Angiotensin-1 converting enzyme (ACE) polymorphism in patients presenting with myocardial infarction or unstable angina.


:A deletion/insertion polymorphism in the ACE gene has been reported previously as a potent factor for myocardial infarction. We have tested the frequency of the deletion (D) allele of the ACE gene in 308 consecutive patients admitted to coronary care with chest pain. The gene frequencies were compared with those of 348 controls recruited from the London area. Of 108 Caucasian patients with myocardial infarction, the DD genotype was found more frequently than the combined DI and II genotypes (Chi-square, chi 2 = 5.07, 2P = 0.024). The overall D gene frequency was higher in myocardial infarction patients (125 of 216, 58%) than in controls (347 of 696, 49.9%) (chi 2 = 3.79, 2P = 0.052). In contrast, the DD genotype and D allele frequencies in patients with unstable angina were similar to those found in our normal population. A nonsignificant difference in allele frequency between myocardial infarction and unstable angina patients was observed but the small numbers of subjects studied precludes a more formal comparison. Since unstable angina and myocardial infarction represent a spectrum of coronary thrombosis, it is possible that the DD genotype favours the development of myocardial infarction, perhaps through the presence of higher serum ACE concentrations.


J Hum Hypertens


Leatham E,Barley J,Redwood S,Hussein W,Carter N,Jeffery S,Bath PM,Camm A


Has Abstract


1994-08-01 00:00:00












  • Hypertension screening in a salami factory: a worksite hypertension study.

    abstract::The prevalence, awareness and control of hypertension are important epidemiological research topics worldwide. The screening of hypertension in a workplace has some special aspects. We have screened the employees in a Hungarian salami factory (Pick Salami Factory, Szeged, Hungary) for hypertensives. In a cross-section...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Sonkodi B,Fodor JG,Abrahám G,Légrády P,Ondrik Z,Lencse G,Sonkodi S

    更新日期:2004-08-01 00:00:00

  • The emerging role of non-coding RNA in essential hypertension and blood pressure regulation.

    abstract::Unravelling the complete genetic predisposition to high blood pressure (BP) has proven to be challenging. This puzzle and the fact that coding regions of the genome account for less than 2% of the entire human DNA support the hypothesis that genetic mechanism besides coding genes are likely to contribute to BP regulat...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,评审


    authors: Marques FZ,Booth SA,Charchar FJ

    更新日期:2015-08-01 00:00:00

  • Increased nighttime blood pressure or nondipping profile for prediction of cardiovascular outcomes.

    abstract::At present, clinic blood pressure (BP) evaluation is being increasingly complemented by ambulatory BP measurements for the evaluation of haemodynamic patterns during daily activities and sleep. Nondipping pattern, a measure of decreased attenuation of nighttime over daytime BP, has been correlated with enhanced target...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,评审


    authors: Tsioufis C,Andrikou I,Thomopoulos C,Syrseloudis D,Stergiou G,Stefanadis C

    更新日期:2011-05-01 00:00:00

  • Relationship of serum immunoglobulin levels to blood pressure and hypertension in an adult population.

    abstract::Evidence suggests long-term chronic inflammation, as the pathological basis of formation and development, plays an important part in atherosclerosis. Immunoglobulins (Igs) provided key information on the humoral immune status. However, few studies have evaluated the correlation between Igs and hypertension and blood p...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Wang X,Li Y,Li H,Gu Y,Song Y,Zhang Q,Liu L,Meng G,Yao Z,Wu H,Xia Y,Bao X,Shi H,Su Q,Fang L,Yang H,Yu F,Sun S,Wang X,Zhou M,Jiao H,Jia Q,Song K,Wu Y,Chang H,Niu K

    更新日期:2018-03-01 00:00:00

  • Detection and treatment of hypertension in general health-care practice: a patient-based study.

    abstract::The aim of this study was to describe the pattern of blood pressure (BP) distribution in a multiethnic primary care practice in relation to sociodemographic characteristics, lifestyle and risk factors. Another aim was to analyse the quality of diagnosis and effectiveness of hypertension (HT) treatment. In all, 470 adu...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Al-Windi A

    更新日期:2005-10-01 00:00:00

  • Improvement of cardiovascular risk profile in an elderly population of low social level: the ICON (Improving Cardiovascular risk profile in Older Neapolitans) study.

    abstract::Older age and low socio-economic conditions are associated with poor control of cardiovascular risk factors (RFs). We assessed the prevalence and awareness of cardiovascular RFs in 503 elderly outpatients of low social status attending two public Internal Medicine clinics in Naples, and studied the interaction of educ...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Marotta T,Viola S,Ferrara F,Ferrara LA

