Abstract:
:In a 10 year prospective study, we investigated the utility of the level of serum gamma-glutamyl transferase (GGT), a biological marker of alcohol consumption, in predicting the development of hypertension in Japanese male drinkers, all of whom lived in a rural community. The study included 77 men, aged 30-69 years, who were normotensive (SBP < or = 140 mmHg and DBP < or = 90 mmHg) and who had no prior history of antihypertensive treatment at baseline (1979-80). Hypertension was defined as SBP of > 140 mmHg and/or DBP of > 90 mmHg and/or starting antihypertensive medication. The age-adjusted relative risk for subjects with a serum GGT level of 20 U/l or higher compared with those with a level of < 10 U/l was 4.18 (95% confidence interval, 1.59-11.01, P = 0.004). The relative risk remained significant after adjustment for baseline BP level and the amount of alcohol consumption. These results suggest that the serum GGT levels may predict the future development of hypertension among drinkers.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Miura K,Nakagawa H,Nakamura H,Tabata M,Nagase H,Yoshida M,Kawano Ssubject
Has Abstractpub_date
1994-06-01 00:00:00pages
445-9issue
6eissn
0950-9240issn
1476-5527journal_volume
8pub_type
杂志文章abstract::Often a single blood pressure (BP) measurement is used to diagnose and manage hypertension in busy clinics. However, repeated BP measurements have been shown to be more representative of the true BP status of the individual. Improper measurement of office BP can lead to inaccurate classification, overestimation of a p...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/s41371-019-0200-4
更新日期:2019-08-01 00:00:00
abstract::The objectives of the study were to appraise the knowledge which the patients have about their hypertension, and to assess the knowledge and involvement of pharmacists in the management of the hypertensive patient. All the pharmacies in the Poitou-Charentes area were invited both to participate in a training session a...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001859
更新日期:2005-07-01 00:00:00
abstract::In patients with severe hypertension, chronic heart failure or a history of stroke, the lower limit of autoregulation of cerebral blood flow (CBF) is shifted to higher levels of blood pressure (BP) than those observed in healthy subjects. The aim of pharmacotherapy for hypertensive patients with an impaired autoregula...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001735
更新日期:2004-10-01 00:00:00
abstract::Hypertension may influence the atherosclerotic process of large arteries via pressure and shear forces. The pressure force dilates and stiffens arteries because of the non-linear elastic behaviour of arterial walls. This partly explains the increased diameter and decreased compliance of the brachial artery in hyperten...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:
更新日期:1991-08-01 00:00:00
abstract::Left ventricular hypertrophy (LVH) is a powerful cardiovascular risk factor and has previously been related to endothelium-dependent vasodilation (EDV) in hypertensive patients. In the Prospective Investigation of the Vasculature in Uppsala Seniors study, different techniques to evaluate EDV in different types of vess...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2008.61
更新日期:2008-11-01 00:00:00
abstract::This study endeavours to clarify the effect of alcohol consumption on changes in the blood pressure of Japanese men. The subjects, who were followed from 1990 to 1995, were 2189 male normotensive steelworkers aged from 40 to 54 years in 1990. Drinking habits were represented by two variables: average daily baseline al...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001191
更新日期:2001-06-01 00:00:00
abstract::Low-dose diuretics are recommended for the initial choice of antihypertensive therapy in the 7th US Joint National Committee report and are accepted as an appropriate choice among other classes of drugs in the 2003 European Society of Hypertension guidelines. The rationales for the use of low-dose diuretics include th...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:10.1038/sj.jhh.1001798
更新日期:2004-12-01 00:00:00
abstract::Systemic hypertension is a common condition associated with significant morbidity and mortality. Hypertension confers cardiovascular risk by causing target-organ damage that includes retinopathy in addition to heart disease, stroke, renal insufficiency and peripheral vascular disease. The recognition of hypertensive r...
journal_title:Journal of human hypertension
pub_type: 杂志文章,评审
doi:10.1038/sj.jhh.1001472
更新日期:2002-10-01 00:00:00
abstract::We have studied prospectively the acute blood pressure lowering effect on an oral dose of captopril, 25 mg in 240 hypertensive patients. The mean relative reduction of systolic and diastolic BP was 16 and 15% respectively and the mean time to the mean arterial pressure nadir was 59 minutes. Systolic BP fell by more th...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract::To investigate the involvement of the sympathetic nervous system and cell membrane sodium transport in hypertensive cardiac hypertrophy, we divided 51 middle-aged male patients with essential hypertension into cardiac hypertrophy and noncardiac hypertrophy groups. We then compared the plasma noradrenaline concentratio...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract::It has been suggested that the prevalence of coronary artery disease (CAD) is steadily increasing in sub-Saharan Africa. To address this issue, we conducted a Medline search of English language articles on cardiovascular diseases-and specifically CAD in Africa- from 1966 to 1997. The prevalence of CAD and related comp...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001562
更新日期:2003-06-01 00:00:00
abstract::This is the first report of long-term use (one year) of isradipine, a new dihydropyridine calcium channel blocker, in the treatment of elderly patients with essential hypertension. Patients completing a three month, double-blind, multicentre study comparing isradipine to hydrochlorothiazide (HCTZ) were eligible to enr...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:1994-12-01 00:00:00
abstract::This study investigates socioeconomic differences in prevalence, awareness, control and self-management of hypertension in rural China. A cross-sectional survey was conducted among four ethnic minority groups in Yunnan Province: Na Xi, Li Shu, Dai and Jing Po. Approximately 5532 consenting individuals aged ⩾35 years (...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2016.87
更新日期:2017-06-01 00:00:00
