Abstract：
:It is not known whether serum potassium levels affect blood pressure response to antihypertensive medication. The African American Study of Kidney Disease and Hypertension (AASK) Genomics Study (N=828) is a subset of the AASK trial that randomized 1094 African American men and women with hypertensive nephrosclerosis to ramipril, amlodipine or metoprolol. Participants were also randomized to a usual (102-107 mm Hg) or low (≤92 mm Hg) mean arterial pressure (MAP) treatment goal. Time-to-event analyses were used to determine the relationship between serum potassium at randomization and time (days) to reach an MAP of 107 mm Hg. Mean baseline serum potassium was 4.22 mmol l(-1) (s.d.±0.56 and range 2.8-6.0) and the median days to reach target MAP was 32 (interquartile range 8-95). The adjusted hazard ratio (HR) for each 1 mmol l(-1) increase in serum potassium was 1.31 (95% confidence interval (CI): 1.08-1.59) in the usual MAP group, and 1.21 (95% CI: 1.02-1.44) in the low MAP group. Secondary findings suggested that women in the usual MAP group on amlodipine were more likely to reach target MAP compared with women randomized to ramipril (HR: 2.05, 95% CI: 1.30-3.21). Older subjects in the low MAP group (≥55 years) were also more likely to reach target MAP on amlodipine compared with ramipril (HR: 1.57, 95% CI: 1.03-2.38). Serum potassium appears to be a significant predictor of time to blood pressure response, independent of drug class. The effect of serum potassium on blood pressure response to antihypertensive medications needs to be further studied in different patient populations.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Bhalla M,Aziz H,Richard E,Lipkowitz MS,Bhatnagar Vdoi
10.1038/jhh.2012.47subject
Has Abstractpub_date
2013-06-01 00:00:00pages
393-6issue
6eissn
0950-9240issn
1476-5527pii
jhh201247journal_volume
27pub_type
杂志文章,随机对照试验abstract：:A 16 year old boy presented with accelerated hypertension and urinary tract obstruction caused by phimosis. Relief of the obstruction by circumcision reversed the hypertension. We believe that accelerated hypertension secondary to phimosis has not previously been described. ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:Often a single blood pressure (BP) measurement is used to diagnose and manage hypertension in busy clinics. However, repeated BP measurements have been shown to be more representative of the true BP status of the individual. Improper measurement of office BP can lead to inaccurate classification, overestimation of a p...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-019-0200-4
更新日期：2019-08-01 00:00:00
abstract：:The media of most blood vessels is occupied by vascular smooth muscle cells. In areas they may be replaced by glomus cells, pericytes or renin-secreting myoepithelioid cells. These cells may be regarded as phenotypic variants of vascular smooth muscle cells. In disease, ordinary vascular smooth muscle cells may also a...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：
更新日期：1995-06-01 00:00:00
abstract：:Left ventricular hypertrophy (LVH) is a powerful cardiovascular risk factor and has previously been related to endothelium-dependent vasodilation (EDV) in hypertensive patients. In the Prospective Investigation of the Vasculature in Uppsala Seniors study, different techniques to evaluate EDV in different types of vess...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2008.61
更新日期：2008-11-01 00:00:00
abstract：:The objective of the study was to determine trends in age-specific blood pressure (BP) distribution and hypertension prevalence in an urban Indian population. In successive hypertension epidemiological studies (1995 and 2002), randomly selected 2212 subjects (1412 men, 797 women) in the first and 1123 subjects (550 me...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001588
更新日期：2003-08-01 00:00:00
abstract：:Endothelin-1 (ET-1) is a potent vasoconstrictor peptide derived from endothelium. The presence of ET-1 in human vascular endothelium and in the plasma suggests that it may play a role in the regulation of vascular tone and blood pressure (BP) in humans. The aim of this study was to evaluate the behaviour of plasma ET-...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
abstract：:The presence of hepatic steatosis was determined in 180 middle-aged male workers by ultrasonography and was found in 39 (22%) of them. Body mass index (BMI), systolic and diastolic blood pressure (BP) and serum levels of asparate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transpeptidase ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-02-01 00:00:00
