Abstract:
:Calcium plays a central role in maintaining vascular tone. Recent studies indicate that there are continuous relationships between systemic calcium metabolism and BP, as over the whole range of normal and raised BPs there is an inverse correlation between plasma ionised calcium concentration and BP. Twenty-two subjects with normal or moderately elevated BP participated in the present study, undertaken to investigate the interactions between systemic calcium metabolism and BP during a two-hour constant-rate calcium infusion in the absence and in the presence of concomitant verapamil infusion. During the infusion there was an increase in plasma ionised calcium by 0.40 mmol/l, SBP rose by 14 mmHg, and DBP by 9.7 mmHg. Higher basal plasma ionised calcium and lower basal serum parathyroid hormone concentrations were associated with a more pronounced diastolic pressor response to the calcium infusion. A greater DBP increase was also accompanied by more pronounced parathyroid hormone suppression, determined as cyclic adenosine monophosphate excretion, and greater tissue uptake of calcium during the infusion. Conversely, higher basal BPs were associated with greater tissue calcium uptake during the infusions. This relationship was abolished when verapamil was present. The present findings extend the previous observations of continuous relationships between indices of calcium metabolism and BP and indicate that both a direct effect of the calcium ion and indirect effects, as evidenced by cyclic adenosine monophosphate excretion, affect the BP response to acute hypercalcaemia.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Hvarfner A,Mörlin C,Wide L,Ljunghall Ssubject
Has Abstractpub_date
1989-08-01 00:00:00pages
211-20issue
4eissn
0950-9240issn
1476-5527journal_volume
3pub_type
杂志文章abstract::Altitude affects blood pressure (BP) depending on duration and absolute altitude of exposure. Until now changes in BP during exposure to altitude were studied only in Caucasians. It is not known whether BP is affected differently in black and white people in response to altitude. During a 6-day climb on Kilimanjaro, B...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1000468
更新日期:1997-07-01 00:00:00
abstract::Renin-angiotensin (RAS) genes, a group of promising candidate genes involved in essential hypertension (EH), play a key role in blood pressure regulation. Recently, a series of novel RAS gene polymorphisms were reported, which significantly influence the rate of the gene transcription. This study was designed to explo...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2008.123
更新日期:2009-03-01 00:00:00
abstract::The influence of high density lipoproteins (HDL) on platelet function were examined in vivo and in vitro. Intraplatelet, ionised calcium concentrations ([Ca2+]i) were measured using the fluorescent dye Quin-2. In vitro, platelet responses to AVP were measured in the presence or absence of HDL. Pre-treating platelets f...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
abstract::Hypertension is a common and potentially serious disease and accurate measurement of blood pressure (BP) is important for its diagnosis and management. The aim of this study was to assess the knowledge of hospital staff on the basic principles of BP measurement. Consultants, junior doctors and nurses in a large teachi...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1000480
更新日期:1997-08-01 00:00:00
abstract::Hypertension is poorly managed. Hospital-based pharmacists working with physicians have been shown to improve the rate of achievement of "target" blood pressure in selected patients. It is unknown if such schemes can operate in the community and to what extent they would attract volunteers with poorly managed blood pr...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001220
更新日期:2001-08-01 00:00:00
abstract::Although 24-h urine collection is widely considered the 'gold standard' for estimation of population sodium intake, spot urine collection is increasingly used as a convenient and affordable alternative. We used four published formulae to convert spot urine sodium into estimates of 24-h sodium excretion in order to est...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2014.10
更新日期:2014-11-01 00:00:00
abstract::Elevated 2-h plasma glucose concentration (2hPG) from an oral glucose tolerance (OGTT) test more strongly predicts risk of subsequent cardiovascular disease than fasting plasma glucose (FPG), but the association between these glucose measurements and hypertension risk is less clear. We examined the association between...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1002316
更新日期:2008-03-01 00:00:00
