Abstract：
:A study of doxazosin added to baseline therapy with a beta-adrenoceptor blocker plus a diuretic in the treatment of patients 'resistant' to the baseline therapy, showed that it was effective and generally well tolerated. The study was, however, open-label and lacked comparison with other third-line drugs.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Maclean D,McDevitt DGsubject
Has Abstractpub_date
1990-10-01 00:00:00pages
50-1eissn
0950-9240issn
1476-5527journal_volume
4 Suppl 3pub_type
临床试验,杂志文章abstract：:We compared the effects on blood pressure (BP) of three isocaloric diets with reduced total fat and saturated fatty acid (SAFA) contents but with different proportions of monounsaturated (MUFA) and polyunsaturated fatty acids (PUFA). Diet LF (low fat) provided 20 en% fat (7.9% SAFA, 7.8% MUFA, 3.0% PUFA); diet HP (hig...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.jhh.1000610
更新日期：1998-06-01 00:00:00
abstract：:Dopamine is a natriuretic hormone which is synthesised within the kidney. We have previously found that some ethnic groups (e.g. British Caucasians and Thais) show strong positive correlations between 24 h urinary sodium and dopamine outputs. However no such relationship was found in Iranians and black West Africans. ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：:The anti-hypertensive efficacy and safety of extended-release (ER) felodipine (5, 10 or 20 mg) and amlodipine (5 or 10 mg) once daily were compared in patients with mild to moderate essential hypertension in a double-blind, double-dummy, randomised, comparative study. One hundred and eighteen patients were randomised ...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1995-03-01 00:00:00
abstract：:Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important circulating serine protease in low-density lipoprotein cholesterol (LDL-C) metabolism. Increased plasma PCSK9 levels lead to increased plasma levels of LDL-C and an increased risk of cardiovascular disease (CVD). LDL-C is positively correlated with ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2017.56
更新日期：2017-11-01 00:00:00
abstract：:We tested the utility of qualitative microalbuminuria (MAU) screening in an office practice setting, in assessing the response of MAU to drug treatment. We enrolled general practitioners throughout Germany, who obtained histories, physical examinations, and routine laboratory values as clinically indicated on > 6000 n...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1996-08-01 00:00:00
abstract：:The treatment of hypertension is based on an assessment of the balance between the effects of therapy on survival on the one hand and effects of the patient's symptoms and well-being on the other. The concept of quality of life is used to summarise the latter effects. Preservation of quality of life involves both the ...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：
更新日期：1993-02-01 00:00:00
abstract：:Beta-blockers are not very effective at lowering blood pressure in elderly hypertensive patients or in Afro-Caribbeans and these two groups represent a large proportion of people with raised blood pressure. Furthermore they do not prevent more heart attacks than the thiazide diuretics. Beta-blockers can also be danger...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1000701
更新日期：1998-12-01 00:00:00
abstract：:Sympathetic activation has been associated with the development and complications of hypertension. While the prevalence of hypertension and its cardiovascular risks in women are found to be less than in men and tend to become similar to men after the menopause, there have been no data on the level of sympathetic activ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2008.31
更新日期：2008-08-01 00:00:00
abstract：:The present study was conducted to determine whether Valyl-Tyrosine (VY) has an antihypertensive effect on high-normal blood pressure and mild essential hypertension, as well as spontaneous hypertensive rats (SHR). A randomised double-blind placebo-controlled study was carried out on 29 volunteers. A 100-ml drink cont...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.jhh.1001065
更新日期：2000-08-01 00:00:00
abstract：:The objective of the study was to assess factors associated with treatment satisfaction among patients receiving antihypertensive therapy. A weighted cross-sectional online survey was conducted with hypertensive patients participating in a chronic disease panel in the US. Patients on monotherapy with medications from ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001899
更新日期：2005-10-01 00:00:00
abstract：:High leptin levels are often observed in human obesity and are implicated in obesity-related hypertension. Leptin levels have been found to be higher in hypertensive obese African-American women compared to normotensive African-American women, but a direct association between leptin and blood pressure could not be obt...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001856
更新日期：2005-07-01 00:00:00
abstract：:The current study comprehensively examined the association between common variants in the Na(+)-coupled bicarbonate transporter (NCBT) genes and blood pressure (BP) responses to dietary sodium intervention. A 7-day low-sodium followed by a 7-day high-sodium dietary intervention was conducted among 1906 Han participant...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章
doi：10.1038/jhh.2015.113
更新日期：2016-09-01 00:00:00
abstract：:To identify the prevalence and magnitude of clinic changes in blood pressure and determine their effects on the diagnosis and treatment of hypertension, 268 patients with a BP greater than or equal to 160/95 mmHg on three consecutive occasions (twice in the general practitioner's surgery and once in the hospital clini...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:The aim of this preliminary study was to determine whether young offspring of first cousin hypertensive parent(s), have higher blood pressure (BP) reactivity in response to their first BP measurement, as compared to the offspring of first cousin normotensive parents. The BP of 135 boys aged 9-10 years was measured, fo...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001284
更新日期：2001-12-01 00:00:00
