当前位置： SCI文献检索 > JOURNAL OF HUMAN HYPERTENSION期刊下所有文献 > SNP-by-fitness and SNP-by-BMI interactions from seven candidate genes and incident hypertension after 20 years of follow-up: the CARDIA Fitness Study.

SNP-by-fitness and SNP-by-BMI interactions from seven candidate genes and incident hypertension after 20 years of follow-up: the CARDIA Fitness Study.

Abstract：

:The association of single nucleotide polymorphisms (SNPs) from seven candidate genes, including genotype-by-baseline fitness and genotype-by-baseline body mass index (BMI) interactions, with incident hypertension over 20 years was investigated in 2663 participants (1301 blacks, 1362 whites) of the Coronary Artery Risk Development in Young Adults Study (CARDIA). Baseline cardiorespiratory fitness was determined from duration of a modified Balke treadmill test. A total of 98 SNPs in blacks and 89 SNPs in whites from seven candidate genes were genotyped. Participants that became hypertensive (295 blacks and 146 whites) had significantly higher blood pressure and BMI (both races), and lower fitness (blacks only) at baseline than those who remained normotensive. Markers at the peroxisome proliferative activated receptor gamma coactivator 1α (PPARGC1A) and bradykinin β2 receptor (BDKRB2) genes were nominally associated with greater risk of hypertension, although one marker each at the BDKRB2 and endothelial nitric oxide synthase-3 (NOS3) genes were nominally associated with lower risk. The association of baseline fitness with risk of hypertension was nominally modified by genotype at markers within the angiotensin converting enzyme, angiotensinogen, BDKRB2 and NOS3 genes in blacks and the BDKRB2, endothelin-1 and PPARGC1A genes in whites. BDKRB2 rs4900318 showed nominal interactions with baseline fitness on the risk of hypertension in both races. The association of baseline BMI with risk of hypertension was nominally modified by GNB3 rs2301339 genotype in whites. None of the above associations were statistically significant after correcting for multiple testing. We found that SNPs in these candidate genes did not modify the association between baseline fitness or BMI and risk of hypertension in CARDIA participants.

journal_name

J Hum Hypertens

journal_title

Journal of human hypertension

authors

Sarzynski MA,Rankinen T,Sternfeld B,Fornage M,Sidney S,Bouchard C

doi

10.1038/jhh.2010.94

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

509-18

issue

8

eissn

0950-9240

issn

1476-5527

pii

jhh201094

journal_volume

25

pub_type

杂志文章

相关文献

JOURNAL OF HUMAN HYPERTENSION文献大全
  • The role of angiotensin II receptor antagonists in hypertension management: focus on candesartan cilexetil.

    abstract：:The prevention and treatment of hypertension both from the viewpoint of individual patient care and in terms of population health presents a considerable challenge to the medical profession. To assist in meeting this challenge, various bodies have produced guidelines for the management of hypertension during the past ...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章,评审

    doi：10.1038/sj.jhh.1001072

    authors： Mancia G,Grassi G

    更新日期：2000-10-01 00:00:00

  • Elevated microRNA-34a contributes to trophoblast cell apoptosis in preeclampsia by targeting BCL-2.

    abstract：:Preeclampsia (PE) is one of the most common pregnancy-specific pathologic complications, and is characterised by onset of hypertension and proteinuria. Placental trophoblast cell apoptosis is generally accepted as a major cause of PE. However, the details of the mechanism underlying the condition remain unclear. Here,...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章

    doi：10.1038/jhh.2017.65

    authors： Guo M,Zhao X,Yuan X,Li P

    更新日期：2017-12-01 00:00:00

  • Characteristics of the patients referred to a Hypertension Unit between 1989 and 2003.

    abstract：:The level of blood pressure, the type of antihypertensive treatment and the prevalence of resistant hypertension at the first examination were evaluated in 6254 patients referred to a hospital Hypertension Unit from 1989 to 2003. From 1989-1993 to 1999-2003, we observed a reduced prevalence of grade 2 and grade 3 hype...

