Abstract:
:The objectives of this study were two-fold: to identify tear histamine content and its relationship to changes in tear histaminase activity during the early (EPR) and late phases (LPR) of the allergic reaction induced by a conjunctival provocation test (CPT) and to evaluate the effects of lodoxamide on histamine release and allergic signs and symptoms during EPR and LPR. A baseline CPT was administered to 20 allergic patients with no baseline signs or symptoms of allergy. Clinical signs and symptoms were evaluated after 20 minutes and 6 hours. Tear samples were taken after 5-10 minutes and after 6 hours for subsequent analyses of cytology and histamine content (ELISA). Patients were then randomly assigned to receive lodoxamide or placebo four times daily for one week in a double-masked fashion. A second CPT was done after this therapy and the same parameters were re-evaluated. During EPR, tear histamine increased significantly with respect to baseline values (p < 0.05). During LPR, tear histamine increased significantly (p < 0.05) only in histamine inactivated samples. Histaminase enzymes were also significantly less active during the EPR (5.5 +/- 0.7) than the LPR (9.9 +/- 2.3) and at baseline. Histamine levels significantly correlated with allergic signs and symptoms (p < 0.05) only during the EPR. Lodoxamide significantly reduced histamine release during EPR (p < 0.05), allergic signs and symptoms during both EPR (p < 0.001) and LPR (p < 0.005), and tear cytology counts during LPR. In conclusion, greater histaminase activity may account for the smaller amount of tear histamine generally found during LPR, while these enzymes seem to play less of a role during the surge of histamine release and activity in the EPR. Lodoxamide was shown to ideally inhibit various aspects of the allergic reaction: clinical signs and symptoms in both the early and late phases, the primarily EPR-related peak of histamine release, and the primarily LPR-related changes in tear cytology.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Leonardi AA,Smith LM,Fregona IA,Salmaso M,Secchi AGsubject
Has Abstractpub_date
1996-04-01 00:00:00pages
106-12issue
2eissn
1120-6721issn
1724-6016journal_volume
6pub_type
临床试验,杂志文章,随机对照试验abstract:PURPOSE:To compare retinal nerve fiber layer thickness (RNFLT) and inner macula thickness changes measured with Fourier-domain optical coherence tomography (FD-OCT) and scanning laser polarimetry during the course of acute optic neuritis (ON). METHODS:Nine eyes of 7 consecutive patients with multiple sclerosis (MS) we...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/EJO.2010.5844
更新日期:2011-07-01 00:00:00
abstract:INTRODUCTION:The aim of the study was to evaluate complications of cataract surgery in eyes filled with silicone oil. METHODS:This retrospective, noncomparative, consecutive case series analyzed medical files of patients with eyes filled with silicone oil undergoing cataract surgery. Phacoemulsification with posterior...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672117753700
更新日期:2018-07-01 00:00:00
abstract:PURPOSE:To evaluate perioperative changes in blood coagulation in patients undergoing retinal detachment surgery. MATERIALS:Prospective study of 56 patients, aged from 19 to 82 (mean +/- S.D. 53 +/- 16.8) years, undergoing retinal detachment surgery (encirclement with scleral buckling) under general anesthesia. Exclud...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210001000408
更新日期:2000-10-01 00:00:00
abstract::Idiopathic macular holes have long been considered to be a stable, untreatable condition with little or no chance of spontaneous visual improvement. Within the last few years, surgical intervention has been developed for the management of idiopathic Stage 3 and Stage 4 holes. With pars plana vitrectomy surgery, at lea...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,评审
doi:
更新日期:1994-01-01 00:00:00
abstract:PURPOSE:Currently there is little information available about the corneal thickness values of healthy emmetropic subjects. Therefore, the authors decided to analyze the corneal thickness in healthy emmetropic subjects. METHODS:The authors analyzed the difference in thickness values between the thinnest corneal site an...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210601600207
更新日期:2006-03-01 00:00:00
abstract:PURPOSE:This is a report of 2 cases of cutis aplasia and cutis marmorata telangiectasia with associated retinal detachment. METHODS:Retrospective case report. RESULTS:Illustration of ophthalmic associations of the rare congenital dermatologic presentations and description of successful treatment with laser photocoagu...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000137
