Abstract：
:Predispositions to essential hypertension and cardiovascular diseases are possibly associated with gene polymorphisms of the renin-angiotensin system. Gene polymorphisms of angiotensinogen and angiotensin-converting enzyme genes have been suggested to be risk factors for hypertension and myocardial infarction. Concerning the polymorphism of aldosterone synthase (CYP11B2) gene, earlier studies have shown inconsistent results in terms of its relation to hypertension. In the present case-control study, we investigated the association of -344T/C polymorphism in the promoter region of human CYP11B2 gene with genetic predisposition to hypertension. The genotype of -344T/C polymorphism was determined in essential hypertension subjects (n=250) and normotensive subjects (n=221). The distributions of three genotypes (TT, TC, and CC) were significantly different between the hypertensive and the normotensive groups (chi(2)=9.61, P=0.008). Namely, the frequency of C allele was higher in the hypertensive patients than in the normotensive subjects (34.2 vs 26.5%, P=0.010). Our data suggest that the -344C allele of CYP11B2 gene polymorphism is associated with the genetic predisposition to develop essential hypertension.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Tsukada K,Ishimitsu T,Teranishi M,Saitoh M,Yoshii M,Inada H,Ohta S,Akashi M,Minami J,Ono H,Ohrui M,Matsuoka Hdoi
10.1038/sj.jhh.1001484subject
Has Abstractpub_date
2002-11-01 00:00:00pages
789-93issue
11eissn
0950-9240issn
1476-5527journal_volume
16pub_type
杂志文章abstract：:Unravelling the complete genetic predisposition to high blood pressure (BP) has proven to be challenging. This puzzle and the fact that coding regions of the genome account for less than 2% of the entire human DNA support the hypothesis that genetic mechanism besides coding genes are likely to contribute to BP regulat...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/jhh.2014.99
更新日期：2015-08-01 00:00:00
abstract：:Often a single blood pressure (BP) measurement is used to diagnose and manage hypertension in busy clinics. However, repeated BP measurements have been shown to be more representative of the true BP status of the individual. Improper measurement of office BP can lead to inaccurate classification, overestimation of a p...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-019-0200-4
更新日期：2019-08-01 00:00:00
abstract：:Obstructive sleep apnoea (OSA) and hyperaldosteronism are very common in subjects with resistant hypertension. We hypothesized that aldosterone-mediated chronic fluid retention may influence OSA severity in patients with resistant hypertension. We tested this in an open-label evaluation by assessing the changes in the...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章
doi：10.1038/jhh.2009.96
更新日期：2010-08-01 00:00:00
abstract：:Longstanding and therapy-resistant hypertension may cause cerebral, renal, cardiac and retinal end-organ damage (EOD). Retinal hypertensive abnormalities are correlated with an increased risk of cardiovascular (CV) disease in general but are not included in CV risk assessment tools. Research into prevalence and determ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2016.49
更新日期：2017-02-01 00:00:00
abstract：:A blood pressure recording is strictly speaking only relevant for the circumstances under which it is measured. There is increasing evidence that ambulatory recordings have more predictive power than casual BP recordings and are a better discriminator between high and low risk groups of patients, particularly within t...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1990-10-01 00:00:00
abstract：:Hypertension (HTN) related to health-promoting behaviors (HPB) and quality of life (QOL) in older Chinese has not been clearly identified. We sought to compare the HPB and QOL of elderly adults (aged ≥60) living with HTN in China to a community normotensive control group. Using multistage stratified cluster sampling, ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-018-0073-y
更新日期：2018-09-01 00:00:00
abstract：:Exercise has been proved to promote the number and activity of circulating endothelial progenitor cells (EPCs) in humans, which contributes to improvement in endothelial function and maintenance of cardiovascular homoeostasis. However, the mechanism underlying the effect of exercise on circulating EPCs in healthy subj...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1002171
更新日期：2007-06-01 00:00:00
abstract：:This article reviews the current literature regarding the role of home measurement of blood pressure (BP) in the management of hypertension. Subjects with hypertension can use simple automated devices to measure their own BP at home. The results can be accurate and reliable, and because multiple readings allow a mean ...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1001423
更新日期：2002-07-01 00:00:00
abstract：:Consistent reports indicate that hypertension is a particularly common finding in black populations. Hypertension occurs at younger ages and is often more severe in terms of blood pressure levels and organ damage than in whites, resulting in a higher incidence of cardiovascular disease and mortality. This review provi...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/jhh.2017.18
更新日期：2017-08-01 00:00:00
abstract：:The aims of this study were to determine: (1) the proportion of elderly hypertensive subjects currently attending a hospital hypertension clinic suitable for a trial of antihypertensive drug withdrawal, (2) the proportion of suitable patients who can be successfully withdrawn from drug therapy while receiving nonpharm...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1994-11-01 00:00:00
abstract：:A group of 175 patients have attended for four years a microcomputer based, nurse practitioner managed clinic for the long term care of hypertension. Improvement in blood pressure (BP) control was seen initially and has been maintained. Drug treatment has been with a beta blocker followed if necessary by a diuretic an...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1987-09-01 00:00:00
abstract：:The aim of this preliminary study was to determine whether young offspring of first cousin hypertensive parent(s), have higher blood pressure (BP) reactivity in response to their first BP measurement, as compared to the offspring of first cousin normotensive parents. The BP of 135 boys aged 9-10 years was measured, fo...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001284
更新日期：2001-12-01 00:00:00
