Abstract：
:To assess vascular compliance in patients with antiphospholipid syndrome (APS), or antiphospholipid antibodies (aPLs) positivity in comparison to healthy people and diabetes mellitus patients. Twenty-five patients with APS or aPLs, 33 healthy people (HP), 28 patients with diabetes mellitus (DM) underwent pulse wave analysis. Data calculated included the small artery elasticity (SAE), large artery elasticity (LAE) and systemic vascular resistance (SVR). Statistical analysis was performed as appropriate. The patient group was divided into two subgroups: APS-1 with warfarin treatment, and APS-2 without warfarin treatment. All patients and healthy subjects were matched by gender, body mass index and lipid profiles. Patients in APS-1 group were significantly younger in comparison to three other groups. After the adjustment for age, we found that SAE in APS-1 group did not differ from SAE in the HP group (6.4+/-1.8 ml/mmHg x 100 and 5.54+/-3.4 ml/mmHg x 100, respectively, P>0.05). In contrast, SAE in the group APS-2 was significantly lower (3.41+/-1.2 ml/mmHg x 100) than in the APS-1 and was almost equal to SAE in the DM group (4.2+/-2.37 ml/mmHg x 100). The SAE in the APS-2, DM and HP groups was inversely correlated with age, whereas in the APS-1 group we did not find such correlation. This pilot study showed abnormal small vascular elasticity in the patients with positive aPL, relative to the healthy subjects. The APS patients, treated with warfarin had the normal vascular function. This data support the hypothesis that APS may be associated with diffuse changes in the arterial wall, and may be a risk factor for atherosclerotic disease.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Reitblat T,Polishchuk I,Zamir D,Isakov I,Oren Sdoi
10.1038/sj.jhh.1002020subject
Has Abstractpub_date
2006-07-01 00:00:00pages
504-9issue
7eissn
0950-9240issn
1476-5527pii
1002020journal_volume
20pub_type
杂志文章abstract：:Gender-specific determinants of blood pressure (BP) values and control have not been the focus of clinical hypertension research. The purpose of this analysis was to identify gender-specific and multi-level (physician and patient) determinants of BP values and predictors of uncontrolled BP. We completed a subgroup ana...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/jhh.2010.71
更新日期：2011-06-01 00:00:00
abstract：:Losartan, enalapril and amlodipine reduced the number of premature ventricular contractions (PVCs) in patients with essential hypertension as well as blood pressure. The effect of losartan was the most prominent among the three drugs. ...
journal_title：Journal of human hypertension
pub_type： 临床试验,信件
doi：10.1038/jhh.2008.122
更新日期：2009-04-01 00:00:00
abstract：:Genetic influences in cerebrovascular disease (CVD) may act either independently or by predisposing to, or modulating, the effect of risk factors such as hypertension. Factors involved in the pathogenesis of atherosclerosis, thrombosis and vasoconstriction are important in CVD. The angiotensinogen gene has recently be...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-08-01 00:00:00
abstract：:Despite the association of childhood blood pressure (BP) with hypertension later in the life course, there remains dearth of information regarding the prevalence and emergence of hypertension in children, especially in China. To investigate the current status of BP, prevalence of elevated BP and related factors in Chi...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究
doi：10.1038/jhh.2015.104
更新日期：2016-04-01 00:00:00
abstract：:The aim of the present longitudinal study was to describe determinants of blood pressure (BP) and echocardiographically calculated left ventricular mass in adolescents with a variable risk of future hypertension. BP was measured and M-mode echocardiography was performed in 52 children, 29 male and 23 female, at a mean...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：:The cholesterol:phospholipid ratio was measured in platelet plasma membrane, red blood cell (RBC) membranes, low density lipoprotein (LDL) and whole plasma in patients with primary hypertension and in matched normal controls. The cholesterol:phospholipid ratio was raised in the platelet membrane from hypertensive pati...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:Low-dose diuretics are recommended for the initial choice of antihypertensive therapy in the 7th US Joint National Committee report and are accepted as an appropriate choice among other classes of drugs in the 2003 European Society of Hypertension guidelines. The rationales for the use of low-dose diuretics include th...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1001798
更新日期：2004-12-01 00:00:00
