Abstract：
:In the pre-awakening hours, diastolic blood pressure (DBP) is normally at its lowest, and diastolic hypotension is a risk factor for cardiac ischemia. We investigated pre-awakening DBP values and its predictors in treated hypertensive patients who underwent ambulatory blood pressure monitoring. The pre-awakening period was defined as the 3-h period ending 1 h before awakening (most frequently 03:00-06:00). In 269 included subjects, office DBP was 86.4±12.0 mm Hg, 24-h DBP was 78.6±9.6 mm Hg, mean pre-awakening DBP was 70.3±10.9 mm Hg, and trough pre-awakening DBP was 62.5±11.2 mm Hg. Half of the patients (51%) had a mean pre-awakening DBP <70 mm Hg, and 14% had <60 mm Hg. Trough pre-awakening DBP <60 mm Hg was seen in 36% and <50 mm Hg in 12% of patients. Office DBP was the most important predictor of mean and trough pre-awakening DBP (both beta=0.4; P<0.001), and of pre-awakening DBP <70 mm Hg and <60 mm Hg (both P⩽0.001). Diabetes mellitus was associated with a lower trough pre-awakening DBP (beta=-3.2; P=0.02). Among variables that failed to independently predict low pre-awakening DBP were age, a history of vascular disease, and classes and number of antihypertensive drugs. We found that many hypertensive patients have low DBP in the pre-awakening period. Office DBP is the main predictor of low pre-awakening DBP. Further studies are needed to define the prognostic relevance and potential risks of low pre-awakening DBP.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Zheng KH,Serné EH,Kooter AJ,Smulders YMdoi
10.1038/jhh.2015.80subject
Has Abstractpub_date
2016-05-01 00:00:00pages
322-7issue
5eissn
0950-9240issn
1476-5527pii
jhh201580journal_volume
30pub_type
杂志文章abstract：:Despite the availability of multiple nonpharmacological and pharmacological antihypertensive regimens large scale control of BP on a population basis is still unsatisfactory. To achieve a better quality in hypertension care we have developed and evaluated a structured outpatient hypertension treatment and teaching pro...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:We compared the effects on blood pressure (BP) of three isocaloric diets with reduced total fat and saturated fatty acid (SAFA) contents but with different proportions of monounsaturated (MUFA) and polyunsaturated fatty acids (PUFA). Diet LF (low fat) provided 20 en% fat (7.9% SAFA, 7.8% MUFA, 3.0% PUFA); diet HP (hig...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.jhh.1000610
更新日期：1998-06-01 00:00:00
abstract：:The National Blood Pressure Programme in Germany (NBP) was established in 1985. The NBP is committed to a process of programme development and implementation that incorporates public health relevance, recent research results, and attempts of scientific module evaluation. Among selected examples of successful modules, ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：:Patients with severe hypertension (>180/110 mm Hg) require large blood pressure (BP) reductions to reach recommended treatment goals (<140/90 mm Hg) and usually require combination therapy to do so. This 8-week, multicenter, randomized, double-blind, parallel-group study compared the tolerability and antihypertensive ...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/sj.jhh.1002220
更新日期：2007-10-01 00:00:00
abstract：:There is growing evidence that hypertension, one of the major modifiable risk factors for cardiovascular disease (CVD), is established early in life. Given this, it is important to discover when hypertension first becomes apparent. Further, it is of particular importance to examine the ethnic differences in blood pres...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1001674
更新日期：2004-04-01 00:00:00
abstract：:This study endeavours to clarify the effect of alcohol consumption on changes in the blood pressure of Japanese men. The subjects, who were followed from 1990 to 1995, were 2189 male normotensive steelworkers aged from 40 to 54 years in 1990. Drinking habits were represented by two variables: average daily baseline al...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001191
更新日期：2001-06-01 00:00:00
abstract：:Hypertension is a modifiable risk factor for cardiovascular disease, but its aetiology has not been fully elucidated. Recently, attention has been focused on the direct relations of plasma homocysteine (Hcy) to blood pressure (BP). The purpose of this study was to determine the relationship of Hcy with BP and other ca...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001911
更新日期：2005-11-01 00:00:00
abstract：:Hypertension is strongly influenced by genetic factors. Although hypertension prevalence in some Hispanic sub-populations is greater than in non-Hispanic whites, genetic studies on hypertension have focused primarily on samples of European descent. A recent meta-analysis of 200 000 individuals of European descent iden...
