Abstract：
:A deletion/insertion polymorphism in the ACE gene has been reported previously as a potent factor for myocardial infarction. We have tested the frequency of the deletion (D) allele of the ACE gene in 308 consecutive patients admitted to coronary care with chest pain. The gene frequencies were compared with those of 348 controls recruited from the London area. Of 108 Caucasian patients with myocardial infarction, the DD genotype was found more frequently than the combined DI and II genotypes (Chi-square, chi 2 = 5.07, 2P = 0.024). The overall D gene frequency was higher in myocardial infarction patients (125 of 216, 58%) than in controls (347 of 696, 49.9%) (chi 2 = 3.79, 2P = 0.052). In contrast, the DD genotype and D allele frequencies in patients with unstable angina were similar to those found in our normal population. A nonsignificant difference in allele frequency between myocardial infarction and unstable angina patients was observed but the small numbers of subjects studied precludes a more formal comparison. Since unstable angina and myocardial infarction represent a spectrum of coronary thrombosis, it is possible that the DD genotype favours the development of myocardial infarction, perhaps through the presence of higher serum ACE concentrations.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Leatham E,Barley J,Redwood S,Hussein W,Carter N,Jeffery S,Bath PM,Camm Asubject
Has Abstractpub_date
1994-08-01 00:00:00pages
635-8issue
8eissn
0950-9240issn
1476-5527journal_volume
8pub_type
杂志文章abstract：:We examined the association between serum lipoprotein subclasses and the three measures of arterial stiffness, that is, (i) carotid-femoral pulse wave velocity (cfPWV), which is a gold standard measure of central arterial stiffness, (ii) brachial-ankle PWV (baPWV), which is emerging as a combined measure of central an...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究
doi：10.1038/jhh.2013.60
更新日期：2014-02-01 00:00:00
abstract：:The interaction between doctors and their hypertensive patients still suffers from a number of shortcomings owing to ignorance and misconceptions on both sides as well as poorly defined mutual goals. In this paper, an attempt is made to define common goals of doctors and patients and to describe the information status...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:It is not known whether serum potassium levels affect blood pressure response to antihypertensive medication. The African American Study of Kidney Disease and Hypertension (AASK) Genomics Study (N=828) is a subset of the AASK trial that randomized 1094 African American men and women with hypertensive nephrosclerosis t...
journal_title：Journal of human hypertension
pub_type： 杂志文章,随机对照试验
doi：10.1038/jhh.2012.47
更新日期：2013-06-01 00:00:00
abstract：:A group of 175 patients have attended for four years a microcomputer based, nurse practitioner managed clinic for the long term care of hypertension. Improvement in blood pressure (BP) control was seen initially and has been maintained. Drug treatment has been with a beta blocker followed if necessary by a diuretic an...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1987-09-01 00:00:00
abstract：:Longstanding and therapy-resistant hypertension may cause cerebral, renal, cardiac and retinal end-organ damage (EOD). Retinal hypertensive abnormalities are correlated with an increased risk of cardiovascular (CV) disease in general but are not included in CV risk assessment tools. Research into prevalence and determ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2016.49
更新日期：2017-02-01 00:00:00
abstract：:The acute effects of the renin-angiotensin system (RAS) blockers may be important in some clinical settings. To assess the acute impact of such drugs on arterial function, we studied the effects of captopril 25 mg, quinapril 20 mg and telmisartan 80 mg on 100 hypertensive patients, according to a randomized, double-bl...
journal_title：Journal of human hypertension
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.jhh.1002211
更新日期：2007-08-01 00:00:00
abstract：:Hypertension in women has received less attention than hypertension in men, and the major controlled trials of antihypertensive therapy have been carried out in populations made up predominantly of and have emphasised outcomes in men. Recently it has been recognised that women develop high blood pressure, particularly...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1001095
更新日期：2000-10-01 00:00:00
abstract：:The media of most blood vessels is occupied by vascular smooth muscle cells. In areas they may be replaced by glomus cells, pericytes or renin-secreting myoepithelioid cells. These cells may be regarded as phenotypic variants of vascular smooth muscle cells. In disease, ordinary vascular smooth muscle cells may also a...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：
更新日期：1995-06-01 00:00:00
abstract：:Primary aldosteronism (PA), the most common cause of secondary hypertension, is a well-recognized condition that can lead to cardiovascular and renal complications. PA is frequently left undiagnosed and untreated, leading to aldosterone-specific morbidity and mortality. In this review we highlight the evidence linking...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/s41371-019-0294-8
更新日期：2020-01-01 00:00:00
abstract：:Autonomic dysfunction is implicated in prehypertension, and previous studies have suggested that therapies that improve modulation of sympathovagal balance, such as biofeedback and slow abdominal breathing, are effective in patients with prehypertension at rest. However, considering that psychophysiological stressors ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2015.27
更新日期：2016-02-01 00:00:00
abstract：:This multicentre, double-blind, trial in subjects with severe hypertension compared the efficacy and tolerability of two parallel drug regimens: A/B (amlodipine/benazepril: 5/20 or 10/40 mg daily, if necessary) with A (amlodipine: 5 or 10 mg daily, if necessary). The principal dependent variable was the proportion of ...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/jhh.2009.80
更新日期：2010-06-01 00:00:00
abstract：:A sodium intervention project was carried out in Tianjin, China, as part of the Tianjin Project, which is a national pilot, community-based intervention programme to reduce non-communicable diseases. The aim of this 3 year sodium project was to evaluate the feasibility and effects of sodium reduction in the population...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：:Hypertension is regarded as a major contributor to vascular disease. Vascular disease is a fairly common denominator in a large percentage of cases of dementia. Despite this strong connecting link, dementia is often not considered as a mainstream problem consequent to hypertension, though there is an alarming increase...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/s41371-019-0205-z