    journal_title：Journal of human hypertension

    pub_type： 信件

    doi：10.1038/sj.jhh.1002285

    authors： Leotta G,Rabbia F,Canadè A,Testa E,Papotti G,Mulatero P,Veglio F

    更新日期：2008-02-01 00:00:00

  • Blood pressure changes after high- and low-salt diets: are intermittent arm measures and beat-by-beat finger measures equivalent?

    abstract：:The assessment of sodium sensitivity requires to measure the difference in mean arterial pressure (MAP) at the end of sodium-loading (SLoad) and sodium-depletion (SDepl) maneuvers with an arm-cuff manometer. Aim of this study is to evaluate whether MAP measuring devices based on the volume-clamp method at the finger c...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章

    doi：10.1038/jhh.2014.110

    authors： Castiglioni P,Parati G,Di Rienzo M,Brambilla V,Brambilla L,Gualerzi M,Lazzeroni D,Coruzzi P

    更新日期：2015-07-01 00:00:00

  • Once-daily treatment of patients with hypertension: a placebo-controlled study of amlodipine and benazepril vs amlodipine or benazepril alone.

    abstract：OBJECTIVE:To compare the efficacy, tolerability, and safety of once-daily therapy with amlodipine 5 mg/benazepril 10 mg vs amlodipine 5 mg, benazepril 10 mg, and placebo. DESIGN:Randomised, double-blind, placebo-controlled, parallel-group, multicentre trial. SETTING:Twenty-two clinical centres, including private prac...

    journal_title：Journal of human hypertension

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1038/sj.jhh.1001217

    authors： Pool J,Kaihlanen P,Lewis G,Ginsberg D,Oparil S,Glazer R,Messerli FH

    更新日期：2001-07-01 00:00:00

  • Positive association of CYP11B2 gene polymorphism with genetic predisposition to essential hypertension.

    abstract：:Predispositions to essential hypertension and cardiovascular diseases are possibly associated with gene polymorphisms of the renin-angiotensin system. Gene polymorphisms of angiotensinogen and angiotensin-converting enzyme genes have been suggested to be risk factors for hypertension and myocardial infarction. Concern...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章

    doi：10.1038/sj.jhh.1001484

    authors： Tsukada K,Ishimitsu T,Teranishi M,Saitoh M,Yoshii M,Inada H,Ohta S,Akashi M,Minami J,Ono H,Ohrui M,Matsuoka H

    更新日期：2002-11-01 00:00:00

  • Plasma homocysteine concentration and blood pressure in healthy Iranian adults: the Tehran Homocysteine Survey (2003-2004).

    abstract：:Hypertension is a modifiable risk factor for cardiovascular disease, but its aetiology has not been fully elucidated. Recently, attention has been focused on the direct relations of plasma homocysteine (Hcy) to blood pressure (BP). The purpose of this study was to determine the relationship of Hcy with BP and other ca...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章

    doi：10.1038/sj.jhh.1001911

    authors： Fakhrzadeh H,Ghotbi S,Pourebrahim R,Heshmat R,Nouri M,Shafaee A,Larijani B

    更新日期：2005-11-01 00:00:00

  • Urinary sodium excretion and blood pressure in chronic psychiatric in-patients.

    abstract：:Studies of populations or communities with no rise in blood pressure (BP) with advancing age and low prevalence of hypertension, may provide aetiological clues on the cause of hypertension. Within westernised societies, low blood pressures have been reported amongst chronic psychiatric in-patients and closed order sec...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章

    doi：10.1038/sj.jhh.1000853

    authors： Lip GY,Douglas M,Gupta A,Beevers DG

    更新日期：1999-07-01 00:00:00

  • Left ventricular remodelling in asymptomatic HIV infection on chronic HAART: comparison between hypertensive and normotensive subjects with and without HIV infection.

    abstract：:The high cardiovascular risk of HIV infected (HIV+) patients is still partly unexplained. We aimed to evaluate if HIV infection and highly active antiretroviral therapy (HAART) are linked per se to left ventricular (LV) remodelling, independently of blood pressure (BP) values. We enrolled 4 groups of patients matched ...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章

    doi：10.1038/jhh.2011.81

    authors： Grandi AM,Nicolini E,Giola M,Gianni M,Maresca AM,Marchesi C,Guasti L,Balsamo ML,Venco A,Grossi PA