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:Cataract formation represents a serious problem in the elderly, and has a large impact on healthcare budget. The oxidative stress form and intensity might determine the cataract type and pigmentation, making efforts in the cataract prevention challenge more complex. METHODS:This is a retrospective cross-sectio...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210801800501
更新日期:2008-09-01 00:00:00
abstract:PURPOSE:Polymethylmethacrylate (PMMA) segments are normally used in additive surgery to treat both corneal ectasia post laser-assisted in situ keratomileusis and keratoconus. The aim of this work was to develop an experimental animal model to induce wound healing in the deep stroma in corneas of hens. METHODS:PMMA seg...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067211002000108
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:To evaluate visual and anatomic outcomes following pars plana vitrectomy and intravitreal or subretinal tissue plasminogen activator for submacular hemorrhage in patients with age-related macular degeneration. METHODS:This was a retrospective study on patients with a minimum follow-up of 12 months undertaken a...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119891625
更新日期:2019-12-09 00:00:00
abstract:PURPOSE:To estimate the incidence of retinopathy of prematurity and other ocular problems in a population of preterm infants. METHODS:This retrospective study included all infants with gestational age (GA) <32 weeks and birth weight (BW) <1500 g cared for in the neonatal intensive care unit (NICU) over a period of nin...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210201200610
更新日期:2002-11-01 00:00:00
abstract:PURPOSE:To report on whole body positron emission tomography/computed tomography (PET/CT) screening for metastasis at diagnosis of primary uveal melanoma. METHODS:Since August 2003, 333 consecutive patients were diagnosed with uveal melanoma and underwent whole body screening for metastatic disease with PET/CT along w...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000049
更新日期:2012-03-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of 3 different surgical techniques for convergence excess esotropia: augmented medial rectus recession, medial rectus recession plus Faden, and slanted medial rectus recession. METHODS:Twenty-nine patients with convergence excess esotropia were divided into 3 groups. Group A included 9...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.2010.5225
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:The main purpose of this prospective study was to compare the efficacy, local tolerance, and safety of topical lomefloxacin 0.3% and topical ofloxacin 0.3% in the treatment of acute bacterial conjunctivitis. PATIENTS AND METHODS:Forty patients with acute bacterial conjunctivitis were included in a randomized, ...
journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1999-10-01 00:00:00
abstract:PURPOSE:While elevated intraocular pressure (IOP) is a major risk factor for glaucoma, only about 1% of patients with 25 mmHg develop the condition each year. Since a sizeable proportion of the ganglion cells are already lost when the visual field losses are apparent, the aim is to identify patients with elevated IOP i...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1177/112067210101102s05
更新日期:2001-07-01 00:00:00
abstract:PURPOSE:To assess corneal tissue modifications after riboflavin-UVA-induced cross-linking of corneal collagen in patients with progressive keratoconus as well as regeneration of epithelium and subepithelial nerve plexus by in vivo HRT II system confocal microscopy in humans. METHODS:Ten patients with progressive kerat...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210601600405
更新日期:2006-07-01 00:00:00
abstract:PURPOSE:To report a case of recurrent cytomegalovirus (CMV) corneal endotheliitis after penetrating keratoplasty. METHODS:Penetrating keratoplasty (PK) was performed in a 49-year-old man with bullous keratopathy. Pigmented keratic precipitates (KPs) were found in the corneal endothelium of the graft 13 days after surg...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067211002000231
更新日期:2010-03-01 00:00:00
abstract:PURPOSE:To describe the management with intracameral recombinant tissue plasminogen activator (rtPA) of severe fibrin effusion after phacoemulsification, and its prevention with sustained-release dexamethasone intravitreal implant. METHODS:A 59-year-old man with chronic HLA-B27-associated uveitis underwent phacoemulsi...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000442
更新日期:2014-07-01 00:00:00
abstract::Bruch's membrane, an extracellular matrix located between the retinal pigment epithelium and the choroid, plays a vital role as structural and functional support to the retinal pigment epithelium. Dysfunction of Bruch's membrane in both age-related macular degeneration and other ocular diseases is caused mostly by ext...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1177/1120672120919337
