Abstract:
:The E/A ratio (of peak mitral blood flow velocity during early diastole to that during atrial contraction) has limitations in the assessment of diastolic function. Previous studies have suggested that peak blood flow velocity is normally maintained or increased towards the cardiac apex but that it decreases in diastolic dysfunction. We evaluated the proposal that intraventricular dispersion of E wave velocity is an effective means of assessing diastolic function in hypertensives. Fifty-five untreated hypertensive patients underwent echocardiographic examination. Pulsed-wave Doppler recordings were made from the apical four-chamber view. Peak flow velocities were measured during early diastole at the level of the mitral valve (E0), and 3 cm distally (E3), and during atrial contraction at the level of the mitral valve (A). Mean peak flow velocities were 64.4 +/- 16.1 m/s for E0, 50.6 +/- 17.9 m/s for E3 and 61.1 +/- 12.1 m/s for A. Peak flow velocity during early diastole slowed towards the cardiac apex in most patients (E3/E0 range: 0.42-1.86, mean 0.81 +/- 0.29). There was no significant difference in E3/E0 between those with and without left ventricular hypertrophy (LVH) (0.76 +/- 0.25 vs 0.82 +/- 0.29, P = 0. 39). E3/E0 did not correlate with age (r = -0.02, P = 0.89), systolic blood pressure (BP) (r = 0.17, P = 0.20), diastolic BP (r = 0.21, P = 0.12) or LVMI (r = -0.11, P = 0.40). In contrast the E/A ratio correlated strongly with age (r = -0.66, P < 0.0001) and negatively, though not significantly, with systolic BP (r = -0.24, P = 0.07), diastolic BP (r = -0.23, P = 0.09) and LVMI (r = -0.23, P = 0.08). Although there is some intraventricular dispersion of E wave velocity in this group of hypertensive patients, the ratio of E3/E0 correlates poorly with parameters which are known to influence diastolic function. In spite of its limitations, the E/A ratio appears to be a more reliable measure of diastolic function in hypertensive heart disease than intraventricular dispersion of early diastolic filling.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Chapman JN,Mayet J,Foale RA,Thom SAdoi
10.1038/sj.jhh.1000905subject
Has Abstractpub_date
1999-12-01 00:00:00pages
867-9issue
12eissn
0950-9240issn
1476-5527journal_volume
13pub_type
临床试验,杂志文章abstract::Nineteen patients with essential hypertension on regular treatment with nifedipine tablets 20 mg twice daily and whose DBP was < 95 mmHg on at least two occasions two weeks apart were entered in a double-blind randomised crossover study of three weeks treatment with nifedipine coat core (new formulation) either as 30 ...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1994-04-01 00:00:00
abstract::Footshocks increases mean arterial pressure and heart rate. Systemic or intracerebroventricular (IVT) administration of losartan, a specific angiotensin AT1 receptor antagonist, not only inhibited the pressor response to footshocks but resulted in vasodepression. Peripheral or IVT administration of PD 123319, a specif...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1000986
更新日期:2000-04-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
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journal_title:Journal of human hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1038/jhh.2016.72
更新日期:2017-03-01 00:00:00
abstract::miR-33a has been described as a key regulator in the initiation and progression of atherosclerosis. However, its role in arterial hypertension (HTA) has not been elucidated. Therefore, the aim of this study was to determine the association between the expression of miR-33a (5p and 3p) and the carotid intima-media thic...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/s41371-018-0102-x
更新日期:2018-10-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2017.14
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/s41371-019-0183-1
更新日期:2019-05-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2013.129
更新日期:2014-07-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章,多中心研究
doi:10.1038/jhh.2014.2
更新日期:2014-10-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2014.23
更新日期:2015-01-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1000942
更新日期:2000-01-01 00:00:00
abstract::We carried out univariate and bivariate linkage analyses to identify genomic regions that may influence plasma levels of C-reactive protein (CRP) and fibrinogen and exert pleiotropic effects on both traits. Subjects included African American (AA, n=1310, mean age 62.7+/-9.4 years) and non-Hispanic white (NHW, n=796, m...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1002297
更新日期:2008-02-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1990-10-01 00:00:00
abstract::Hypertension is a major risk factor for cardiovascular disease, which is the leading cause of mortality in women in developed countries. This pooled analysis assessed the antihypertensive efficacy, safety and tolerability of monotherapy with the direct renin inhibitor aliskiren (150 mg and 300 mg) over 8-12 weeks in w...
journal_title:Journal of human hypertension
pub_type: 杂志文章,meta分析
doi:10.1038/jhh.2010.11
更新日期:2010-11-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1987-12-01 00:00:00
abstract::The high cardiovascular risk of HIV infected (HIV+) patients is still partly unexplained. We aimed to evaluate if HIV infection and highly active antiretroviral therapy (HAART) are linked per se to left ventricular (LV) remodelling, independently of blood pressure (BP) values. We enrolled 4 groups of patients matched ...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2011.81
更新日期:2012-10-01 00:00:00
abstract::A group of 175 patients have attended for four years a microcomputer based, nurse practitioner managed clinic for the long term care of hypertension. Improvement in blood pressure (BP) control was seen initially and has been maintained. Drug treatment has been with a beta blocker followed if necessary by a diuretic an...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1987-09-01 00:00:00
abstract::The treatment of hypertension in the elderly has to take into account co-existing pathology. However, the benefit from treatment are large in terms owing to the frequency of cardiovascular events in the elderly. The benefits observed in randomised controlled trials are reviewed together with the adverse effects of the...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:10.1038/sj.jhh.1000675
更新日期:1998-09-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001856
更新日期:2005-07-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
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更新日期:2014-07-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1991-06-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2013-05-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.jhh.1001372
更新日期:2002-04-01 00:00:00
abstract::Systemic hypertension is a common condition associated with significant morbidity and mortality. Hypertension confers cardiovascular risk by causing target-organ damage that includes retinopathy in addition to heart disease, stroke, renal insufficiency and peripheral vascular disease. The recognition of hypertensive r...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:10.1038/sj.jhh.1001472
更新日期:2002-10-01 00:00:00
abstract::Low plasma adiponectin levels are related to a higher risk of development of metabolic and cardiovascular disorders, including hypertension (HT). To date, there have been no studies supporting the relationship between epicardial adipose tissue (EAT) expression of adiponectin and HT. We collected samples of EAT from 11...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2008.75
更新日期:2008-12-01 00:00:00
abstract::Left ventricular hypertrophy (LVH) is a powerful cardiovascular risk factor and has previously been related to endothelium-dependent vasodilation (EDV) in hypertensive patients. In the Prospective Investigation of the Vasculature in Uppsala Seniors study, different techniques to evaluate EDV in different types of vess...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2008.61
更新日期:2008-11-01 00:00:00
abstract::This paper addresses approaches to evaluating the importance of different childhood behaviours on subsequent risk of high blood pressure and related cardiovascular risk factors and outlines results of a randomised controlled trial of nutrition and exercise interventions in schoolchildren. Clustering of cardiovascular ...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1996-02-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章
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更新日期:2017-02-01 00:00:00
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journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:10.1038/sj.jhh.1002024
更新日期:2006-07-01 00:00:00
abstract::Diabetes mellitus (DM)-linked metabolic alterations and hypertension concomitantly accelerate or precipitate cerebrovascular and coronary heart disease, nephropathy, retinopathy and widespread macroangiopathy, thereby conferring to diabetic patients a very high risk of morbidity, disability and early death. Therefore,...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:
更新日期:1992-12-01 00:00:00