abstract：:Chronic dynamic (aerobic) exercise decreases central arterial stiffness, whereas chronic resistance exercise evokes the opposite effect. Nevertheless, there is little information available on the effects of acute bouts of exercise. Also, there is limited data showing an increase of central arterial stiffness during ac...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2008.4
更新日期：2008-05-01 00:00:00
abstract：:For nearly two decades, the National High Blood Pressure Education Programme has administered a programme of public, patient, and professional education in an effort to reduce uncontrolled hypertension, an important public health problem in the USA. A broad network has been established and many partners have joined fo...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：
更新日期：1992-12-01 00:00:00
abstract：:The purpose of this study was to examine the pattern of diurnal variation of blood pressure in normotensive working women, and to assess the effect of work stress on this pattern. The subjects were 121 normotensive (based on clinic readings less than 140/90 mmHg) young women (age = 30.2 +/- 7.3 years; range 20-50) who...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：:Consistent reports indicate that hypertension is a particularly common finding in black populations. Hypertension occurs at younger ages and is often more severe in terms of blood pressure levels and organ damage than in whites, resulting in a higher incidence of cardiovascular disease and mortality. This review provi...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/jhh.2017.18
更新日期：2017-08-01 00:00:00
abstract：:The aim of this study is to investigate how the blood pressure (BP) circadian rhythm (CR) is influenced by life style. Two groups of subjects were recruited from Nepal and Japan because of the extremely different occupational routines of these countries. The Nepalese represent a rural culture, while the Japanese refle...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：:To clarify the natriuretic action of endogenous atrial natriuretic peptide (ANP) in patients with essential hypertension (EHT), we examined the relationship between ANP release and urinary sodium excretion in response to hypertonic saline infusion. Plasma ANP levels increased from 13.3 +/- 2.0 pg/ml to 37.0 +/- 3.0 pg...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Blood pressure (BP) measurement is the basis for the diagnosis and management of arterial hypertension. The aim of this study was to compare BP measurements performed in the office and at home (home blood pressure monitoring, HBPM) in children and adolescents with chronic arterial hypertension. HBPM was performed by t...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2008.167
更新日期：2009-07-01 00:00:00
abstract：:Physical exercise can increase urinary albumin excretion rate (UAER) in diabetic patients without microalbuminuria at rest (stage II diabetic nephropathy) or with baseline microalbuminuria (stage III diabetic nephropathy). The aim of this study was to compare the acute effects of captopril, an ACE inhibitor, and nifed...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1991-06-01 00:00:00
abstract：:Primary aldosteronism (PA), the most common cause of secondary hypertension, is a well-recognized condition that can lead to cardiovascular and renal complications. PA is frequently left undiagnosed and untreated, leading to aldosterone-specific morbidity and mortality. In this review we highlight the evidence linking...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/s41371-019-0294-8
更新日期：2020-01-01 00:00:00
abstract：:Obstructive sleep apnoea (OSA) and hyperaldosteronism are very common in subjects with resistant hypertension. We hypothesized that aldosterone-mediated chronic fluid retention may influence OSA severity in patients with resistant hypertension. We tested this in an open-label evaluation by assessing the changes in the...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章
doi：10.1038/jhh.2009.96
更新日期：2010-08-01 00:00:00
abstract：:A total of 930 patients have been evaluated for safety in a programme of clinical trials for lisinopril-hydrochlorothiazide combination treatment. Combination therapy with these two agents is generally well tolerated. In clinical trials, adverse experiences in patients treated with a lisinopril-hydrochlorothiazide com...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：:Hypertension (HTN) related to health-promoting behaviors (HPB) and quality of life (QOL) in older Chinese has not been clearly identified. We sought to compare the HPB and QOL of elderly adults (aged ≥60) living with HTN in China to a community normotensive control group. Using multistage stratified cluster sampling, ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-018-0073-y
