Abstract:
PURPOSE:To assess corneal tissue modifications after riboflavin-UVA-induced cross-linking of corneal collagen in patients with progressive keratoconus as well as regeneration of epithelium and subepithelial nerve plexus by in vivo HRT II system confocal microscopy in humans. METHODS:Ten patients with progressive keratoconus were treated by riboflavin-UVA-induced cross-linking of corneal collagen, involving assessment of ultrastructural modifications of the corneal epithelium and subepithelial nerve plexus by HRT II system confocal microscopy. Treatment included instillation of 0.1% riboflavin-20% dextrane solution 5 minutes before UVA irradiation and every 5 minutes for a total of 30 minutes. Radiant energy was 3 mW/cm 2 or 5.4 Joule/cm 2 and the source was dual UVA (370 nm) light-emitting LED. The protocol included the operation followed by antibiotic medication and eye dressing with a soft therapeutic contact lens. Changes in epithelium and subepithelial and stromal nerve plexus were assessed by HRT II system confocal microscopy in vivo. RESULTS:After 5 days of soft contact lens wearing, corneal epithelium has a regular morphology and density. Disappearance of subepithelial stromal nerve fibers was observed in the central irradiated area where, 1 month after the operation, initial reinnervation was microscopically observed. No changes in nerve fibers were observed in the peripheral untreated with a clear lateral transition between the two areas. Six months after the operation, the anterior subepithelial stroma was recolonized by nerve fibers with restoration of corneal sensitivity. CONCLUSIONS:HRT II system confocal microscopy confirms corneal epithelium restore and re-innervation after riboflavin-UVA-induced collagen cross-linking directly in vivo in humans.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Mazzotta C,Traversi C,Baiocchi S,Sergio P,Caporossi T,Caporossi Adoi
10.1177/112067210601600405subject
Has Abstractpub_date
2006-07-01 00:00:00pages
530-5issue
4eissn
1120-6721issn
1724-6016journal_volume
16pub_type
杂志文章abstract:PURPOSE:To evaluate the efficacy and safety of intravitreal dexamethasone implant in treatment naïve eyes with diabetic macular edema (DME). METHODS:A retrospective analysis of treatment naïve eyes with DME which received intravitreal dexamethasone implant between January 2016 and March 2018 was done. Demographic deta...
journal_title:European journal of ophthalmology
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journal_title:European journal of ophthalmology
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journal_title:European journal of ophthalmology
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journal_title:European journal of ophthalmology
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journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of ophthalmology
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