abstract：:The haemodynamic effects of 45 min of treadmill exercise (at 70% of resting heart rate reserve) were determined in 5 young adults with hypertension and rapid resting heart rates (greater than 90 beats/min in clinic) and were compared with those of 5 age-matched normotensive subjects. Blood pressure was lower after exe...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：:Hypertension is regarded as a major contributor to vascular disease. Vascular disease is a fairly common denominator in a large percentage of cases of dementia. Despite this strong connecting link, dementia is often not considered as a mainstream problem consequent to hypertension, though there is an alarming increase...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/s41371-019-0205-z
更新日期：2019-08-01 00:00:00
abstract：:The objective of the study is to compare fatal and nonfatal cardiovascular endpoints in hypertensive patients randomised to the calcium-channel blocker, nifedipine GITS or a thiazide diuretic, co-amilozide. A total of 6592 patients from nine countries (UK, France, Israel, Spain, Italy, The Netherlands, Sweden, Denmark...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-09-01 00:00:00
abstract：:Maternal hypertension and preeclampsia are associated with greater risk of hypertension in childhood, and cardiovascular events in adulthood. However, whether preeclampsia affects blood pressure (BP) in the newborn period is unclear. Previous neonatal studies were based on small sample sizes, very low birth weight or ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2014.50
更新日期：2015-02-01 00:00:00
abstract：:To evaluate ethnic differences in cerebral circulation, an index of carotid vascular resistance (RI) was determined by continuous wave Doppler ultrasound. Validation of the index resulted from a significant correlation between RI and carotid vascular resistance obtained from direct measurement of blood pressure and ca...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:Candesartan cilexetil is rapidly and completely hydrolysed to the active compound candesartan during absorption from the gastrointestinal tract. Candesartan is a potent, long-acting, selective angiotensin II AT1 receptor blocker. The pharmacokinetics of candesartan were investigated after single and repeated once-dail...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1997-09-01 00:00:00
abstract：:The high cardiovascular risk of HIV infected (HIV+) patients is still partly unexplained. We aimed to evaluate if HIV infection and highly active antiretroviral therapy (HAART) are linked per se to left ventricular (LV) remodelling, independently of blood pressure (BP) values. We enrolled 4 groups of patients matched ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2011.81
更新日期：2012-10-01 00:00:00
abstract：:Hypertension prevalence rates remain comparatively low in Nigeria, although the associated morbidity and mortality including that due to malignant hypertension (MHT) is considerable. To determine the factors that may be associated with the development of MHT we compared 74 patients with essential MHT (age 48 +/- 9 yea...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000963
更新日期：2000-03-01 00:00:00
abstract：:Hypertension in women has received less attention than hypertension in men, and the major controlled trials of antihypertensive therapy have been carried out in populations made up predominantly of and have emphasised outcomes in men. Recently it has been recognised that women develop high blood pressure, particularly...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1001095
更新日期：2000-10-01 00:00:00
abstract：:miR-33a has been described as a key regulator in the initiation and progression of atherosclerosis. However, its role in arterial hypertension (HTA) has not been elucidated. Therefore, the aim of this study was to determine the association between the expression of miR-33a (5p and 3p) and the carotid intima-media thic...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-018-0102-x
更新日期：2018-10-01 00:00:00
abstract：:Hypertensive disorders of pregnancy (HDP) as a group of medical complications in pregnancy are believed to be associated with an increased risk of poor fetal growth, but the influence on offspring's body composition is not clear. The aim of the present study was to evaluate the association between maternal HDP and ove...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2017.17
更新日期：2017-11-01 00:00:00
abstract：:The aim of the study is to determine the prevalence of hypertension (HTN) and its risk factors in urban and rural India. In Phase I of the Indian Council of Medical Research-India Diabetes (ICMR-INDIAB) study, individuals aged ⩾20 years were surveyed using a stratified multistage sampling design, in three states (Tami...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2014.57
更新日期：2015-03-01 00:00:00
abstract：:The purpose of the study is to observe the relation between anthropometric measurements, focusing on sagittal abdominal diameter (SAD), and insulin sensitivity indices in Chinese hypertensive patients and their siblings. In total, 907 participants, 537 hypertensive and 370 nonhypertensive, from 311 Taiwanese families ...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究
doi：10.1038/sj.jhh.1001532
更新日期：2003-03-01 00:00:00
abstract：:In our study we investigated 36 patients with renal disease, 22 of whom were hypertensive. In all proteinuria was present (4.30 +/- 5.05 g protein/day) and renal lesions were proved by renal biopsy. Blood cadmium in non-smokers was significantly (P less than 0.05) lower than in smokers. We found a positive correlation...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1989-02-01 00:00:00
abstract：:Erythrocyte Na/K flux ratio was examined in relation to a family history of essential hypertension (FH-HT) and plasma and urine electrolytes in 84 normotensive children (13-15 yrs old), and in relation to sodium intake in six children with acute glomerulonephritis or IgA nephropathy who had normal renal function (6-13...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1993-02-01 00:00:00
abstract：:We compared haemodynamic and humoral responses to nifedipine and nilvadipine in 25 elderly hypertensives. The study had a single-blind crossover design. Doppler flowmetry and laboratory examinations were performed before and after nifedipine and nilvadipine. Both nifedipine and nilvadipine significantly reduced mean a...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章
doi：
更新日期：1995-04-01 00:00:00
