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Particle numbers of lipoprotein subclasses and arterial stiffness among middle-aged men from the ERA JUMP study.

Abstract：

:We examined the association between serum lipoprotein subclasses and the three measures of arterial stiffness, that is, (i) carotid-femoral pulse wave velocity (cfPWV), which is a gold standard measure of central arterial stiffness, (ii) brachial-ankle PWV (baPWV), which is emerging as a combined measure of central and peripheral arterial stiffness and (iii) femoral-ankle PWV (faPWV), which is a measure of peripheral arterial stiffness. Among a population-based sample of 701 apparently healthy Caucasian, Japanese American and Korean men aged 40-49 years, concentrations of lipoprotein particles were assessed by nuclear magnetic resonance (NMR) spectroscopy, and the PWV was assessed with an automated waveform analyzer (VP2000, Omron, Japan). Multiple linear regressions were performed to analyse the association between each NMR lipoprotein subclasses and PWV measures, after adjusting for cardiovascular risk factors and other confounders. A cutoff of P<0.01 was used for determining significance. All PWV measures had significant correlations with total and small low-density lipoprotein particle number (LDL-P) (all P<0.0001) but not LDL cholesterol (LDL-C) (all P>0.1), independent of race and age. In multivariate regression analysis, no NMR lipoprotein subclass was significantly associated with cfPWV (all P>0.01). However, most NMR lipoprotein subclasses had significant associations with both baPWV and faPWV (P<0.01). In this study of healthy middle-aged men, as compared with cfPWV, both baPWV and faPWV had stronger associations with particle numbers of lipoprotein subclasses. Our results may suggest that both baPWV and faPWV are related to arterial stiffness and atherosclerosis, whereas cfPWV may represent arterial stiffness alone.

journal_name

J Hum Hypertens

journal_title

Journal of human hypertension

authors

Vishnu A,Choo J,Masaki KH,Mackey RH,Barinas-Mitchell E,Shin C,Willcox BJ,El-Saed A,Seto TB,Fujiyoshi A,Miura K,Lee S,Sutton-Tyrrell K,Kuller LH,Ueshima H,Sekikawa A,ERA JUMP Study Group.

doi

10.1038/jhh.2013.60

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

111-7

issue

eissn

0950-9240

issn

1476-5527

pii

jhh201360

journal_volume

pub_type

杂志文章,多中心研究

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Particle numbers of lipoprotein subclasses and arterial stiffness among middle-aged men from the ERA JUMP study.