Abstract:
:High leptin levels are often observed in human obesity and are implicated in obesity-related hypertension. Leptin levels have been found to be higher in hypertensive obese African-American women compared to normotensive African-American women, but a direct association between leptin and blood pressure could not be obtained. Additionally, increased adiposity has been associated with higher aortic stiffness in obese African-American women, but leptin was not included in the study. The effects of leptin on cardiovascular function in African women have not yet been determined. We hypothesised that leptin is directly associated with blood pressure and decreased arterial compliance and that leptin levels are significantly higher in hypertensive overweight/obese African women compared to normotensive overweight/obese African women. A case-case control study was performed which included 98 African women. The subjects were divided into lean normotensive (lean NT), overweight/obese normotensive (OW/OB NT) and overweight/obese hypertensive (OW/OB HT). The Finometer apparatus was used to obtain a more elaborate cardiovascular profile. Serum leptin and insulin levels as well as the HOMA-IR index were determined. Various anthropometric measures were obtained. Leptin levels were elevated (P < or = 0.05) in the OW/OB NT and HT groups compared to the lean NT group, but were similar in the OW/OB NT and HT groups. After adjusting for obesity, insulin resistance, hyperinsulinaemia and age, a direct positive correlation was obtained between leptin and systolic blood pressure (SBP) (P < or = 0.05; r = 0.68) in the OW/OB HT group. Additionally, leptin also correlated negatively with arterial compliance (P< or = 0.05; r = -0.76) and positively with pulse pressure (P < or = 0.05; r = 0.71) in the OW/OB HT group. In conclusion, even though leptin levels were the same in OW/OB HT and NT African women, leptin was directly and positively associated with SBP and pulse pressure and negatively with C(W) only in OW/OB HT African women, independent of obesity, insulin-resistance, hyperinsulinaemia and age.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Schutte R,Huisman HW,Schutte AE,Malan NTdoi
10.1038/sj.jhh.1001856subject
Has Abstractpub_date
2005-07-01 00:00:00pages
535-41issue
7eissn
0950-9240issn
1476-5527pii
1001856journal_volume
19pub_type
杂志文章abstract::The purpose of our study was to evaluate the behaviour of blood pressure (BP) by ambulatory monitoring of blood pressure (AMBP) in 53 patients with primary hyperparathyroidism (PHPT) compared to 100 essential hypertensive (EH) and 31 healthy subjects (HS). The correlations between calcium-phosphorus metabolism and hae...
journal_title:Journal of human hypertension
pub_type: 杂志文章
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abstract::When captopril was first introduced for the management of hypertension, its short plasma half-life led to its use as a thrice daily regimen. However, further experience suggests that the biological action is more prolonged than the plasma half-life might suggest. This study examined the effect of varying the frequency...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章
doi:
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abstract::Both trandolapril and verapamil are effective and widely used antihypertensive agents. The aim of this study was to estimate the efficacy and tolerability of trandolapril/verapamil (Tr/Ve) combination for blood pressure control and renoprotection. PubMed, EMBASE and Cochrane Library were searched for relevant studies....
journal_title:Journal of human hypertension
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journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1990-10-01 00:00:00
abstract::In view of the concern regarding the potential risks and benefits of sodium restriction, the effect on biochemical and orthostatic responses from a moderate reduction in sodium intake in elderly persons that is sufficient to lower systolic blood pressure (SBP) was examined. Seventeen hypertensive subjects aged 65-79 y...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
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abstract::A screening programme for cardiovascular risk factors in men aged 50-59 was undertaken in North Uist, and the results compared with an age- and sex-matched control group from Dundee screened as part of the Scottish Heart Health Study. Blood pressure levels were higher in the Islanders than in controls (148 +/- 20/89 +...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1988-08-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/s41371-018-0059-9
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1000383
更新日期:1997-02-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/s41371-019-0169-z
更新日期:2019-04-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001358
更新日期:2002-03-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/s41371-018-0073-y
更新日期:2018-09-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-01-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1002316
更新日期:2008-03-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:
更新日期:1995-11-01 00:00:00
abstract::The use of heart rate in clinical practice is limited by its variability under measurement situations. The mean heart rate on ambulatory monitoring provides a more robust statistic for clinical use. We examined the relationship between mean heart rate on initial referral ambulatory blood pressure monitoring (ABPM) to ...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1000586
更新日期:1998-04-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1002098
更新日期:2007-01-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:10.1038/jhh.2010.113
更新日期:2011-05-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2013.102
更新日期:2014-05-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 传,历史文章,杂志文章
doi:
更新日期:1996-03-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1002017
更新日期:2006-06-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章,多中心研究
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001911
更新日期:2005-11-01 00:00:00
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journal_title:Journal of human hypertension
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更新日期:2010-01-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract:AIMS:To define the prevalence of hypertension, a major cause of morbidity and mortality in blacks, and related biosocial factors in an urban African population group. METHODS:The setting was that of a civil service population in Ibadan, a major city in Southwestern Nigeria. Nine hundred and ninety-eight civil servants...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2000-04-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1987-09-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章,meta分析
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更新日期:2019-11-01 00:00:00
abstract::In an in vivo study, spontaneously hypertensive rats (SHR) were treated with an angiotensin II (Ang II) type 1 receptor antagonist of candesartan or hydralazine. Untreated SHR progressively developed severe hypertension, and treatment with candesartan or hydralazine decreased blood pressure. Candesartan reduced left v...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
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