更新日期：2018-09-01 00:00:00
abstract：:Seventeen untreated and 36 treated hypertensives aged 65 years or more were referred to our clinic because of repeated values of systolic blood pressure > or = 160 mmHg and diastolic blood pressure > or = 95 mmHg. All 53 patients underwent 24h blood pressure monitoring during their customary daily activities. Eleven (...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：:Both brachial blood pressure (BP) level and its variability (BPV) significantly associate with left ventricular (LV) structure and function. Recent studies indicate that aortic BP is superior to brachial BP in the association with LV abnormalities. However, it remains unknown whether aortic BPV better associate with L...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2017.37
更新日期：2017-10-01 00:00:00
abstract：:C-reactive protein (CRP), the prototypical acute-phase reactant, is one of the most widely known biomarkers of cardiovascular disease. Circulating levels of CRP are clinically used to predict the occurrence of cardiovascular events and to aide in the selection of therapies based on more accurate risk assessment in ind...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/jhh.2013.111
更新日期：2014-07-01 00:00:00
abstract：:It has been suggested that the deletion polymorphism of the angiotensin-converting enzyme (ACE) genotype may be important in the development of left ventricular hypertrophy (LVH). In order to test this hypothesis we investigated the interaction between blood pressure (BP), LVH and ACE genotype in 86 previously untreat...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000491
更新日期：1997-09-01 00:00:00
abstract：OBJECTIVE:To compare the efficacy, tolerability, and safety of once-daily therapy with amlodipine 5 mg/benazepril 10 mg vs amlodipine 5 mg, benazepril 10 mg, and placebo. DESIGN:Randomised, double-blind, placebo-controlled, parallel-group, multicentre trial. SETTING:Twenty-two clinical centres, including private prac...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/sj.jhh.1001217
更新日期：2001-07-01 00:00:00
abstract：:A study of doxazosin added to baseline therapy with a beta-adrenoceptor blocker plus a diuretic in the treatment of patients 'resistant' to the baseline therapy, showed that it was effective and generally well tolerated. The study was, however, open-label and lacked comparison with other third-line drugs. ...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:Hypertension is common in West Africa and likely to become more common as urbanisation increases. There are at present few facilities for the detection and management of hypertension so the influence it has on overall morbidity and mortality in the population is not clear. The objectives of the study were to assess: (...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000726
更新日期：1999-01-01 00:00:00
abstract：:The treatment of hypertension is based on an assessment of the balance between the effects of therapy on survival on the one hand and effects of the patient's symptoms and well-being on the other. The concept of quality of life is used to summarise the latter effects. Preservation of quality of life involves both the ...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：
更新日期：1993-02-01 00:00:00
abstract：:Little is known about how aortic waveform parameters vary with ethnicity and lifestyle factors. We investigated these issues in a large, population-based sample. We carried out a cross-sectional analysis of 4798 men and women, aged 50-84 years from Auckland, New Zealand. Participants were 3961 European, 321 Pacific, 2...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2016.78
更新日期：2017-05-01 00:00:00
abstract：:The purpose of this study is to review the role of dopamine in hypertension and associated conditions. The analysis of literature indicates that present knowledge is mostly based on poor markers and indirect evidence of dopaminergic activity and only few molecular biological data. Alternative markers such as plasma do...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/sj.jhh.1000870
更新日期：1999-09-01 00:00:00
abstract：:In view of the low sensitivity of Sokolow-Lyon voltage criteria in the assessment of electrocardiographic left ventricular hypertrophy (ECG LVH) in overweight subjects, we determined its clinical utility in 1840 lean and 3555 overweight subjects with hypertension. They were followed prospectively over an average of 11...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究
doi：10.1038/jhh.2008.102
更新日期：2009-01-01 00:00:00
