Abstract：
:Aging is associated with cardiovascular remodeling, which can be accelerated in arterial hypertension (AH). The aim of this study was to evaluate the relation between hemodynamic profile and age, as well as to identify the role of sex in hemodynamic patterns of aging in AH. The study comprised 326 patients with AH (mean age: 44.3 years). Two-dimensional echocardiography was performed to evaluate, that is, left ventricular diastolic dysfunction (LVDD) and ejection fraction (LVEF), and ICG to evaluate, that is, acceleration time index (ACI), velocity index (VI), total arterial compliance (TAC), systemic vascular resistance index (SVRI) and thoracic fluid content (TFC). The statistical analysis included interquartile comparison in subgroups of age <19-37 years (Q1), 38-44 years (Q2), 45-51 years (Q3) and 52-68 years (Q4). Aging was associated with: (1) higher prevalence of LVDD (Q1 vs Q4: 11.0% vs 24.7%, P=0.023); (2) altered LV systolic performance-ACI (81.4 vs 64.0 1/100 Ω s(-2), P=0.0001), VI (50.5 vs 42.8 1/1000 Ω s(-1), P=0.006), LVEF (65.4% vs 67.0%, NS); and (3) increased afterload-TAC (2.25 vs 1.87 ml mm Hg(-1), P=0.0001), SVRI (2182 vs 2407 dyn s m(2) cm(-)(5); P=0.045). The 'U-shaped' relation to age was observed for TFC. The above-mentioned hemodynamic trends were more pronounced in men, whereas females presented the 'middle-aged delay'. The influence of aging on cardiovascular system shows in progressive arterial stiffness and impaired left ventricular function. Thoracic fluid reduction may be compensatory to vasoconstriction but its efficiency declines with age. The patterns of cardiovascular aging are different in men and women.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Krzesiński P,Stańczyk A,Gielerak G,Piotrowicz Kdoi
10.1038/jhh.2015.63subject
Has Abstractpub_date
2016-03-01 00:00:00pages
177-85issue
3eissn
0950-9240issn
1476-5527pii
jhh201563journal_volume
30pub_type
杂志文章abstract：:We evaluated the relationship between renal resistive index (RRI) of the intrarenal vasculature and cardiovascular (CV) organ damage such as left ventricular hypertrophy (LVH), diastolic dysfunction and carotid atherosclerosis in a large sample of hypertensive patients. 566 hypertensive patients underwent echocardiogr...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1002145
更新日期：2007-04-01 00:00:00
abstract：:The Chinese Hypertension Intervention Efficacy Study (CHIEF) is a multi-centre randomized controlled clinical trial comparing the effects of amlodipine+angiotensin II receptor blocker and amlodipine+diuretics on the incidence of cardiovascular events, represented as a composite of non-fatal stroke, non-fatal myocardia...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/jhh.2010.45
更新日期：2011-04-01 00:00:00
abstract：:Studies on the possible association between blood pressure and blood lead have reached divergent conclusions. In a previous meta-analysis, a doubling of the blood lead concentration was associated with a 1.0/0.6 mm Hg increase in systolic and diastolic blood pressure (BP). This meta-analysis updates the analysis origi...