abstract::Adiponectin is a hormone involved in energy homeostasis by regulating glucose and lipid metabolism. In addition, the adiponectin gene (ADIPOQ) has polymorphisms that can modulate the circulating concentration of adiponectin. Abnormal adiponectin levels have been associated with pre-eclampsia (PE); however, the influen...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2013.53
更新日期:2014-02-01 00:00:00
abstract::It has been suggested that risks of hypertension and cardiovascular disease begin in utero and that maternal nutrition plays an important role. We have examined the relation between maternal factors and BP in a study of 1,311 children in which physical measurements at 9-11 years of age have been linked to a parental q...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract::Isolated segments (1-2 mm) of small subcutaneous arteries (diameter 0.1-0.9 mm) and veins (0.1-1.0 mm) from patients with hypertension (essential n = 13, renovascular n = 6) and controls (n = 17) were examined. The relaxant responses to the sensory transmitters calcitonin gene-related peptide (CGRP) and substance P, a...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章
doi:10.1038/sj.jhh.1001294
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Hypertension is an important public health problem, with some variability of its epidemiological properties in different populations. OBJECTIVES:The purpose of this study was to estimate the prevalence of hypertension and to determine the hypertension awareness, treatment and control rates in Aydin, a Turki...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1000824
更新日期:1999-06-01 00:00:00
abstract::This multicentre, double-blind, trial in subjects with severe hypertension compared the efficacy and tolerability of two parallel drug regimens: A/B (amlodipine/benazepril: 5/20 or 10/40 mg daily, if necessary) with A (amlodipine: 5 or 10 mg daily, if necessary). The principal dependent variable was the proportion of ...
journal_title:Journal of human hypertension
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/jhh.2009.80
更新日期:2010-06-01 00:00:00
abstract::The Dead Sea (barometric pressure: 800 mm Hg) is an important balneotherapeutic centre for chronic dermatologic and arthritic diseases. In the past, hypertensive patients have complained sporadically of weakness and dizziness during a stay in the Dead Sea. It was therefore recommended that hypertensives do not stay at...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1000663
更新日期:1998-08-01 00:00:00
abstract::The aim of the study was to investigate the effect of therapy by rilmenidine on endothelial and platelet function in 23 patients with the early stages of untreated essential hypertension. The measurements were carried out before therapy, after 1 week of placebo administration, after 1 week, after 1 month and after 3 m...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章
doi:10.1038/sj.jhh.1001427
更新日期:2002-08-01 00:00:00
abstract::When captopril was first introduced for the management of hypertension, its short plasma half-life led to its use as a thrice daily regimen. However, further experience suggests that the biological action is more prolonged than the plasma half-life might suggest. This study examined the effect of varying the frequency...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章
doi:
更新日期:1988-08-01 00:00:00
abstract::We compared haemodynamic and humoral responses to nifedipine and nilvadipine in 25 elderly hypertensives. The study had a single-blind crossover design. Doppler flowmetry and laboratory examinations were performed before and after nifedipine and nilvadipine. Both nifedipine and nilvadipine significantly reduced mean a...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-04-01 00:00:00
abstract::The aim of the present longitudinal study was to describe determinants of blood pressure (BP) and echocardiographically calculated left ventricular mass in adolescents with a variable risk of future hypertension. BP was measured and M-mode echocardiography was performed in 52 children, 29 male and 23 female, at a mean...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::In the last decades, the prevalence of obesity has increased in the Taiwanese population. This has the potential to impact on the risks of cardiovascular diseases and diabetes. This study investigated trends in the changes in several indices of obesity in the last decade, and the relationship between blood pressure (B...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2010.33
更新日期:2011-02-01 00:00:00
abstract::Both trandolapril and verapamil are effective and widely used antihypertensive agents. The aim of this study was to estimate the efficacy and tolerability of trandolapril/verapamil (Tr/Ve) combination for blood pressure control and renoprotection. PubMed, EMBASE and Cochrane Library were searched for relevant studies....