abstract：:The haemodynamic effects of 45 min of treadmill exercise (at 70% of resting heart rate reserve) were determined in 5 young adults with hypertension and rapid resting heart rates (greater than 90 beats/min in clinic) and were compared with those of 5 age-matched normotensive subjects. Blood pressure was lower after exe...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：:In order to find out the general public's opinion on blood pressure (BP) control in Poland a poll was conducted on a representative sample of 2080 randomly selected subjects. Overall 71% of the subjects were aware of their BP level. The awareness of BP level increased progressively with age and education level. Among ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：:It has been suggested that the deletion polymorphism of the angiotensin-converting enzyme (ACE) genotype may be important in the development of left ventricular hypertrophy (LVH). In order to test this hypothesis we investigated the interaction between blood pressure (BP), LVH and ACE genotype in 86 previously untreat...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000491
更新日期：1997-09-01 00:00:00
abstract：:Within routine clinical practice, white coat hypertension (where blood pressure is persistently higher in the presence of the doctor or nurse but normal outside the medical setting) makes the diagnosis and management of hypertension difficult. There are conflicting data regarding the prevalence and significance of whi...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章
doi：10.1038/sj.jhh.1000924
更新日期：1999-12-01 00:00:00
abstract：:Physical exercise can increase urinary albumin excretion rate (UAER) in diabetic patients without microalbuminuria at rest (stage II diabetic nephropathy) or with baseline microalbuminuria (stage III diabetic nephropathy). The aim of this study was to compare the acute effects of captopril, an ACE inhibitor, and nifed...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1991-06-01 00:00:00
abstract：:The influence of high density lipoproteins (HDL) on platelet function were examined in vivo and in vitro. Intraplatelet, ionised calcium concentrations ([Ca2+]i) were measured using the fluorescent dye Quin-2. In vitro, platelet responses to AVP were measured in the presence or absence of HDL. Pre-treating platelets f...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：:The objective of this study was to examine the effect of angiotensin II (Ang II) and angiotensin II type 1 (AT(1)) receptor blockade on pulse wave velocity (PWV) in healthy humans. We studied nine young male volunteers in a double-blind randomised crossover design. Carotid-femoral PWV (an index of arterial stiffness) ...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.jhh.1001372
更新日期：2002-04-01 00:00:00
abstract：:Aortic pulse wave velocity has emerged as an important predictor of cardiovascular events, but data on ethnic differences in pulse wave velocity remain scarce. We explored differences in pulse wave velocity between people of Asian and African ancestry. Data were used from the cross-sectional Healthy Life in Suriname (...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-018-0144-0
更新日期：2020-02-01 00:00:00
abstract：:In the last decades, the prevalence of obesity has increased in the Taiwanese population. This has the potential to impact on the risks of cardiovascular diseases and diabetes. This study investigated trends in the changes in several indices of obesity in the last decade, and the relationship between blood pressure (B...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2010.33
更新日期：2011-02-01 00:00:00
abstract：:Losartan, enalapril and amlodipine reduced the number of premature ventricular contractions (PVCs) in patients with essential hypertension as well as blood pressure. The effect of losartan was the most prominent among the three drugs. ...
journal_title：Journal of human hypertension
pub_type： 临床试验,信件
doi：10.1038/jhh.2008.122
更新日期：2009-04-01 00:00:00
abstract：:This study evaluated insulin secretion and insulin sensitivity before and after short-term oral administration of doxazosin in patients with essential hypertension. The hypertensive group consisted of 11 nonobese subjects (aged 41.0 +/- 2.5 years (mean +/- SEM), body mass index 24.0 +/- 0.53 kg/m2). The normotensive g...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1994-08-01 00:00:00
abstract：:Syst. China Trial aimed to determine whether titrated antihypertensive treatment could reduce the risk of stroke incidence and other cardiovascular complications among 2,298 older Chinese patients (> or = 60) with isolated systolic hypertension. The data from 3 years follow-up showed that the blood pressure reduction ...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,评审
doi：
更新日期：1996-02-01 00:00:00
abstract：:Primary aldosteronism (PA) is the most common endocrine cause of resistant hypertension. Individuals with PA are at increased cardiovascular risk, and an appropriate management and treatment would ideally reduce such risk. Screening and diagnosis of PA requires a specific diagnostic test which is considered time- and ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-018-0094-6
更新日期：2018-11-01 00:00:00
abstract：:It is rare for a study to address immediate metabolic change in pre-eclamptic pregnancy. Our aim is to study the ante-partum and post-partum metabolic markers in pre-eclampsia. A total of 33 pre-eclamptic and 200 uncomplicated women with singleton pregnancies were recruited for the prospective research. Immediately an...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2010.29
更新日期：2011-01-01 00:00:00
abstract：:The aim of the study was to investigate the effect of therapy by rilmenidine on endothelial and platelet function in 23 patients with the early stages of untreated essential hypertension. The measurements were carried out before therapy, after 1 week of placebo administration, after 1 week, after 1 month and after 3 m...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章
doi：10.1038/sj.jhh.1001427
更新日期：2002-08-01 00:00:00
abstract：:In view of the concern regarding the potential risks and benefits of sodium restriction, the effect on biochemical and orthostatic responses from a moderate reduction in sodium intake in elderly persons that is sufficient to lower systolic blood pressure (SBP) was examined. Seventeen hypertensive subjects aged 65-79 y...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.jhh.1000436
更新日期：1997-06-01 00:00:00
abstract：:A 16 year old boy presented with accelerated hypertension and urinary tract obstruction caused by phimosis. Relief of the obstruction by circumcision reversed the hypertension. We believe that accelerated hypertension secondary to phimosis has not previously been described. ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:Hypertension is the number one risk factor for cardiovascular diseases worldwide and yet its diagnosis among adolescents, based on blood pressure percentiles which are age, height, and sex-specific, is complex. Our study intended to determine the suitability of blood pressure height index in defining adolescent hypert...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-019-0292-x
更新日期：2020-01-01 00:00:00
