Elevated microRNA-34a contributes to trophoblast cell apoptosis in preeclampsia by targeting BCL-2.

Abstract:

:Preeclampsia (PE) is one of the most common pregnancy-specific pathologic complications, and is characterised by onset of hypertension and proteinuria. Placental trophoblast cell apoptosis is generally accepted as a major cause of PE. However, the details of the mechanism underlying the condition remain unclear. Here, we aimed to investigate a possible association between microRNA (miR)-34a and human trophoblast cell apoptosis during PE. We evaluated miR-34a expression in placentas from patients with PE compared with those from healthy pregnant individuals. Furthermore, we measured apoptosis rate after miR-34a mimic and/or inhibitor transfection in vitro, and identified B-cell CLL/lymphoma 2 (BCL-2) as a target of miR-34a. We found that miR-34a levels were significantly higher in placental tissues from patients with PE than in normal placentas. Upregulation of miR-34a induced trophoblast cell apoptosis in PE by inhibiting expression of BCL-2 protein. miR-34a inhibition reversed miR-34a-induced apoptosis in the HTR-8/SVneo human trophoblast cell line. Our findings indicate that miR-34a may be linked to the occurrence of PE via effects on BCL-2 in the human placenta, and may therefore provide a potential therapeutic target for PE.

journal_name

J Hum Hypertens

authors

Guo M,Zhao X,Yuan X,Li P

doi

10.1038/jhh.2017.65

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

815-820

issue

12

eissn

0950-9240

issn

1476-5527

pii

jhh201765

journal_volume

31

pub_type

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