abstract：:The burden of Type II diabetes is growing rapidly worldwide, across high-, middle- and low-income countries. This burden is associated primarily with increased risks of macrovascular and microvascular diseases, and it is agreed that multifactorial treatment regimens are required to reduce it. ADVANCE (Action in Diabet...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1001890
更新日期：2005-06-01 00:00:00
abstract：:Aortic stiffness and proteinuria are cardiovascular risk factors that are generally associated with each other. We analysed whether this is true for patients with chronic kidney disease (CKD). We hypothesized that in CKD patients of young age and predominant sole renal disease, aortic stiffness has no predictive value...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2009.108
更新日期：2010-09-01 00:00:00
abstract：:The haemodynamic effects of 45 min of treadmill exercise (at 70% of resting heart rate reserve) were determined in 5 young adults with hypertension and rapid resting heart rates (greater than 90 beats/min in clinic) and were compared with those of 5 age-matched normotensive subjects. Blood pressure was lower after exe...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：:The use of heart rate in clinical practice is limited by its variability under measurement situations. The mean heart rate on ambulatory monitoring provides a more robust statistic for clinical use. We examined the relationship between mean heart rate on initial referral ambulatory blood pressure monitoring (ABPM) to ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000586
更新日期：1998-04-01 00:00:00
abstract：:The role of the direct renin inhibitor aliskiren in hypertension is not fully established and use of aliskiren in diabetic patients is especially controversial. A systematic review investigating both short-term diastolic and systolic blood pressure (DBP and SBP) reduction and long-term cardiovascular outcomes has not ...
journal_title：Journal of human hypertension
pub_type： 杂志文章,meta分析
doi：10.1038/s41371-018-0149-8
更新日期：2019-11-01 00:00:00
abstract：:Consistent reports indicate that hypertension is a particularly common finding in black populations. Hypertension occurs at younger ages and is often more severe in terms of blood pressure levels and organ damage than in whites, resulting in a higher incidence of cardiovascular disease and mortality. This review provi...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/jhh.2017.18
更新日期：2017-08-01 00:00:00
abstract：:The media of most blood vessels is occupied by vascular smooth muscle cells. In areas they may be replaced by glomus cells, pericytes or renin-secreting myoepithelioid cells. These cells may be regarded as phenotypic variants of vascular smooth muscle cells. In disease, ordinary vascular smooth muscle cells may also a...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：
更新日期：1995-06-01 00:00:00
abstract：:A neurogenic component to primary hypertension (hypertension) is now well established. Along with raised vasomotor tone and increased cardiac output, the chronic activation of the sympathetic nervous system in hypertension has a diverse range of pathophysiological consequences independent of any increase in blood pres...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/jhh.2011.66
更新日期：2012-08-01 00:00:00
abstract：:The contribution of hypertension to adult mortality in Africa has not been well studied. Although cross-sectional surveys have provided data on the prevalence of this condition, the relative risk of death associated with hypertension has not been defined. In the face of high levels of competing mortality from infectio...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
abstract：:In order to find out the general public's opinion on blood pressure (BP) control in Poland a poll was conducted on a representative sample of 2080 randomly selected subjects. Overall 71% of the subjects were aware of their BP level. The awareness of BP level increased progressively with age and education level. Among ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：:The mechanisms underlying the adverse cardiovascular effects of increased salt intake are incompletely understood, but parallel increases in serum sodium concentration may be of importance. The aim of this retrospective cohort study was to investigate the relationship between serum sodium, hypertension and incident ca...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究
doi：10.1038/s41371-018-0115-5
更新日期：2019-01-01 00:00:00