    更新日期：2012-10-01 00:00:00

  • Usefulness of the I/D angiotensin-converting enzyme genotype for detecting the risk of left ventricular hypertrophy in pharmacologically treated hypertensive men.

    abstract：:The insertion/deletion polymorphism (I/D) of the angiotensin-converting enzyme (ACE) gene has been associated in some studies with a higher prevalence of left ventricular hypertrophy (LVH), but few of them were performed on pharmacologically treated hypertensive patients. The present study was undertaken to determine ...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章

    doi：10.1038/sj.jhh.1001005

    authors： López-Contreras J,Blanco-Vaca F,Borrás X,Carreras F,Pons-Lladó G,Gallego F,Solé MJ,Cirera S,Benet MT,Negredo E,Roca-Cusachs A

    更新日期：2000-05-01 00:00:00

  • Optimizing hypertension management in clinical practice.

    abstract：:A clear relationship exists between elevated blood pressure (BP) and various manifestations of cardiovascular disease. Despite the availability of numerous treatment guidelines, hypertension remains inadequately controlled, with only a small proportion of patients achieving target BP levels. Many factors, both patient...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章,评审

    doi：10.1038/sj.jhh.1002079

    authors： Heagerty A

    更新日期：2006-11-01 00:00:00

  • Ethnic differences in the renal dopamine response to an oral salt load.

    abstract：:Dopamine is a natriuretic hormone which is synthesised within the kidney. We have previously found that some ethnic groups (e.g. British Caucasians and Thais) show strong positive correlations between 24 h urinary sodium and dopamine outputs. However no such relationship was found in Iranians and black West Africans. ...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章

    doi：

    authors： Critchley JA,Sriwatanakul K,Charuchinda C,Balali-Mood M,Boye GL,Chan TY,Brocklesby NC,Lee MR

    更新日期：1990-04-01 00:00:00

  • Sympathetic nerve hyperactivity of essential hypertension is lower in postmenopausal women than men.

    abstract：:Sympathetic activation has been associated with the development and complications of hypertension. While the prevalence of hypertension and its cardiovascular risks in women are found to be less than in men and tend to become similar to men after the menopause, there have been no data on the level of sympathetic activ...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章

    doi：10.1038/jhh.2008.31

    authors： Hogarth AJ,Burns J,Mackintosh AF,Mary DA

    更新日期：2008-08-01 00:00:00

  • On the sex ratio of urinary cation excretion obtained from Intersalt and other epidemiological studies.

    abstract：:Large differences exist within populations in the dietary intake of nutrients between men and women and these differences are still largely unknown. Using data obtained from the Intersalt study and from other relevant epidemiological studies, the sex ratio of the 24 h urinary excretion of different cations was obtaine...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章

    doi：

    authors： Kesteloot H,Elliott P,Lesaffre E

    更新日期：1990-12-01 00:00:00

  • In vivo and in vitro studies of the role of HDL in platelet activation in normotensive and hypertensive subjects.

    abstract：:The influence of high density lipoproteins (HDL) on platelet function were examined in vivo and in vitro. Intraplatelet, ionised calcium concentrations ([Ca2+]i) were measured using the fluorescent dye Quin-2. In vitro, platelet responses to AVP were measured in the presence or absence of HDL. Pre-treating platelets f...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章

    doi：

    authors： Graham D,Simpson HD,Dominiczak AF,Caslake M,Davies DL,Kenyon CJ

    更新日期：1995-09-01 00:00:00

  • Comparative efficacy and safety of amlodipine/benazepril combination therapy and amlodipine monotherapy in severe hypertension.

    abstract：:This multicentre, double-blind, trial in subjects with severe hypertension compared the efficacy and tolerability of two parallel drug regimens: A/B (amlodipine/benazepril: 5/20 or 10/40 mg daily, if necessary) with A (amlodipine: 5 or 10 mg daily, if necessary). The principal dependent variable was the proportion of ...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1038/jhh.2009.80

    authors： Izzo JL Jr,Purkayastha D,Hall D,Hilkert RJ

    更新日期：2010-06-01 00:00:00

  • Relationship between electrocardiographic left ventricular hypertrophy criteria and vascular structure and function parameters in hypertensive patients.