    更新日期:2007-01-01 00:00:00

  • The association between longitudinal trends of thyroid hormones levels and incident hypertension in a euthyroid population.

    abstract::Thyroid hormones, including free triiodothyronine (FT3), free thyroxine (FT4), have well-recognized effects on the cardiovascular system. However, the evidence is lacking regarding the relationship between repeated FT3, FT4, and thyroid-stimulating hormone (TSH) measurements and incident hypertension. The aim of this ...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Wang Y,Gu Y,Zhang Q,Liu L,Meng G,Wu H,Zhang S,Zhang T,Wang X,Sun S,Wang X,Zhou M,Jia Q,Song K,Niu K

    更新日期:2021-01-18 00:00:00

  • A genetic risk score for hypertension is associated with risk of thoracic aortic aneurysm.

    abstract::A genetic risk score (GRS) based on 29 single nucleotide polymorpysms (SNPs) associated with high blood pressure (BP) was prospectively associated with development of hypertension, stroke and cardiovascular events. The aim of the present study was to evaluate the impact of this GRS on the incidence of aortic disease, ...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Tagetti A,Bonafini S,Ohlsson T,Engström G,Almgren P,Minuz P,Smith G,Melander O,Fava C

    更新日期:2019-09-01 00:00:00

  • Frederick Akbar Mahomed (1849-1884): pioneer of clinical research.

    abstract::Professional historians generally treat the phrase 'what if' with pardonable scorn. It is a speculation which necessarily will never be tested in the real world. Nevertheless, there is a reasonable likelihood that, if typhoid fever had not carried off Frederick Akbar Mahomed at the age of 35, clinical research in Brit...

    journal_title:Journal of human hypertension

    pub_type: 传,历史文章,杂志文章


    authors: Swales JD

    更新日期:1996-03-01 00:00:00

  • C-reactive protein, atherosclerosis and kidney function in hypertensive patients.

    abstract::Previous studies have shown a relationship between coronary or carotid atherosclerosis and C-reactive protein (CRP) concentrations. In the present investigation, we evaluated the relationship between high-sensitivity CRP (hsCRP) concentrations and the presence of atherosclerotic lesions in the renal arteries and/or ab...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Hommels MJ,van der Ven AJ,Kroon AA,Kessels AG,van Dieijen-Visser MP,van Engelshoven JA,Bruggeman CA,de Leeuw PW

    更新日期:2005-07-01 00:00:00

  • Kinetic characteristics of the erythrocyte sodium-lithium countertransporter in black normotensive subjects compared with three other ethnic groups.

    abstract::Sodium-lithium countertransport activity has been proposed as a marker for hypertension and is lower in black compared to Caucasian subjects both with and without vascular disease. The question arises of what is the primary kinetic locus of the altered behaviour of the countertransporter in black subjects and whether ...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Hardman TC,Croft P,Morrish Z,Anto-Awoakye K,Lant AF

    更新日期:1998-01-01 00:00:00

  • Impact of calcium antagonists on bleeding time in patients with chronic renal failure.

    abstract::Haemorrhagic diathesis develops in chronic renal failure, in which calcium antagonists are used widely as antihypertensive agents. Although calcium antagonists are reported to impair platelet function, it has not been examined whether calcium antagonists alter bleeding time. The present study was conducted to clarify ...

    journal_title:Journal of human hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hayashi K,Matsuda H,Honda M,Ozawa Y,Tokuyama H,Okubo K,Takamatsu I,Kanda T,Tatematsu S,Homma K,Saruta T

    更新日期:2002-03-01 00:00:00

  • Visit-to-visit systolic blood pressure variability in patients with ST-elevation myocardial infarction predicts long-term cardiovascular outcomes.

    abstract::Elevated visit-to-visit blood pressure variability (BPV), independent of mean BP, has been associated with cardiovascular events. However, its impact after ST-elevation myocardial infarction (STEMI) has not been established. This study aimed to investigate the prognostic impact of BPV on patients after STEMI. We analy...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Soh MS,Park JS,Seo KW,Yang HM,Lim HS,Choi BJ,Choi SY,Yoon MH,Hwang GS,Tahk SJ,Shin JH

    更新日期:2019-04-01 00:00:00

  • Circadian variation of haemodynamics in patients with essential hypertension.

    abstract::A Holter BP monitor and a noninvasive, continuous cardiac output (CO) monitor were concurrently attached to 25 middle-aged hospitalized patients with essential hypertension (EH). Blood pressure, heart rate (HR) and CO were measured every 10 minutes over 24 hours. Circadian variation of mean BP was studied. Comparison ...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Mori H