journal_title：Journal of human hypertension
pub_type： 杂志文章,meta分析
doi：10.1038/sj.jhh.1001300
更新日期：2002-02-01 00:00:00
abstract：:Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important circulating serine protease in low-density lipoprotein cholesterol (LDL-C) metabolism. Increased plasma PCSK9 levels lead to increased plasma levels of LDL-C and an increased risk of cardiovascular disease (CVD). LDL-C is positively correlated with ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2017.56
更新日期：2017-11-01 00:00:00
abstract：:The aim of this study is to investigate how the blood pressure (BP) circadian rhythm (CR) is influenced by life style. Two groups of subjects were recruited from Nepal and Japan because of the extremely different occupational routines of these countries. The Nepalese represent a rural culture, while the Japanese refle...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：:A study was undertaken in 298 normotensive, normolipidaemic and normoglycaemic subjects to define the range of erythrocyte sodium-lithium countertransport activity in this cohort and to determine the associations between countertransport activity and markers of vascular risk. Countertransport activity showed a positiv...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-07-01 00:00:00
abstract：:Large-artery stiffness is a risk factor for stroke, including cerebral small-vessel disease. Retinal microvascular changes are thought to mirror those in cerebral microvessels. We investigated the relationship between aortic stiffness and retinal microvascular changes in Asian ischemic stroke patients. We studied 145 ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2011.88
更新日期：2012-12-01 00:00:00
abstract：:This study aims to investigate the trends in prevalence, awareness, treatment and control of hypertension among rural residents aged 35-74 years in northern China during the country's rapid economic development from 1991 to 2011. Two surveys, conducted in 1991 and 2011, included 2196 and 1939 participants aged 35-74 y...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2013.44
更新日期：2014-01-01 00:00:00
abstract：:Plasma gamma-glutamyltransferase (GGT) was suggested to reflect the level of systemic oxidative stress. Oxidative stress induces changes in arterial structure and function and contributes to the development of hypertension. Therefore, GGT may be associated with arterial remodeling and blood pressure (BP) increment, ev...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-020-0337-1
更新日期：2020-04-29 00:00:00
abstract：:The 2017 American Academy of Pediatrics (AAP) guideline for assessing "elevated blood pressure (BP) (90th BP percentile)" and "high BP (95th BP percentile)" includes a large number of BP cut-offs based on sex, age and height, which makes it cumbersome to use in clinical practice. We developed and evaluated the perform...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-018-0128-0
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Hypertension is an important public health problem, with some variability of its epidemiological properties in different populations. OBJECTIVES:The purpose of this study was to estimate the prevalence of hypertension and to determine the hypertension awareness, treatment and control rates in Aydin, a Turki...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000824
更新日期：1999-06-01 00:00:00
abstract：:We have investigated the use of captopril as a screening test for renovascular hypertension and compared the effects of captopril on renal function in patients with renovascular hypertension and those without renovascular hypertension. The captopril test and kidney gamma scintigraphy were carried out in 50 hypertensiv...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：:The commonly used methods of estimating the 24-h urinary sodium (UNa) and urinary potassium (UK) from spot urine (SU) are the Kawasaki method (K-method), INTERSALT method (I-method), and Tanaka method (T-method), but the method that is suitable for use in the general Chinese population is still uncertain. We aimed to ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-019-0274-z
更新日期：2020-02-01 00:00:00
abstract：:Large-scale trials with angiotensin converting enzyme (ACE) inhibitors and angiotensin II type 1 (AT(1))-receptor blockers have clearly shown that blockade of the renin-angiotensin system reduces the deterioration in renal function associated with diabetes. AT(1)-receptor blockers represent a more rational approach to...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1001441
更新日期：2002-08-01 00:00:00
abstract：:A group of 175 patients have attended for four years a microcomputer based, nurse practitioner managed clinic for the long term care of hypertension. Improvement in blood pressure (BP) control was seen initially and has been maintained. Drug treatment has been with a beta blocker followed if necessary by a diuretic an...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1987-09-01 00:00:00
abstract：:Traditional sphygmomanometric measurements may inaccurately reflect the actual blood pressure level over a 24-h period. This is due to several factors which are known to affect cuff blood pressure readings, including the limited number of readings obtainable throughout the 24 h and the alerting reaction and pressor re...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：
更新日期：1989-06-01 00:00:00