    abstract：:The objective of this study was to determine the electrocardiographic left ventricular hypertrophy (LVH) criterion that best correlated with vascular structure and function parameters in hypertensive patients. A cross-sectional study involving 347 hypertensive patients was performed. The mean age of the subjects was 5...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章

    doi：10.1038/jhh.2013.87

    authors： Gómez-Marcos MA,Recio-Rodríguez JI,Patino-Alonso MC,Agudo-Conde C,Rodríguez-Sánchez E,Gómez-Sánchez L,Gómez-Sánchez M,García-Ortiz L,Vaso risk group.

    更新日期：2014-03-01 00:00:00

  • Management of hypertension in general practice: agreements with and variations from the British Hypertension Society guidelines.

    abstract：:A random sample of 200 East Anglian general practitioners was surveyed to establish current trends in the management of hypertension, including measurement of blood pressure (BP), patient investigation, treatment and follow-up. A total of 125 (62.5%) completed questionnaires was returned. Responses were used to assess...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章

    doi：

    authors： Dickerson JE,Garratt CJ,Brown MJ

    更新日期：1995-10-01 00:00:00

  • Lack of association between angiotensinogen polymorphism (M235T) and cerebrovascular disease and carotid atheroma.

    abstract：:Genetic influences in cerebrovascular disease (CVD) may act either independently or by predisposing to, or modulating, the effect of risk factors such as hypertension. Factors involved in the pathogenesis of atherosclerosis, thrombosis and vasoconstriction are important in CVD. The angiotensinogen gene has recently be...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章

    doi：

    authors： Barley J,Markus H,Brown M,Carter N

    更新日期：1995-08-01 00:00:00

  • Arterial waveform parameters in a large, population-based sample of adults: relationships with ethnicity and lifestyle factors.

    abstract：:This corrects the article DOI: 10.1038/jhh.2016.78. ...

    journal_title：Journal of human hypertension

    pub_type： 已发布勘误

    doi：10.1038/jhh.2017.60

    authors： Sluyter JD,Hughes AD,Thom S,Lowe A,Camargo CA Jr,Hametner B,Wassertheurer S,Parker KH,Scragg RKR

    更新日期：2017-11-01 00:00:00

  • Relationship between cardio-ankle vascular index and plasma lipids in hypertension subjects.

    abstract：:An increasing of arterial stiffness is the path physiological characteristic of hypertension. Cardio-ankle vascular index (CAVI) is a new index of arterial stiffness. In the present study, we investigated the relationship between CAVI and plasma lipids in hypertension subjects. A total of 542 subjects (male/female 336...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章

    doi：10.1038/jhh.2014.37

    authors： Wang H,Liu J,Zhao H,Zhao X,Li L,Shi H,Zhan S,Liu J

    更新日期：2015-02-01 00:00:00

  • Non-dipping pattern relates to endothelial dysfunction in patients with uncontrolled resistant hypertension.

    abstract：:Resistant hypertension (RHTN) includes both patients whose blood pressure (BP) is uncontrolled on three or more medications (uncontrolled RHTN (UCRH)) and patients whose BP is controlled with use of four or more drugs (controlled RHTN (CRH)). It is unknown whether endothelial function and nocturnal drop demonstrate a ...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章

    doi：10.1038/jhh.2011.43

    authors： Quinaglia T,Martins LC,Figueiredo VN,Santos RC,Yugar-Toledo JC,Martin JF,Demacq C,Pimenta E,Calhoun DA,Moreno H Jr

    更新日期：2011-11-01 00:00:00

  • Two-hour glucose predicts the development of hypertension over 5 years: the AusDiab study.

    abstract：:Elevated 2-h plasma glucose concentration (2hPG) from an oral glucose tolerance (OGTT) test more strongly predicts risk of subsequent cardiovascular disease than fasting plasma glucose (FPG), but the association between these glucose measurements and hypertension risk is less clear. We examined the association between...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章

    doi：10.1038/sj.jhh.1002316

    authors： Boyko EJ,Barr EL,Zimmet PZ,Shaw JE

    更新日期：2008-03-01 00:00:00

  • Double-blind crossover study of once daily nifedipine coat core in essential hypertension.