journal_title:Journal of human hypertension
pub_type: 杂志文章,meta分析
doi:10.1038/jhh.2010.60
更新日期:2011-03-01 00:00:00
abstract::Cardiovascular risk is subject to circadian variation, with peak morning incidence of myocardial infarction and stroke correlating with the early morning blood pressure (BP) surge (EMBPS). Ideally, antihypertensive therapy should maintain control of BP throughout the 24-h dosing cycle. In two sister studies, Prospecti...
journal_title:Journal of human hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1038/jhh.2009.4
更新日期:2009-09-01 00:00:00
abstract::Increased carotid stiffness and impaired brachial artery flow-mediated dilatation (FMD) associate with cardiovascular events. We have previously reported three FMD patterns based on the time of maximal dilatation. The aim of the present study was to verify whether different FMD patterns associate with carotid artery s...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2015.109
更新日期:2016-08-01 00:00:00
abstract::The burden of Type II diabetes is growing rapidly worldwide, across high-, middle- and low-income countries. This burden is associated primarily with increased risks of macrovascular and microvascular diseases, and it is agreed that multifactorial treatment regimens are required to reduce it. ADVANCE (Action in Diabet...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:10.1038/sj.jhh.1001890
更新日期:2005-06-01 00:00:00
abstract::Hypertension and knee osteoarthritis (OA) are frequent comorbidities. Nonsteroidal anti-inflammatory drugs (NSAIDs) are often used to relieve pain in such patients. In the last decade selective NSAIDs are used more commonly since they lead to less gastrointestinal complications. As has been shown, the treatment with N...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001411
更新日期:2002-06-01 00:00:00
abstract::A Holter BP monitor and a noninvasive, continuous cardiac output (CO) monitor were concurrently attached to 25 middle-aged hospitalized patients with essential hypertension (EH). Blood pressure, heart rate (HR) and CO were measured every 10 minutes over 24 hours. Circadian variation of mean BP was studied. Comparison ...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1990-08-01 00:00:00
abstract::Hypertension may influence the atherosclerotic process of large arteries via pressure and shear forces. The pressure force dilates and stiffens arteries because of the non-linear elastic behaviour of arterial walls. This partly explains the increased diameter and decreased compliance of the brachial artery in hyperten...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:
更新日期:1991-08-01 00:00:00
abstract::A large proportion of hypertensive men and women in Europe and North America are overweight. In obesity, the expanded blood volume increases cardiopulmonary volume, cardiac filling, left ventricular preload, stroke volume and, thereby, left ventricular work. Given enough exposure time, it is probable that all obese pe...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:
更新日期:1990-08-01 00:00:00
abstract::Patients with hypertension, particularly those with diabetes mellitus, are at heightened risk for cardiovascular and renal disease. Accumulated evidence indicates that the majority of hypertensive patients at high risk will require more than one antihypertensive agent to reach their blood pressure (BP) target. A reaso...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:10.1038/sj.jhh.1002254
更新日期:2007-10-01 00:00:00
abstract::Psychosocial work environments may adversely influence blood pressure, but the benefits of altering these factors and introducing coping resources is unclear. We examined whether changing work stressors and coping resources affect the risk of hypertension and elevated BP. A total of 13,145 workers from the Occupationa...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2016.79
更新日期:2017-05-01 00:00:00
abstract::The aims of this study were to determine: (1) the proportion of elderly hypertensive subjects currently attending a hospital hypertension clinic suitable for a trial of antihypertensive drug withdrawal, (2) the proportion of suitable patients who can be successfully withdrawn from drug therapy while receiving nonpharm...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract::It is not known whether serum potassium levels affect blood pressure response to antihypertensive medication. The African American Study of Kidney Disease and Hypertension (AASK) Genomics Study (N=828) is a subset of the AASK trial that randomized 1094 African American men and women with hypertensive nephrosclerosis t...
journal_title:Journal of human hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1038/jhh.2012.47
更新日期:2013-06-01 00:00:00