Abstract：
:Obstructive sleep apnoea (OSA) and hyperaldosteronism are very common in subjects with resistant hypertension. We hypothesized that aldosterone-mediated chronic fluid retention may influence OSA severity in patients with resistant hypertension. We tested this in an open-label evaluation by assessing the changes in the severity of OSA in patients with resistant hypertension after treatment with spironolactone. Subjects with resistant hypertension (clinical blood pressure (BP) >or=140/90 mm Hg on >or=3 antihypertensive medications, including a thiazide diuretic and OSA (defined as an apnoea-hypopnoea index (AHI) >or=15) had full diagnostic, polysomnography before and 8 weeks after spironolactone (25-50 mg a day) was added to their ongoing antihypertensive therapy. In all, 12 patients (mean age 56 years and body mass index 36.8 kg m(-2)) were evaluated. After treatment with spironolactone, the AHI (39.8+/-19.5 vs 22.0+/-6.8 events/h; P<0.05) and hypoxic index (13.6+/-10.8 vs 6.7+/-6.6 events/h; P<0.05), weight and clinic and ambulatory BP were significantly reduced. Plasma renin activity (PRA) and serum creatinine were significantly higher. This study provides preliminary evidence that treatment with a mineralocorticoid receptor antagonist substantially reduces the severity of OSA. If confirmed in a randomized assessment, it will support aldosterone-mediated chronic fluid retention as an important mediator of OSA severity in patients with resistant hypertension.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Gaddam K,Pimenta E,Thomas SJ,Cofield SS,Oparil S,Harding SM,Calhoun DAdoi
10.1038/jhh.2009.96subject
Has Abstractpub_date
2010-08-01 00:00:00pages
532-7issue
8eissn
0950-9240issn
1476-5527pii
jhh200996journal_volume
24pub_type
临床试验,杂志文章abstract：:The aim of this study was to assess the effect of alcohol on blood pressure and arterial compliance over 24 h in a group of volunteers, comparing the same group of subjects on two consecutive but separate days, one with alcohol intake (alcohol day) and one free of alcohol (control day). We studied 18 healthy subjects ...
journal_title：Journal of human hypertension
pub_type： 杂志文章,随机对照试验
doi：10.1038/jhh.2015.19
更新日期：2016-01-01 00:00:00
abstract：:A sodium intervention project was carried out in Tianjin, China, as part of the Tianjin Project, which is a national pilot, community-based intervention programme to reduce non-communicable diseases. The aim of this 3 year sodium project was to evaluate the feasibility and effects of sodium reduction in the population...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：:Several studies have proposed a relationship between blood pressure and inflammation. Interleukin-6 (IL-6) is a multifunctional cytokine involved in inflammation and tissue injury and potentially influencing blood pressure. Recently, a common polymorphism of the IL-6 gene, associated with differences in the transcript...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001462
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abstract：:Blood pressure, one of the important vital signs, is affected by multiple genetic and environmental factors. Recently, several genome-wide association (GWA) studies have successfully identified genetic factors that influence blood pressure and hypertension risk. In this study, we report results of the Korean Associati...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2009.86
更新日期：2010-06-01 00:00:00
abstract：:New onset of seizures in young adults is frequently related to alcohol withdrawal, toxic exposure, central nervous system trauma and neoplasm. We describe a young soldier presenting to the emergency department with seizures and transient coma. On admission, he had hypertension, marked leukocytosis, hyper-glycaemia, ac...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001499
更新日期：2003-01-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/jhh.2011.66
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,随机对照试验
doi：10.1038/jhh.2009.4
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abstract：:The effect of sulindac on ACE inhibitor-induced cough was studied in eight hypertensive subjects in a randomised placebo-controlled double blind cross-over trial. There was no significant improvement in cough or sense of well-being. Blood pressure, renal function, plasma renin and ACE activity were unchanged. Sulindac...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1989-12-01 00:00:00
abstract：:This study aimed to test the role of family social support, depression, anxiety and self-efficacy on specific self-care behaviours. In a local community health center, 318 patients with hypertension completed a questionnaire assessing self-care, family social support, depression, anxiety and self-efficacy in 2012. Eac...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2014.58
更新日期：2015-03-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-020-0306-8
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1001798
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journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-02-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章
doi：10.1038/sj.jhh.1001197
更新日期：2001-10-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000480
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journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究
doi：10.1038/jhh.2009.52
更新日期：2010-02-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章
doi：10.1038/sj.jhh.1000776
更新日期：1999-02-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：
更新日期：1989-06-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,meta分析
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更新日期：2010-11-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
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journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
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journal_title：Journal of human hypertension
pub_type： 杂志文章
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-019-0183-1
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journal_title：Journal of human hypertension
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journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：1991-06-01 00:00:00
abstract：:The phenomenon that blood pressure rises sharply in the morning is called 'Morning Blood Pressure Surge' (MBPS). Serum gamma-glutamyltransferase (GGT) is a proinflammatory marker involved in the pathogenesis of cardiovascular diseases. Although both are novel cardiovascular risk factors associated with inflammation an...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2014.74
更新日期：2015-05-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-02-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1993-06-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
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更新日期：2011-05-01 00:00:00