journal_title：Journal of human hypertension
pub_type： 杂志文章,meta分析,多中心研究
doi：10.1038/jhh.2016.29
更新日期：2016-12-01 00:00:00
abstract：:The purpose of this study was to estimate the current prevalence and distribution of hypertension in an adult Tehranian population. Data were collected for 3343 men and 5148 women aged 20-69 years in the Tehran Lipid and Glucose Study (TLGS), which is a cross-sectional phase of a large epidemiologic study, first estab...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001399
更新日期：2002-05-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.jhh.1002211
更新日期：2007-08-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究
doi：10.1038/s41371-018-0115-5
更新日期：2019-01-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究
doi：10.1038/jhh.2014.2
更新日期：2014-10-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-019-0183-1
更新日期：2019-05-01 00:00:00
abstract：:Isolated segments (1-2 mm) of small subcutaneous arteries (diameter 0.1-0.9 mm) and veins (0.1-1.0 mm) from patients with hypertension (essential n = 13, renovascular n = 6) and controls (n = 17) were examined. The relaxant responses to the sensory transmitters calcitonin gene-related peptide (CGRP) and substance P, a...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章
doi：10.1038/sj.jhh.1001294
更新日期：2002-01-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2008.75
更新日期：2008-12-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究
doi：10.1038/jhh.2013.148
更新日期：2014-11-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001723
更新日期：2004-08-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2009.108
更新日期：2010-09-01 00:00:00
abstract：:Aortic pulse wave velocity has emerged as an important predictor of cardiovascular events, but data on ethnic differences in pulse wave velocity remain scarce. We explored differences in pulse wave velocity between people of Asian and African ancestry. Data were used from the cross-sectional Healthy Life in Suriname (...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-018-0144-0
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journal_title：Journal of human hypertension
pub_type： 杂志文章,随机对照试验
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更新日期：2016-01-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1001095
更新日期：2000-10-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1989-12-01 00:00:00
abstract：:The effects of propranolol and diltiazem on left ventricular systolic and diastolic function in hypertensive subjects (DBP 90-114 mmHg) were examined with M-mode and 2D echocardiograms in 21 patients in a double-blind fashion prior to and after 4 months of treatment. Systolic function was assessed by measurement of fr...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1990-12-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2015-01-01 00:00:00
abstract：:Syst. China Trial aimed to determine whether titrated antihypertensive treatment could reduce the risk of stroke incidence and other cardiovascular complications among 2,298 older Chinese patients (> or = 60) with isolated systolic hypertension. The data from 3 years follow-up showed that the blood pressure reduction ...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,评审
doi：
更新日期：1996-02-01 00:00:00
abstract：:A sodium intervention project was carried out in Tianjin, China, as part of the Tianjin Project, which is a national pilot, community-based intervention programme to reduce non-communicable diseases. The aim of this 3 year sodium project was to evaluate the feasibility and effects of sodium reduction in the population...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
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journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：
更新日期：1995-11-01 00:00:00
abstract：:A blood pressure recording is strictly speaking only relevant for the circumstances under which it is measured. There is increasing evidence that ambulatory recordings have more predictive power than casual BP recordings and are a better discriminator between high and low risk groups of patients, particularly within t...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1990-10-01 00:00:00
abstract：:Haemorrhagic diathesis develops in chronic renal failure, in which calcium antagonists are used widely as antihypertensive agents. Although calcium antagonists are reported to impair platelet function, it has not been examined whether calcium antagonists alter bleeding time. The present study was conducted to clarify ...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.jhh.1001327
更新日期：2002-03-01 00:00:00
