BPs from the placebo limb of th...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:
更新日期:1995-06-01 00:00:00
abstract::This work examines the association between hypertension and hypothyroidism in geriatric patients seen at a primary care medical office. One hundred and twenty-two geriatric patients with elevated thyroid stimulating hormone (TSH) levels were selected for the study. An equal number of euthyroid geriatric individuals we...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1000799
更新日期:1999-04-01 00:00:00
abstract::Primary aldosteronism (PA) is the most common endocrine cause of resistant hypertension. Individuals with PA are at increased cardiovascular risk, and an appropriate management and treatment would ideally reduce such risk. Screening and diagnosis of PA requires a specific diagnostic test which is considered time- and ...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/s41371-018-0094-6
更新日期:2018-11-01 00:00:00