更新日期：2019-08-01 00:00:00
abstract：:To clarify the natriuretic action of endogenous atrial natriuretic peptide (ANP) in patients with essential hypertension (EHT), we examined the relationship between ANP release and urinary sodium excretion in response to hypertonic saline infusion. Plasma ANP levels increased from 13.3 +/- 2.0 pg/ml to 37.0 +/- 3.0 pg...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:In phaeochromocytoma, sudden hypertensive or arrhythmic episodes are believed to be associated with excessive free catecholamine excretion. However, lack of correlation between blood pressure (BP) and plasma catecholamine levels has been reported. Therefore an attempt was made to assess the sympathovagal balance befor...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:To investigate blood pressure (BP) as well as other risk factors before the onset of myocardial infarction in hypertensive patients, we analysed the BP and metabolic variables in 94 hypertensive patients who had been followed up in our out-patient clinic before the first onset (M1 group; n = 42, 69 +/- 1 years, mean +...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000697
更新日期：1998-10-01 00:00:00
abstract：:The influence of high density lipoproteins (HDL) on platelet function were examined in vivo and in vitro. Intraplatelet, ionised calcium concentrations ([Ca2+]i) were measured using the fluorescent dye Quin-2. In vitro, platelet responses to AVP were measured in the presence or absence of HDL. Pre-treating platelets f...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：:Unravelling the complete genetic predisposition to high blood pressure (BP) has proven to be challenging. This puzzle and the fact that coding regions of the genome account for less than 2% of the entire human DNA support the hypothesis that genetic mechanism besides coding genes are likely to contribute to BP regulat...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/jhh.2014.99
更新日期：2015-08-01 00:00:00
abstract：:The aim of the study is to determine the prevalence of hypertension (HTN) and its risk factors in urban and rural India. In Phase I of the Indian Council of Medical Research-India Diabetes (ICMR-INDIAB) study, individuals aged ⩾20 years were surveyed using a stratified multistage sampling design, in three states (Tami...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2014.57
更新日期：2015-03-01 00:00:00
abstract：AIMS:To define the prevalence of hypertension, a major cause of morbidity and mortality in blacks, and related biosocial factors in an urban African population group. METHODS:The setting was that of a civil service population in Ibadan, a major city in Southwestern Nigeria. Nine hundred and ninety-eight civil servants...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/sj.jhh.1000975
更新日期：2000-04-01 00:00:00
abstract：:In addition to high blood pressure, hypertension is characterised by metabolic and cardiovascular abnormalities, including decreased arterial compliance. To evaluate arterial involvement in early hypertension, we have employed a technique that analyses the arterial pulse wave contour to separately quantify proximal co...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:Cardiovascular risk is subject to circadian variation, with peak morning incidence of myocardial infarction and stroke correlating with the early morning blood pressure (BP) surge (EMBPS). Ideally, antihypertensive therapy should maintain control of BP throughout the 24-h dosing cycle. In two sister studies, Prospecti...
journal_title：Journal of human hypertension
pub_type： 杂志文章,随机对照试验
doi：10.1038/jhh.2009.4
更新日期：2009-09-01 00:00:00
abstract：:Plasma gamma-glutamyltransferase (GGT) was suggested to reflect the level of systemic oxidative stress. Oxidative stress induces changes in arterial structure and function and contributes to the development of hypertension. Therefore, GGT may be associated with arterial remodeling and blood pressure (BP) increment, ev...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-020-0337-1
更新日期：2020-04-29 00:00:00
abstract：:New onset of seizures in young adults is frequently related to alcohol withdrawal, toxic exposure, central nervous system trauma and neoplasm. We describe a young soldier presenting to the emergency department with seizures and transient coma. On admission, he had hypertension, marked leukocytosis, hyper-glycaemia, ac...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001499
更新日期：2003-01-01 00:00:00
abstract：:Physical exercise can increase urinary albumin excretion rate (UAER) in diabetic patients without microalbuminuria at rest (stage II diabetic nephropathy) or with baseline microalbuminuria (stage III diabetic nephropathy). The aim of this study was to compare the acute effects of captopril, an ACE inhibitor, and nifed...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1991-06-01 00:00:00
abstract：:To understand the prevalence of high blood pressure among the general adult population under the new diagnostic criteria. PubMed and Embase databases were systematically searched. Two investigators independently performed data extraction and quality assessment, and the disagreements were resolved by consensus with a t...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/s41371-020-00454-8
更新日期：2020-12-08 00:00:00
abstract：:We have investigated the use of captopril as a screening test for renovascular hypertension and compared the effects of captopril on renal function in patients with renovascular hypertension and those without renovascular hypertension. The captopril test and kidney gamma scintigraphy were carried out in 50 hypertensiv...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：:Clinical studies have shown that aldosterone and salt are independently related to hypertension, cardiovascular morbidity and mortality. More recently, studies in humans have demonstrated that, similarly to animals, endogenous aldosterone and dietary salt intake have not only separate, but also combined effects to acc...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/jhh.2012.27
更新日期：2013-01-01 00:00:00
abstract：:The association between masked hypertension and metabolic syndrome (MS) or insulin resistance is unclear. We investigated an untreated nationwide population sample (n = 1582, age 44-74 years). Duplicate office blood pressure (BP) measurements were taken on one visit and duplicate morning and evening home measurements ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2013.129
更新日期：2014-07-01 00:00:00
abstract：:Dopamine is a natriuretic hormone which is synthesised within the kidney. We have previously found that some ethnic groups (e.g. British Caucasians and Thais) show strong positive correlations between 24 h urinary sodium and dopamine outputs. However no such relationship was found in Iranians and black West Africans. ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
