Effect of oral calcium supplementation on blood pressure in patients with previously untreated hypertension: a randomised, double-blind, placebo-controlled, crossover study.

Abstract:

:It has been claimed that calcium lowers BP. The present randomised, double-blind, placebo-controlled crossover study is the first to investigate the effect on BP of a high oral dose of calcium given for a long period to patients with previously untreated hypertension. Elemental calcium (2 g) was administered for 12 weeks interchanging with a period of 12 weeks of placebo. Twenty patients completed the protocol. There was no significant difference in change of BP during the period of additional calcium intake when compared with placebo (P = 0.33). The risk of not detecting a real BP-lowering effect of calcium of at least 3 mmHg was < 5%. No evidence for the existence of a subgroup of 'responders' was found. It is concluded that a high daily dose of calcium supplementation given for 12 weeks does not decrease BP in previously untreated patients with mild to moderate hypertension.

journal_name

J Hum Hypertens

authors

Galløe AM,Graudal N,Møller J,Bro H,Jørgensen M,Christensen HR

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

43-5

issue

1

eissn

0950-9240

issn

1476-5527

journal_volume

7

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 杂志文章,meta分析

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    pub_type: 临床试验,杂志文章

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