abstract::Endothelin-1 (ET-1) is a potent vasoconstrictor peptide derived from endothelium. The presence of ET-1 in human vascular endothelium and in the plasma suggests that it may play a role in the regulation of vascular tone and blood pressure (BP) in humans. The aim of this study was to evaluate the behaviour of plasma ET-...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1995-11-01 00:00:00
abstract::We have investigated 59 patients with mild-to-moderate uncomplicated essential hypertension in order to estimate whether salt sensitivity is associated with greater urinary albumin excretion. Patients whose average mean blood pressure (BP) value on day 5 of the high-sodium regimen (300 mmol/l NaCl) exceeded 10 mm Hg o...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract::The current study comprehensively examined the association between common variants in the Na(+)-coupled bicarbonate transporter (NCBT) genes and blood pressure (BP) responses to dietary sodium intervention. A 7-day low-sodium followed by a 7-day high-sodium dietary intervention was conducted among 1906 Han participant...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章
doi:10.1038/jhh.2015.113
更新日期:2016-09-01 00:00:00
abstract::Ambulatory blood pressure variability (ABPV) is a predictor of cardiovascular risk in hypertensives. Factors that contribute to ABPV are not well described. This pilot study aimed to investigate the relationship between ABPV and urine catecholamine metabolites in order to rationalise further therapeutic intervention i...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2014.23
更新日期:2015-01-01 00:00:00
abstract::The study objective was to compare blood pressure (BP) measurement by the Hawksley random-zero sphygmomanometer and the standard mercury sphygmomanometer. Comparison of simultaneous 'blind' BP measurements were made using the Hawksley random-zero sphygmomanometer and the standard mercury sphygmomanometer linked by a Y...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1995-05-01 00:00:00
abstract::In the last decades, the prevalence of obesity has increased in the Taiwanese population. This has the potential to impact on the risks of cardiovascular diseases and diabetes. This study investigated trends in the changes in several indices of obesity in the last decade, and the relationship between blood pressure (B...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2010.33
更新日期:2011-02-01 00:00:00
abstract::A 16 year old boy presented with accelerated hypertension and urinary tract obstruction caused by phimosis. Relief of the obstruction by circumcision reversed the hypertension. We believe that accelerated hypertension secondary to phimosis has not previously been described. ...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::Maternal hypertension and preeclampsia are associated with greater risk of hypertension in childhood, and cardiovascular events in adulthood. However, whether preeclampsia affects blood pressure (BP) in the newborn period is unclear. Previous neonatal studies were based on small sample sizes, very low birth weight or ...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2014.50
更新日期:2015-02-01 00:00:00
abstract::Since endothelin production is stimulated in vitro by insulin, we performed this study to evaluate in vivo the relationships between endothelin and insulin plasma levels during a glucose load. We studied 28 subjects; 17 with normal glucose tolerance (NGT) and 11 with impaired glucose tolerance (IGT). Ten of the subjec...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1000386
更新日期:1997-01-01 00:00:00
abstract::The reasons why women and men are treated with different antihypertensive drugs are not clear. Whether socioeconomic factors influence prescription patterns and blood pressure control differently in women and men has not been investigated. This cross-sectional study performed in a cohort of hypertensive patients from ...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2014.100
更新日期:2015-06-01 00:00:00
abstract::The increased viscosity of blood of hypertensive patients can be assumed to be a risk factor for the development of cardiovascular diseases. The aim of the present study was to elucidate whether anti-hypertensive treatment has any impact on blood rheology. Twenty patients with previously untreated hypertension who con...
journal_title:Journal of human hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1996-03-01 00:00:00
abstract::Irregular atrial pressure, defective folate and cholesterol metabolism contribute to the pathogenesis of hypertension. However, little is known about the combined roles of the methylenetetrahydrofolate reductase (MTHFR), apolipoprotein-E (ApoE) and angiotensin-converting enzyme (ACE) genes, which are involved in metab...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2014.53
更新日期:2015-02-01 00:00:00
abstract::The aim of this study was to evaluate the prevalence of renal artery stenosis in patients with clinical signs of peripheral vascular disease and hypertension. One hundred patients, mean age 69 years (range 45-88) with symptoms and clinical signs of severe peripheral ischemia, underwent aortography to determine the deg...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:
更新日期:1996-02-01 00:00:00
abstract::Reactive oxygen species are produced during exercise. The antioxidants prevent or limit tissue damages by these species in physiological conditions. In particular, ascorbate and urate scavenge peroxynitrite, which can alter the function of many molecules, including the lecithin-cholesterol acyltransferase (LCAT) enzym...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/sj.jhh.1001617
更新日期:2003-11-01 00:00:00
abstract::Hypertension (HTN) is an important cause for chronic kidney disease (CKD). There is a paucity of studies exploring the association of HTN with CKD from rural India. The objective of the study was to determine the prevalence and the determinants for HTN in a rural population in South India, focusing on the association ...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/jhh.2016.81
更新日期:2017-05-01 00:00:00
abstract::This corrects the article DOI: 10.1038/jhh.2016.78. ...
journal_title:Journal of human hypertension
pub_type: 已发布勘误
doi:10.1038/jhh.2017.60
更新日期:2017-11-01 00:00:00
abstract::Early life prevention of obesity and associated metabolic disease is necessary to address the current obesity epidemic. Latino children have a higher risk of obesity, and associated comorbidities such as hypertension than Caucasian children. This study focuses on perinatal childhood and maternal risk factors associate...
journal_title:Journal of human hypertension
pub_type: 杂志文章
doi:10.1038/s41371-020-0306-8
更新日期:2020-11-01 00:00:00