abstract：:When captopril was first introduced for the management of hypertension, its short plasma half-life led to its use as a thrice daily regimen. However, further experience suggests that the biological action is more prolonged than the plasma half-life might suggest. This study examined the effect of varying the frequency...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：:The assessment of sodium sensitivity requires to measure the difference in mean arterial pressure (MAP) at the end of sodium-loading (SLoad) and sodium-depletion (SDepl) maneuvers with an arm-cuff manometer. Aim of this study is to evaluate whether MAP measuring devices based on the volume-clamp method at the finger c...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2014.110
更新日期：2015-07-01 00:00:00
abstract：:Nineteen patients with essential hypertension on regular treatment with nifedipine tablets 20 mg twice daily and whose DBP was < 95 mmHg on at least two occasions two weeks apart were entered in a double-blind randomised crossover study of three weeks treatment with nifedipine coat core (new formulation) either as 30 ...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-04-01 00:00:00
abstract：:QT-interval parameters are potential indicators of increased cardiovascular risk. We evaluated prospectively their prognostic value, in relation to other risk markers, for cardiovascular fatal and nonfatal events in a cohort of 271 hypertensive type 2 diabetic outpatients. QT intervals were measured from 12-lead stand...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001815
更新日期：2005-03-01 00:00:00
abstract：:It is rare for a study to address immediate metabolic change in pre-eclamptic pregnancy. Our aim is to study the ante-partum and post-partum metabolic markers in pre-eclampsia. A total of 33 pre-eclamptic and 200 uncomplicated women with singleton pregnancies were recruited for the prospective research. Immediately an...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2010.29
更新日期：2011-01-01 00:00:00
abstract：:The aim of this study was to describe the pattern of blood pressure (BP) distribution in a multiethnic primary care practice in relation to sociodemographic characteristics, lifestyle and risk factors. Another aim was to analyse the quality of diagnosis and effectiveness of hypertension (HT) treatment. In all, 470 adu...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001902
更新日期：2005-10-01 00:00:00
abstract：:At present, clinic blood pressure (BP) evaluation is being increasingly complemented by ambulatory BP measurements for the evaluation of haemodynamic patterns during daily activities and sleep. Nondipping pattern, a measure of decreased attenuation of nighttime over daytime BP, has been correlated with enhanced target...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/jhh.2010.113
更新日期：2011-05-01 00:00:00
abstract：:Mild to moderate hypertension is usually asymptomatic and therefore the impact on quality of life and side-effects of the antihypertensive treatment can have a negative effect on treatment compliance. A number of comparative studies have addressed quality of life issues with various antihypertensive agents, and the re...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
abstract：:Thyroid hormones, including free triiodothyronine (FT3), free thyroxine (FT4), have well-recognized effects on the cardiovascular system. However, the evidence is lacking regarding the relationship between repeated FT3, FT4, and thyroid-stimulating hormone (TSH) measurements and incident hypertension. The aim of this ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-020-00474-4
更新日期：2021-01-18 00:00:00
abstract：:The objectives of the study were to appraise the knowledge which the patients have about their hypertension, and to assess the knowledge and involvement of pharmacists in the management of the hypertensive patient. All the pharmacies in the Poitou-Charentes area were invited both to participate in a training session a...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001859
更新日期：2005-07-01 00:00:00
abstract：:We investigated the effect of elevated concentrations of fasting plasma glucose (FPG) or hemoglobin A1c (HbA1c) on the risk of development of hypertension among apparently healthy Japanese. Studied were 9584 individuals without known diabetes and hypertension. During a 5-year follow-up period, 1098 individuals develop...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2014.77
更新日期：2015-04-01 00:00:00
abstract：:Although 24-h urine collection is widely considered the 'gold standard' for estimation of population sodium intake, spot urine collection is increasingly used as a convenient and affordable alternative. We used four published formulae to convert spot urine sodium into estimates of 24-h sodium excretion in order to est...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2014.10
更新日期：2014-11-01 00:00:00