    更新日期:1990-08-01 00:00:00

  • Balanced 24-hour blood pressure control by angiotensin-converting enzyme inhibitors administered once daily.

    abstract::Traditional sphygmomanometric measurements may inaccurately reflect the actual blood pressure level over a 24-h period. This is due to several factors which are known to affect cuff blood pressure readings, including the limited number of readings obtainable throughout the 24 h and the alerting reaction and pressor re...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,评审


    authors: Parati G,Ravogli A,Trazzi S,Omboni S,Frattola A,Lattuada S,Libretti A,Mancia G

    更新日期:1989-06-01 00:00:00

  • Dysglycaemia in non-diabetic hypertensive patients: comparison of the impact of two different classifications of impaired fasting glucose on the cardiovascular risk profile.

    abstract::The clinical correlates and risk profile of prediabetes (fasting plasma glucose (FPG) values in the upper normal limits but below the diabetic threshold) in hypertension, an insulin-resistant, prodiabetogenic condition, are scarcely known. For this reason, we evaluated 982 non-diabetic (FPG,<126 mg 100 ml(-1) and no a...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Dell'Omo G,Penno G,Del Prato S,Mariani M,Pedrinelli R

    更新日期:2009-05-01 00:00:00

  • The epidemiology of elevated blood pressure as an estimate for hypertension in Aydin, Turkey.

    abstract:BACKGROUND:Hypertension is an important public health problem, with some variability of its epidemiological properties in different populations. OBJECTIVES:The purpose of this study was to estimate the prevalence of hypertension and to determine the hypertension awareness, treatment and control rates in Aydin, a Turki...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Sönmez HM,Başak O,Camci C,Baltaci R,Karazeybek HS,Yazgan F,Ertin I,Celik SC

    更新日期:1999-06-01 00:00:00

  • INTERMAP: background, aims, design, methods, and descriptive statistics (nondietary).

    abstract::Blood pressure (BP) above optimal (< or =120/< or =80 mmHg) is established as a major cardiovascular disease (CVD) risk factor. Prevalence of adverse BP is high in most adult populations; until recently research has been sparse on reasons for this. Since the 1980s, epidemiologic studies confirmed that salt, alcohol in...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,评审


    authors: Stamler J,Elliott P,Dennis B,Dyer AR,Kesteloot H,Liu K,Ueshima H,Zhou BF,INTERMAP Research Group.

    更新日期:2003-09-01 00:00:00

  • Blood pressure during siesta: effect on 24-h ambulatory blood pressure profiles analysis.

    abstract::Blood pressure (BP) during siesta declines to levels similar to those of night time sleep. The objective of the study was to assess the effect of siesta on 24-h ambulatory BP (ABP) data. Two different approaches were employed for the definition of day and night periods: (1) actual patient reported day and night interv...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Stergiou GS,Malakos JS,Zourbaki AS,Achimastos AD,Mountokalakis TD

    更新日期:1997-02-01 00:00:00

  • Physiopharmacological approach to mechanical factors of hypertension in the atherosclerotic process.

    abstract::Hypertension may influence the atherosclerotic process of large arteries via pressure and shear forces. The pressure force dilates and stiffens arteries because of the non-linear elastic behaviour of arterial walls. This partly explains the increased diameter and decreased compliance of the brachial artery in hyperten...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,评审


    authors: Simon AC,Pithois-Merli I,Levenson J

    更新日期:1991-08-01 00:00:00

  • Influence of target organ lesion detection (assessment of microalbuminuria and echocardiogram) in cardiovascular risk stratification and treatment of untreated hypertensive patients.

    abstract::European guidelines indicate the importance of the evaluation of global cardiovascular risk (CVR) to determine the management of the hypertensive patients (EH). However, in primary care, the diagnostic work-up (PCD) only includes the metabolic risk factors. The aim of this study was to assess the importance of microal...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Luque M,de Rivas B,Alvarez B,Garcia G,Fernandez C,Martell N

    更新日期:2006-03-01 00:00:00

  • How early should blood pressure control be achieved for optimal cardiovascular outcomes?

    abstract::As a consequence of the aging population and the increasing prevalence rates for conditions such as type 2 diabetes and chronic kidney disease (CKD), management of hypertension will be focusing more and more on the high-risk patient. Clinical practice guidelines for managing hypertension in the United States recommend...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章,评审


    authors: Weir MR,Zappe D,Orloski LA,Sowers JR

    更新日期:2011-04-01 00:00:00

  • Arterial compliance and baroreceptor sensitivity after chronic treatment with indapamide.

