Abstract：
:It is important to understand what genetic risk factors lead to hypertension and how genotype-specific dietary and lifestyle modification can mitigate the risk of developing hypertension. The ATP2B1 rs17249754 gene, which encodes a calcium pump expressed in vascular smooth muscle was identified as having variants that conferred higher or lower risk of hypertension-with the major allele carriers being increased at risk. However, the effects of dietary intakes on risk of hypertension among carriers of the different alleles have not been fully elucidated. Therefore, we evaluated ATP2B1 rs17249754 and its interaction with dietary intakes of sodium (Na), potassium (K) and calcium (Ca) on the risk of developing hypertension using the Ansan/Ansung (n=8842) and City-Rural (n=5512) cohorts from the Korean Genome and Epidemiology Study. Carriers of the major allele of ATP2B1 rs17249754 were at greater risk of developing hypertension and high Na intake and low Ca increased the risk more in major allele than among minor allele carriers. High potassium intake was more protective against hypertension in the subjects expressing minor alleles and a low Na/K intake ratio was the most consistently beneficial to the subjects expressing the minor allele. When controlling for Na and K, low Ca intake was associated with a substantially higher risk for high systolic blood pressure in the major allele carriers compared with minor allele, suggesting good calcium status is especially important for the major allele carriers. In conclusion, people with the major allele of ATP2B1 rs17249754 are susceptible to hypertension especially in low intake of Ca and high ratio of Na and K.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Daily JW,Kim BC,Liu M,Park Sdoi
10.1038/jhh.2017.72subject
Has Abstractpub_date
2017-12-01 00:00:00pages
787-794issue
12eissn
0950-9240issn
1476-5527pii
jhh201772journal_volume
31pub_type
杂志文章abstract：:Aging is associated with cardiovascular remodeling, which can be accelerated in arterial hypertension (AH). The aim of this study was to evaluate the relation between hemodynamic profile and age, as well as to identify the role of sex in hemodynamic patterns of aging in AH. The study comprised 326 patients with AH (me...
journal_title：Journal of human hypertension
pub_type： 杂志文章
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abstract：:Renin-angiotensin (RAS) genes, a group of promising candidate genes involved in essential hypertension (EH), play a key role in blood pressure regulation. Recently, a series of novel RAS gene polymorphisms were reported, which significantly influence the rate of the gene transcription. This study was designed to explo...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2008.123
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abstract：:We investigated whether inappropriately high left ventricular (LV) mass, defined as observed LV mass exceeding the level of individual LV mass predicted from gender, height, and stroke work, may be associated with an imbalance between growth-promoting and growth-inhibitory factors and/or structural vascular changes. I...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001720
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001484
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1989-08-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-018-0029-2
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journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/sj.jhh.1001744
更新日期：2004-11-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,随机对照试验
doi：10.1038/jhh.2010.53
更新日期：2011-04-01 00:00:00
abstract：:South Asians (SA) suffer from a higher burden of heart disease and stroke compared with White Caucasians (CA). We hypothesized that increased arterial stiffness in older adults of SA origin would be associated with greater cerebrovascular pulsatile pressure and flow characteristics compared with CA older adults. Forty...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2015.76
更新日期：2016-05-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001601
更新日期：2003-10-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1002079
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究
doi：10.1038/jhh.2013.148
更新日期：2014-11-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,meta分析
doi：10.1038/jhh.2010.11
更新日期：2010-11-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001176
更新日期：2001-05-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-018-0159-6
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 临床试验,信件
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
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journal_title：Journal of human hypertension
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-019-0201-3
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000958
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-020-0318-4
更新日期：2021-01-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1000747
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：
更新日期：1993-02-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-020-0337-1
更新日期：2020-04-29 00:00:00