    abstract：:Nineteen patients with essential hypertension on regular treatment with nifedipine tablets 20 mg twice daily and whose DBP was < 95 mmHg on at least two occasions two weeks apart were entered in a double-blind randomised crossover study of three weeks treatment with nifedipine coat core (new formulation) either as 30 ...

    journal_title：Journal of human hypertension

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Missouris CG,Cappuccio FP,Markandu ND,Singer DR,MacGregor GA

    更新日期：1994-04-01 00:00:00

  • Salt reduction in the United Kingdom: a successful experiment in public health.

    abstract：:The United Kingdom has successfully implemented a salt reduction programme. We carried out a comprehensive analysis of the programme with an aim of providing a step-by-step guide of developing and implementing a national salt reduction strategy, which other countries could follow. The key components include (1) settin...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章,评审

    doi：10.1038/jhh.2013.105

    authors： He FJ,Brinsden HC,MacGregor GA

    更新日期：2014-06-01 00:00:00

  • The association between antihypertensive drug therapies and plasma lipid levels in the general population.

    abstract：OBJECTIVE:To assess the association between different antihypertensive drug regimens and plasma lipid levels in the general population. METHODS:The Monitoring Project on Cardiovascular Risk Factors was conducted from 1987 to 1991 as a cross-sectional study in The Netherlands. Antihypertensive drug-users and untreated ...

    journal_title：Journal of human hypertension

    pub_type： 临床试验,杂志文章

    doi：10.1038/sj.jhh.1001197

    authors： Maitland-van der Zee AH,Klungel OH,Kloosterman JM,Seidell JC,Leufkens HG,de Boer A

    更新日期：2001-10-01 00:00:00

  • Left ventricular mass is related to endothelium-dependent vasodilation in the forearm, but not in the brachial artery, in elderly subjects: the Prospective Investigation of the Vasculature in Uppsala Seniors study.

    abstract：:Left ventricular hypertrophy (LVH) is a powerful cardiovascular risk factor and has previously been related to endothelium-dependent vasodilation (EDV) in hypertensive patients. In the Prospective Investigation of the Vasculature in Uppsala Seniors study, different techniques to evaluate EDV in different types of vess...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章

    doi：10.1038/jhh.2008.61

    authors： Lind L

    更新日期：2008-11-01 00:00:00

  • Disparities in the impact of overweight on hypertension among Asians: a Japanese and Thai population-based study.

    abstract：:The divergence in cardiovascular disease risk among Asian countries may be related to differences in economics, lifestyles, and cultural backgrounds. We examined the differential association of overweight and hypertension between the high- and middle-income Asian countries, namely Japan and Thailand and extended to co...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章

    doi：10.1038/s41371-018-0118-2

    authors： Kotruchin P,Hoshide S,Kanegae H,Pongchaiyakul C,Kario K

    更新日期：2019-02-01 00:00:00

  • People with the major alleles of ATP2B1 rs17249754 increases the risk of hypertension in high ratio of sodium and potassium, and low calcium intakes.

    abstract：:It is important to understand what genetic risk factors lead to hypertension and how genotype-specific dietary and lifestyle modification can mitigate the risk of developing hypertension. The ATP2B1 rs17249754 gene, which encodes a calcium pump expressed in vascular smooth muscle was identified as having variants that...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章

    doi：10.1038/jhh.2017.72

    authors： Daily JW,Kim BC,Liu M,Park S

    更新日期：2017-12-01 00:00:00

  • ACE inhibitors and the heart: hypertrophy reversal and antiarrhythmic effects.

    abstract：:Sudden death has been shown to be due in the majority of cases to ventricular arrhythmia. Left ventricular hypertrophy (LVH) may be implicated in the aetiology of some arrhythmia and sudden death. Recent evidence suggests that the relationship between LVH and arrhythmia may be complex and that there may be an interact...

    journal_title：Journal of human hypertension

    pub_type： 杂志文章,评审

    doi：

    authors： Jones JV,James MA

    更新日期：1990-10-01 00:00:00