    abstract::Arterial compliance, assessed by the ratio of stroke volume to pulse pressure, and baroreceptor sensitivity (Oxford method), were determined in ten patients with essential hypertension, treated with placebo or indapamide (2.5 mg/day), in a cross-over, single blind study. After three months of therapy, mean arterial pr...

    journal_title:Journal of human hypertension

    pub_type: 临床试验,杂志文章


    authors: Carretta R,Fabris B,Bardelli M,Muiesan S,Fischetti F,Vran F,Bianchetti A,Campanacci L

    更新日期:1988-10-01 00:00:00

  • Socioeconomic differences in prevalence, awareness, control and self-management of hypertension among four minority ethnic groups, Na Xi, Li Shu, Dai and Jing Po, in rural southwest China.

    abstract::This study investigates socioeconomic differences in prevalence, awareness, control and self-management of hypertension in rural China. A cross-sectional survey was conducted among four ethnic minority groups in Yunnan Province: Na Xi, Li Shu, Dai and Jing Po. Approximately 5532 consenting individuals aged ⩾35 years (...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Cai L,Dong J,Cui WL,You DY,Golden AR

    更新日期:2017-06-01 00:00:00

  • Albuminuria induced by exercise in hypertensive type I and type II diabetic patients: a randomised, double-blind study on the effects of acute administration of captopril and nifedipine.

    abstract::Physical exercise can increase urinary albumin excretion rate (UAER) in diabetic patients without microalbuminuria at rest (stage II diabetic nephropathy) or with baseline microalbuminuria (stage III diabetic nephropathy). The aim of this study was to compare the acute effects of captopril, an ACE inhibitor, and nifed...

    journal_title:Journal of human hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Romanelli G,Giustina A,Cravarezza P,Caldonazzo A,Agabiti-Rosei E,Giustina G

    更新日期:1991-06-01 00:00:00

  • Left ventricular hypertrophy, blood pressure and ACE genotype in untreated hypertension.

    abstract::It has been suggested that the deletion polymorphism of the angiotensin-converting enzyme (ACE) genotype may be important in the development of left ventricular hypertrophy (LVH). In order to test this hypothesis we investigated the interaction between blood pressure (BP), LVH and ACE genotype in 86 previously untreat...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Mayet J,O'Kane KP,Elton R,Johnstone HA,Shahi M,Ozkor MA,Stanton AV,Poulter NR,Sever PS,Foale RA,Webb DJ,Thom SA

    更新日期:1997-09-01 00:00:00

  • Doxazosin in 'resistant' hypertension.

    abstract::A study of doxazosin added to baseline therapy with a beta-adrenoceptor blocker plus a diuretic in the treatment of patients 'resistant' to the baseline therapy, showed that it was effective and generally well tolerated. The study was, however, open-label and lacked comparison with other third-line drugs. ...

    journal_title:Journal of human hypertension

    pub_type: 临床试验,杂志文章


    authors: Maclean D,McDevitt DG

    更新日期:1990-10-01 00:00:00

  • Haemodynamic contributions to post-exercise hypotension in young adults with hypertension and rapid resting heart rates.

    abstract::The haemodynamic effects of 45 min of treadmill exercise (at 70% of resting heart rate reserve) were determined in 5 young adults with hypertension and rapid resting heart rates (greater than 90 beats/min in clinic) and were compared with those of 5 age-matched normotensive subjects. Blood pressure was lower after exe...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Floras JS,Wesche J

    更新日期:1992-08-01 00:00:00

  • Knowledge of blood pressure measurement among a teaching hospital staff in a developing nation.

    abstract::Hypertension is a common and potentially serious disease and accurate measurement of blood pressure (BP) is important for its diagnosis and management. The aim of this study was to assess the knowledge of hospital staff on the basic principles of BP measurement. Consultants, junior doctors and nurses in a large teachi...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Ahmed ME

    更新日期:1997-08-01 00:00:00

  • Arterial compliance: is it reduced in antiphospholipid syndrome?

    abstract::To assess vascular compliance in patients with antiphospholipid syndrome (APS), or antiphospholipid antibodies (aPLs) positivity in comparison to healthy people and diabetes mellitus patients. Twenty-five patients with APS or aPLs, 33 healthy people (HP), 28 patients with diabetes mellitus (DM) underwent pulse wave an...

    journal_title:Journal of human hypertension

    pub_type: 杂志文章


    authors: Reitblat T,Polishchuk I,Zamir D,Isakov I,Oren S

    更新日期:2006-07-01 00:00:00