abstract：:This study investigates socioeconomic differences in prevalence, awareness, control and self-management of hypertension in rural China. A cross-sectional survey was conducted among four ethnic minority groups in Yunnan Province: Na Xi, Li Shu, Dai and Jing Po. Approximately 5532 consenting individuals aged ⩾35 years (...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2016.87
更新日期：2017-06-01 00:00:00
abstract：:Blood pressure and other risk factors of cardiovascular diseases were studied in two rural communities of 631 adults (greater than or equal to 18 years old) with different socio-economic statuses, populations A and B. Population A (n = 381) lived in a tourist village on an island, and population B (n = 250) in a remot...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
abstract：:The prevention and treatment of hypertension both from the viewpoint of individual patient care and in terms of population health presents a considerable challenge to the medical profession. To assist in meeting this challenge, various bodies have produced guidelines for the management of hypertension during the past ...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1001072
更新日期：2000-10-01 00:00:00
abstract：:In coronary artery disease (CAD), a potentially reversible factor leading to cardiac death is left ventricular hypertrophy (LVH). While the electrocardiogram (ECG) is a widely available way to diagnose LVH, its sensitivity and specificity has never been assessed in this particular patient group where added ischaemic c...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2008.18
更新日期：2008-06-01 00:00:00
abstract：:The genetic mechanisms responsible for the formation of adrenocortical adenomas which autonomously produce aldosterone are largely unknown. The adrenal renin-angiotensin system has been implicated in the pathophysiology of these tumours. Angiotensin-converting enzyme (ACE) catalyses the generation of angiotensin II, a...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
abstract：:To evaluate ethnic differences in cerebral circulation, an index of carotid vascular resistance (RI) was determined by continuous wave Doppler ultrasound. Validation of the index resulted from a significant correlation between RI and carotid vascular resistance obtained from direct measurement of blood pressure and ca...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:The study objective was to compare blood pressure (BP) measurement by the Hawksley random-zero sphygmomanometer and the standard mercury sphygmomanometer. Comparison of simultaneous 'blind' BP measurements were made using the Hawksley random-zero sphygmomanometer and the standard mercury sphygmomanometer linked by a Y...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1995-05-01 00:00:00
abstract：:A clear relationship exists between elevated blood pressure (BP) and various manifestations of cardiovascular disease. Despite the availability of numerous treatment guidelines, hypertension remains inadequately controlled, with only a small proportion of patients achieving target BP levels. Many factors, both patient...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1002079
更新日期：2006-11-01 00:00:00
abstract：:The purpose of this study was to examine the pattern of diurnal variation of blood pressure in normotensive working women, and to assess the effect of work stress on this pattern. The subjects were 121 normotensive (based on clinic readings less than 140/90 mmHg) young women (age = 30.2 +/- 7.3 years; range 20-50) who...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：:The interactions of intrarenal dopamine (DA) synthesis and natriuresis were studied in 11 healthy volunteers by giving a low and high sodium diet (LoSo, 50 mmol Na+; HiSo, 250 mmol Na+). On 2 days in both dietary phases an acute saline load was given, without or with an infusion of the DA precursor 3, 4-dihydroxypheny...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
abstract：:Randomized trials have shown significant blood pressure (BP) reductions after increased protein compared with carbohydrate intake, but the effect on BP maintenance after initial weight loss is unclear. We examined the effect of a high-protein diet on the maintenance of reduced BP after weight loss in 420 overweight ad...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/jhh.2014.30
更新日期：2015-01-01 00:00:00
abstract：:Although 24-h urine collection is widely considered the 'gold standard' for estimation of population sodium intake, spot urine collection is increasingly used as a convenient and affordable alternative. We used four published formulae to convert spot urine sodium into estimates of 24-h sodium excretion in order to est...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2014.10
更新日期：2014-11-01 00:00:00
abstract：:Several studies have proposed a relationship between blood pressure and inflammation. Interleukin-6 (IL-6) is a multifunctional cytokine involved in inflammation and tissue injury and potentially influencing blood pressure. Recently, a common polymorphism of the IL-6 gene, associated with differences in the transcript...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001462
更新日期：2002-09-01 00:00:00
abstract：:Adiponectin is a hormone involved in energy homeostasis by regulating glucose and lipid metabolism. In addition, the adiponectin gene (ADIPOQ) has polymorphisms that can modulate the circulating concentration of adiponectin. Abnormal adiponectin levels have been associated with pre-eclampsia (PE); however, the influen...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2013.53
更新日期：2014-02-01 00:00:00