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To evaluate the effect of IOP lowering on the capillary density of optic nerve head and retinal nerve fiber layer in patients with primary open angle glaucoma. METHODS:Twenty eyes of 14 glaucomatous patients and 15 eyes of nine normal patients were enrolled. The most appropriate hypotonic treatment was applied...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120967233
更新日期:2020-10-29 00:00:00
abstract:PURPOSE:To investigate the impact of diabetes mellitus-induced changes on intraocular pressure measurements using Goldmann applanation tonometry, Ocular Response Analyzer, and Corvis ST. METHODS:Measurements were done using Goldmann applanation tonometry, Ocular Response Analyzer, and Corvis ST in 69 diabetic patients...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119890517
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To report the evolution of optic disk noncalcified astrocytic hamartomas in a patient with retinitis pigmentosa throughout 8 years of follow-up. METHODS:Case report. RESULTS:A 42-year-old white man with a diagnosis of retinitis pigmentosa was referred to our medical retinal center for the first time in 2010, ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672118804386
更新日期:2019-09-01 00:00:00
abstract:PURPOSE:To quantify the maximal level of temperature and the time the maximal temperature is achieved and correlate the temperature parameters to the mean rate of endothelial cell loss after standardized ultrasound delivery assisted with four viscoelastic substances or different temperature of balanced salt solution (B...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:2005-11-01 00:00:00
abstract:PURPOSE:To examine the nature and frequency of ocular side effects due to systemic target therapy with BRAF and MEK inhibitors as well as immunotherapy with cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed cell death 1 (PD-1) monoclonal antibodies used in the treatment of cutaneous malignant melanoma (CMM). DE...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120930688
更新日期:2020-05-31 00:00:00
abstract::Abstracts from the 25th Meeting of the European Association for the Study of Diabetes Eye Complications Study Group (EASDec). Turin, Italy - June 26-28, 2015. ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000612
更新日期:2015-04-22 00:00:00
abstract:INTRODUCTION:Parinaud syndrome, caused by midbrain infarction, usually manifests as an ocular conjugate upgaze palsy. However, this sign should not point out straightforwardly to Parinaud syndrome, as other lesions in the central nervous system could cause it. CASE DESCRIPTION:The case of a 47-year-old woman showing a...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119855845
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To evaluate the effect on lacrimal function and ocular complications in patients with severe acne vulgaris during systemic treatment with 13-cis-retinoic acid (isotretinoin). METHODS:Forty patients with acne vulgaris were treated with systemic isotretinoin at dosages of 0.5-1 mg/kg per day for two months. Full...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:To assess the role of 10-2 visual field (VF) test in different stages of glaucoma. METHODS:In our prospective comparative study, 24-2 and 10-2 VF tests were done for 115 eyes with different stages of glaucomatous damage or glaucoma suspects. Optical coherence tomography (OCT) was performed in 79 eyes. We com...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119836904
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE OF THE STUDY:Inborn lens opacity is the most frequent cause of childhood blindness. In this study, we aimed to define the presumed genetic cause of a congenital cataract present in a Mauritanian family over the last nine generations. METHODS:A family history of the disease and eye examination were carried ou...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672118804757
更新日期:2019-11-01 00:00:00
abstract::Ultrasound tissue characterization parameters of size and acoustic concentration can be used to sub-classify uveal melanoma and estimate the patient's risk of death. Histologically determined microcirculation patterns have also been found to sub-classify uveal melanoma and predict patient's risk of death. This study e...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1995-04-01 00:00:00
abstract:PURPOSE:To report a case of Escherichia coli endophthalmitis after trans-scleral resection of an uveal melanoma. METHODS:A large ciliary body melanoma was treated by trans-scleral resection and full-thickness sclerectomy because of epibulbar tumor extrusion, followed by adjuvant ruthenium plaque therapy. RESULTS:Two ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210201200517
更新日期:2002-09-01 00:00:00